모반세포성 모반에서 발생한 악성 흑자 1 예

장대성(Dae Sung Chang),심주현(Joo Hyun Shim),서성준(Seong Jun Seo),송계용(Kye Yong Song),홍창권(Chang Kwun Hong) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.5

Lentigo maligna(LM) is a pigmented lesion that occurs on the sun-exposed skin of an older patients and may become lentigo maligna melanoma(LMM). Currently the percentage of LM type melanoma appears to be increasing, and this rise has been attributed to increasing UV radiation exposure. In addition to UV radiation, estrogen and progesterone, and nonpermanent hair dyes have been proposed as risk factors. A case is a 66-year-old female with a 3 years history of pigmented patch. She had a gradually enlarging irregular bordered brown to black mottled patch on the right temple area. Histologic examination revealed atypical melanocytes along the basal layer of atrophic epidermis, arranged in solitary units and small nests. Perilesional skin showed many scattered melanophages and regressing nevus cell nests which suggested preexisting nevus underwent regressive change. On the basis of clinicopathologic examination we diagnosed this case as lenigo maligna arising from nevocytic nevus and then we removed the lesion by wide surgical excision and could not find any recurrence until now.

당뇨병에 있어서의 피부발현

홍창권,노병인,장진요 중앙대부설한국의과학연구소 1988 한국의과학 Vol.20 No.2

Guinea Pig에서 국소 부신피질 홀몬제에 의한 피부 부작용

이주협,서성준,김명남,홍창권,노병인 중앙대부설한국의과학연구소 1991 한국의과학 Vol.23 No.3

가족에서 발생한 신경종성 상피병을 보이는 신경섬유종증 2예

한은실(Eun Sil Han),서성준(Seong Jun Seo),홍창권(Chang Kwun Hong),노병인(Byung In Ro) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.4

We reported two cases of elephantiasis neurofibromatosa in a family. The first case was the son of the second case. Both patients showed huge masses and bone changs. They were treated by surgical excision due t,o functional and cosmetic problems. The histopatholog.c findings of the two cases were consistent with neurofibroma, (Kor J Dermatol 1994; 32(4): 724-723)

The Effect of Evening Primrose Oil for the Prevention of Xerotic Cheilitis in Acne Patients Being Treated with Isotretinoin: A Pilot Study

( Kui Young Park ),( Eun Jung Ko ),( In Su Kim ),( Kap Sok Li ),( Beom Joon Kim ),( Seong Jun Seo ),( Myeung Nam Kim ),( Chang Kwun Hong ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.6

Background: The most common adverse effects of oral isotretinoin are cheilitis, skin dryness, dry eyes, and conjunctivitis, whereas evening primrose oil (EPO) is known to improve skin moisture and transepidermal water loss (TEWL) in healthy adults and atopic patients. Objective: To evaluate the clinical efficacy and safety of EPO in preventing xerotic cheilitis in acne patients being treated with oral isotretinoin. Methods: Forty Korean volunteers of Fitzpatrick skin types III and IV, having moderate acne, were enrolled and randomized to receive either isotretinoin with or without EPO for 8 weeks. The efficacy of treatment was evaluated on the basis of global acne grading system scores, number of inflammatory and noninflammatory lesions, TEWL, corneometry, physician’s global assessment, and patient satisfaction. Results: The results after 8 weeks of treatment showed that the TEWL of the lip increased significantly during isotretinoin treatment, whereas the TEWL of the hand dorsum showed no significant change. The increase of the TEWL of the lip was more definite in the control group than in the experimental group. The number of acne lesions decreased significantly in both groups, and there were no differences between them. Conclusion: Our study suggests that the addition of EPO improved xerotic cheilitis in acne patients being treated with oral isotretinoin. However, besides TEWL and corneometry assessments, additional studies are required for a complete understanding of the role of EPO in xerotic cheilitis in acne patients being treated with oral isotretinoin. (Ann Dermatol 26(6) 706∼712, 2014)

P035 Randomized clinical trial to evaluate the efficacy and safety of 1,064-nm short-pulsed Nd:YAG laser for onychomycosis

( Chang Kwun Hong ),( Beom Joon Kim ),( Yeon A No ),( Joon Seok ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Background: Onychomycosis is one of the most prevalent fungal diseases in the general population. However, treatment is of limited effectiveness and must be administered for long periods of time. Systemic antifungal agents are associated with adverse effects. Objectives: We evaluated the clinical efficacy and safety of a 1,064-nm Nd:YAG laser with amorolfine nail lacquer to treat onychomycosis. Methods: The 128 patients were randomly divided to 2 groups: 64 in the experimental group were treated with 1,064-nm Nd:YAG laser therapy and amorolfine nail lacquer; the other 64 were in a control group treated with topical amorolfine lacquer monotherapy. Efficacy was assessed as response rate from standardized photographs with Image Pro^® analysis, microscopic examination, and subjective evaluation. Results: At 16 weeks, the experimental group showed a significantly higher cumulative cure rate than the control group. Clinical therapeutic effects were linked to patient satisfaction. The percent of "very satisfied" or "satisfied" responses was higher in the test group than the control group. The treatment regimen was well tolerated, with transient discomfort observed in the test group. Conclusion: The 1,064-nm Nd:YAG laser with amorolfine nail lacquer was effective and safe for treating onychomycosis. This therapy should be considered an alternative treatment, especially for patients with contraindications to systemic antifungal agents.

P082 Targeting of sebaceous glands to treat acne by micro-insulated needles with radio frequency in a rabbit ear model

( Chang Kwun Hong ),( Jong Hwan Kim ),( Won Jong Oh ),( Beom Joon Kim ),( Hee Su Kim ),( Joon Seok ),( Dong-ho Bak ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Background: Many studies have investigated the application of micro-insulated needles with radio frequency (RF) to treat acne in humans; however, the use of a micro-insulated needle RF applicator has not yet been studied in an animal model. Objectives: The purpose of this study was to evaluate the effectiveness of a micro-insulated needle RF applicator in rabbit ear acne (REA) model. Methods: We investigated the effect of selectively destroying the sebaceous glands using a micro-insulated needle RF applicator on the formation of comedones induced by application of 50% oleic acid and intradermal injection of Propionibacterium acnes in the orifices of the external auditory canals of rabbits. The effects of the device were evaluated using regular digital photography, 3D Primos^® imaging evaluation, skin Visiometer^® microscopic photography and histologic analyses. Results: Use of the applicator resulted in successful selective destruction of the sebaceous glands and attenuated TNF-alpha release in an REA model. The mechanisms may involve inhibition of comedone formation, triggering of the wound healing process, and destruction of the sebaceous glands and papules. Conclusion: The use of micro-insulated needles with RF applicators provides a safe and effective method for improving the appearance of symptoms in an REA model. The current in vivo study confirms that the micro-insulated needle RF applicator is an effective alternative treatment for acne.

Keratoacanthoma in Co - existence with Nevus Sebaceus

Hong, Chang Kwun,Chun, Tae Jong,Ahn, Seung Won,Seo, Seong Joon 대한피부과학회 2000 Annals of Dermatology Vol.12 No.2

Nevus sebaceus of Jadassohn has been referred to as a organoid nevus that classically evolves through three stages and may be associated with a range of skin tumors, and of these, syringocystadenoma papilliferum and basal cell carcinoma have been commonly reported to occur. The occurrence of keratoacanthoma is a very rare event in nevus sebaceus. Herein we report on a 23-year-old man with nevus sebaceus of the cheek. He represents a keratoacanthoma arising within nevus sebaceus.

안드로겐성 탈모증 환자에서 사이토퓨린(Cytopurine)과 펜타데칸산글리세리드(Pentadecanoic Glyceride) 배합 육모제의 유효성 및 안전성 평가에 관한 임상연구

홍창권 ( Chang Kwun Hong ),한태영 ( Tae Young Han ),강한철 ( Han Chyul Kang ),안승원 ( Seung Won Ahn ),안지영 ( Ji Young Ahn ),서성준 ( Seong Jun Seo ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.12

Background: Androgenetic alopecia (AGA) is the most common type of hair loss found in both males and females. Oral finasteride and topical minoxidil are the only drugs approved, till now, by the Food and Drug Administration of USA for the treatment of this condition. Unfortunately, these treatment options are not satisfactory. Therefore, it has been necessary to develop new agents for this psychologically frustrating disease. Objective: This is a 16-week, double-blinded, placebo-controlled, randomized clinical trial to determine whether a new topical agent, cytopurine/pentadecanoic glyceride topical solution, is effective in showing clinical improvements in patients with AGA. Methods: A total of 74 men and 21 women (24∼55 years old) with AGA were treated either with the new topical solution or a placebo, twice daily. Efficacy was evaluated by daily shed hair count, phototrichogram and patients` subjective and investigators` subjective assessments for clinical improvement. All adverse effects were reported during the study. Results: After 16 weeks of therapy, combination cytopurine/pentadecanoic glyceride topical solution treatment resulted in a significant improvement from the baseline in total hair count and daily shed hair count. But there were no statistically significant differences in anagen hair count, mean hair diameter, patients` subjective and investigators` subjective assessments for clinical improvement and side effects between the cytopurine/pentadecanoic glyceride treated and placebo group. Conclusion: We have confirmed the efficacy of combination cytopurine/pentadecanoic glyceride topical solution in treating AGA, by an objective assessment with phototrichogram. (Korean J Dermatol 2007;45(12):1233∼1239)

Tumor Necrosis Factor - α가 각질형성세포의 Superoxide Radical과 Superoxide Dismutase 활성도에 미치는 영향

홍창권(Chang Kwun Hong),서성준(Seong Jun Seo),노병인(Byung In Ro) 대한피부과학회 1995 大韓皮膚科學會誌 Vol.33 No.1

Bsckgaund : Superoxide dismutases(SOD) are important metallo-enzymes which scavenge and dismutase the superoxide free radical. They are thought to be the main enzymes in the antioxidant defense system. In the several cell lines the induction of Mn-SOD expresion by tumor necrosis factor (TNF)-a, which is a known inflammatory cytokine, suggest that Mn-SOD may play a role in the inflammatory process. However, this effect is cell type specific. Objsctive : The present study was undertaken to deterr or whether the induction of SOD expression by TNF-a in the keratinocytes is occurred Methods : Primary keratinocyte cultures from neonatal or skins were grown in complete MCDB 153 medium. Measurement of superoxide radical and SOD activity were performed according to Babicr and Fridovich methods, respectvey. Results : 1. The release of supercxide radical were measured after 30, 60, 90 minutes exposure to 10 ng/ml TNF-a, the results shows 2.94+0.30 nmol/2x10, 3 5+0.52 nmol/2x10, 4.13+0. 70 nmol/2 x10 respectively, The increase of superoxide raduial release was detectable in a time dependent manner. 2. Total SOD activity without treatment of TNF-e at 2 hours was 18.46+2.85. Total SOD activities after treatment of 1, 10, 100 ng/ml TNF-a a 4 hours were 36.47+6.80, 88.01+7.79, 94.50+8.97 respectively, which suggested that TNF-a induced increase of total SOD significantly(P<0.05). TNF-a stimulate total SOD incuction in a dose and time dependent manner, although the effects were not outstanding Mn-SOD activity after treatment of 100 ng/ml TNF a at 48 hours was 84.12+14.83, which was approximately 10.5 fold of that of the untreated case. TNF-a also induced Cu,Zn-SOD activity, but the effect was not so much a in the case of Mn-SOD. Conclusion : TNF-a induces production of total SOD acivities, especially Mn-SOD in the human keratinocytes, which may be to protect cells from, inflammation mediated. oxidative damage, namely prrduction of total SOD protein, esrcally Mn-SOD in response to TNF-a induced and scavrged overproduced superoxide ralic which in turn may result in protection of the keratinocytes. (Kor J Dermatol 1995; 33(1): 19-27)