TRANSIENT ISCHEMIA-INDUCED EXPRESSION AND CHANGES OF TYROSINE KINASE A IN THE HIPPOCAMPAL DENTATE GYRUS OF THE GERBIL

HWANG, IN,LEE, HYEON,YOO, KI-YEON,KIM, DAE,KIM, JUNG,KIM, CHANG,LIM, BEONG,KANG, TAE-CHEON,BANG, KYUNG,SEONG, NAK,LEE, HAK,KIM, JONG,WON, MOO Taylor Francis 2006 International journal of neuroscience Vol.116 No.8

<P>The present study examined ischemia-related changes in tyrosine kinase A (trkA) immunoreactivity and its protein content in the dentate gyrus after 5 min of transient forebrain ischemia in gerbils. One day after ischemic insult, cresyl violet-positive polymorphic cells showed ischemic degeneration. The ischemia-induced changes in trkA immunoreactivity were found in the polymorphic layer (PL) and granule cell layer (GCL) of the dentate gyrus. In the sham-operated group, trkA immunoreactivity in the dentate gyrus was very weak. From 30 min after ischemia, trkA immunoreactivity was increased in the dentate gyrus and peaked in the dentate gyrus at 12 h after ischemia-reperfusion. Thereafter, trkA immunoreactivity was decreased time-dependently after ischemia-reperfusion. Four days after ischemic insult, trkA immunoreactivity was similar to that of the sham-operated group. In addition, it was found that ischemia-related changes in trkA protein content were similar to the immunohistochemical changes. These results suggest that the chronological changes of trkA in the dentate gyrus after transient forebrain ischemia may be associated with ischemic damage in polymorphic cells of the dentate gyrus.</P>

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1997)

김재홍,문득곤,김정수,김용준,임동진,박상훈,김희성,이민수,송기훈,김갑형,김형석,성소영,이인섭,김석우,황지환,조창근,김경문,부태성 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

Background : In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. Objective & Methods : For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1997. 99 strains of N. gonorrhoeae were isolated, among which 45(45.5%) were PPNG. Conclusion : The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 45.5% in 1997.

Ischemia-Related Changes in Galanin Expression in the Dentate Hilar Region after Transient Forebrain Ischemia in Gerbils

LEE, Hyeon Yong,HWANG, In Koo,KIM, Dae Ho,KIM, Jung Hwa,KIM, Chang Ho,LIM, Beong Ou,KANG, Tae-Cheon,BANG, Kyung Hwan,SEONG, Nak Sul,LEE, Hak Ju,KIM, Jong Dai,WON, Moo Ho Japanese Association for Laboratory Animal Science 2005 EXPERIMENTAL ANIMALS Vol.54 No.1

<P>Although galanin (GAL) protects hippocampal neurons from ischemic damage, no study has examined ischemia-related changes in endogenous GAL in the hippocampal dentate gyrus. We investigated the chronological changes of GAL, well-known as the potassium channel opener, expression in the dentate gyrus at various times after 5 min of transient forebrain ischemia in gerbils. A few GAL-immunoreactive (IR) neurons were found in the polymorphic layer of the sham-operated group. Three hours after ischemia-reperfusion, the pattern of GAL immunoreactivity was similar to that of the sham-operated group and the number of GAL-IR neurons and immunoreactivity were highest 12 h after ischemic insult. At this time, GAL-IR neurons in the polymorphic layer showed strong GAL immunoreactivity. Thereafter, GAL-IR neurons and immunoreactivity significantly decreased in the dentate hilar region. Four days after ischemic insult, GAL-IR neurons were not detectable. In addition, the results of a Western blot study showed a pattern of GAL expression similar to the immunohistochemical changes. GAL protein content also was highest 12 h after ischemia. In conclusion, the increased expression of endogenous GAL in the dentate gyrus after ischemia is related to response to the ischemic damage.</P>

Salt and pepper appearance of the skin associated with mixed connective tissue disease

( Sang-hyeon Won ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

The salt-and-pepper appearance of skin is composed of salt (vitiligo-like depigmentation) and pepper(perifollicular pigmentation). This characteristic feature can be a clinical clue for the diagnosis of systemic sclerosis. Mixed connective tissue disease(MCTD) is a distinct disease entity with mixed features of systemic lupus erythematosus, systemic sclerosis, myositis and rheumatoid arthritis with high titers of antibodies to U1 small nuclear ribonucleoprotein(U1 snRNP). Therefore, MCTD is known to have a wide spectrum of cutaneous manifestations which may be the presenting signs of the disease. However, there are few reports of pigmentary changes in MCTD. A 51-year old woman presented with variably sized hypopigmented macules along with relative hyperpigmentation of the perifollicular areas. She was diagnosed with MCTD by Raynaud’s phenomenon and high titer anti-RNP corresponding to a speckled antinuclear antibody of 1:1280 in Rheumatology clinic. A biopsy specimen showed dermal sclerosis. Pigment loss and melanophages were observed in the papillary dermis. Hypo- and hyperpigmentation were confirmed histologically by S100 and Fontana-Masson stain. To our knowledge, ‘salt and pepper appearance of the skin’ has rarely been reported in MCTD. The diagnosis of MCTD can be challenging due to its diverse characteristics. Therefore, we suggest that MCTD should be regarded as a differential diagnosis in patient with this pigmentary change.

기후변화가 축산업에 미치는 경제효과

공현석(Hyeon Seok Gong),정경수(Kyeong Soo Jeong),김민경(Min Kyoung Kim),장재봉(Jae Bong Chang) 한국농식품정책학회 2020 농업경영정책연구 Vol.47 No.2

Adopting the Ricardian approach, this study investigates the economic effects of climate changes such as average temperature and rainfalls on Korean livestock farm revenue. The explanatory variables of empirical model were selected based on the previous literature. The pseudo-panel analysis is employed to resolve the imperfectness of the panel data. The results indicate that the control variables such as farming experience, household size, employment, ownership of heavy machinery, technology use, full-time farming and male owner affect the livestock farm revenue positively, and the age does negatively. The impact of summer average temperature on farm revenue was significant and negative, while that of winter was significant and positive. The marginal change of the summer temperature decrease farm revenue per head by 2.48%. This paper suggests that the livestock farm’s revenue responds sensitively to changes in summer and winter average temperature, and so we need to establish the long-term countermeasures against rapid climate change.

Hypersensitivity Reaction Incidence Patterns and Risk Factors of Iodinated Contrast Media

김동휘(Dong-Hwi Kim),문종현(Jong-Hyeon Mun),김준환(Jun-Hwan Kim),윤승완(Seung-Wan Yun),박환상(Hwan-Sang Park),김창곤(Chang-Kon Kim),김영덕(Yeong-Deok Kim) 대한CT영상기술학회 2023 대한CT영상기술학회지 Vol.25 No.1

본 연구의 조사 대상은 본 원 에서 요오드화 조영제를 정맥으로 투여받고 CT 검사를 시행한 72,910명과 과거 조영제 과민반응을 겪었던 환자 2,798명을 대상으로 후향적 조사를 시행하였다. 나이, 성별, 과민반응 증상, 조영제 과민반응 기왕력 환자 전처치방법, 사용한 조영제 등을 분석하였다. 조영제 과민반응 발생은 여성과 60대 미만에서 발생 위험이 높고 과거 조영제 과민반응기왕력이 있더라도 적절한 전처치 약물 투여, 조영제 성분 변경을 시행하면 과민반응 발생 위험이 감소한다. 조영제 성분별과민반응 발생률은 Iopromide가 유의하게 과민반응 발생률이 높았고, Iohexol과 Ioversol이 낮은 발생률을 보였다. 조영제 과민반응 재발을 예방하기 위해서는 전처치 약물 단독 사용보다 선행적으로 원인 조영제를 재사용하지 않고 다른 성분의 조영제로 변경하여 사용하는 것이 우선적으로 시행되어야 하고 더불어 전처치 약물 투여와 함께하는 것이 재발을 예방할 수 있을 것이다. The subjects of this study were 2,798 patients who experienced hypersensitivity reaction of contrast media among 72,910 who had had iodinated contrast media administered intravenously and CT examination at our hospital. Retrospective survey was conducted with these subjects. Their age, gender, hypersensitivity reaction symptoms, prepare methods for the patients who had previous hypersensitivity reaction of contrast media, and contrast media administered were analyzed. When it came to the hypersensitivity reaction incidence of contrast media, women and patients aged less than 60 had the high risk of the reaction. Even if patients had previous contrast media hypersensitivity reaction, their hypersensitivity reaction incidence risk was reduced as they had an appropriate premedication drug administered and contrast media were changed. Regarding the hypersensitivity reaction incidence rate by contrast media, Iopromide’s hypersensitivity reaction incidence rate was significantly high, whereas Iohexol and Ioversol had low incidence rates. In order to prevent contrast media hypersensitivity reaction recurrence, it is preferentially necessary to change a contrast media to a different one without reuse of causative contrast media, rather than to use a premedication drug only. Along with that, it is necessary to administer a premedication drug.

열원에 따른 구리선의 미세조직 및 조성 변화

박성우,장익수,김윤희,김상현,이경화,김진표,한승희,김영만,김영도,오낭렴 내무부 국립과학수사연구소 2000 國立科學搜査硏究所年報 Vol.32 No.-

Fatigue analysis of floating wind turbine support structure applying modified stress transfer function by artificial neural network

Kim, Hyeon-Jin,Jang, Beom-Seon,Park, Chang-Kyu,Bae, Yoon Hyeok Elsevier 2018 Ocean engineering Vol.149 No.-

<P><B>Abstract</B></P> <P>The frequency-domain approach has been studied as a potential replacement modality for the time-domain method in fatigue analysis of offshore wind turbine structures. It is assumed that in the frequency-domain approach, the stress response spectra induced by wind and wave loads can be expressed by a stress transfer function. To obtain the stress transfer function, coupled analysis should be performed in advance. However, since the response of a wind turbine to different average wind speeds is non-linear, the stress transfer function is bound to change with wind speed. This means that repeated simulation is needed in order to calculate the stress transfer function according to wind speed change. The problem, though, is that if the number of simulations is large, prohibitively high computational and time costs probably will be incurred. In this study, to reduce the number of simulations and, at the same time, increase the accuracy of results, a correction factor of the stress transfer function induced by wind load was artificial-neural-network-approximated as a function of mean wind speed and frequency. Sensitivity analysis was conducted to determine how many sample points are required and how to select them. Also, a superposition model is proposed to improve the accuracy of the ANN model. This model is designed so that the peaks in the stress spectrum have a dominant influence on fatigue damage. In order to better simulate the correction factor around the peak, the model considering only the data of the periphery of the peaks and the model reflecting the whole data are superimposed. The total stress spectrum were calculated by summing stress spectrum induced by wind load from the ANN model and induced by inertia load from motion analysis based on linear wave theory. Numerical analysis for a 10 MW class wave and offshore wind hybrid power generation (WWHybrid) system, which is a kind of semi-submersible wind turbine platform, was performed to verify the performance of the proposed model. It was confirmed that the superposition model improves the accuracy by 20–50% compared with the single ANN model.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This paper proposes a procedure to apply the regression model to predict the fatigue life of a floating wind turbine support structure. </LI> <LI> The proposed procedure shows the stress transfer function induced by wind loads as a function of mean wind speed and frequency through a neural network model. </LI> <LI> A sampling strategy for constructing a model and a superimposed model concept for reflecting different weights between samples to a model are suggested. </LI> </UL> </P>

Design of a VCM Actuator Using Halbach Magnet Array for Active Vibration Isolation System

Kim, Myeong Hyeon,Kim, Hyun Chang,Hong, Dong Pyo,Gweon, Dae Gab Trans Tech Publications, Ltd. 2014 Advanced materials research Vol.945 No.-

<P>This paper proposes the concept development and design of a VCM actuator for Active Vibration Isolation System (AVIS). Active vibration isolating method was constructed passive isolator and active isolator. Spring was used for isolating passively and actuator like voice coil motor was used for active isolating. The proposed active vibration isolating system could isolate a six degree-of-freedom disturbance effectively. In case of AVIS, payload is variable according to the type of instruments. Therefore, actuator should maintain uniform performance with payload change. The proposed VCM actuator satisfied this performance through relative relation between magnet array and coils. In addition, for maximizing actuator performance, actuator should generate large force density. Therefore, we apply the Halbach magnet array to proposed actuator. The Halbach magnet array helps with reinforcing magnetic flux field. The reinforced magnetic field takes a role to generate more powerful Lorentz force to isolate disturbance. Finally, in this paper, we propose the actuator that novel type using voice coil motor with the Halbach magnet array and optimize each design variables to generate maximum output. These AVIS can use to eliminate disturbance in Maglev stage. Maglev stage need AVIS to increase its performance is necessary. In the future, AVIS and Maglev system will be integrated.</P>

Effects of one or two applications of all-in-one adhesive on microtensile bond strength to unground enamel

Son, Chang-Yong,Kim, Hyeon-Cheol,Jur, Bock,Park, Jeong-Kil 대한치과보존학회 2006 Restorative Dentistry & Endodontics Vol.31 No.6

이 연구에서는 미세인장결합강도 실험과 주사전자현미경을 이용하여 unground enamel에 대한 all-in-one adhesive의 1회 또는 2회 적용에 따른 효과를 평가하였다. 발거된 하악 대구치의 설측 치관부를 사용하여 3개씩 5개의 군으로 분류하였다. SE군은 Clearfil™ SE Bond를 적용하였다. LP1 군, LP2 군은 Adper Prompt L-Pop™을 각각 1회 , 2회 적용하였다. XN1 군, XN2 군은 Xeno^(®) Ⅲ를 각각 )회, 2회 적용하였다. 그런 다음 복합 레진 Z100을 적층 충전하였다. 법랑질 표면의 접착제를 아세톤으로 제거하고 주사 전자 현미경을 이용하여 산 부식 양상을 관찰하였다. 미세인장결합강도 측정을 위해 표본을 절단하여 레진과 치아의 접착 계면이 1 ㎟이 되도록 하여 실험하였다. 실험의 결과는 One-way ANOVA를 사용해 분석한 다음 Duncan's post-hoc test로 사후 검정 하였다. 본 연구의결과 a11-in-one adhesive의 1회와 2회 적용간에는 유의한 차이가 나타나지 않았으며 two-step self-etching adhesive와 a11-in-one adhesive의 산 부식 양상 모두 얕고 불규칙 하였다. The purposes of this study were to compare the effects of one or two applications of all-in-ne adhesives on microtensile bond strengths (TBS) to unground enamel and to investigate the morphological changes in enamel surfaces treated with these adhesives using a scanning electron microscopy (SEM). Twenty-five noncarious, unrestored human mandibular molars were used. The unground enamel surfaces were cleansed with pumice. The following adhesives were applied to lingual, mid-coronal surfaces according to manufacture's directions; Clearfil SE bond in SE group, Adper Prompt L-Pop™1 coat in LP1 group, 2 coats in LP2 group, Xeno^(®) Ⅲ1 coat in XN1 group, and 2 coats in XN2 group. After application of the adhesives, a hybrid light-activated resin composite was built up on the unground enamel. Each tooth was sectioned to make a cross-sectional area of approximately 1.0 ㎟ for each stick. The microtensile bond strength was determined. Each specimen was observed under SEM to examine the morphological changes. Data were analyzed with one-way ANOVA. The results of this study were as follows; 1. The microtensile bond strength values were; SE (19.77 ± 2.44 MPa), LP1 (13.88 ± 3.67 MPa), LP2 (14.50 ± 2.52 MPa), XN1 (14.42 ± 2.51 MPa) and XN2 (15.28 ±2.79 MPa). SE was significantly higher than the other groups in bond strength (p < 0.05). All groups except SE were not significantly different in bond strength (p < 0.05). 2. All groups were characterized as shallow and irregular etching patterns.