3차 병원의 병동에서 시행된 심폐소생술의 분석

류진호,정경운,위준선,문정미,전병조,문원식,김용권,소정일,허탁,민용일 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: Although cardiopulmonary resuscitation(CPR) is a very effective therapy in cardiac arrest, it is hard to prove the true effectiveness of CPR. Several studies about out-of-hospital and emergency department CPR exist, but only a few reports about in-hospital CPR are available. This study was designed to investigate in-hospital cardiac arrest, to analyze the result of CPR, and to evaluate the problems associated with in-hospital CPR. Methods: A clinical analysis of 71 cases of in-hospital CPR announcement from January 2000 to August 2000 was performed. The initial rhythm on cardiac arrest, return of spontaneous circulation(ROSC), and the survivals were analyzed in the case of the 46 true cardiac arrest patients. Results: During 8 months, there were 71 cases of in-hospital CPR announcement. Among them, there were 46 cases of true cardiac arrest and 25 cases of non-cardiac arrest. Of the 46 true cardiac-arrest cases, 27(58.7%) experienced ROSC, 15(32.6) survived for over 24 hours, and 7(15.2%) survived to be discharged. The initial rhythms on cardiac arrest were 30 cases(65.2%) of asystole, 14(30.4%) of PEA(pulseless electrical activity), and 2(4.3%) of ventricular fibrillation, with ROSC being 17 cases(56.7%), 9(64.3%) and 1(50.0%) cases and discharged survivors being 4 cases(13.3%), 3(21.4%) and 0(0.0%) cases, respectively. Conclusion: Extraordinarily high proportions of asystole and PEA were seen in the initial rhythm of cardiac arrest, and those were associated with high survival rates. Although further study is needed to evaluate the course leading to this high proportion of asystole and PEA, this result suggests that if the EMS system in the hospital is activated promptly and systematically, a better outcome will be achieved in case of cardiac arrest with asystole and PEA.

丹參飮이 實驗動物의 心血管係에 미치는 影響

申善澔,李基商,文病淳 圓光大學校 韓醫學硏究所 1995 원광한의학 Vol.5 No.1

The present experiment was desinged to investigate the effects of Dansamyeum water extracts on the Cardivascular System in the Experimental Animals. Thus, the changes of blood pressure and heart rate were measured after oral administration. Measurments of Mortality rate were observed for measuring the effects of Dansamyeum water extract. Dansamyeum water extracts against pulmonary thromboembolism induced by collagen the mixture 90.1㎖/10g, 2㎖/㎏ B.W) plus serotonin(5㎎/㎏ B.W) in mouse. The effect of Dansamyeum water extract was examined by observing the change of collagen-induced platelet aggregation coagulation activity, ex vivo and in vitro fibrinolytic activity of euglobulin fraction in rats. The results were summarized as followings. 1. Dansamyeum dropped the blood pressure in spontaneous hypertensive rat. 2. The drug increased the auricular blood flow in rabbit. 3. The drug relaxed the artery contraction by pretreated norepinephrine in rat. 4. The drug inhibited the death rate of mouse which were led to thromboembolism by serotonin and collagen. 5. The drug inhibited the platelet aggregation in rat. 6. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 7. The drug increased the antithrombin activity in rat and the fibrinogen lyses time was reduced and lyses area was increased. 8. Dansamyeum reduced fibrinogen lyses time of rat in vitro assay. According to the above mentioned results, Dansamyium increased the blood flow and dropped the blood pressure by the dilation of blood vessel. And the drug presented the antithrombin acivity, inhibited the platelet aggregation.

프로폴리스 농도가 항균활성에 미치는 영향

김병문,송근호,이광래 江原大學校 産業技術硏究所 2007 産業技術硏究 Vol.27 No.B

The objetives of this study are to set up optimum extraction temperature, time and organic solvent for propolis extraction, to investigate chemical properties, and to develop health foods from propolis preparation. In this study, ethanol and ultrasonic extracts method performed to optimum extraction temperature was at 60, 2012, optimum extraction time was at 12, 4 hours and optimum extraction amount of solvent was at 20, 15 times of propolis weight. When various ethanol solutions were used, whereas flavonoid content was highest in 70, 80% aqueous ethanol, respectively. So the ultrasonic extracts method used gave better results than the ethanol extracts method in this work. Extraction of propolis with etanol and ultrasonic extracts method was performed by using the water and various concentrations of aqueous ethanol as solvent. Sensidvity of propolis samples to Staphylococcus aureus was invesdgated and the results were shown. Samples of water extract did not inhibit microbial growth, where as 50% aqueous ethanol extract the largest inhibitory zone for Staphylococcus aureus, then decreased inhibition with increasing ethanol concentrations.

음낭 Sparganosis 1예

소병억,김유찬,문장호,이순호,김세철 중앙대부설한국의과학연구소 1983 한국의과학 Vol.15 No.4

복숭아 유리나방의 성 페로몬의 한 성분인 (Z,Z)-3,13-옥타데카디엔-1-일 아세테이트의 합성

姜錫久,文炳昊 성균관대학교 기초과학연구소 1987 論文集 Vol.38 No.2

A synthesis of (Z, Z)-3, 13-octadecadien-1-yl acetate, one component of the sex pheromone of Synanthedon hector, Butler is described. Starting from 1,9-nonanediol, a sterocontrolled synthesis of (Z, Z)-3, 13-octadecadien-1-yl acetate with high sterochemical purity was achieved by the use of Wittig-olefination reaction and catalytic hydrogenation for the introduction of (Z)-double bond.

폐암에서 CYFRA 21-1과 다른 종양표지자의 진단적 의의

이상구,이호현,전병철,김성자,이영현,김문연,하경임 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

폐암의 확실한 조직학적 진단이 어려울 경우 종양표지자의 검사가 보조적인 진단 수단이 되고, 조기 진단이나 경과 관찰에 이용되고 있다. 이에 저자는 CYFRA 21-1이 폐암의 종양표지자로서 효용성이 있는지 판정하고, CYFRA 21-1과 다른 폐암 종양표지자인 SCC Ag, CEA, NSE의 폐암의 조직학적 유형에 따른 민감도와 특이도를 비교하였다. 그리고 병기 진행에 따른 CYFRA 21-1치의 증가 여부를 관찰하고, 4가지 종양표지자를 동시에 측정하였을 때의 진단적 효용성을 비교하고자 하였다. 이 연구는 1994년 12월부터 1995년 11월까지 동국대학병원에 입원한 폐암 환자 40명과 양성 폐질환 환자 40명을 대상으로 하였다. 편평상피세포암 21명, 선암 10명, 소세포암 7명, 대세포암 2명이었다. 혈청 CYFRA 21-1의 cytokeratin 19 분절에 대한 쥐의 두 가지 단일 클론항체(KS 19-1과 BM 19-21)를 이용하는 RIA방법으로 측정하였다. CEA는 MEIA 방법으로, SCC 항원과 NSE는 RIA로 측정 하였다. 1. CYFRA 21-1의 혈중 농도는 폐암군 22.08±43.00ng/mL, 양성 폐질환군 1.14±1.04ng/mL로 폐암군에서 양성 폐질환군보다 유의하게 높았다(P<0.05). 폐암환자군에서 55%의 양성율을 보였고, SCC 항원 30%, CEA 44.7%, NSE 54.5%의 양성율을 나타내 CYFRA 21-1이 가장 높은 양성율을 보였다. 2.CYFRA 21-1은 비소세포암군 23.79±44.49ng/mL, 소세포암군 13.90±33.57ng/mL로 양군에서 유의한 차이를 보였다. 폐암환자군에서 민감도와 특이도는 CYFRA 21-1 55.0%와 96.7%, SCC항원 30.0%와 96.4%, CEA 42.5%와 92.8%, NSE 36.4%, 76.9%로 CYFRA 21-1에서 가장 높은 민감도와 특이도를 보였다. 폐암의 조직학적 유형에 따른 민감도는 편평상피세포암에서 CYFRA 21-1이 61.9%로 CYFRA 21-1의 민감도가 가장 높았고, 선암에서는 CEA가 88.8%로, 소세포암에서는 NSE가 85.7%로 가장 민감도가 높은 것으로 나타났다. 3. 비소세포암군에서 CYFRA 21-1치는 병기가 진행됨에 따라 증가하는 경향을 보였으나 통계학적으로 유의하지는 않았다. 4. 폐암환자에서 단일 종양표지자를 측정하는 것 보다 동시에 여러 종양표지자를 측정하는 것이 특이도는 떨어지나 민감도는 80.0%로 더 높은 것으로 나타났으며 정확도에는 큰 차이가 없었다. 양성 표지나 수에 따른 비교분석시 폐암의 상대 예측도는 두 표지자 양성인 경우가 76.5%, 3가지 표지자와 4가지 모든 표지자에서 양성으로 나온 경우는 100%로 나타났다. 본 연구 결과 CYFRA 21-1은 새로운 폐암의 종양표지자로 기존의 종양표지자 보다 민감도가 높고 비소세포암 특히, 편평상피세포암에 유용한 표지자로 사료되며, 폐암이 의심되는 환자에서 단일 종양 표지자를 측정하는 것 보다 수종의 종양표지자를 동시에 측정하는 것이 진단에 더욱 도움이 되리라 생각된다. Background: Cytokeratin 19 is a subunit of cytokeratin intermediate filament expressed in simple epithelia and their malignant counterparts. A fragment of cytokeratin subunit 19 can be measured in serum with a immunoradiometric assay using two mouse MoAb KS 19-1 and BM 19-21. Thus this cytokeratin 19 fragment is referred to as CYFRA 21-1. The aims of this study are to evaluate the clinical utility of CYFRA 21-1 in the diagnosis of lung cancer and to compare the diagnostic sensitivity and specificity of CYFRA 21-1 with those of CEA, SCC Ag, NSE according to histological type of lung cancer. Methods: In 40 patients with lung cancer(21 with squamous cell carcinoma, 10 with adenocarcinoma, 7 with small cell carcinoma, 2 with large cell carcinoma) and 40 patients with non-malignant lung disease, serum CYFRA 21-1 was measured by solid-phase immunoradiometric assay(CIS Bio International, France). Serum NSE and SCC Ag were measured by immunoradiometric assay, and CEA was measured by microparticle enzyme immunoassay. Results: 1) The mean value of CYFRA 21-1 was 22.08±43.00ng/mL in the lung cancer and 1.11±1.04ng/mL in me non-malignant lung disease group(P<O.O5). 2) Using the cut-off value of 3.3ng/mL, the sensitivity and specificity of CYFRA 21-1 were 55.0%, 96.7% in the lung cancer. The sensitivity of CYFRA 21.1 was 61.9% in squamous cell carcinoma 3) The level of CYFRA 21-1 was increasing tendency with the progression of stage in non-small cell carcinoma but statistically not significant. 4) Simultaneous determination of four tumor markers revealed increased sensitivity to 50.0% in lung cancer. As the number of positive markers was increased, the relative possibility of lung cancer was also increased. If two markers were positive, it increased to 76.5% and three markers were positive, it increased to 100%.5 Conclusions: CYFRA 21-1 is a useful serum marker for patients with lung cancer, especially in squamous cell carcinoma of the lung. The simultaneous measurement of CYFRA 21-1, CEA. SCC Ag and NSE would provide additional information for the diagnosis of lung cancer, especially in patients with high risk group of lung cancer.

공기 제습용 무기막의 제조 및 특성

김정은,김병문,송근호,장화익,이광래 강원대학교 산업기술연구소 2006 産業技術硏究 Vol.26 No.B

Recently, the humidity adjustment of indoor air is of great importance in air conditioning system as a applied, in buildings, vehicles, and containers for storage and transport of perishable products. Membrane dehumidification or air is potentially attractive because it offers low capital and operating costs, along with low energy consumption. And membrane dehumidification process attracted the attention of the public instead of the other dehumidification processes, such as adsorption, absorption, and refrigeration cycles and so on. In this study, the prepared hydrophilic inorganic membrane-based dehumidifiers (membrane air dehumidification) examined the performance of dehumidification. The surface-modified inorganic membrane prepared in this study showed high dehumidification efficiency (over 80%). Thc membrane might be very useful for dehumidification industries.

흰쥐 심방벽 소혈관 분포의 특징

이무삼,이흥철,송창호,고병문,김봉천,정철현 대한해부학회 1995 Anatomy & Cell Biology Vol.28 No.1

I-SSR 標識子를 利用한 호도나무屬의 識別 및 類緣關係 分析

黃錫仁,曺炅眞,李文鎬,李在善,李炳實,李郁 한국임학회 2004 한국산림과학회지 Vol.93 No.7

DNA 표지자를 이용한 호도나무 품종의 유연관계 및 품종구분을 위하여 I-SSR 9개 표지를 이용하여 104개의 유의적인 표지가 얻어졌으며, 신품종 호도나무를 포함한 83개 국내외 품종(종)에 대해 DNA 지문에 의한 품종식별이 가능하였다. 수원 1호, 수원 2호, 왕호도는 모두 Conrord, McKinster 등 미국에서 도입된 대립성 품종과의 인공교배로 육성된 품종으로 유전적 유연관계가 상촌 4호 등 국내 선발종보다는 산성 4호×Concord의 교배종과 더 가까웠다. 국내 선발종 호도나무인 상촌 2호, 상촌 4호 및 산성 4호 이들 끼리 한 그룹을 이루고 있는데 이는 국내의 호도나무가 외국품종과 구분되는 유전적 동질성이 있음을 보여주었다. 영동은 개체선발로 육성되었으나 외국종과 교배에 의하여 육성된 교잡종들과 같은 무리에 속하였는데, 이는 영동 품종은 외국 품종의 교배에 의해 외래 유전자 일부가 유입된 것이 아닌가 추정된다. Concord×상촌 1호., Concord×상촌 2호, Concord×대부 1호가 한 무리를 이루었고 Lake×상촌 2호가 이들과 구분되는 것은 교배차대가 유전적으로 화분수보다는 모수의 영향을 더 많이 받고 있음을 보여준다. Using 104 fragments amplified from 9 I-SSR primers, a total of 83 cultivars in Juglans spp. including new cultivars used for the present study were identified. The new cultivars 'Suwon No.1', 'Suwon No.2', and 'Wanghodo' are hybrids between the domestic cultivars and the introduced cultivars such as 'Concord' and 'McKinster' bearing big nuts. Consequently, these cultivars were closer to the hybrid between 'Sansung 4×Concord' than to domestically selected cultivars such as 'Sangehon 4' from the viewpoint of genetic relationship. The domestic cultivars such as 'Sangchon 2', 'Sangchon 4', and 'Sansung 4' belonged to the same group and were genetically distinctive from the introduced cultivars. This suggests that there would be difference in genetic structure between the domestic and the introduced cultivars. The cultivar 'Yeongdong' was clustered into the group of hybrids between the domestic and the introduced cultivars although it was developed by the selection of a tree from a domestic population. This might be because the genes were introduced from the introduced cultivars into the domestic population via open-pollination. The 'Concordx×Sangchon 1', 'Concord×Sangchon 2', and 'Concord×Daebu 1' were Clustered into the same group whereas 'Lake×Sangchon 2' was clustered into the different group. This ndicates that the genetic characteristics of hybrids may be influence more strongly by the mother tree than by the father tree.

NMR study and biological activity test of six flavonoid glucosides

Byoung-Ho Moon(문병호),Youngshim Lee(이영심),Joong-Hoon Ahn(안중훈),Yoongho Lim(임융호) 한국생물공학회 2005 한국생물공학회 학술대회 Vol.2005 No.10