보조호르몬요법을 받는 여성 유방암 환자의 모발 변화와 치료 실태에 대한 기초 연구

이재경 ( Jae Kyung Lee ),김창현 ( Chang-hyun Kim ),홍동균 ( Dongkyun Hong ),정경은 ( Kyung Eun Jung ),서영준 ( Young-joon Seo ),김창덕 ( Chang-deok Kim ),이진선 ( Jin Sun Lee ),권인선 ( In Sun Kwon ),박상현 ( Sanghyun Park ),이영 대한피부과학회 2021 대한피부과학회지 Vol.59 No.7

Background: Hormone therapy, which includes tamoxifen and aromatase inhibitors, is the most common adjuvant therapy used for breast cancer. However, only a few studies have reported endocrine therapy induced alopecia. Objective: We investigated the effects of long-term adjuvant hormone therapy on hair in patients with breast cancer, in addition to patients’ concerns and current treatment for hair loss. Methods: Patients completed a questionnaire that included information on self-perceived hair changes after each adjuvant therapy session, distress, and current treatment for hair loss. Using a folliscope, we measured hair density and thickness in each patient and in healthy controls. Results: The study included 93 patients with breast cancer (mean age 51.9±9.8 years). The density and hair thickness were 106.36±21.85 hairs/cm2 and 0.07±0.01 mm in the patient group and 147.86±30.67 hairs/cm2 and 0.07±0.01 mm in the control group (n=98, mean age 52.10±8.40 years), respectively. The mean hair density was significantly lower in the patient group than in the control group; however, no statistically significant intergroup difference was observed in hair thickness. Among 76 patients who perceived hair changes after adjuvant therapy, 71.1% (n=54) were distressed with regard to hair changes. However, only 7.8% of the patients, including two who were treated by dermatologists, currently received treatment for hair changes. Conclusion: Dermatologists should be familiar with hair changes in patients with breast cancer and provide appropriate education to encourage patients to consult dermatologists for hair loss and thinning after breast cancer treatment. (Korean J Dermatol 2021;59(7):521∼526)

선천눈꺼풀처짐 교정술 후 발생한 난시변화

이동섭,김준모,우경인,장혜란,Dong Sub Lee,Joon Mo Kim,Kyung In Woo,Hae Ran Chang 대한안과학회 2006 대한안과학회지 Vol.47 No.9

Purpose: To determine postoperative astigmatic changes after surgery for congenital ptosis and the astigmatic changes depending on surgical method and to discern cases of postoperatively developed anisometropia or amblyopia. Methods: Fifty-one patients who underwent surgery due to congenital ptosis were reviewed. Refraction or cycloplegic refraction was conducted preoperatively and 3 to 6 months after surgery to measure astigmatic changes. Astigmatic changes in operated eyes were compared to control eyes. Astigmatic changes were compared depending on surgical method. Results: The mean astigmatism was 1.33±1.29D preoperatively and 1.48±1.13D postoperatively (P=0.10) and the mean astigmatic change in the ptotic and control eye was an increase in cylinder +0.56±0.55D and +0.68±0.72D (P=0.37). The mean astigmatic change of patients receiving frontalis sling was +0.57±0.67D which was similar to those who received levator resection (+0.56±0.50D). Newly developed anisometropia was found in three patients postoperatively due to an increase in astigmatism, but newly developed amblyopia was not found. Conclusions: The increase of astigmatism by ptosis surgery was not statistically significant and there was no statistically significant difference when accounting for surgical method. However, it is necessary to monitor refractive error carefully in younger patients to prevent amblyopia because postoperative increase of astigmatism can cause anisometropia.

濟州島 陸上競技 長距離選手들의 記錄變化에 관한 調査硏究 : 道一周 驛傳競走大會를 中心으로 With Priority Given to the Long-distance Relay Around Cheju Island

李昌俊 제주대학교 1984 논문집 Vol.18 No.-

1971年 第1回 道一周驛傳競走大會부터 1984年 第14回 大會까지 出戰한 高等部 一般部 選手들을 對象으로 調査하였고 記錄變化를 分析한 結果를 要約하면 다음과 같다. 1. speed面에서 區間優勝者들은 第1回부터 4回까지 平均記錄은 高等部 256.2m/min, 一般部 263.4m/min, 第5回부터 8回까지 平均記錄은 高等部 293.5m/min, 一般部 298.5m/min, 第9回부터 14回까지 高等部 298.8m/min, 一般部 306.8m/min로 큰 變化를 가져왔다. 2. 濟州大學校 選手들의 5,000m記錄은 1982年의 平均은 16분 38초 8, 1983年은 16분 09초 4, 1984年은 15분 57초의 變化가 있었다. 3. 大會의 區間別 新記錄은 1982年이 高等部 4個, 一般部 9個, 1983年이 高等部 2個, 一般部 16個, 1984年이 高等部 16個, 一般部 7個의 記錄變化를 나타냈다. 4. 大會時에서 氣溫, 濕度, 地形, 風速, 風向이 記錄變化에 큰 影響을 미쳤다. The records of the high-school runners and the adult runners who participated in fourteen long-distance relays around Cheju Island from the year of 1971 to that of 1984 have been investigated. The changes in their records are summarized as follows; 1. In speed, the average record of the section winners from the 1st relay to the 4th was 256.2m/min for the high-school runners and 263.4m/min for the adult runners; from the 5th relay to the 8th, 293.5m/min for the high-school runners and 298.5m/min for the adult runners; from the 9th relay to the 14th, 298.8m/min for the high-school runners and 306.8m/min for the adult runners. The changes are enormous. 2. The average records of Cheju National University runners for 5,000m were 16min 38sec 8 in 1982, 16min 09sec 4 in 1983, and 15min 57sec in 1984. Such changes are revealed. 3. The new section records were 4 for the high-school runners and 9 for the adult runners in 1982; 2 for the high-school runners and 16 for the adult runners in 1983; and 16 for the high-school and 7 for the adult runners in 1984. Changes are shown in the part of new section records. 4. The changes of records were greatly influenced by temperature, humidity, terrain, wind velocity, and the direction of wind during the days of the relays.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

Latobacillus plantarum AF1이 생성한 조항진균 물질의 흰쥐에 대한 반복투여독성

이환 ( Hwan Lee Myung ),이명렬 ( Yul Lee Hae ),장해춘 ( Choon Chang Jae ),이재준 ( Joon Lee ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2013 한국식품저장유통학회지 Vol.20 No.3

본 연구는 김치산막효모억제 유산균인 Lb. plantarum AF1이 생산한 조항진균 물질 부분 정제물을 SD계통의 흰쥐에게 4주간 반복 경구투여를 통하여 장기투여에 의한 안전성을 확인하였다. 암·수 흰쥐에 Lb. plantarum AF1이 생산한 조항진균 물질 부분 정제물을 0, 500, 1,000 및 2,000mg/kg/day의 용량으로 4주간 반복 경구투여한 후 사망률, 일반증상, 체중변화, 사료섭취량, 수분섭취량, 부검소견, 장기무게 변화, 혈액학적, 혈액생화학적 및 병리조직학적 검사를 실시하였다. 모든 시험군에서 전 시험기간 시험물질로 인한 임상증상 및 사망동물이 관찰되지 않았다. Lb. plantarum AF1이 생산한 조항진균 물질 부분 정제물의 경구투여 결과 체중이 4주간 지속적으로 증가되었지만 대조군과 유의성 있는 변화가 없었다. 또한 장기의 육안적 관찰, 장기 중량변화,혈액학적, 혈액생화학적 및 병리조직학적 검사에서도 모든 시험물질 투여군이 대조군과 유의성이 있는 차이를 보이지 않았으며, 모두 정상 범위의 수치로 시험물질에 기인하는 이상 소견을 발견할 수 없었다. 이상의 결과 4주 반복투여 독성시험 결과 Lb. plantarum AF1이 생산한 조항진균 물질 부분 정제물은 저독성의 안전한 물질로 판정되었다. This study was performed to investigate the four-week repeated-dose toxicity of the crude antifungal compounds produced by Lactobacillus plantarum AF1 (Lb. plantarum AF1), a lactic acid bacterium isolated from kimchi, in male and female rats. Sprague-Dawley male and female rats were divided into four groups, with 10 animals in each group. The test article was administered once daily by gavage to rats at dosage levels of 0, 500, 1,000, and 2,000 mg/kg/day for four weeks. There were no test-article-related deaths or abnormal clinical signs in both the male and female rats during the observation period. Furthermore, no differences in the body weight changes, food intake and water consumption levels of the control and treatment groups were found. The hematological parameters, serum biochemical analysis results, histopathological examination results and all other findings also showed no significant or dose-dependent changes. There were also no changes in the organ weights upon the administration of the crude antifungal compounds produced by Lb. plantarum AF1. These results suggest that the oral administration of the crude antifungal compounds produced by Lb. plantarum AF1 had no adverse effects up to a dosage level of 2,000 mg/kg in both male and female rats.

運動競技와 關聯된 選手들의 心理的 變化 分析

이창준,오기녕 濟州大學敎 體育科學硏究所 1997 체육과학연구 Vol.3 No.-

There are violent emotion-changes, that is joy and anger, concerned with the outcome of a game through hot competition, sacrifice. endurance, and physical pain, and the like in sports activities. These make athletes feel their anxiety and burden psychologically. These also bring much difficulties and barriers to them. Thus their psychology is important, because the outcome of a game is up to how to control their emotional and psychological changes. This study is to examine and analyze the psychological changes of middle school students. high school students and university students which have bad effects on their sports activity. The results from such an analysis are as follows; 1) In exercising, they have a tendency to feel their own technique, the honor of their school, and their coach's attention in this order. They are also eager to do their best. 2) In a sports game, middle school students take part in the game with feeling much more psychological difficulties and barriers than those of high school students and university students. 3) After a game, all classes of students reflect on it and make up their minds to do their best for the next game. This attitude is shown by unversity students more than any other class. 4) In the relationship between a athlete and a coach, there is little consultation. This tendency has to do with all classes of the students. Above all, high school students have much more distance from their coach than any other class. So far as the kind of sport games is concerned. this tendency has little to do with team athletes. To have high confidence between athletes and their coach there needs to be familiar consultation and the methods of teaching athletes needs to be according to their individual personalities and peculiarities.

Hand Ball 選手들의 體格 體力에 關한 縱斷的 硏究

李昌俊,權純昌 제주대학교 1988 논문집 Vol.27 No.-

The paper aims at comparing and analyzing the physiques and physical of 20hand ball players of the regular national team from 1984 to 1987 in a yearly order. The results of this study are as follows. 1. In general, the physique factors of the players such as standing height, body weight, girth of chest and sitting height have a gradual increase every year. 2. In the items of muscular strength, agility and power, there becomes a gradual change every year and vice versa in the item of flexibility. On the other hand, some remarkable change can be seen in the items of muscular endurance and endurance. 3. In comparison with the physical fitness and physique of the world standard players, those of Korean players are not so good. However, if Korean players are stystematically trained with a scientific method, it is regarded that they make a good record in many games.

新文學批評 方法에 依한 韓國現代詩의 分析

李昌俊 檀國大學校英美文化硏究所 1981 英美文化 Vol.1 No.-

The analytical approach follows the critical methods of the so-called New Critics, I.A. Richarads, T.S. Eliot, Robert Penn Warren, Allen Tate, Philip Wheelwright, and so forth. The present writer proposes to analyze the poems by Lee Sang-wha, Kim So-wol, Han Yong-woon, Kim Ki-rim, Zeong Zi-yong, Kim Kwang-kyun, etc. The approach is based on an assumption that this kind of analysis will be contributive to the writing of Korean poetry as well as the criticism itself, for almost all studies on Korean poetry, undertaken by Korean critics, have been limited to source studies, explanations about the backgrounds, biographical studies, or the like. In "The Frontiers of Criticism," Eliot asserts that "there are limits, exceeding which in one direction literary criticism ceases to be literary and exceeding which in another it ceases to be criticism." He seems to be right when he maintains that Lowes's The Road to Xanadu, a study of the source and creative process for Coleridge's poems, "Kubla Khan" and "The Ancient Mariner," is a typical example that exceeds the limits of literary criticism. The kind of criticism that Eliot denounces causes the reader to lose contact with the poem as poem, and leads him to focus his attention to the poet himself. The Eliot's opinion-the present writer also agrees with it-that the critic's major task is to promote the understanding and enjoyment of the literary work itself seems to be most appropriate in Korea, since most of the literary critical essays have so for been on source studies, biographical studies, etc. I.A. Richards distinguishes the poetry of inclusion from that of exclusion. According to him, the poetry of inclusion widens experience and never excludes the opposite impulses. He maintains that the poetry of inclusion belongs to the highest order of poetry. On the other hand, the poetry of exclusion narrows down the experience and the opposite impulses, making the results lamentably sentimental. The poems by Lee Sang-wha and Kim So-wol may be considered to be good examples of the poetry of exclusion. Robert Penn Warren tries to define the pure and impure poetry. For example, the poem of Shelley and Tennyson, especially the former's "The Indian Serenade," are pure, but unfortunately their poetic effect tends to be unwholesome and sentimental; while the poems of Shakespeare, but their poetic effect, on the other hand, is more convincing and persuasive. The poems of Han Yong-woon are apparently impure, and therefore convincing and persuasive; while those of Kim So-wol, pure. In this respect, the poems of Han Yong-woon can be considered to be monumental in the history of Korean poetry. Allen Tate lops off the prefixes from intension and extension, thus making his metaphor, or Arnoldian touchstone, the "tension." He explains the extension to be equal to denotation, and the intension, to connotation. His view is that in a good poem the intension and the extension of language are one and the same thing and reinforce each other, while in bad poems they collide with each other and commit "the fallacy of communication." Seen from this point of view, the poems by Kim Ki-rim, Zeong Zi-yong, and Kim Kwang-kyun can be regarded as bad poems, for they are unsuccessful in communication, thus committing the fallacy of communication. Philip Wheelwright asserts that poetic language becomes alive and vibrant by reason of its semantic multiplicity-in-unity, and his so-called "semantic multiplicity-in-unit" leads to "plurisignation," which, he declares, differs from Empson's ambiguity as "both-and" differs from "either-or." The first one is a controlled variation and plurality of reference; the second is a looseness and duplicity of reference. He also insists that there is a tendency in poetic language for simile and plurisignation to blend into a metaphoric unit-in-diversith. Thus, he expains the plurisignative depth in a poem of Emily Bronte¨ wherein similes are expressed in very explicity terms, concluding that her poem approaches a metaphoric unity-in-diversity. the present writer attempts to analyze Zeong Zi-yong's "Measles" in order to demonstrate how well Wheelwrights theory can be applicable to the analysis of Korean poetry, for the "Measles" can be considered to be parallel to Bronte¨'s poem. In short, there are very few critiques which adopt the New Criticism methods to analyze the poem as poem in Korea, so there often exists a danger that this might mislead the poets to writing poems which may have no readers. Kim So-wol and Lee Sang-wha can be grouped into a poetic school whose mission seems to be narrowing down their experiences. There is a term "intellectual poetry" in Korea, and this word itself is a clear evidence that the Korean poets have been writing "the poetry of exclusion." Most Korean poets wrote poetry, making use of the poetic materials such as beautiful scenery in nature with the exception of Han Yong-woon, for he became a prodigy like an enfant terrible by writing impure poems, and left an everlasting monument in the history of Korean poetry. The poets like Kim Ki-rim and Kim Kwang-kyun are the ones who began the modernist movement. When we read the early poems of them, we can easily detect what poetasters they were. However, the poems of some poets like Kim So-wol, Zeong Zi-yong, and Han Yong-woon, especially the last poet, show many latent powers and possibilities of good poetry.

Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구

장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.