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증례 : 호흡기 ; GM-CSF 흡입치료로 호전된 폐포단백증 1예
장복순 ( Bok Soon Chang ),노정원 ( Jung Won Noh ),옥창수 ( Chang Soo Ok ),이가연 ( Ga Yeon Lee ),손서영 ( Seo Young Sohn ),방선하 ( Sun Ha Bahng ),정만표 ( Man Pyo Chung ) 대한내과학회 2011 대한내과학회지 Vol.80 No.5
표준치료법인 전 폐하세척술에서 효과를 보지 못했던 폐포단백증 환자에서 GM-CSF 흡입법을 이용하여 임상적으로 증상, 폐기능, 흉부단층촬영에서 호전을 보인 증례를 보고하고자 한다. Pulmonary alveolar proteinosis (PAP) is a rare condition that is treated using whole lung lavage. A recent study suggested that granulocyte-macrophage colony stimulating factor (GM-CSF) plays roles in both the pathogenesis and treatment of PAP. We present a 69-year-old man with PAP who deteriorated despite bilateral whole lung lavage; that said, his symptoms, chest X-ray findings, and pulmonary function test improved after GM-CSF inhalation therapy over 12 months. GM-CSF therapy is an effective treatment modality for PAP.
장성만,손지훈,이준영,최지환,조성진,전홍진,함봉진,이동현,조맹제 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5
목적 국내의 여러 역학 조사에 따르면 한국인은 서구에 비하여 우울증의 유병률이 낮은 것으로 보고되고 있다. 낮은 유병률에 대하여 서구에서 정의하는 우울증의 진단 기준이 한국인의 문화에 맞지 않다는 진단 기준의 오류를 제시하거나, 실제로 유병률이 낮다는 설명을 시도하기도 하였다. 본 연구는 DSM-IV에서 제시하는 우울증의 진단 기준에 대하여 한국인의 반응 특성을 알아보고자 한다. 방법 2001년 KECA 연구에 응답한 만 18세 이상 65세 미만의 6,275명을 대상으로 하였다. 한국어판 CIDI (K-CIDI)를 통해 정신장애의 이환을 진단하였으며, K-CIDI 내의 우울장애 진단 기준만을 추출하여 분석하였다. 분석은 문항반응이론(Item Response Theory)을 적용하였다. 결과 한국인에서 DSM-IV의 주요우울장애 진단 기준의 오류는 없었으나, 진단 기준의 역치는 높았다. 한국인이 호소하는 우울증상으로서 "피로감"과 "집중력 저하", "수면 변화"는 진단되는 우울증의 초기부터 잘 나타나는 증상 들이며, "정선운동변화", "죽음/자살사고", "무가치함/죄책감"은 보다 심한 우울증에서 잘 나타나는 증상들이었다. 결론 DSM-IV가 제시하는 주요우울장애 진단 기준은 한국인의 우울증을 평가하는 데 있어 타당하기는 하나, 진단 기준의 역치가 높다. 우울증의 중증도에 따라 호소하는 증상들이 달랐다. Baekgrounds : Many Korean epidemiologic studies reported lower prevalence rates of depression than those of Western countries. For the low prevalence, it is explained that there's something wrong in the direct application of diagnostic criteria of depression to Korean culture, i.e. categorical fallacy, or it may be truly low-prevalent. We will analyze diagnostic criteria for depression detined by Western. Methods : Six thousand and two hundred seventy-five cummunity dwelling subjects, aged 18-64 years were interviewed by using Korean version of Composite International Diagnostic Interview (K-CIDI). Diagnostic criteria for depression defined by DSM-IV were analyzed using the item response theory. Rcsults : We could not find any fallacies of diagnostic critcria tbr depression defined by DSM-IV when assessing depre-ssion among Koreans. Fatigue, concentration difficultics, and sleep disturbance appeared more fequently in mild depression, while psychomotor change, death/suicide, and worthlessness/guilt did not appear until severe depression. Cunclusion : The diagnostic criteria for depression defined by DSM-IV arc appropriate for the Koreans. There are different responding levels, i.e. threshold, of depressive criteria according to severities of depression. Koreans with depression are more likely to complain of appetite change, but less of worthless or guilty feelings than Western people.
Chang, Hee Jin,Jung, Kyung Hae,Kim, Dae Yong,Jeong, Seung-Yong,Choi, Hyo Seong,Kim, Young Hoon,Sohn, Dae Kyung,Yoo, Byong Chul,Lim, Seok-Byung,Kim, Dae-Hyun,Ahn, Joong-Bae,Kim, Il-Jin,Kim, Jin Man,Yoo Elsevier 2005 Human pathology Vol.36 No.4
<P><B>Summary</B></P><P>In an attempt to improve local control and survival in patients with advanced rectal carcinoma, neoadjuvant chemoradiation therapy (CRT) has been increasingly used in patient management. However, a significant proportion of patients shows poor response to adjuvant CRT. Thus, the ability to predict CRT responsiveness in patients with rectal cancer would benefit effective management. Several molecular markers related to regulation of cell cycle, apoptosis, or DNA repair have been proposed as candidate predictors of therapeutic response to CRT, but, to date, none has been definitively proven to be predictive of CRT response. To evaluate the use of various molecular markers as predictors of the response to CRT in rectal carcinoma, we investigated immunohistochemical expressions of p53, p21<SUP>WAF1/CIP1</SUP>, Bcl-2, Bax, Ki-67, Ku-70, and 2 new candidate markers (histone deacetylase 1 and metabotropic glutamate receptor 4) in pretreatment biopsy samples of 130 rectal carcinomas. We further compared the expressions of these molecular markers with the pathological responses of the tumors after therapy. We found that Bax expression, among the markers studied, was exclusively related to tumor regression. Its expression was significantly higher in the complete response group as compared with the partial response group (54% versus 29%, <I>P</I> = .017). This result confirms that apoptosis plays an important role in tumor response to CRT and provides evidence that Bax may serve as a predictable molecular marker for chemoradiosensitivity in rectal carcinoma.</P>
Sohn, Sang-Kwon,Chang, Man-Sik,Chung, Young-Kuk,Kim, Kyu-Bong,Woo, Tae-Wook,Kim, Sung-Gyu,Choi, Wahn-Soo The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.3
This study was designed to determine biochemical and pharmacological properties of a newly synthesized benzimidazole derivative, 2-amino-4, 5-dihydropyrido [1, 2-a] thiazolo [5, 4-g] benzimidazole (YJA20379-5) in vitro and in vivo. In the leaky membrane vesicles of pig gastric mucosa, YJA20379-5 inhibited the $K^+$-stimulated $H^+$, $K^+$-ATPase activity in a concentration- and time-dependent manner, with $IC_{50}$ values being $43{\mu}\textrm{M}$ and $43{\mu}\textrm{M}$ at pH 6.4 and 7.4, respectively. YJA20379-5, given intraduodenally, had a potent inhibitory effect on the gastric acid secretion in pylorus-ligated rats. The $ED_{50}$ value for acid secretion was 15.4 mg/kg. YJA20379-5, administered orally, also suppressed gastric damages induced by water-immersion stress, indomethacin and ethanol, and duodenal damage induced by mepirizole in rats; the $ED_{50}$ values were 17.6, 4.7, 3.0 and 18.7 mg/kg, respectively. Furthermore, repeated oral administration of YJA20379-5 accelerated the spontaneous healing of acetic acid-induced gastric ulcers in rats. It is concluded that the a-ntisecretory activity of YJA20379-5 appears to be associated with inhibition of $H^+$, $K^+$-ATPase, while its antigastric and antiduodenal lesion activities are primarily related to the antisecretory effect.
정신질환에 의한 기능장애 : 비정신병적 정신질환이 작업상실일수에 미치는 영향
손지훈,조맹제,이준영,최지환,이해우,전홍진,함봉진,장성만 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.1
Objectives : This study was conducted to explore the relationship between non-psychotic, common mental disorders and work loss days, using data from 2001 KECA survey. Methods : Six thousands and two hundred seventy-five community dwelling subjects, aged 18 years or older, were interviewed by using the Korean version of Composite International Diagnostic Interview (K-CIDI). Common mental disorders during last 12 months were assessed by work loss days of past month with questions from the WHO Disablement Assessment Scale version 2 (WHODAS-II). Main analysis was done by Linear and Logistic regressions to identify the association between mental disorders and work loss days. Results : As expected, mental disorders were associated with substantial work loss days. Subjects with major depression had highest work loss days. Many common anxiety disorders like social phobia, specific phobia and posttraumatic stress disorder were also associated with high work loss days. Conclusion : Our results show that a number of common mental disorders might have substantial effect on job function, quality of life and, subsequently, social productivity. Therefore it seems that more attention for public mental health efforts is warranted.