Effect of Body Position on High-resolution Esophageal Manometry Variables and Final Manometric Diagnosis

( Carlo G Riva ),( Stefano Siboni ),( Davide Ferrari ),( Marco Sozzi ),( Matteo Capuzzo ),( Emanuele Asti ),( Cristina Ogliari ),( Luigi Bonavina ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2020 Journal of Neurogastroenterology and Motility (JNM Vol.26 No.3

Background/Aims According to the Chicago classification version 3.0, high-resolution manometry (HRM) should be performed in the supine position. However, with the patient in the upright/sitting position, the test could more closely simulate real-life behavior and may be better tolerated. We performed a systematic review of the literature to search whether the manometric variables and the final diagnosis are affected by positional changes. Methods A literature search was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Studies published in English that compared HRM results in different body positions were included. Moreover, the change in diagnosis of esophageal motility disorders according to the shift of body position was investigated. Results Seventeen studies including 1714 patients and healthy volunteers met the inclusion criteria. Six studies showed a significant increase in lower esophageal sphincter basal pressure in the supine position. Integrated relaxation pressure was significantly higher in the supine position in 10 of 13 studies. Distal contractile index was higher in the supine position in 9 out of 10 studies. One hundred and fifty-one patients (16.4%) out of 922 with normal HRM in the supine position were diagnosed with ineffective esophageal motility (IEM) when the test was performed in the upright position (P < 0.001). Conclusions Performing HRM in the upright position affects some variables and may change the final manometric diagnosis. Further studies to determine the normal values in the sitting position are needed. (J Neurogastroenterol Motil 2020;26:335-343)

Echocardiographic Visualization of Retroaortic Anomalous Coronary Artery

Noemi Bruno,Ilaria Ferrari,Francesco Pelliccia,Carlo Gaudio,Luca Monzo 한국심초음파학회 2022 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.30 No.1

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Diet, Sleep and Metabolic Syndrome Among a Legal Amazon Population, Brazil

( Poliana Rodrigues Dos Santos ),( Graziele Souza Lira Ferrari ),( Carlos K B Ferrari ) 한국임상영양학회 2015 Clinical Nutrition Research Vol.4 No.1

Metabolic syndrome incidence is increasing worldwide then it is important to study the possible risk and protective factors. Our previous study suggested an association between coffee consumption and metabolic syndrome. The aim of this study was to address possible associations between dietary lifestyle factors with metabolic syndrome. In a case-control study we compared 74 metabolic syndrome patients with 176-matched controls attended at a public health central unit. Incident cases diagnosed according to ATP III criteria were matched with control group composed of healthy subjects performing routine examinations. Having lower educational level compared to highest levels tend to increase metabolic syndrome prevalence, which was not statistically significant. Similar pattern was observed for marital status. No difference was found regarding gender and metabolic syndrome odds. Interestingly, daily drinking two to three cups of coffee (OR = 0.0646, 95% CI, 0.0139-0.3005, p = 0.0005) or until 2 cups of milk were inversely associated with metabolic syndrome odds (OR = 0.5368, 95% CI, 0.3139-0.9181, p = 0.0231). Sleeping seven to eight hours per night was also associated with decreased odds of metabolic syndrome (OR = 0.0789, 95% CI, 0.0396-0.1570, p < 0.0001). Eating at least two portions of chocolate was also associated with decreased risk of metabolic syndrome (OR = 0.3475, 95% CI, 0.1865-0.6414, p = 0.0009). Adequate sleeping and dietary intake of some foods materially decreased the metabolic syndrome.

Type three secretion system in Salmonella Typhimurium: the key to infection

Anamaria M. P. dos Santos,Rafaela G. Ferrari,Carlos A. Conte‑Junior 한국유전학회 2020 Genes & Genomics Vol.42 No.5

Background Type Three Secretion Systems (T3SS) are nanomachine complexes, which display the ability to inject effector proteins directly into host cells. This skill allows for gram-negative bacteria to modulate several host cell responses, such as cytoskeleton rearrangement, signal transduction, and cytokine production, which in turn increase the pathogenicity of these bacteria. The Salmonella enterica subsp. enterica serovar Typhimurium (ST) T3SS has been the most characterized so far. Among gram-negative bacterium, ST is one of enterica groups predicted to have two T3SSs activated during different phases of infection. Objective To comprise current information about ST T3SS structure and function as well as an overview of its assembly and hierarchical regulation. Methods With a brief and straightforward reading, this review summarized aspects of both ST T3SS, such as its structure and function. That was possible due to the development of novel techniques, such as X-ray crystallography, cryoelectron microscopy, and nano-gold labelling, which also elucidated the mechanisms behind T3SS assembly and regulation, which was addressed in this review. Conclusion This paper provided fundamental overview of ST T3SS assembly and regulation, besides summarized the structure and function of this complex. Due to T3SS relevance in ST pathogenicity, this complex could become a potential target in therapeutic studies as this nanomachine modulates the infection process.

Bonding effects of cleaning protocols and time-point of acid etching on dentin impregnated with endodontic sealer

Manzoli Tatiane Miranda,Zaniboni Joissi Ferrari,Besegato João Felipe,Guiotti Flávia Angélica,Dantas Andréa Abi Rached,Kuga Milton Carlos 대한치과보존학회 2022 Restorative Dentistry & Endodontics Vol.47 No.2

Objectives This study aimed to investigate the bonding effects of cleaning protocols on dentin impregnated with endodontic sealer residues using ethanol (E) or xylol (X). The effects of dentin acid etching immediately (I) or 7 days (P) after cleaning were also evaluated. For bonding to dentin, universal adhesive (Scotchbond Universal; 3M ESPE) was used. The persistence of sealer residues, hybrid layer formation and microshear bond strength were the performed analysis. Materials and Methods One hundred and twenty bovine dentin specimens were allocated into 4 groups (n = 10): G1 (E+I); G2 (X+I); G3 (E+P); and G4 (X+P). The persistence of sealer residues was evaluated by SEM. Confocal laser scanning microscopy images were taken to measure the formed hybrid layer using the Image J program. For microshear bond strength, 4 resin composite cylinders were placed over the dentin after the cleaning protocols. ANOVA followed by Tukey test and Kruskal-Wallis followed by Dunn test were used for parametric and non-parametric data, respectively (α = 5%). Results G2 and G4 groups showed a lower persistence of residues (p < 0.05) and thicker hybrid layer than the other groups (p < 0.05). No bond strength differences among all groups were observed (p > 0.05). Conclusions Dentin cleaning using xylol, regardless of the time-point of acid etching, provided lower persistence of residues over the surface and thicker hybrid layer. However, the bond strength of the universal adhesive system in etch-and-rinse strategy was not influenced by the cleaning protocols or time-point of acid etching. Objectives This study aimed to investigate the bonding effects of cleaning protocols on dentin impregnated with endodontic sealer residues using ethanol (E) or xylol (X). The effects of dentin acid etching immediately (I) or 7 days (P) after cleaning were also evaluated. For bonding to dentin, universal adhesive (Scotchbond Universal; 3M ESPE) was used. The persistence of sealer residues, hybrid layer formation and microshear bond strength were the performed analysis. Materials and Methods One hundred and twenty bovine dentin specimens were allocated into 4 groups (n = 10): G1 (E+I); G2 (X+I); G3 (E+P); and G4 (X+P). The persistence of sealer residues was evaluated by SEM. Confocal laser scanning microscopy images were taken to measure the formed hybrid layer using the Image J program. For microshear bond strength, 4 resin composite cylinders were placed over the dentin after the cleaning protocols. ANOVA followed by Tukey test and Kruskal-Wallis followed by Dunn test were used for parametric and non-parametric data, respectively (α = 5%). Results G2 and G4 groups showed a lower persistence of residues (p < 0.05) and thicker hybrid layer than the other groups (p < 0.05). No bond strength differences among all groups were observed (p > 0.05). Conclusions Dentin cleaning using xylol, regardless of the time-point of acid etching, provided lower persistence of residues over the surface and thicker hybrid layer. However, the bond strength of the universal adhesive system in etch-and-rinse strategy was not influenced by the cleaning protocols or time-point of acid etching.

Repercussions of Breastfeeding by Diabetic Women for Breast Cancer

Franca, Eduardo Luzia,Franca-Botelho, Aline Do Carmo,Franca, Juliana Luzia,Ferrari, Carlos Kusano Bucalen,Honorio-Franca, Adenilda Cristina Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Diabetes represents a serious health problem. In the diabetic state, alterations in metabolism, increased susceptibility to infections and immunological changes occur. The suppression of the immune response has been identified as a relevant factor that contributes to the increase in the rate of infections in these patients. At the same time, breast cancer is the most frequent malignant tumor in women. The molecular and cellular mechanisms underlying cancer development have revealed that immune cells functionally regulate epithelial cancer development and progression. Breastfeeding has been hypothesized to reduce the risk of breast cancer. However, early systematic reviews have not yielded consistent findings for this association. The demand for human milk is increasing due to the promotion and consumer acceptance of the health benefits of consuming a natural product rich in bioactive components. However, due to changes in glucose metabolism, the components of the milk from diabetic women are modified depending on the time of evaluation. In this literature review, we summarize important new findings revealing the paradoxical role of breastfeeding in preventing the onset of breast cancer in diabetic mothers. We hypothesized that the milk component production in diabetic mothers is affected by changes in glucose metabolism. Therefore, adequate maternal glycemic control and an adequate duration of breastfeeding for diabetic mothers are crucial to ensure that the immunity components are able to confer protection against breast cancer.

Impact of long-term high-intensity interval and moderate-intensity continuous training on subclinical inflammation in overweight/obese adults

José Gerosa-Neto,Barbara M.M. Antunes,Eduardo Z. Campos,Jhennyfer Rodrigues,Gustavo D. Ferrari,José C. Rosa Neto,Carlos R. Bueno Junior,Fábio S. Lira 한국운동재활학회 2016 JER Vol.12 No.6

Knowledge of Diabetes Mellitus: Does Gender Make a Difference?

Patrı´cio Fernando Lemes dos Santos,Poliana Rodrigues dos Santos,Graziele Souza Lira Ferrari,Gisele Almeida Amaral Fonseca,Carlos Kusano Bucalen Ferrari 질병관리본부 2014 Osong Public Health and Research Persptectives Vol.5 No.4

Objective: Diabetes mellitus (DM) is a chronic disease considered an important public health problem. In recent years, its prevalence has been exponentially rising in many developing countries. Chronic complications of DM are important causes of morbidity and mortality among patients, which impair their health and quality of life. Knowledge on disease prevention, etiology, and management is essential to deal with parents, patients, and caregivers. The aim of this study was to evaluate the knowledge regarding DM in an adult population from a Middle-western Brazilian city. Methods: This was a cross-sectional study covering 178 adults, aged 18-64 years, who answered a diabetes knowledge questionnaire. In order to identify the difference between groups, analysis of variance was used. Results: Higher knowledge scores were found regarding the role of sugars on DM causality, diabetic foot care, and the effects of DM on patients (blindness, impaired wound healing, and male sexual dysfunction). However, lower scores were found amongst types of DM, hyperglycemic symptoms, and normal blood glucose levels. Females tended to achieve better knowledge scores than males. Conclusion: Women had better knowledge regarding types of DM, normal blood glucose values, and consequences of hyperglycemia revealed that diabetes education should be improved.