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박히준,채윤병,차웅석,박종배,이혜정,이향숙,인창식,고형균,김수영,최일환,김강식,문정배,배기태,유경환,육근영,정병주,손인철,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-
Background : The cun measurement System, an essential and convenient method in locating acupoints, has been widely used in the practice of acupuncture. However, traditional cun measurement has been criticized for its lack of reliability. Objectives : The purposes of this study are to determine if one cun measured by the directional methods have a consistency with that of proportional methods and to investigate which factors are related with these differences, especially in forearm. Methods : The distance between the elbow crease and the wrist crease of forearm was compared to a reference value of one cun obtained by the directional method. In this method, one cun is one third of the distance between index finger and Small finger of a subject, measured at proximal interphalangeal joint. In addition, to investigate the factors influencing the differences between these two methods, we measured the height and body weight and calculated body mass index (BMI). Finally we analyzed the factors correlated with these lengths by linear regression test. Results : The results showed that one cun obtained by the directional methods were significantly different from one cun by the proportional methods in forearm. It was demonstrated that the length acquired with the directional method was more correlated with body weight and body mass index, while the length obtained by the proportional method was more correlated with the height.
재발성 췌장염으로 발현한 췌장 상피내 종양(PanIN-3) 1예
손병석 ( Byeong Seok Sohn ),이성구 ( Sung Koo Lee ),김명환 ( Myung Hwan Kim ),서동완 ( Dong Wan Seo ),이상수 ( Sang Soo Lee ),김송철 ( Song Cheol Kim ),장세진 ( Sae Jin Jang ) 대한내과학회 2008 대한내과학회지 Vol.74 No.3
췌장 상피내 종양은 전암성 병변으로, 췌장암의 조기 진단 가능성 및 치료에 대한 기대로 인해 관심을 받고 있다. 췌장 상피내 종양은 원칙적으로 현미경 소견 이외에는 확인할 방법이 없으나, 최근 췌장 상피내 종양이 흔히 췌관 협착을 동반한 섬유화와 함께 발견되는 예가 보고되고 있어 이를 통한 조기 진단에 기대를 모으고 있다. 본례에서는 췌장 체부에 국소 만성 췌장염에 의한 섬유화 종괴의 발생과 이 종괴에 의한 재발성 췌장염 증상으로 내원하여 수술적 치료 시행하고, 병리 소견에서 섬유화 종괴 내에서 췌장 상피내 종양(PanIN-III)을 확인한 1예를 보고한다. Acute recurrent pancreatitis has a variety of etiologies. We experienced a case of a tumor-forming pancreatitis in a 49 year old Korean woman who also had pancreatic intraepithelial neoplasm III (PanIN-III), and this manifested just like recurrent pancreatitis. She had a history of recurrent pancreatitis. She was found to have an early stage of pancreatic cancer via computed tomography and magnetic resonance cholangiopancreatography. EUS guided fine needle aspiration (FNA) showed only many acinar cells of the pancreas. But due to the possibility of her having pancreatic carcinoma, she underwent distal pancreatectomy and splenectomy with lymph node dissection. Pathologically, the tumor of the pancreatic body showed secondary changes with focal fibrosis from the localized chronic pancreatitis. PanIN-III was observed in the pancreatic duct within the tumor, and there were no cancerous findings in the 13 dissected lymph nodes. (Korean J Med 74:310-314, 2008)
인터넷을 통한 소비자 정보탐색 및 구매행동에 영향을 주는 요인 : 개념적 연구 Conceptual Framework and Research Propositions
문병준,손용석 한국소비자학회 2000 소비자학연구 Vol.11 No.4
This study provides an exploratory model to understand the factors that influence consumers to use the Internet instead of traditional channels for marketing communication and distribution. To do this, the authors reviewed previous established theories on consumer decision making in off-line environments and research findings regarding consumer behavior in on-line environment. The authors extended the contingent consumer decision making model provided by Bettman et al. (1991) and classified the factors that influence consumers to use the on-line channel instead of traditional channel into three groups--person, problem, and context. That is, the influencing factors of consumer information search and buying behavior through the Internet are classified into three categories--consumer characteristics, objectives of information search, and web site characteristics. On the other hand, consumer information search through the Internet affects consumer buying behavior through the Internet. The possibility that consumers will buy products or services through the Internet after they search information through the Internet is likely to be moderated by the three groups of factors--product type, benefit of the Internet transaction, risk of the Internet transaction. Concurrently, these factors may directly affect consumer buying through the Internet. Research propositions regarding the influencing factors are provided.
손병석,Byeong Seok Sohn 대한소화기암연구학회 2022 Journal of digestive cancer reports Vol.10 No.1
Immune checkpoint inhibition has been established as a new treatment option for various types of carcinoma, and many clinical trials are being actively conducted as a treatment for advanced or metastatic gastric cancer, either as a monotherapy with an immune checkpoint inhibitor or as a combination therapy with standard chemotherapy. In the CheckMate-649 clinical trial to confirm the efficacy of the combination of nivolumab and chemotherapy (FP) in advanced gastric cancer and gastroesophageal junction cancer, nivolumab group showed improvement in overall survival in programmed death ligand 1-positive cancer patients compared with placebo group. Also, the combination therapy of pembrolizumab, trastuzumab and chemotherapy (FP) in first-line treatment was tested through the KEYNOTE-811 trial. The pembrolizumab group showed 22.7% of improvement in objective response rate compared with placebo group. Accordingly, the combination of nivolumab/pembrolizumab with standard chemotherapy was approved for the first-line treatment. In KEYNOTE-059 trials for patients with progressive disease after at least two lines of chemotherapy, pembrolizumab monotherapy showed improvement in objective response rate and overall survival, and the use of pembrolizumab was approved for the third-line or more treatment. In this article, we review the result of clinical trials related to immune checkpoint inhibitors that have been recently introduced in the treatment of gastric cancer.
Seo, Myung-Seok,Jeong, Inyoung,Park, Joon-Suh,Lee, Jinwoo,Han, Il Ki,Lee, Wan In,Son, Hae Jung,Sohn, Byeong-Hyeok,Ko, Min Jae The Royal Society of Chemistry 2016 Nanoscale Vol.8 No.22
<P>We fabricated perovskite solar cells with enhanced device efficiency based on vertically oriented TiO2 nanostructures using a nanoporous template of block copolymers (BCPs). The dimension and shape controllability of the nanopores of the BCP template allowed for the construction of one-dimensional (1-D) TiO2 nanorods and two-dimensional (2-D) TiO2 nanowalls. The TiO2 nanorod-based perovskite solar cells showed a more efficient charge separation and a lower charge recombination, leading to better performance compared to TiO2 nanowall-based solar cells. The best solar cells employing 1-D TiO2 nanorods showed an efficiency of 15.5% with V-OC = 1.02 V, J(SC) = 20.0 mA cm(-2) and fill factor = 76.1%. Thus, TiO2 nanostructures fabricated from BCP nanotemplates could be applied to the preparation of electron transport layers for improving the efficiency of perovskite solar cells.</P>
Uhm, Ji Eun,Park, Byeong-Bae,Ahn, Myung-Ju,Lee, Jeeyun,Ahn, Jin Seok,Kim, Sang We,Kim, Heung-Tae,Lee, Jong Seog,Kang, Jin Hyung,Cho, Jae Yong,Song, Hong Suk,Park, Se Hoon,Sohn, Chang Hak,Shin, Sang Wo Elsevier 2009 Journal of thoracic oncology Vol.4 No.9
<P>Erlotinib (Tarceva, OSI Pharmaceuticals, Melville, NY) is an oral, epidermal growth factor receptor tyrosine kinase inhibitor that has antitumor activity and good tolerability in non-small cell lung cancer (NSCLC). In particular, higher response rates have been reported in Asian patients than in Western patients. The aim of this study conducted by the Korean Cancer Study Group was to evaluate the efficacy and tolerability of erlotinib monotherapy as a palliative treatment for advanced NSCLC patients in Korea.</P>
Song, Hyejin,Kwon, Yunik,Sohn, Seok Su,Koo, Minseo,Kim, Nack J.,Lee, Byeong-Joo,Lee, Sunghak Elsevier 2018 Materials science & engineering. properties, micro Vol.730 No.-
<P><B>Abstract</B></P> <P>In this study, (austenite+ferrite+κ-carbide) triplex microstructures were obtained from the hot-rolling and subsequent 800 °C-annealing of Fe-0.8C-(12,15,20)Mn-7Al (wt%) lightweight steels, and their effects on ultra-high strength along with good ductility were investigated in relation with microstructural evolutions occurring during the tensile deformation. In the 12-wt%-Mn hot-rolled specimen, lamellar κ-carbides were populated along austenite grain boundaries, which seriously deteriorated the ductility. When the Mn content increased to 15 or 20 wt%, the volume fraction of κ-carbide decreased, and slip bands were sufficiently formed inside austenite grains during the deformation, which resulted in excellent ductility as well as ultra-high strengths. Very high yield strength was also achieved by forming triplex microstructures, in which the austenite deformed during the hot rolling greatly contributed to the strength enhancement. In the 800 °C-annealed specimens, the decreased volume fraction and morphological change from lamellar to polygonal-particle type of κ-carbides enhanced the ductility in spite of the slightly reduced strengths. This was because slip bands were sufficiently formed in austenite grains during the deformation, while voids were formed inside well-developed slip bands. The existence of a large amount of austenite was highly valuable for increasing the ductility by developing fine dislocation substructures such as Taylor lattices as a key feature of deformation mechanisms.</P>