Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

최근 30년간 스포로트리쿰증 임상 병형의 추세에 대한 관찰

임채성,권경술,장호선,정태안,오창근 대한의진균학회 1997 대한의진균학회지 Vol.2 No.1

Background: The clinical types of sporotrichosis are generally classified into four group: lymphocutaneous, fixed cutaneous, and cutaneous disseminated, and hematogenous. Of these, the lymphocutaneous variety is the most frequently encountered pattern, constituting 80% of sporotrichosis patients and the fixed cutaneous sporotrichosis is the next. Potassium iodide (KI) was the most commonly used drug for the treatment of sporotrichosis. Many studies about these clinical findings of sporotrichosis have been reported, but comparative study on the changes in clinical findings has not been reported. Objective: The purpose of this study is to clarify the changes of the clinical findings in sporotrichosis in Korea. Methods: A total of 58 patients with sporotrichosis who had visited the Department of Dermatology, Pusan National University were divided into 2 groups according to the period and then the clinical findings of sporotrichosis were compared. Results: The results of study are summarized as follows: 1. During this period, there were 58 cases of sporotrichosis. In the past period (1967~1979) there were 35 cases of sporotrichosis, and there were 23 cases in the recent period (1980~1997) 2. In the past period, most cases (71.4%) were lymphocutaneous type, however in the recent period, most cases (69.2%) were fixed cutaneous type. 3. The most commonly affected site was right upper extremity in the past period, but face fright upper extremity were the most commonly affected sites in the recent period. 4. In the past period, 2nd and 3rd decades were prevalent age group, but 5th to 7th decades were prevalent age group in the recent period. 5. In the treatment of sporotrichosis, potassium iodide (KI) was the choice of treatment in the past period, however itraconazole is gradually used in the recent period. Conclusion: According to this study, many changes in clinical findings of sporotrichosis were noted, especially in the clinical type. We found that clnical type of sporotrichosis changed from lymphocutaneous type to the fixed cutaneous type with time. And we suggest that further observation would be necessary to define the meaning of these changes.

Finding key vulnerable areas by a climate change vulnerability assessment

Kim, Ho Gul,Lee, Dong Kun,Jung, Huicheul,Kil, Sung-Ho,Park, Jin Han,Park, Chan,Tanaka, Riwako,Seo, Changwan,Kim, Ho,Kong, Wooseok,Oh, Kyusik,Choi, Jinyong,Oh, Young-Ju,Hwang, Gangseok,Song, Chang-Keun Springer Netherlands 2016 Natural hazards Vol.81 No.3

<P>Extreme climate events such as typhoons, heat waves, and floods have increased in frequency with climate change. Many municipalities within the Republic of Korea (ROK) have experienced damage from these events, necessitating countermeasures. Vulnerability assessment has been suggested in the implementation of a national plan for reducing damage resulting from climate change. Thus, in this study, we assess the vulnerability of the ROK and identify key vulnerable municipalities in support of the national adaptation plan. We create a framework for assessing the vulnerability of all 232 municipalities of the ROK with respect to 32 items in 7 fields. The framework regards decision makers' comprehension and availability of data as important factors. We assess the vulnerability index of each municipality by using variables of climate exposure, sensitivity, and adaptation capacity. The weights of variables are determined by the Delphi method. We used the representative concentration pathways 8.5 climate scenario to reflect future climate exposure for the vulnerability assessment. From the analysis, vulnerability maps are prepared for the 32 items of 7 fields, and key vulnerable municipalities are identified by aggregating the maps. The distribution of vulnerable municipalities changes with the future climate conditions. These maps provide a scientific and objective basis for the ROK government to establish adaptation plans and allocate resources. The ROK government can utilize the results to identify the characteristics of highly vulnerable areas, and municipalities can use the results as a basis for requesting support from the national government.</P>

경상남도 창녕에서 집단 발생한 피부 탄저병의 임상양상

박찬원,박정래,정종윤,이선희,장철훈,오차재,조병만,임재영,오창근,권경술 대한감염학회 2002 감염 Vol.34 No.4

교도행정 실태 및 개선방안에 관한 연구

오창근 全北行政學會 2001 全北行政學報 Vol.15 No.1

미국을 비롯한 서구 선진국예서는 범죄자에 대한 교도행정을 교정복지 차원에서 억류나 처벌보다는 교도소 밖의 사회내 처우로 전환하려는 연구가 활발하다. 그러나 우리 사회에서는 여전히 처벌 중심의 교도행정과 제한된 범위의 교정처우예 머무르고 있으며, 교정인력이나 예산규모 역시 매우 열악한 수준에 있다. 즉, 수형자의 사회적응을 위한 교정활동에 대해 정부의 소극적 태도와 사회적 외면은 우리 사회에서 전과자들이 제대로 사회에 적응하기 어렵게 만드는 중요한 요인이 되고 있다. 따라서 이 연구는 우리 나라의 교도행정 실태를 교도행정 현황과 교정처우를 중심으로 고찰하였고, 이를 토대로 출소자의 사회적응이라는 교정의 목적을 효율적으로 달성하기 위한 몇 가지 방안들을 계시하고 있다.

장거리 육상선수들의 생리적 특성에 관한 고찰

오창석,이근일 龍仁大學校 1997 용인대학교 논문집 Vol.14 No.-

The purpose of this study is to analyze the statistical contribution of anthropometrical and physiological characteristics underlying 5,000 meter running performance in 5 high schools(group A) and 5 national representative(group B) male distance runners. 1.The relationship between heights(168.80cm vs 169.40cm) in 5,000 meter running performance was not significant in group A and group B, but the relationship between weights(53.80kg vs 59.20kg) in 5,000 meter running performance was significant in grouts B. 2.There were no differences in maximal heart rates(192 vs 192.40) between two groups A and B. 3.There was no significant relationship between VO2 max and 5,000 meter performance for both(76.96㎖/kg/min vs 79.80㎖/kg/min). 4.Blood lactate concentration of recovery phase was shown a significantly high lactate removal ability in group B, compared with group A(P<.02, P<.04, P<.01). 5.It was pointed out that the important causes of anthropometrical and physical attributes were ① before lactate acid ② weight ③ height (r=0.82, -0.75, 0.64) in group A. ① before lactate acid ② recovery blood lactate ③ VO2 max (r=0.75, -0.65, 0.65) in group B in the long distance running performance. As a result, it was been pointed out that a number of anthropometrical and physical attributes such as body size, body composition, running economy, pulmonary function, cardiovascular-respiratory function and running history as well as maximal oxygen consumption are relatively relevant to success in the long distance running performance. Based on the statistical analysis, high school(group A) male distance runners made more oxygen consumption and lactate than those of group B.

Ethylnitrosourea가 치배 및 치주조직에 미치는 영향에 관한 실험적 연구

오창근,조한국 慶熙大學校 齒科大學 1994 慶熙齒大論文集 Vol.16 No.1

The purpose of this study was to evaluate the effect of ethylnitrosourea(N-ethyl-N-nitrosourea ; ENU, Sigma Co.) on the tooth germs and its surrounding tissues. Forty male Wistar rats; one month of age and 100-130gm in body weight, were used in this experiment, which were devided into 3 experimental groups and 2 control groups. Ten animals of experimental group 1 were given local injection of 1% ENU solution which were dissolved in physiologic saline into the region of incisor tooth germ of the right mandible every other day for 19 days (a total of 10 times). Ten animals of experimental group 2 received ENU injections as the same manner as group 1 and were given mechanical injuries on the same regions at 2nd, 8th and 15th days after beginning of experiment. And fifteen animals of experimental group 3 received mechanical injuries as well as ENU injections as the same manner of group 2, and were given 4% ethanol as drinking water and subcutaneous injections of 2.5mg prednisolone acetate at 2 times per week. Three animals a control group 4 were treated as the same manner with experimental group 3, but received injections of physiologic saline instead of ENU, and two animals of control group 5 were not treated. All animals were sacrificed at the end of the sixth month, and the mandibles were removed, fixed in 10% N-fornialin, decalcified with electrolytic decalcification method, embedded in paraffin, sectioned in 4-6/tm thickness, and stained with Hematoxylin and eosin, and Masson's trichrome. The results were as follows ; 1. Various polycystic structures with fibrous connective tissue wall and neoplasm-like proliferation were revealed at the ENU-injected areas of the tooth germs, the periodontal ligaments and the salivary glands. 2. The epithelium of the tooth germ revealed irregular epithelial hyperplasia and disturbance of dentinogenesis. 3. The stratum intermedium of the tooth germ revealed severe adenomatous proliferations, therefore suggesting a potential of odontogenic tumors. 4. Malassez's epithelial rests in the periodontal membrane of the posterior teeth revealed mild hyperplastic proliferation. 5. Gingival hyperplasia at the posterior teeth and the formation of epithelial islands resembling with enamel organ at the affected interdental papillae were observed. 6. The ductal epithelium of the intercalated ducts and the secretory ducts of the accessory salivary glands revealed basal cell adenomatous proliferations, 7. Group 2 and 3 revealed more prominent histopathological changes than group 1, therefore it suggested that these changes would develop to odontogenic tumors.

한국 주택정책의 문제점과 발전방향에 관한 연구

오창근 전주대학교 사회과학연구소 1995 社會科學論叢 Vol.11 No.-

An urban in the contemporary give rising to variety problems concurrently with a developmental function from industrialization. One serious problem of these is due to population concentration into urban, such phenomenon is happening in every country in today. Population concentration has leaded the price rising of land and house, so housing shortage of the populace is increasing as time goes by making slum as bad house, unhealthy house, and unauthorized house etc. Because of these problems, each nation including Korea has formulated and practiced variety policies for housing life of the poor. But the policy that Korea has practiced housing shortage by this time at best was being temporary means far away from essential goal of the housing policy as stabilize housing supply to the poor has praticed in Western countries, Europe and America successfully. This is case of the formal and the impratical housing policies in Korea. First, the supply quantity of public house to the poor have pettied less than a form. Second, the formal pattern of housing supply is been unification. this pattern not only has been the cause of a large sized accident, also has obsructed the construction of a healthy community. Third, the housing financial policy of Korea is other problem. Under the present policy, the size of housing financial support is petty, the low-income brackets have very difficulty in buying a house. In comparison with industrially advanced nations, our orientation of effective housing policy to stabilization of the poor's housing life is following. First, we must improve sharply the present policy for housing financial support. Second, we must grope new direction differ from uniform development of high density housing complex is caused serious urban problem. Third, we must fix anew of housing related laws to coincide with essencial goal of housing policy. Last, it is demended that contradictory housing tract system is improved to supply fo house for needed in stability.

악골관계에 따른 전치부교합의 보상적 적응에 관한 연구

오창근,윤영주,김광원 대한치과교정학회 2000 대한치과교정학회지 Vol.30 No.2

대학에 재학 중인 성인 남녀의 구강검사를 통해 대구치의 전후방관계는 Angle씨 Ⅰ급 관계를 보이고, 전치부는 정상 범위내의 수평피개교합 및 수직피개교합를 지니면서 교정치료의 경험이 없는 남자 51명 여자 50명, 합계 101명 (평균 나이: 남자 23.6세, 여자 21.5세) 의 표본을 연구대상으로 하여 다양한 악골관계에 따라 정상교합을 이루기 위한 치아, 치조의 보상적 변화의 양상을 상하악골과 치아, 치조의 배열간의 상관관계를 분석하여 파악한 결과,다음과 같은 결론을 얻었다. 1.정상교합의 표본에서도 전후방적, 수직적 악골관계 및 치아, 치조관계를 나타내는 변수의 계측치 들은 그 변이의 정도가 매우 다양하였다. 2.상하악전치의 치축경사도는 악골의 전후방적 위치관계와 높은 상관관계를 보였으며 상악골에 대하여 하악골이 후방에 위치할수록 상악전치는 설측경사, 하악전치는 순측경사의 경향을 보였다 (p〈0.01). 3.상하악 치조의 높이는 악골의 수직적 위치관계를 나타내는 하안면고경의 크기와 매우 높은 상관관계를 보였다. 4.상하악 치조의 높이와 악골의 전후방적인 위치관계에 대해서는 상호간의 관련성이 없었다 (p〉0.05). 5.상하악 전치의 치축경사와 악골의 수직적 위치와의 관계는 상악전치부가 하악 전치부에 비해 더욱 긴밀히 관련되었다. 이상의 연구에서 정상적인 교합을 보이는 경우에도 개인에 따라 악골의 배열 및 치아, 치조의 배열에 있어서 차이가 많음을 인식할 수 있으며, 악골의 전후방적 위치와 전치부 치축경사도간, 그리고 악골의 수직고경과 상하악 전치부 치조의 높이간에는 밀접한 관련성이 있고 이는 달라진 악골의 위치에 따른 보상적 변화로 결론 지을 수 있을 것이다. The purpose of this study was to identify the compensatory adaptation of dentoalveolar structure according to the various skeletal relation through the statistical correlation between the anteroposterior, vertical skeletal and dentoalveolar relation. For this study, the sample were consisted of 101 adult subjects (51ma1e and 50 female, mean age; male 23.6 years, female 21.5 years) who had good occlusion with the range of normal overjet and overbite and acceptable Angle's class I molar relationship which had not been related orthodontically. The results were as follows : 1.Even though acceptable normal occlusion, the range of measurements which represent anteroposterior, vertical skeletal relation and dentoalveolar relation were very wide. 2.Upper and lower incisor axis were significantly correlated with anteroposterior skeletal relation, which means the more lingual inclination of upper anterior teeth and the more labial inclination of lower anterior teeth according to the more anterior position of mandible to the maxilla (p〈0.01). 3.Upper and lower anterior alveolar bone height was statistically correlated with the lower anterior vertical skeletal height. 4.Upper and lower alveolar bone height were not correlated with anteroposterior skeletal relation (p〉0.05). 5.The correlation between the incisor axis and vertical skeletal was more closely related in upper anterior teeth than the lower anterior teeth. To summarize the above results, even though acceptable normal occlusion, skeletal and dentoalveolar relation was very widely ranged, and there were close relationship between the anteropostenor skeletal relation and the inclination of upper and lower anterior teeth and between the vertical skeletal relation and upper and lower anterior alveolar bone height. These finding can be concluded as compensatory adaptation to the different skeletal relationship.

내인성 혈장 리튬 농도와 정신분열병

오채근,김종인,이병학,윤재항,김창현,김성재 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.1

Objectives : The aim of this study was to compare endogenous plasma lithium concentrations among schizophrenic patients classified by DSM-IV subtype and control groups and to investigate the correlation of endogenous plasma lithium concentration and psychotic symptoms in schizophrenia. Methods : Schizophrenic patients were selected among psychiatric inpatients without lithium medication and then classified by DSM-IV schizophrenia subtype, Schizophrenic patient groups were composed of 15 disorganized type, 15 paranoid type and 15 undilferentiated type schizophrenic patients. The control group was composed of 15 healthy subjects without any psychiatric disease,Endogenous plasma lithium concentrations were estimated by inductively coupled plasma atomic emission spectrometer. The psychotic symptoms in schizophrenic patients were classified as positive symptoms, negative symptoms and disorganized symptoms according to andreasen classificationl about SANS and SAPS items. Endogenous plasma lithium Con-centration among three subtypes of schizophrenia and control group was compared, and correlation between endogenous plasma lithium concentrations and psychotic symptoms was examined. Rcsults : 1) Schizoprenic patients showed higher endogenous plasma lithium concentration than control groups (p=0.033). Endogenous plasma lithium concentrations were significantly different among three subtypes of schizophrenia (p=0.001). Compared with the control group, disorganized type showed higher endogenous plasma lithium concentration, but paranoid type and undifferentiated type were not significantly different. 2) Disorganized symptoms correlated with endogenous plasma lithium concentration (r=0.416, P=0.004), but negative symptom and positive symptom did not significantly correlate with endogenous plasma lithium concentration (r=0.202, P=0.184. r= -0.216, P=0.155). Conclusion : These results suggested that schizophrenic patients with disorganized symptom show the differences in utilization or distribution of endogenous lithium.