Methotrexate 치료를 받고 있는 활동성 류마티스 관절염 환자에서 etanercept의 유효성과 안전성에 관한 연구

최병렬,강태영,정청일,이혜순,엄완식,김태환,전재범,유대현,배상철 대한내과학회 2004 대한내과학회지 Vol.66 No.5

목적 : 류마티스 관절염을 앓고 있는 한국인 중에 기존 DMARDs로 치료 실패하였고, 고정용량의 MTX를 복용하고 있는 환자들에 있어서 etanercept의 유효성과 안전성을 평가하고자 하였다. 방법 : 기존 DMARDs로 치료 실패한 활동성 류마티스 관절염 환자 76명을 대상으로 하여 단일군, 공개시험을 하였다. 대상 환자들은 고정용량의 MTX를 복용하면서 etanercept 25 mg을 1주일에 두 번 피하 주사하였으며 12주간 투여하였다. 유효성은 ACR 20, ACR 50,조조강직 시간으로 평가하였고, 약제의 안전성은 이상반응 등으로 평가하였다. 결과 : 대상 환자는 총 76명으로 평균 연령은 45.2세, 남자 5명, 여자 71명이었다. 84.4%인 54명이 12주째에 ACR 20을 만족하였고, 53.1%인 34명이 12주째에 ACR 50을 만족하였다. 조조 강직 시간은 치료 전 203.3분에서 치료 12주째 42.6분을 평균 74.5% 호전되었다. 가장 흔한 이상반응은 주사부위 반응이었다. 이외에도 상기도 감염, 오심, 안면부종 등이 발생하였으나 심각한 부작용은 없었다. 결론 : etanercept는 효과적이고, 안전한 류마티스 관절염 치료 방법이며 특히 MTX치료에도 불구하고 활동성인 류마티스 관절염에 기대되는 치료라고 할 수 있다. Background : This study was performed to investigate the efficacy and safety of etanercept in active rheumatoid arthritis patients with stable dose of methotrexate in Korean. Methods : In a 12 week, single arm, open trial, we assigned 76 patients with active rheumatoid arthritis who had an inadequate response to disease-modifying antirheumatic drugs. Patients received twice-weekly subcutaneous injections of etanercept 25 ㎎ while containing to receive methotrexate at a stable dose of 7.5~25 ㎎ per week. The clinical response was defined as the percent improvement in disease activity according to the criteria of the American Collage of Rheumatology (ACR) at 12 weeks. Results : Etanrecept led to significant improvements in disease activity and was safe and well tolerated. At 12 week, 84.4% of the patients receiving 25 ㎎ of etanercept achieved a 20% ACR response, and 53.1% of those receiving etanercept achieved a 50% ACR response. The most common adverse event was injection-site reaction. Other advanse events were upper respiratory infection, nausea, and facial edema, but there were no serious adverse events associated with etanercept. Conclusion : In active rheumatoid arthritis patients, etanercept was safe, well tolerated, and provided rapid clinical improvements.

성인의 경부 전면 중앙부위에서 발생한 기형종 1예

최월용,정효진,채종인,하태인,정상렬,이광재,채병도,최영식 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1

Teratomas are embryonal neoplasms that show characteristics of three germ cell layers(ectoderm, mesoderm, and endoderm). They are distributed in the following regions: sacrococcygeal(57%), gonadal(29%), mediastinal(7%), cervical(3%), retroperitoneal(4%), and intracranial(3%) regions. Non-gonadal treatomas present in infancy whereas gonadal are seen in adolescence. Especially, teratomas that occurred in midline neck of adult are very rare and are confused with thyroglossal duct cysts, cystic hygromas, and thyroid tumors. We report, along with the review of appropriate literature, a case of histopathologically confirmed benign teratoma in the midline neck of a 33 years old woman.

게임 데이터 전송 프로토콜 설계 연구

최성,진병률 남서울대학교 2005 남서울대학교 논문집 Vol.11 No.2

From online game the big small data is frequent, it moves group and it occurs. Currently like this game undergarment data use the TCP or the UDP with transmission protocol and they are transmitted. It transmits the data of online game from the dissertation which it sees and there is a place where it controls and it reveals, if use of the TCP or the UDP rain efficiency is proper a proper protocol in the game transmission which is new, in online game data quality and and it presents hazard loss priority (Packet Loss Priority) gives the efficiency improvement of the Internet traffic and specially the TCP traffic the technique which it proposes. The algorithm which it proposes re-transmission phay khis raises the PLP and re-transmission phay khis it diminishes it enters in the condition where the TCP is incongruent the fact that a loss from inside watch. Dignity technique it will listen to and it applied it researched the plan against a new game data transfer protocol.

近似的混合 分布識別의 새로운 方法

許文烈,崔秉洙 成均館大學校 韓國産業硏究所 1988 韓國經濟 Vol.16 No.-

PVD 방법에 의한 TiN barrier metal 형성과 공정개발

염병렬,박형호,최치규,이종덕,김건호,이정용,서경수,강민성 濟州大學校 基礎科學硏究所 1997 基礎科學硏究 Vol.10 No.2

Ar과 N₂?가스가 혼합된 분위기에서 반응성 스퍼터링 방법에 의하여 TiN 박막을 증착하였다. N₂ 가스의 농도는 화학양론적으로 TiN이 형성되는 조건에 맞도록 조절하였으며, 기판의 온도는 실온에서 부터 700℃의 범위내로 유지하였다. (111) texture 구조를 가지면서 화학양론적으로 Ti??N??인 박막은 기판의 온도가 600℃ 이상에서 형성되었고, 기판의 온도가 600℃ 이하에서는 형성된 박막은 N-과다형이었다. XRD, XPS 및 RBS 분석 결과 TiN 박막의 조성비는 기판의 온도에서 다소 의존하였으나 약 5% 이내에 불과하였다. TiN 박막의 면저항은 기판온도의 증가에 따라 감소하였고, 기판온도가 600℃에서 증착된 TiN 박막의 면저항능 14.5Ω/□ 였고, Ar―가스 분위기에서 700℃로 30초간 열처리한 후는 8.9Ω/□ 이었다. 따라서 반응성 스퍼터링방법에 의하여 형성되는 양질의 TiN 박막은 기판온도가 600℃이상이 최적조건임을 알았다. Titanium nitride (TiN) films were prepared by reactive sputter deposition in mixed gas of Ar+N₂?. The volume percentage of N₂ in the working gas was chosen so as to grow stoichiometric TiN films and the substrate temperature during film growth was set from room temperature to 700℃. stoichiometric Ti??N?? films with (111) texture were grown at temperatures over 600℃, while films prepared at temperatures below 600℃ showed N-rich TiN. The composition x and y in the Ti??N?? films determined by XPS and RBS varied within 5% with the substrate temperature. The sheet resisstance of the TiN films decreases as the substrate temperature increased. TiN film prepared at 600℃ showed 14.5Ω/□, and it decreased to 8.9Ω/□ after the sample was annealed at 700℃, 30 sec in Ar-gas ambient by RTA. By far, high quality stoichiometric TiN films by reactive sputtering in the mixed gas ambient could be prepared at substrate temperature over 600℃.

사료지방의 공급과 젖소의 생산성

손용석,최병렬 高麗大學校 自然資源科學硏究所 1998 自然資源科學硏究 Vol.6 No.-

소뇌출혈후 신경인성방광으로 배뇨장애를 주소로 한 환자 치험 1例

안정조,최영,조현경,임승민,김민상,오병렬,유병찬,설인찬 대전대학교 한방병원 2002 惠和醫學 Vol.11 No.1

In patients with Cerebral vascular accident, Voiding Dysfunction is very usual, but if with no improvement for a long time, it can cause many complexed-problems as urinarytract injury, infection or inflamation and patients suffering from pain, inconvenience and anxiety. In this case 58-year-old female with Voiding Dysfunction with Neurogenic Bladder after Cerebellum Hemorrhage, for 6 monts there was no interval change on symptom, We prescribed appropeiate herbal medication, and perform acupuncture and moxa. 5 days later after admission in Taejeon Oriental Hospital, The patien was able to have self-voiding and gradually improved. So we report it for the better treatment.

Gullian Barre Syndrome 患者 1例에 대한 症例報告

임승민,안정조,최영,조현경,김민상,유병찬,오병렬,김윤식,설인찬 대전대학교 한방병원 2002 惠和醫學 Vol.11 No.1

Gullian Barre Syndrome is an acute symmetric polyradiculoneuropathy that typically presents as a progressive flaccid paralysis. The pathology is believed to be caused by both cellular and humoral immune processes The possibility of death is 3-5% and About 20% of patients require mechanical ventilaton. Recently We have experienced a patient who had suspected Gullian Barre Syndrome for 60days, his condition weakness and pain was impoved through the herb and acupucture Therefore I reported it for the treatment.

Supra Pubic Catheter를 施行한 腦卒中 患者 1例에 對한 證例報告

유병찬,오병렬,김민상,안정조,임승민,최영,설인찬 대전대학교 한방병원 2002 惠和醫學 Vol.11 No.1

According to the literary study on catheterization of bladder in one case of patient with C.V.A. who was treated by supra pubic catheterization, the results were as follows. 1. If not immediately treat ischuria, emergency disease, very great danger to life can happen by loss of kidney function. So we must treat ischuria instantly by consideration of treatment from the factor. 2. Catheterization of bladder generally acted in emergency room, is emergency treatment only in the lower part of urethral obstruction. 3. Catheterization of bladder was put on record in Son Saimiao's Qianjinyaofang, which is the first book on it. It had been developed by Luo Qianyi, Zhang Jiepin, and Wang Dao. 4. Ancient times, an urethral catheter was made of green onion leaf, pig bladder, goose feather and so on. 5. Nelaton is catheterization of bladder in functional or momentary ischuria. Indwelling catheterization is treatment keeping in urethral canal for a long time. 6. Supra pubic catheterization is a surgical operating catheterization when urethral catheterization is impossible, is very easy and can decrease risk of infection. 7. After catheterization, for decreasing risk of the infection, a complication of catheterization, it is must be taken precedence, ascetic treatment, constantly management and sterilization, anti-biotic medication. 8. At times, increasing patient of emergency disease, as C.V.A etc., the needing of catheterization of bladder is increasing also for preventing infection and bed sore by ischuria and incontinence of urine. Therefore a specialty knowledge and skill about it is necessary.

경피내시경하 위루술(PEG)을 시행한 중풍후유증 환자 1례에 대한 증례보고

임승민,안정조,최영,조현경,오병렬,설인찬 대전대학교 한방병원 2002 惠和醫學 Vol.11 No.1

According to the case study of patient with seguela of C.V.A who was treated by Percutaneous Endoscopic Gastrotomy(PEG), his chief complaint is the dysphagia. We treated him by a viewpoint of oriental medicine and got the good clinical symtom.