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( Da Hyun Lee ),( Buhyun Lee ),( Jeong Su Park ),( Yu Seol Lee ),( Jin Hee Kim ),( Yejin Cho ),( Yoonjung Jo ),( Hyun-seok Kim ),( Yong-ho Lee ),( Ki Taek Nam ),( Soo Han Bae ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.3
Acetaminophen (APAP) overdose can cause hepatotoxicity by inducing mitochondrial damage and subsequent necrosis in hepatocytes. Sirtuin2 (Sirt2) is an NAD<sup>+</sup>-dependent deacetylase that regulates several biological processes, including hepatic gluconeogenesis, as well as inflammatory pathways. We show that APAP decreases the expression of Sirt2. Moreover, the ablation of Sirt2 attenuates APAP-induced liver injuries, such as oxidative stress and mitochondrial damage in hepatocytes. We found that Sirt2 deficiency alleviates the APAP-mediated endoplasmic reticulum (ER) stress and phosphorylation of the p70 ribosomal S6 kinase 1 (S6K1). Moreover, Sirt2 interacts with and deacetylates S6K1, followed by S6K1 phosphorylation induction. This study elucidates the molecular mechanisms underlying the protective role of Sirt2 inactivation in APAP-induced liver injuries. [BMB Reports 2019; 52(3): 190-195]
Lee, Chi-Seung,Lee, Jae-Myung,Youn, BuHyun,Kim, Hyung-Sik,Shin, Jong Ki,Goh, Tae Sik,Lee, Jung Sub Elsevier 2017 Journal of the mechanical behavior of biomedical m Vol.65 No.-
<P><B>Abstract</B></P> <P>A new type of constitutive model and its computational implementation procedure for the simulation of a trabecular bone are proposed in the present study. A yield surface-independent Frank–Brockman elasto-viscoplastic model is introduced to express the nonlinear material behavior such as softening beyond yield point, plateau, and densification under compressive loads. In particular, the hardening- and softening-dominant material functions are introduced and adopted in the plastic multiplier to describe each nonlinear material behavior separately. In addition, the elasto-viscoplastic model is transformed into an implicit type discrete model, and is programmed as a user-defined material subroutine in commercial finite element analysis code. In particular, the consistent tangent modulus method is proposed to improve the computational convergence and to save computational time during finite element analysis. Through the developed material library, the nonlinear stress–strain relationship is analyzed qualitatively and quantitatively, and the simulation results are compared with the results of compression test on the trabecular bone to validate the proposed constitutive model, computational method, and material library.</P>