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녹차 및 결명자 추출물의 교정용 브라켓과 치면 사이의 경계부에서 분리된 mutans streptococci에 대한 항균작용
임성훈,서정순,윤영주,김광원,유소영,김화숙,국중기,이병래,차종희,박재윤 대한치과교정학회 2003 대한치과교정학회지 Vol.33 No.5
본 연구는 치아우식증에 관련된 Mutans streptococci 표준균주 및 임상분리 균주의 성장억제를 유도할 수 있는 천연 생약추출물을 검색하기 위하여 실시되었다. 녹차추출물은 CHMC-2032를 사용하였으며, 결명자 추출물은 50% 에탄올을 이용하여 얻었다. 이들 추출물의 Mutans streptococci 표준균주 및 교정환자들에서 브라켓과 치면 사이의 경계부에서 분리된 각각 10 균주씩의 S. mutans 및 S. sobrinus에 대한 최소성장억제농도를 액체배지 희석법으로 구하였다. 그 결과 CHMC-2032의 S. mutans 및 S. sobrinus의 표준 균주, S. sobrinus의 대부분 임상분리 균주에 대한 최소성장억제농도는 5 mg/ml이었다. 그러나 결명자 추출물에 의한 S. mutans 및 S. sobrinus에 대한 세균 성장억제 효과는 미미하였다. 본 연구 결과 치아우식증의 예방적 측면에서 결명자차보다는 녹차를 마시는 것이 유리하며, CHMC-2032를 이용하여 구강양치용액을 제조하여 사용할 경우 교정환자를 포함하여 대부분의 사람에게서 치아우식증 예방 효과가 있으리고 추정된다. Mutans streptococci is the major causative factor in dental caries. Especially, orthodontic patients with fixed appliance are a risk group for dental caries. Because fixed appliances attached on teeth may change the environment of dental plaque, the enamel decalcification or dental caries around the bracket and band is a major side effect of orthodontic treatment. The aim of this study was to search plant extracts that have antimicrobial effect on mutans streptococci. Seed-extract of Casio tora were prepared with ethanol and CHMC-2032, the leaf-extracts from Camellia sinensis extract, was obtained extract, 2 type strains and 20 clinical isolates of mutans streptococci isolated from the interface between orthodontic brackets and tooth surfaces in the orthodontic patients were used in this study. The minimal inhibitory concentration of CHMC-2032 was 5 mg/ml on the S. mutans KCTC 3065, S. sobrinus KCTC 3088, and 8 clinical isolates of S. sobrinus. However, there was no antibacterial effect of seed-extract of C. tora on mutans streptococci. These data suggest that green tea may be more effective than the tea prepared from C. tora in the prevention of enamel decalcification or dental caries around brackets.
( So Young Park ),( Sang Min Lee ),( Jong Wook Shin ),( Byoung Whui Choi ),( Hojoong Kim ),( Jae Seung Lee ),( Sang Do Lee ),( Sung Soo Park ),( Hwa Sik Moon ),( Yong Bum Park ) 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.2
Background/Aims: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is diff icult for numerous reasons and is related with a poor prognosis. In Korea, the incidence of CTEPH and its clinical features are unknown. Thus, in this study, we evaluated the clinical characteristics and outcomes of CTEPH in a Korean cohort. Methods: This study included South Korean patients diagnosed with CTEPH between September 2008 and October 2011. Baseline characteristics, treatments and outcomes were analyzed. Results: A total of 134 patients were included in this study with 76 females (56.7%). Their median age was 58.3 ± 15.9 years and dyspnea (112 patients, 83.5%) was the most common presenting symptom. Sixty-three patients (47%) had a history of acute pulmonary embolism or deep vein thrombosis, and six (4.5%) had pulmonary tuberculosis. In total, 28 patients (21%) underwent pulmonary thromboendarterectomy (PTE), and 99 patients had medical therapy. During the study period, 18 patients (13.4%) died. In a multivariate analysis, higher hemoglobin (relative risk [RR], 1.516; 95% confidence interval [CI], 1.053 to 2.184; p = 0.025) and lower total cholesterol levels (RR, 0.982; 95% CI, 0.965 to 0.999; p = 0.037) were associated with increased mortality. Conclusions: This was the first national cohort study of Korean patients with CTEPH. Accurate diagnosis, characterization and distributions of CTEPH are imperative for prompt treatment in patients, particularly those undergoing PTE.
Expression Pattern of Gangliosides during Co-culture of Human and Micro-pig Endothelial Cells
So-Dam Lee,Dong-Hoon Kwak,Young-Choon Lee,Keon-Bong Oh,Hwi-Cheul Lee,Ji-Su Kim,Byoung-Boo Seo,Jae-Sung Ryu,So-Hyun Lee,Ju-Taek Lee,Yoon-Ju Na,Su-Bin Lee,Kyu-Tae Chang,Young-Kug Choo 한국당과학회 2011 한국당과학회 학술대회 Vol.2011 No.1
Ganglioside are ubiquitous membrane component in mammalian cells and suggested to play important roles in various cell functions such as cell-cell recognition, differentiation and transmembrane signaling. These compounds are localized in a glycosphingolipid-enriched microdomain on the cell surface and regulated by the glycosphingolipid composition. However, the role that gangliosides play in the adhesive interaction response by xenotransplantation is not yet clearly understood. In this study, we investigated expression patterns of gangliosides in tight contact between human umbilical vein endothelial cells (HUVECs) and micro-pig aortic endothelial cells (MPAECs). Analysis of ganglioside expression pattern showed that differential expression patterns of ganglioside in tight contact between HUVECs and MPAECs. Furthermore, we confirmed that cell adhesion molecule expression in tight contact between HUVECs and MPAECs. Taken together, these results suggested that differential expression of gangliosides in tight contact between HUVECs and MPAECs may play a role in adhesive interaction response in successful clinical xenotransplantation.
Roles of Urban Planning to Prevent Climate Change Disasters in Vietnam
Byoung Jae Lee,So Yoon Kim 위기관리 이론과 실천 2019 Crisisonomy Vol.15 No.10
기후변화로 인한 홍수의 피해와 영향을 받을 위험이 가장 큰 나라 중 하나인 베트남은 국가 비전으 로서 기후변화와 지속가능한 발전에 대한 적극적인 대응을 추구하고 있다. 그러나, 베트남은 경제성 장에 따른 급격한 도시화로 인해 자연재해 취약성이 증가하고 있으나, 도시 계획적 재해예방을 위한 체계적 지원기술이 부족한 실정이다. 기후변화로 인한 재난대응 대책 수립 관련하여 한국의 도시 급성장 사례가 베트남 현재 상황에 대한 시사점이 크다. 이에 본 논문에서는 한국의 재해 예방형 도시계획 제도의 베트남 적용에 대한 여건을 분석하고 시사점을 도출하고자 하였다. 베트남 기후변 화 재해 특성, 도시계획 분야 기후변화 재해예방 제도 및 정책 현황, 도시 계획적 기후변화 재해예방 대책 수립 한계 분석을 통해 베트남 재해 예방형 도시계획 도입을 위한 정책적, 기술적, 경제적 방안 및 시사점을 제시하였다. Vietnam, one of the countries at the greatest risk of being damaged and affected by climate change, attempts to make an active response to climate change and sets sustainable development as a national vision. However, Vietnam lacks systematic support of technology for disaster prevention within urban planning framework, although the vulnerability of natural disasters has been increasing due to rapid urbanization along with economic growth. Korea’s experience in handling rapid urban growth would provide some insights to Vietnam on establishing measures to cope with climate change disasters. Thus, this paper analyzed the applicability of the Korean urban planning system for disaster prevention to Vietnam and derived some implications. Through the analysis of the characteristics of climate change disasters in Vietnam and the current status and limitations of the Vietnam’s urban planning and policies for the prevention of climate change disasters, policy, technical and economic measures and implications were provided for the introduction of disaster-preventive urban planning in Vietnam.
A case of perialar extraorbital sebaceous carcinoma
( Byoung Joon So ),( Jae Beom Park ),( Seung Hyun Chun ),( Ji Hyun Park ),( Sang Wook Son ),( Il Hwan Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Sebaceous carcinoma is rare aggressive neoplasm that usually located on the ocular adnexa, especially meibomian gland and zeiss gland, but few cases of sebaceous carcinoma are arising from extraocular sites. Extraocular sebaceous carcinoma is commonly affect the head and neck area, rarely affect the trunk and extremities in elderly. A 58-year-old male who had 0.5ⅹ0.6cm sized slow-growing yellowish plaque on below the left nasal ala for several years visited our hospital. The histologic examination with 3mm punch biopsy shows irregular tumor nest composed of sebaceous undifferentiated cells variation in the shape and size of each nuclei, confirmed the diagnosis of sebaceous carcinoma. The lesion was totally removed by 5mm-margin wide surgical excision and showed no recurrence for three years. We experienced an unusual case of extraorbital sebaceous carcinoma that successfully treated with 5mm-margin wide surgical excision without recurrence.
So-Hyun Lee,Dong-Hoon Kwak,Hyung-Keun You,Beom-Su Kim,Kyung-A Hwang,Byoung-Boo Seo,Hwi-cheul Lee,Jae-Sung Ryu,So-Dam Lee,Ju-Taek Lee,Yoon-Ju Na,Su-Bin Lee,Kyu-Tae Chang,Young-Kug Choo 한국당과학회 2011 한국당과학회 학술대회 Vol.2011 No.1
Gangliosides, sialic acid-conjugated glycosphingolipids, are involved in cell proliferation and differentiation. This study investigated the possible role of gangliosides in the dopaminergic neuron-like cells of human mesenchymal stem cells (hMSCs). We have reported the in vitro conditions for inducing hMSCs into dopaminergic neuron-like cells. hMSCs were induced in vitro to become dopaminergic neuron-like cells in 12 days by using a cocktail that includes sonic hedgehog and fibroblast growth factors. First, we investigated the characterization of hMSCs through FACS analysis. The mesenchymal stem cell specific markers, CD44 and CD105, were expressed in hMSCs while the hematopoetic markers, CD45 and CD117 were not. The cells developed a neuronal morphology expressing the neuronal markers Map2 and βⅢtubulin. RT-PCR analysis revealed the expression of dopamine specific genes such as TH, Pitx3, Nurr1 and DA transporter. Immunocytochemistry showed that hMSCs expressed GM3, GM2, GD1a, GD3 and GT1b based on tyrosine hydroxylase (TH) expression. Specifically, a significant decrease in GM3 and GT1b expression was observed during dopaminergic neuron differentiation. These results suggest that ganglioside GT1b may play a role in the dopaminergic neuron differentiation and development process of hMSCs.
Jae Yong Lee,So Yeon Lee,Yoo Jin Lee,Jin Wook Lee,Jeong Seok Kim,Ju Yup Lee,Byoung Kuk Jang,Woo Jin Chung,Kwang Bum Cho,Jae Seok Hwang 영남대학교 의과대학 2023 Yeungnam University Journal of Medicine Vol.40 No.4
Background: Differentiating between bacterial and nonbacterial colitis remains a challenge. We aimed to evaluate the value of serum procalcitonin (PCT) and C-reactive protein (CRP) in differentiating between bacterial and nonbacterial colitis. Methods: Adult patients with three or more episodes of watery diarrhea and colitis symptoms within 14 days of a hospital visit were eligible for this study. The patients’ stool pathogen polymerase chain reaction (PCR) testing results, serum PCT levels, and serum CRP levels were analyzed retrospectively. Patients were divided into bacterial and nonbacterial colitis groups according to their PCR. The laboratory data were compared between the two groups. The area under the receiver operating characteristic curve (AUC) was used to evaluate diagnostic accuracy. Results: In total, 636 patients were included; 186 in the bacterial colitis group and 450 in the nonbacterial colitis group. In the bacterial colitis group, Clostridium perfringens was the commonest pathogen (n=70), followed by Clostridium difficile toxin B (n=60). The AUC for PCT and CRP was 0.557 and 0.567, respectively, indicating poor discrimination. The sensitivity and specificity for diagnosing bacterial colitis were 54.8% and 52.6% for PCT, and 52.2% and 54.2% for CRP, respectively. Combining PCT and CRP measurements did not increase the discrimination performance (AUC, 0.522; 95% confidence interval, 0.474–0.571). Conclusion: Neither PCT nor CRP helped discriminate bacterial colitis from nonbacterial colitis.