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崔炳烈,孫彰奎 대전대학교 한의학연구소 2001 혜화의학회지 Vol.10 No.1
Clinical studies were carried out 62 cases of patients with lung cancer treated by Hangamdan(抗癌丹) from January 1th 1998 to September 30th 2000. The results were summarized as follows; 1. Distribution of those attached by lung cancer, by sex, showd that Male is more then Female, by age, showed that the number of sixties is majority. 2. Distribution of diagnostic stage, in descending order; stage Ⅳ(43.6%,top), stage Ⅲ(35.5%), stage Ⅱ(17.7%), stage Ⅰ(3.2%). 3. The effects of maintenance and improvement in the symptoms with traditional oriental therapy(83.3%) and combined treatment of western and oriental therapy(84.0%) were observed. The effects of the symptoms were as follows; cough(50.0%), anorexia(48.4%), chest discomfort(31.0%), sputum(24.2%), general body weakness(11.3%), hemoptysis(9.7%) and etc. in orders. 4. Analysis of hematology attached by lung cancer, maintenance and increasing of WBC(98.4%), RBC(74.2%), Hgb(71.0%), Platelet(96.7%) were observed. After taken Hangamdan, the safety of the liver and kidney were as follows; maintenance and decreasing of AST(91.5%), ALT(93.2%), γ-GTP(95.0%), BUN(82.7%), Creatinine(93.3%) were observed. 5. Analysis of IL-12 and IFN-γ attached by lung cancer, increasing of IL-12(31.3%), IFN-γ(72.7%) were observed. 6. Analysis of QOL attached by lung cancer, maintenance and improvement of combined treatment of western and oriental therapy(94.0%), traditional oriental therapy(91.7%) were observed. 7. Analysis of survival in patients with Ⅳ stage of lung cancer, above 7 months(22.2%), 12 months(70.4%). 8. Analysis of antitumor effects, maintenance of traditional oriental therapy(50.0%) and maintenance and improvement of combined treatment of western and oriental therapy(80.0%) were observed. 9. Analysis of curative valuation, maintenance and improvement of traditional oriental therapy(50.0%), combined treatment of western and oriental therapy(60.0%) were observed. From the above resutls, it is suggested that Hangamdan has significant effects of antitumor and immune activity, also could be usefully applied for lung cancer patients by combinatin with western therapy or alone.
최병렬,이지영,송기철,조정효 대전대학교 한방병원 2002 惠和醫學 Vol.11 No.1
After treating a patient suffering from hepatitis A, a significant result is gained as follows. This study was done from the patient who were at the Oriental Medicine Hospital of Daejeon University during 20 days, from 5. 22 to 6. 9, 2001. A 26-year-old patient had complained an general body jaundice, fatigue, nausea, dizziness and general body weakness. During the hospital periods, the kinds of therapy are acupuncture and Herbal Medication. Given the treatment, he felt so satisfied about his symptom's improvement, and the numerical value of a laboratory examination was improved.
안태규,최병렬,송기철,이용연,유화승,서상훈,최우진,조정효,이연월,손창규,조종관 대전대학교 한방병원 2001 惠和醫學 Vol.10 No.1
In the literatual study on Holotrichia, the results were obtained as follows ; 1. Holotrichia is larva of Holotrichia diomphalia Bates etc. powder or liquor of Holotrichia is used medically. 2. Appearance of Holotrichia is shape of kidney, yellowish color. 3. The oriental characters of Holotrichia is warm, toxicant, salty. 4. The significant efficancy of Holotrichia is breaking the stagnant blood. 5. Holotrichia can be applied to the diseases related to thrombosis, and recover the demage of liver. 6. Holotrichia avails Liver diseases such as Hepatitis, Liver cirrhosis, Hepatosplenomegaly, Hepatoma etc.
최병렬(Byung-Lyul Choi),이갑성(Gab-Seong Lee),최동훈(Dong-Hoon Choi) 한국자동차공학회 2006 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
This research proposes a design process considering uncertainties to obtain optimal hardpoints and bush stiffness coefficients of the automotive suspension systems. To execute the kinematic and compliance analysis of the suspension system, we utilizes ADAMS/Car model of the McPherson strut type front suspension system. The proposed design process consists of 3 steps. The first step is to define the uncertainties. In this step, the properties of automotive parts are considered as random variables. To randomize their nonlinear properties, the engineering sense is needed. The second step is to analyze the influence on suspension system uncertainties. The final step is to optimize the hardpoints considering random variables. In this research, all design studies are executed by the FRAMAX, it is one of the PIDO tools. In conclusion, the design process under uncertainties is proposed and is applied on the automotive suspension system. As a result, the optimal hardpoints and bush stiffness coefficients can be obtained to satisfy target reliabilities of the design requirements.
K & C 특성의 신뢰성 향상을 위한 차량 현가장치의 최적설계
최병렬(Byung-Lyul Choi),최진호(Jin-Ho Choi),최동훈(Dong-Hoon Choi) 한국자동차공학회 2004 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
This study introduces the Reliability-Based Design Optimization(RBDO) to enhance the kinematic and compliance (K & C) characteristics of automotive suspension system. In previous studies, the deterministic optimization has been performed to enhance the K & C characteristics. Unfortunately, uncertainties in the real world have not been considered in the deterministic optimization. In the design of suspension system, design variables with the uncertainties, such as the bushing stiffness, have a great influence on the variation of the suspension performances. There is a need to quantify these uncertainties and to apply the RBDO to obtain the design, satisfying the target reliability level. In this research, design variables including uncertainties are dealt as random variables and reliability of the suspension performances, which are related the K & C characteristics, are quantified and the RBDO is performed. The RBD-optimum is compared with the deterministic optimum to verify the enhancement in reliability. Thus, the reliability of the suspension performances is estimated and the RBD-optimum, satisfying the target reliability level, is determined.
내구수명 및 K&C 특성 향상을 위한 토션빔현가액슬 최적설계
최병렬(Byung-Lyul Choi),민준홍(Junhong Min),최동훈(Dong-Hoon Choi),전광기(Kwangki Jeon),박정원(Jungwon Park),최성진(Sungjin Choi),고정민(Jungmin Ko) 한국자동차공학회 2007 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
This research proposes an automatic torsion beam axle optimization process and obtains the optimal torsion design parameters, such as thickness and shape. In order to construct an automatic analysis process, the multidisciplinary analysis models, such as modal analysis, roll mode dynamic analysis, and fatigue analysis, were equipped as batch mode. To understand a design space, the parametric study using torsion beam thickness and shape was executed. Considering the roll durability and K&C characteristics, a torsion beam axle could be optimized. For the automatic design process, the PIDO tool, called as P.I.A.n.O., are utilized. In conclusions, we could reduce a computer-aided simulation time and enhance the durability and K&C characteristics of torsion beam by optimizing thickness and shape.
윤병구 ( Byung Koo Yoon ),김도관 ( Doh Kwan Kim ),김종원 ( Jong Won Kim ),최두석 ( Doo Seok Choi ),배덕수 ( Duk Soo Bae ),나덕렬 ( Duk Lyul Na ) 대한폐경학회 2003 대한폐경학회지 Vol.9 No.1
배경 및 목적 : 치매는 낙상 가능성의 증가를 통하여 골절의 위험을 높힌다. 진행된 치매에서 관찰되는 골다공증은 영양실조에 의한 2차성 부갑상선항진증과 운동부족이 중요한 원인으로 알려져 있다. 본 연구의 목적은 알쯔하이머병 여성 환자에서 골다공증에 대한 유병률을 조사하는 것이다. 대상 및 방법 : 80명의 알쯔하이머병 환자를 대상으로 하였으며, 초기 치매는 임상치매척도가 1 이하이며, 운동 기능은 정상인 경우로 정의하였다. 과거력상 비외상성 골절의 유무를 조사하였고, osteocalcin과 deoxypyridinoline 등의 골대사지표와 함께 이중에너지 방사선흡수계측법을 이용하여 골밀도를 측정하였다. 결과 : 전체적으로 알쯔하이머병 여성에서 골다공증의 유병률은 58%이었다. 80명중 45명이 초기 치매에 해당하였다. 초기 치매환자에서 골다공증성 골절의 과거력이 38%, 골교체률이 증가한 경우가 72%이었으며 골다공증의 유병률은 62%이었다. 결론 : 여성에서 영양상태와 운동기능이 정상인 초기 알쯔하이머병은 골다공증과 매우 높은 연관성을 보이며, 이는 난포호르몬-알쯔하이머병 가설을 뒷받침하는 연구 결과이다. Background and objective : Dementia is one of the risk factors of fracture via increasing risk of falling down. Osteoporosis occurring in advanced dementia might be causally related to secondary hyperparathyroidism resulting from poor nutrition and physical activity. The purpose of this study is to examine the prevalence of osteoporosis (OP) in patients with Alzheimer`s disease (AD). Materials and methods : Past history of non-traumatic fracture, bone turnover markers such as osteocalcin and deoxypyridinoline and bone mineral density (BMD) using dual energy X-ray absorptiometry were assessed in 80 women with AD. Early AD was defined as clinicla dementia rating scale ≤ 1 and physical activity unimpaired. Results : In general, the prevalence of OP (T value on BMD ≤ -2.5) was 58% in women with AD. Forty-five out of 80 patients belonged to early AD. Thirty-eight percentage of early AD patients had history of fragility fracture, 72% increased bone turnover rate, and 62% osteoporosis. Conclusions : Early AD with normal nutritional status and physical activity might be highly associated with OP, which supports estrogen-AD hypothesis.