우리나라 일부지역의 입자상 물질 농도에 대한 연구

손부순,공미연,박종안,양원호,김종오 대한위생학회 2003 대한환경위생공학회지 Vol.18 No.4

Recent epidemiologic studies revealed that the concentration of air pollutants and fine particulated matter have some effects on health status and are associated with increased mortality and morbidity. The purpose of this study was to characterize background mass concentration of fine particle (PM2.5) and metallic composition from September 2001 to August 2002 in comparison with a medium city, Asan and metropolitan city, Seoul. Conclusively, proper management for fine particles was required in a medium city, Asan, considering the concentrations of metallic elements in fine particles in Asan were relatively higher than those in Seoul. The results were as followed. 1. Average mass concentrations of fine particles in Asan and Seoul were 37.70(±18.41 ㎍/㎥) and 5.83(±38.50)㎍/㎥, respectively. When the weather conditions were classified as normal and yellow-sand, measured average mass concentrations of fine particles in yellow-sand weather condition was significantly higher than those of normal weather condition in both cities (p<0.05). 2. Depending on seasons, measured average mass concentrations of fine particles in Asan and Seoul in spring were 47.76(±19.07) ㎍/㎥m and 61.53 (±4.37) ㎍/㎥, respectively. In summer, the average mass concentrations of fine particles in Asan and Seoul were 29.44(±9.85) ㎍/㎥ and 25.42(±8.10) ㎍/㎥, respectively. Especially, the concentration was the highest in spring and the lowest in summer among four seasons. 3. Average concentrations of manganese(Mn), iron(Fe), chromium(Cr), cadmium(Cd), lead(Pb) and silicon(Si) in fine particles in Asan were significantly higher in Seoul (p<0.05). Average concentration of Si in fine particle in Asan was statistically higher than that of Seoul during yellow-sand condition (p<0.05). 4. Considering the characterization of four seasons, average Pb concentration of fine particle in Asan is significantly higher than that of Seoul in spring(p<0.01). In summer, average Mn and Cr concentrations of fine particle in Asan is higher than those of Seoul (p<0.05). Average Mn. Fe. Cr and Si concentrations in fall (p<0.05), and average Mn, Fe, Cr, Pb, and Si concentrations in winter (p<0.05) in Asan were higher than those of Seoul, respectil'ely. 5. Mass concentrations of each Mn, Fe, Cd and Si in fine particles were significantly correlated with both cities. In normal weather condition, Mn, Cu and Si concentrations are statistically significant in Asan, while Mn, Fe, Cu and Si concentrations are statistically significant in Seoul. Mn, Fe and Si concentrations in both cities were statistically significant during yellow-sand weather.

무선 기반의 실내 온도 측정 시스템 설계

차부상,정우철,류정탁,김연보 대구대학교 정보통신연구소 2004 情報通信硏究 Vol.3 No.2

최근 홈 네트워크 산업이나 지능형 주거관리 시스템의 필요성과 관심이 증가하고 있다. 이와 같은 분야에서는 무엇보다 효율적인 측정 시스템에 대한 연구가 선행되어야 한다. 따라서 본 논문에서는 센서 측정 시스템 설계에 관한 기초 연구로서 실내 환경에 적합한 온도 측정 시스템을 설계해 보고 그 특성에 대해 나타내었다. 설계한 시스템의 구성은 크게 온도 센서로부터 온도 변화를 검출하는 데이터 획득부, 신호처리를 위한 제어부 그리고 측정된 온도 데이터를 전송하기 위한 RF 송수신부로 나누어진다. 설계된 측정 시스템에 거리변화 및 장애물 유무에 따른 영향을 살펴보고, 안테나 변경에 따른 성능 차이를 살펴보았다. 실험 결과 10m 이내의 실내 환경에서는 본 논문에서 제안하고 설계한 측정 시스템을 사용하여 데이터의 실시간 처리가 가능하였다. 또한 이를 바탕으로 다중 센서 측정 시스템 구현이 가능함을 알 수 있었다. Recently, the need for intelligent sweet home systems and home network industry is increasing. In this field, a study on efficient measurement system is preceded by the other subjects. Therefore, in this paper, a study on efficient sensor measurement system, temperature measurement system suitable for room environment is designed and its property is given. We designed temperature measurement systems consisting of data acquisition part as a temperature sensor, control unit for signal processing and RF moduls for data transmit. The results of experiment showed real-time processing in the room environment within 10 meter. It also showed the possibility of multi-sensors measurement system.

강섬유보강 콘크리트 슬래브의 내력 및 균열특성에 관한 실험적 연구

박승범,조광연,장석호,김부일 忠南大學校 産業技術硏究所 1997 산업기술연구논문집 Vol.12 No.2

This Study is aimed to investigate the effect of load and deflection on steel fiber reinforced concrete slab. Slabs were made with Hooked and Straight types steel fiber and compared a change of steel fiber contents and fiber type. Test were carried out to evaluate the first crack load, maximum load and deflection of slab. AT this result, the first crack load, maximum load and energy absorption capacity were increased remarkably as steel fiber contents were increased. And we found that the deflection of slab at same load were decreased as steel fiber contents were increased, too. As the aspect ratio was increased, the first crack load, maximum load and energy absorption capacity were increased.

Production of gastrodin and 4-hydroxybenzyl alcohol by metabolic engineering of 4-hydroxybenzoate-producing Corynebacterium glutamicum

Bu-yeon KIM,Lenny FERRER,Jin-Ho LEE 한국생물공학회 2018 한국생물공학회 학술대회 Vol.2018 No.10

Nur77 upregulates HIF-α by inhibiting pVHL-mediateddegradation

Bu-Yeon Kim,Eun-Jung Cho,Hong-Duk Youn,Hyungsoo Kim 생화학분자생물학회 2008 Experimental and molecular medicine Vol.40 No.1

In this study, we investigated the role of Nur77, an orphan nuclear receptor, in HIF-α transcriptional activity. We found that Nur77 associates and stabilizes HIF-1α via indirect interaction. Nur77 was found to interact with pVHL in vivo via the α-domain of pVHL. By binding to pVHL, Nur77 competed with elongin C for pVHL binding. Moreover, Nur77-binding to pVHL inhibited the pVHL-mediated ubiquitination of HIF-1α and ultimately increased the stability and transcriptional activity of HIF-1α. The ligand-binding domain of Nur77 was found to interact with pVHL and the expression of this ligand-binding domain was sufficient to stabilize and transactivate HIF-1α. Under the conditions that cobalt chloride was treated or pVHL was knocked down, Nur77 could not stabilize HIF-α. Moreover, Nur77 could not further stabilize HIF-2α in A498/VHL stable cells, which is consistent with our finding that Nur77 indirectly stabilizes HIF-α by binding to pVHL. Thus, our results suggest that an orphan nuclear receptor Nur77 binds to pVHL, thereby stabilizes and increases HIF-α transcriptional activity under the nonhypoxic and ultimately increased the stability and transcriptional activity of HIF-1α. The ligand-binding domain of Nur77 was found to interact with pVHL and the expression of this ligand-binding domain was sufficient to stabilize and transactivate HIF-1α. Under the conditions that cobalt chloride was treated or pVHL was knocked down, Nur77 could not stabilize HIF-α. Moreover, Nur77 could not further stabilize HIF-2α in A498/VHL stable cells, which is consistent with our finding that Nur77 indirectly stabilizes HIF-α by binding to pVHL. Thus, our results suggest that an orphan nuclear receptor Nur77 binds to pVHL, thereby stabilizes and increases HIF-α transcriptional activity under the nonhypoxic conditions. In this study, we investigated the role of Nur77, an orphan nuclear receptor, in HIF-α transcriptional activity. We found that Nur77 associates and stabilizes HIF-1α via indirect interaction. Nur77 was found to interact with pVHL in vivo via the α-domain of pVHL. By binding to pVHL, Nur77 competed with elongin C for pVHL binding. Moreover, Nur77-binding to pVHL inhibited the pVHL-mediated ubiquitination of HIF-1α and ultimately increased the stability and transcriptional activity of HIF-1α. The ligand-binding domain of Nur77 was found to interact with pVHL and the expression of this ligand-binding domain was sufficient to stabilize and transactivate HIF-1α. Under the conditions that cobalt chloride was treated or pVHL was knocked down, Nur77 could not stabilize HIF-α. Moreover, Nur77 could not further stabilize HIF-2α in A498/VHL stable cells, which is consistent with our finding that Nur77 indirectly stabilizes HIF-α by binding to pVHL. Thus, our results suggest that an orphan nuclear receptor Nur77 binds to pVHL, thereby stabilizes and increases HIF-α transcriptional activity under the nonhypoxic and ultimately increased the stability and transcriptional activity of HIF-1α. The ligand-binding domain of Nur77 was found to interact with pVHL and the expression of this ligand-binding domain was sufficient to stabilize and transactivate HIF-1α. Under the conditions that cobalt chloride was treated or pVHL was knocked down, Nur77 could not stabilize HIF-α. Moreover, Nur77 could not further stabilize HIF-2α in A498/VHL stable cells, which is consistent with our finding that Nur77 indirectly stabilizes HIF-α by binding to pVHL. Thus, our results suggest that an orphan nuclear receptor Nur77 binds to pVHL, thereby stabilizes and increases HIF-α transcriptional activity under the nonhypoxic conditions.

Key compound groups for the neuroprotective effect of roots of Polygonum cuspidatum on transient middle cerebral artery occlusion in Sprague-Dawley rats.

Kim, Jinmo,Kim, Mi-Yeon,Leem, Kang-Hyun,Moon, Sangkwan,Jamakattel-Pandit, Nirmala,Choi, Hoyoung,Kim, Hocheol,Bu, Youngmin Taylor Francis Health Sciences 2010 NATURAL PRODUCT RESEARCH Vol.24 No.13

<P>Polygonum cuspidatum is a potent anti-oxidant herb that is well known for its various bioactivities. The current study investigates which compound group is most effective, to establish the key compound groups for quality assessment, especially in terms of neuroprotective effects. The roots of P. cuspidatum were extracted with 85% methanol and fractionated with hexane, ethyl acetate, n-butanol and water. Each fraction was applied to an in vitro radical scavenging assay, a lipid peroxidation assay in brain homogenates and an in vivo assay using a transient focal cerebra ischemia model induced by a middle cerebral artery occlusion in a Sprague-Dawley rat. The ethyl acetate fraction was the most effective fraction in both in vitro and in vivo assays, having the highest stilbene and anthraquinone contents. These results suggest that stilbenes and anthraquinones may be key compound groups for the quality assessment of the anti-oxidative and neuroprotective effects of P. cuspidatum.</P>

Reciprocal negative regulation between the tumor suppressor protein p53 and B cell CLL/lymphoma 6 (BCL6) via control of caspase-1 expression

Kim, Min-Kyeong,Song, Ji-Yang,Koh, Dong-In,Kim, Jin Young,Hatano, Masahiko,Jeon, Bu-Nam,Kim, Min-Young,Cho, Su-Yeon,Kim, Kyung-Sup,Hur, Man-Wook American Society for Biochemistry and Molecular Bi 2019 The Journal of biological chemistry Vol.294 No.1

<P>Even in the face of physiological DNA damage or expression of the tumor suppressor protein p53, B cell CLL/lymphoma 6 (BCL6) increases proliferation and antagonizes apoptotic responses in B cells. BCL6 represses <I>TP53</I> transcription and also appears to inactivate p53 at the protein level, and additional findings have suggested negative mutual regulation between BCL6 and p53. Here, using <I>Bcl6</I><SUP>−/−</SUP> knockout mice, HEK293A and HCT116 <I>p53</I><SUP>−/−</SUP> cells, and site-directed mutagenesis, we found that BCL6 interacts with p53 and thereby inhibits acetylation of Lys-132 in p53 by E1A-binding protein p300 (p300), a modification that normally occurs upon DNA damage–induced cellular stress and whose abrogation by BCL6 diminished transcriptional activation of p53 target genes, including that encoding caspase-1. Conversely, we also found that BCL6 protein is degraded via p53-induced, caspase-mediated proteolytic cleavage, and the formation of a BCL6–p53–caspase-1 complex. Our results suggest that p53 may block oncogenic transformation by decreasing BCL6 stability via caspase-1 up-regulation, whereas aberrant BCL6 expression inactivates transactivation of p53 target genes, either by inhibiting p53 acetylation by p300 or repressing <I>TP53</I> gene transcription. These findings have implications for B cell development and lymphomagenesis.</P>

Neuroprotective effect of HT008-1, a prescription of traditional Korean medicine, on transient focal cerebral ischemia model in rats

Bu, Youngmin,Kwon, Sungeun,Kim, Yun Tai,Kim, Mi-Yeon,Choi, Hoyoung,Kim, Jae Goo,Jamarkattel-Pandit, Nirmala,Doré,, Sylvain,Kim, Sung-Hoon,Kim, Hocheol John Wiley Sons, Ltd. 2010 Phytotherapy research Vol.24 No.8

<P>HT008-1 is one of the prescriptions used in Traditional Korean Medicine for the treatment of mental and physical weakness. It is composed of Panax ginseng, Acanthopanax senticosus, Angelica sinensis and Scutellaria baicalensis, which have been reported to have various pharmacological effects on the central nervous system. The study investigated whether HT008-1 has neuroprotective effects in a focal cerebral ischemia rat model. Stroke was induced in rats by 2 h of middle cerebral artery occlusion (MCAo) followed by 22 h of reperfusion. HT008-1 (30, 100 and 300 mg/kg) and the component herbs (300 mg/kg) were administered orally twice at 0 and 2 h after ischemia. Oral administration of 300 mg/kg HT008-1 reduced brain infarction by 45.7%, prolonged the latency time by 24.8% in the rotarod test, and enhanced the score by 17.0% in the balance beam test. Only P. ginseng and S. baicalensis showed protective effects, and HT008-1 showed a greater effect than its component herbs. HT008-1 down-regulated the COX-2 and OX-42 expression in the penumbra region. In conclusion, the results show that HT008-1 may be effective in a rat stroke model by an antiinflammatory mechanism and may improve sensory-motor function by reducing damage in the cortex and caudoputamen. Copyright © 2010 John Wiley & Sons, Ltd.</P>

Poster Session 1 : Genomics and Bioinformatics Proteomics ; Molecular discrimination of hepatocellular carcinoma by gene expression profiling

( Bu Yeo Kim ),( Je Geun Lee ),( Sun Hoo Park ),( Jae Yeon Ahn ),( Jin Haeng Chung ),( Chul Ju Han ),( Yeun Jin Ju ),( Young Il Yeom ),( Sang Soo Kim ),( Yong Sung Lee ),( Chang Min Kim ),( Woo Ho Kim 한국생화학분자생물학회 (구 한국생화학회) 2003 생화학분자생물학회 춘계학술발표논문집 Vol.2003 No.-

자산구성비율이 회계이익과 장부가치의 상대적 가치관련성에 미치는 영향

김연용(Kim Yeon-Yong),기현희(Ki Hyun-Hee),김민철(Kim Min-Chul),주부식(Ju Bu-Sik) 한국국제회계학회 2009 국제회계연구 Vol.0 No.27

본 연구는 대차대조표를 구성하고 있는 자산항목들의 구성비율이 회계이익과 장부가치의 가치관련성에 미치는 영향을 분석하였다. 연구결과 전반적으로 회계이익에 비해 장부가치의 가치관련성이 높은 것으로 나타났으며, 손실이 발생한 기업은 그러한 경향이 더 크게 나타났다. 실증분석결과를 구체적으로 살펴보면 다음과 같다. 첫째, 유동자산의 비율이 높은 기업은 유동자산의 비율이 낮은 기업에 비해 장부가치의 가치관련성이 높고, 회계이익의 가치관련성은 낮게 나타났다. 둘째, 투자자산의 비율이 높은 기업은 투자자산의 비율이 낮은 기업에 비해 장부가치의 가치관련성이 낮고, 회계이익의 가치관련성은 높게 나타났다. 셋째, 유형자산의 비율이 높은 기업은 유형자산의 비율이 낮은 기업에 비해 장부가치의 가치관련성이 낮고, 회계이익의 가치관련성은 높게 나타났다. 넷째, 무형자산의 비율이 낮은 기업은 회계이익보다 장부가치의 표준화 회귀계수와 증분설명력이 큰 것으로 나타났다. 그러나 무형자산의 비율이 높은 기업은 장부가치보다 회계이익의 가치관련성이 높은 것으로 나타났다. 또한 무형자산의 비율이 높은 기업은 무형자산의 비율이 낮은 기업에 비해 장부가치의 가치관련성이 낮고, 회계이익의 가치관련성은 높게 나타났다. The purpose of this study is to investigate the effect of the component ratio of assets on the value relevance of accounting information represented by reported earnings and book values. More specifically, we compare the value relevance of book values versus reported earnings. The value relevance of book values and reported earnings is measured by explanatory power and regression coefficient. The sample of this study are selected from the manufacturing firms, listed on the Exchange, as of the calendar year end, during 2005-2007. In general, book values are relatively more important determinants of equity value for all firms. Our results show that the component ratio of assets affects the value relevance of accounting information represented by reported earnings and book values. And the component ratio of assets affects the degree of relative value relevance of book value over earnings and vice versa.