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- 저자 : ( Byeong Geun Song ) (검색결과 137 건)
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세포질내 정자주입법(ICSI)에 있어서 정자흡입 및 난자내 주입방법에 관한 연구
이택후,김항진,송건호,김대근,전상식,박윤규,서태광,전병균,류은경,이은숙,문진수,김광철 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1
Study on Method of Sperm Aspiration and Injection into an Oocyte in Intracytoplasmic Sperm Injection(ICSI) Immobilization of spermatozoa prior to intracytoplasmic sperm iniection(ICSI) sometimes results in crooked tail and this makes it difficult to aspirate sperm into an injection pipette tail first. Head-first sperm aspiration into an injection pipette avoid this problem due to the bigger size of the sperm head. The effect of head or tail-first sperm injection into an oocyte on fertilization cleavage, percentage of grade I embryos and development to blastocyst stage in ICSI program has been studied. A single living immobilized spermatozoa from oligoasthenozoospermic patient was injected into an oocyte head-first or tail-first according to the treatment. Eighteen hours after microinjection, oocytes ware inspected for survival and fertilization Fertilized oocytes with two pronuclei were cultured in 30μl drop of mHTF supplemented with 10% heat-inactivated follicular fluid(FF) at 37℃. On day 2. embryo transfer was performed with cleaved embryos. The remaining 2-8 cell stage embryos were co-cultured with BRL cells in mHTF + 10% FF for 72 hours and the developmental stage was observed. The data were analyzed by Analysis of Variance. A total of 164 oocytes from 36 cycles were assigned to earth treatment and ICSI was performed(88 head-first, tail-first). The rates of normal fertilization were 81.8% and 76.3% for head-first and tail-first, respectively. Of the fertilized oocytes, the percentage of cleaved embryos and the percentage of grade 1 embryo among cleaved embryos were 88.9% and 68.8%, 93.1% and 74.1% for head-first and tail-first, respectively. Of the 2-8 cell embryos cultured, 44.4%(16/36) and 50.0%(10/20) for head first and tail first, respectively developed to blastocyst stage. There were no differences in fertilization, cleavage, rates of grade 1 embryos, and development to blastocyst stage. In conclusion, head-first or tail-first sperm injection into an oocyte in ICSI program does not affect fertilization and subsequent embryo development to blastocyst stage in vitro.
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( Byeong Geun Song ),( Min Ji Kim ),( Dong Hyun Sinn ),( Wonseok Kang ),( Geum-youn Gwak ),( Yong-han Paik ),( Moon Seok Choi ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Seung Woon Paik ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: We compared the clinical outcome of Barcelona Clinical Liver Cancer (BCLC) stage 0 hepatocellular carcinoma (HCC) patients in a different time period, to see whether the outcomes of BCLC stage 0 patients has improved, and if so, what are the reasons behind the noted improved outcome. Methods: A total of 591 patients with BCLC stage 0 HCC diagnosed and managed at Samsung Medical Center, Seoul, Korea between year 2007-2009 and year 2013-2015 were analyzed in this study. The patients were grouped into two group based on year of diagnosis (earlier cohort; 2007-2009 and later cohort; 2013-2015). Results: The overall survival was improved for BCLC stage 0 patients at later cohort (5-year survival rate: 82.1% vs. 92.0% for earlier cohort and later cohort, P=0.015). However, in reviewing a fully-adjusted model, the treatment period was not an independent factor for overall survival (HR 0.66, 95% CI 0.39-1.13), especially when the albumin-bilirubin grade was adjusted. In this case, the age, albumin-bilirubin grade, and initial treatment modality were considered to be an independent factor which was associated with the patient’s overall survival. When cause-specific mortality was assessed, the incidence of liver cirrhosis-related death was increased from 10.4% to 33.3%, while the incidence of HCC-related death decreased from 57.5% to 28.6% in the latter cohort. The initial treatment modality and treatment period were a risk factor for HCC-related death; whereby older age and ALBI grade 2 were risk factor for liver cirrhosis-related death, respectively. As noted, the temporal improvement in overall survival was most noticeable for those treated with ablation, and patients showed a similar overall survival to patients treated with resection (96.0% vs. 93.9% at 5-years, P=0.40). Conclusions: The survival improvement of BCLC stage 0 patients was largely explained by better liver function at diagnosis. Mortality from liver cirrhosis-related death was increasing, which calls for careful attention for finding strategies for preserving the liver function for BCLC stage 0 patients.
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Changes in the prevalence of hepatitis B and metabolic abnormalities among young men in Korea
Byeong Geun Song,Dong Hyun Sinn,Wonseok Kang,Geum-Youn Gwak,Yong-Han Paik,Moon Seok Choi,Joon Hyeok Lee,Kwang Cheol Koh,Seung Woon Paik 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.5
Changes in the prevalence of disease over time provide valuable information from a public health perspective. We used data from Korea Military Manpower Administration medical examinations for conscription between 2003 and 2019 (n = 5,355,941), which involved young men aged 19 years, to observe changes in liver disease over time at a population level. Trends in the prevalence of hepatitis B surface antigen (HBsAg), elevated alanine aminotransferase (ALT) levels, the fibrosis-4 (FIB-4) index, obesity, and hypertension were assessed. The prevalence of HBsAg steadily decreased from 3.19% for men born in 1984 to 0.18% for men born in 2000. Among HBsAg-negative subjects, the prevalence of elevated ALT levels increased from 13.15% for men born in 1986 to 16.48% for men born in 2000. The prevalence of obesity, hypertension and the proportion with high FIB-4 scores (≥ 1.45) also increased. This population-based nationwide analysis showed a decreasing trend of HBsAg and increasing trends of possible non-alcoholic fatty liver disease.
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Song, Byeong Gu,Kim, Gwang Ha,Lee, Bong Eun,Jeon, Hye Kyung,Baek, Dong Hoon,Song, Geun Am Hindawi 2017 Gastroenterology Research and Practice Vol.2017 No.-
<P><B>Aims</B></P><P> To investigate the feasibility and safety of endoscopic submucosal dissection (ESD) of gastric epithelial neoplasms in the remnant stomach (GEN-RS) after various types of partial gastrectomy. </P><P><B>Methods</B></P><P> This study included 29 patients (31 lesions) who underwent ESD for GEN-RS between March 2006 and August 2016. Clinicopathologic data were retrieved retrospectively to assess the therapeutic ESD outcomes, including en bloc and complete resection rates and procedure-related adverse events. </P><P><B>Results</B></P><P> The en bloc, complete, and curative resection rates were 90%, 77%, and 71%, respectively. The types of previous gastrectomy, tumor size, macroscopic type, and tumor histology were not associated with incomplete resection. Only tumors involving the suture lines from the prior partial gastrectomy were significantly associated with incomplete resection. The procedure-related bleeding and perforation rates were 6% and 3%, respectively; none of the adverse events required surgical intervention. During a median follow-up period of 25 months (range, 6–58 months), there was no recurrence in any case. </P><P><B>Conclusions</B></P><P> ESD is a safe and feasible treatment for GEN-RS regardless of the previous gastrectomy type. However, the complete resection rate decreases for lesions involving the suture lines.</P>
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Byeong Geun Song,Yang Won Min,Hyuk Lee,Byung-Hoon Min,Jun Haeng Lee,Poong-Lyul Rhee,Jae J Kim 대한소화기 기능성질환∙운동학회 2019 Journal of Neurogastroenterology and Motility (JNM Vol.25 No.1
Background/Aims Esophagogastric junction outflow obstruction (EGJOO) is a diagnostically heterogeneous group with variable clinical relevance. We studied whether evaluation of bolus transit by multichannel intraluminal impedance (MII) is useful for discriminating clinically relevant EGJOO. Methods A total 169 patients diagnosed as having EGJOO between June 2011 and February 2018 were analyzed. All the patients received a combined MII and high-resolution manometry (CMII-HRM). MII was reported as having abnormal liquid bolus transit (LBT) if < 80% of swallows had complete bolus transit. EGJOO was defined as a median integrated relaxation pressure of > 20 mmHg and when the criteria for achalasia were not met. Patients who progress to achalasia, show significant passage disturbance, or require pneumatic dilatation were defined as having a clinically relevant EGJOO. Results Among the patients with EGJOO (n = 169), the clinically relevant group (n = 10) is more likely to have dysphagia (100% vs 25.2%, P < 0.001), compartmentalized pressurization (CP; 90.0% vs 22.0%, P < 0.001), and abnormal LBT (100% vs 66.7%, P = 0.032) compared to the non-relevant group (n = 159). The combination of dysphagia, CP, and abnormal LBT showed the best predictive power for clinically relevant EGJOO (sensitivity 90%, specificity 92.5%, positive predictive value 42.9%, negative predictive value 99.3%, positive likelihood ratio 11.9, and negative likelihood ratio 0.1). When CMII-HRM was used, an additional 8.3% of clinically relevant EGJOO cases were identified as compared with HRM alone. Conclusion Clinically relevant EGJOO can be predicted using CMII-HRM.
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( Byeong Geun Song ),( Dong Hyun Sinn ),( Wonseok Kang ),( Geum-youn Gwak ),( Yong-han Paik ),( Moon Seok Choi ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: In the era of antiviral therapy, fibrotic burden has been suggested as an effective tool to stratify the risk of developing hepatocellular carcinoma (HCC) in patients with chronic hepatitis B infection. We tested whether liver stiffness (LS) measured using transient elastography and two non-invasive predictors of fibrosis [the aspartate aminotransferase to platelet ratio index (APRI) and the Fibrosis-4 (FIB-4)] can effectively stratify the risk of HCC. Methods: A retrospective cohort of 1,156 chronic HBV patients [mean age = 50.6 ± 9.4 years; male = 825 (71.4%)] was analyzed for the development of HCC. The HCC risk was compared according to LS values (6.0), APRI (0.5) and FIB-4 values (1.45), that can rule out significant fibrosis. Results: During median 3.7 years (min-max: 0.5-8.2 years) of follow- up, HCC was diagnosed in 42 patients (3.6%). The HCC incidence rate at 3 years was higher for those with higher fibrotic burden, as estimated by LS (1.3% vs. 5.2% for LS ≤ 6 vs. > 6, p < 0.001), APRI (1.9% vs. 6.5% for APRI < 0.5 vs. ≥ 0.5, p < 0.001), and FIB-4 (1.3% vs. 5.0% for FIB-4 <1.45 vs. ≥ 1.45, p < 0.001), respectively. When patients were categorized according to LS, APRI and FIB-4, HCC incidence rate at 3-years were highest for those with evidence of fibrosis by all of three non-invasive predictors (7.7%, n = 257), but was not null for those without any evidence of fibrosis by all of three non-invasive predictors (1.2%, n = 351). Conclusions: Although non-invasive predictors of fibrotic burdens can classify HCC risk among chronic hepatitis B patients under antiviral therapy, HCC development was not null among patients without evidence of fibrotic burden. Our finding suggests that HCC surveillance for chronic hepatitis B patients should be considered for those without fibrotic burden.
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Song Byeong Geun,Lim Min Gi,Bae Joo Hwan,Hong Joo Hyun,Lee Sang-Geul,Park Se Hoon,강철인 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.4
Cushing's syndrome is characterized by excessive cortisol and immuno-suppression. We experienced a case of Cushing's syndrome caused by adrenocortical carcinoma that was complicated by multiple opportunistic infections. A 37-year-old woman with adrenocortical carcinoma (ACC) presented with decreased mental ability and high fever one week after undergoing chemotherapy. Her initial blood culture revealed methicillin-resistant Staphylococcus aureus (MRSA) bacteremia accompanied by septic pneumonia. We admitted her to the intensive care unit and treated her for invasive pulmonary aspergillosis (IPA), Pneumocystis jirovecii pneumonia (PJP), candidemia, and Stenotrophomonas maltophilia pneumonia with broad-spectrum antibiotics and antifungal agents. Nevertheless, her clinical course worsened and she died. Herein, we report a case of Cushing's syndrome associated with cortisol-secreting ACC that presented with multiple opportunistic infections, including MRSA bacteremia, septic pneumonia, candidemia, PJP, and IPA, illuminating a relationship between hypercortisolemia and opportunistic infections.
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Song, Young Geun,Shim, Young-Seok,Kim, Sangtae,Han, Soo Deok,Moon, Hi Gyu,Noh, Myoung Sub,Lee, Kwangjae,Lee, Hae Ryong,Kim, Jin-Sang,Ju, Byeong-Kwon,Kang, Chong-Yun Elsevier Sequoia 2017 Sensors and actuators. B Chemical Vol.248 No.-
<P><B>Abstract</B></P> <P>We report the highly sensitive and selective downsized gas sensors for the IoT application. Sensing areas of Pt-interdigitated electrodes (IDEs) were varied to investigate the relation between sensing materials and electrodes. In<SUB>2</SUB>O<SUB>3</SUB> nanocolumns were deposited on the pre-patterned Pt IDEs using glancing angle deposition (GLAD). The effect of the interface resistance between electrodes and sensing materials, and the intergrain resistance between nanocolumns is analyzed by linear regression at different sensing area and incident angle of GLAD. In<SUB>2</SUB>O<SUB>3</SUB> (angle: 85°, sensing area: 0.3mm×0.3mm) nanocolumns with double Schottky barriers show the highest response and selectivity with fast response time of 10s to VOCs among the samples fabricated in this study. The analysis reveals that the intrinsic response of In<SUB>2</SUB>O<SUB>3</SUB> (angle: 85°, sensing area: 0.3mm×0.3mm) nanocolumns are dominantly affected by intergrain resistance, resulting in a high response. Our demonstration for the fundamental aspect of downsizing gas sensor makes an important contribution to the chemical sensor field with broad interest.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The sensing areas are varied to investigate the relation between sensing materials and electrodes. </LI> <LI> The effect of the interface resistance and the intergrain resistance are analyzed by linear regression. </LI> <LI> The performance of the downsizing gas sensor is greatly influenced by the interface resistance. </LI> </UL> </P>
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