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        장애 영유아의 아버지가 참여한 국내 연구 동향

        남보람 ( Nam¸ Boram ),장영선 ( Chang¸ Youngseon ),박지연 ( Park¸ Jiyeon ) 한국특수아동학회 2021 특수아동교육연구 Vol.23 No.3

        연구목적: 본 연구는 장애 영유아의 아버지가 참여한 국내 문헌을 체계적으로 분석하여 전반적인 연구 동향을 살펴보고, 이를 바탕으로 장애 영유아 아버지 지원의 실제와 후속연구에 주는 시사점을 모색하고자 하였다. 연구방법: 2000년부터 현재까지 수행된 장애 영유아 가족 참여 연구 중 아버지의 역할이 명확하거나 아버지 변인을 정확히 구분하여 제시한 연구 총 21편을 대상으로 전반적인 동향과 연구설계별 특징을 분석하였다. 연구결과: 첫째, 장애 영유아의 가족이 참여한 연구 중에서 아버지 참여가 명확하게 드러난 연구는 극히 소수였다. 둘째, 양적연구 16편 중 11편이 조사연구였으며 조사연구의 주요 주제는 양육참여, 양육스트레스, 행복감, 지원 요구 등이었다. 나머지 5편은 실험연구로, 아버지가 참여한 부모실행중재의 긍정적 성과를 보고하였다. 셋째, 질적 연구는 5편이었으며, 아버지의 양육경험을 기반으로 삶의 어려움과 극복, 성장 등이 제시되었다. 결론: 연구 결과를 바탕으로 장애 영유아 아버지 참여 활성화를 위한 방안을 제시하였다. Purpose: This study examined the overall trends in Korean studies that involved the fathers of young children with disabilities, and their implications on the practices and future research for the father support. Method: The articles that clearly describe the fathers’ involvement or specify the father-related variables were selected among the studies published from 2000 to the present. Twenty-one studies were selected and the overall trends were analyzed. As well, the studies were categorized by research design and the specific characteristics of the studies were analyzed for each category. Results: First, only a few studies have clearly demonstrated the father involvement. Second, 16 articles were quantitative research and 11 among them were survey studies. The main themes of the survey studies were the fathers’ participation in parenting, parenting stress, happiness, support needs, etc. The rest five experimental studies reported the positive outcomes as the results of parent-implemented interventions conducted by the fathers. Third, in the five qualitative studies, the fathers seemed to have overcome and outgrown the difficulties of life through parenting experiences. Conclusion: Suggestions for revitalizing the father involvement in interventions and support for young children with disabilities were discussed.

      • KCI등재

        Efficacy of ferric carboxymaltose in iron deficiency anemia patients scheduled for pancreaticoduodenectomy

        Jangho Park,Sang-Jae Park*,Sung-Sik Han*,Hyeong Min Park,Jihye Yu,Boram Park,Young-Woo Kim,Sun-Whe Kim 대한외과학회 2023 Annals of Surgical Treatment and Research(ASRT) Vol.105 No.2

        Purpose: Perioperative transfusion is reported to be an independent risk factor not only for postoperative complications but also for early recurrence of periampullary carcinoma after pancreaticoduodenectomy (PD). The purpose of this study was to evaluate the safety and efficacy of ferric carboxymaltose (FCM) in reducing the need for perioperative transfusion in iron deficiency anemia patients scheduled for PD. Methods: Twenty-two male patients (hemoglobin [Hb] 7 to <13 g/dL) and 18 female patients (Hb 7 to <12 g/dL) were enrolled in the study group and administered FCM 1–3 weeks before PD. The perioperative transfusion rate was the primary endpoint; morbidity, length of postoperative hospital stay, change in hematological parameters after FCM injection, and adverse effects of FCM were also investigated. Results: The perioperative transfusion rate of the study group was 22.5% (9 of 40). Hb level was significantly higher on the day of the operation compared to baseline (P < 0.001). Levels of Hb, transferrin saturation, and ferritin were higher at the follow-up compared to baseline (P = 0.008, P = 0.033, and P < 0.001, respectively). Conclusions FCM administration was associated with a reduced need for perioperative transfusion and can safely stabilize hematological parameters.

      • A BENCHMARK ANALYSIS: EVALUATING FAIR TRADE E – RETAILING WEBSITES

        Pielah Kim,Songyee Hur,Boram Park,Leslie Stoel 글로벌지식마케팅경영학회 2015 Global Fashion Management Conference Vol.2015 No.06

        Introduction In 2011, consumers spent $ 6.6 billion on certified fair-trade products, for a 12% increase worldwide (Thompson, 2012). Fair-trade is a social movement aiming to set fair prices for products, alleviate poverty, and assist producers and workers marginalized by the traditional economic model. Online stores have emerged as an effective marketing channel for fair trade products due to their ability to inform and reach a broad range of customers for very low cost. And this trend piques our interest in examining fair trade online stores. How do online fair trade retail stores rate in terms of usability? This is important because usability constitutes a key factor of online store quality. Usability refers to the perceived ease of navigating and/or making purchases through the retail website (Flavian et al., 2006). Previous studies find evidence that the richness of information related to products, culture, and artisans are criteria for success in fair-trade business (Lee & Littrell, 2005). Incorrect and/or low quality information undermine consumer interest in ethical products and subsequently, reduce credibility of fair trade retailers and their products (Carrigan & Attalla, 2001; Maignan & Ferrell, 2004). Usability is a way to ensure information is presented in a manner that will engender the trust of consumers. Trust is defined as the willingness of a consumer to be vulnerable to the actions of a retailer based on the expectation that the retailer will perform a particular action (cf. Mayer et al., 1995). Trust is known to be an antecedent in building relationships (Rotter, 1971). Fair trade retailers operating online stores must consider two types of trust. One type is customers’ trust toward fair trade retailers. To create such trust, fair trade retailers must convey that the marginal price differences between fair trade products and commercial products will be used to help producers (Castaldo et al, 2009), and must be transparent in communicating the operational processes underlying fair trade retailing. The other type of trust is related to the website and reflects skepticism about completing transactions online (Gefen & Straub, 2003). Compared to a brick-and-mortar store, online customer’s trust is critical since a customer’s perceived risk in purchasing goods online can be reduced by trust (Ha & Stoel, 2008; Pavlou, 2003). Lack of social presence for an online store impedes development of a customer’s trust toward the retailer (Gefen & Straub, 2003). Building upon the existing literature, we posit that a low level of usability, due to its role in developing online interactivity and engagement, will lead to lack of trust building, which is critical in promoting the sale of fair trade products. The purposes of this study are (1) to propose how usability, interactivity, and engagement can improve trust building, and (2) to provide empirical evidence of the lack of usability, interactivity, and engagement in current fair trade online stores. Website usability allowing consumer interactivity and engagement is an essential website attribute for formulating trust. Thus, the goal of this study is to provide suggestions for competitive e-retailing strategies for fair trade retailers based on results of a benchmarking study comparing websites of commercial and fair trade retailers. Literature Review Website Usability. Usability is created through the use of advanced website attributes that allow greater involvement of customers. Website usability not only influences consumer attitudes but also trust toward the website or company (Childers et al, 2001; Roy et al., 2001). Recently, scholars have suggested usability is related to engagement (Quesenbery, 2003). For instance, insufficient usability may be a factor in failing to engage consumers with the website; conversely, engagement can be sustained when attributes of usability meet user needs (O’Brien & Toms, 2008). Website usability may have a direct impact on enhancing interactivity. Interactivity. Interactivity refers to the extent to which users can participate in communication, user control, and entertainment (cf. McMillan & Hwang, 2002). Based on this notion, two types of interactivity within the e-commerce context are examined: (1) website interactivity concerns the website design and attributes enabling consumer interaction with the site to make decisions and personalize content (Merrilees & Fry, 2003), and (2) social interactivity promotes ‘consumer-to-consumer’ and ‘consumer-to-company’ communicative interactions within virtual social space provided by the retailer (Chan & Li, 2010; Nambisan & Watt, 2011). The outcomes of interactivity are two-fold. First, interactivity promotes customer engagement with brands (Ha & James, 1998). Consumers’ interaction with other consumers and the company (via social interactivity) and navigating and personalizing the website (via website-interactivity) create psychological engagement with the company. Second, interactivity entices consumers to acquire greater amounts of information from the website, which subsequently has a positive impact on trust towards the online retailer (Ballantine, 2005; Chen et al, 2005). Consistent with this view, Merrillees and Fry (2003) claim that the level of perceived interactivity is a predominant determinant in constructing trust in the online domain. Engagement. Consumer engagement behavior refers to the creation of an enduring and meaningful relationship between the company and the consumer (Doorn et al. 2010). Consumer engagement involves a highly interactive and experiential process. Highly engaged consumers integrate product knowledge and exchange information with other consumers (Borle et al. 2007). Engagement behaviors facilitate consumer trust towards products and the company (e.g. Pigg & Crank, 2004). Social engagement, the spontaneous information exchange among users, can justify one’s purchase decision. The consumer-generated content becomes a more trustworthy source of knowledge than the information promoted by the retailer (Chan et al., 2010). The relationship between interactivity and engagement is reciprocal. Consumers highly involved in engaging with others are likely to utilize more website attributes promoting interactivity. Method The data for this study were collected from 28 commercial apparel retailers and 22 fair trade apparel retailers based in the US. The 22 fair trade retailers consisted of 13 for-profits and 9 non-profits. The sample was selected based on previous studies (i.e., Lee, Geistfeld, & Stoel 2007; Halepete & Park, 2006; Park & Stoel, 2002), trade publications, and a Google search. A binary measurement instrument was employed to categorize website content as either ‘available’ or ‘not available’ on both the commercial and fair trade store websites. In order to minimize any bias occurring from subjective evaluation of website content, two graduate students separately coded the data, and compared coding sheets. Differences were discussed until agreement was reached. Frequency counts were used to describe the availability of website and social interactivity related content. Chi-square analysis was used to identify statistically significant differences between commercial and fair trade online retailers. Results To assess website interactivity, we examined six attributes that facilitated convenience for consumers in locating information or customizing website content. They included (1) search engine navigation, (2) picture enlargement, (3) matching item suggestion, (4) log-in to own personal account, (5) styling suggestions by other consumers, and (6) picture rotation function. Analysis (chi-square) confirmed significant differences in availabilities of search engine navigation, picture enlargement, matching item suggestion, and log-in to own personal account. Interestingly, only two commercial retailers and one fair trade company were equipped with a product or styling suggestion technology. The use of 360-degree view of products was not used by any of the sample companies [commercial retailers (n=0); fair trade retailers (n= 0)]. To assess social interactivity, we analyzed attributes that facilitate relationships. The attributes are categorized into the following dimensions: 1) social media utilization, 2) social commerce, and 3) customer engagement. We examined the following five attributes constituting social interactivity: 1) existence of social media sites including Facebook, Twitter, and YouTube, 2) consumer Facebook sharing, 3) link to other retailers’ websites, 4) online chatting, and 5) consumer review section. Analysis showed the differences between commercial and fair trade retailers were all statistically significant. Conclusion & Implications This study examined the differences between commercial and fair trade retailers to evaluate the current status of fair trade retailers in terms of interactivity and engagement in managing their websites. We identified attributes where fair trade retailers lagged and these could hinder trust development with consumers. We address three implications applicable to fair trade retailers, and more broadly, retailers selling ethical products. First, website interactivity attributes that provide effective ways to communicate product, store and fair trade information are critical when the concept of fair trade is still unknown to a large segment of consumers. The focus of fair trade retailers should remain not only in delivering creative and high quality products, but also well-managed websites that can attract, educate, and engage consumers via interesting cultural products (Lee & Littrell, 2006). In doing so, advanced website interactivity attributes that enhance the convenience of online shopping, increase ease of navigation, and ensure competent delivery of information should be incorporated in fair trade company websites. Second, the lack of use of social media by fair trade retailers is concerning. Word-of-mouth (WOM) communication is innate to social media, and encourages spontaneous communications among consumers. Utilizing various social media platforms is an efficient way to generate consumers’ voluntary exposure to fair trade products at a minimal cost. Encouraging customers to share WOM would be a natural path to increase engagement, and spread the concept of fair trade. Moreover, when a consumer spreads fair trade product information on his or her social media networks, the people who will be viewing the information have already established a relationship with him or her, and such messages are perceived to be more credible than information shared by the company or unknown strangers (Chu & Kim, 2011). In addition, virtual space inviting consumer feedback on the company website or social media sites can stimulate interactions with unknown consumers. The third person point of view by unknown consumers compared to fair trade retailers may be perceived to be unbiased, and consequently accepted as more trustworthy. Third, the concept of social commerce, referring to the practice of featuring links of other company websites on one’s own website, is critical to enhance the overall visibility and traffic to fair trade e-commerce sites. The unique feature distinct to fair trade retailers is their shared use of ‘certified fair trade’ labeling. While commercial apparel retailers promote their brand to generate corporate profits, the vision of fair trade retailers is to promote their products to bring social welfare. Thus, the union of fair trade retailers and collective initiatives can create synergy. Integrating the concept of social commerce with collective initiatives is one practical way to achieve this objective. Considering this common denominator across fair trade retailers, the use of fair trade labeling and links to other fair trade retailers on the website will support greater exposure to potential consumers and engagement with diverse fair trade retailers. Two major challenges fair trade retailers face are that: (1) their small size fails to generate economies of scale, and (2) due to the absence of national chains or organizations managing fair trade stores, brick-and-mortar fair trade stores are not evenly distributed geographically. Therefore, an interactive and engaging online presence for fair trade retailers is critical in resolving these limitations. It is a way to reach a large segment of consumers who do not reside around brick-and-mortar fair trade stores. We hope that interactivity and engagement will increase consumer exposure to fair trade retailers and ultimately increase fair trade sales.

      • Genomic alterations in <i>BCL2L1</i> and <i>DLC1</i> contribute to drug sensitivity in gastric cancer

        Park, Hansoo,Cho, Sung-Yup,Kim, Hyerim,Na, Deukchae,Han, Jee Yun,Chae, Jeesoo,Park, Changho,Park, Ok-Kyoung,Min, Seoyeon,Kang, Jinjoo,Choi, Boram,Min, Jimin,Kwon, Jee Young,Suh, Yun-Suhk,Kong, Seong-H National Academy of Sciences 2015 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.112 No.40

        <P><B>Significance</B></P><P>Gastric cancer (GC) is one of the major causes of cancer-related deaths worldwide, but targeted therapy for GC is limited. Here, we identified two druggable targets from genomic alteration profiling of 103 patients with GC from Asia and validated the target suitability using patient-derived GC xenograft models, which recapitulate the tumor biology observed in patients. Combination therapy of irinotecan (standard treatment) with a <I>BCL2L1</I> (<I>BCL2</I>-like 1)-targeted drug was effective in size reduction of GC tumors having amplification of the <I>BCL2L1</I> gene, and genomic mutations of deleted in liver cancer 1 (<I>DLC1</I>) were associated with increased sensitivity to a ROCK inhibitor. Therefore, our study strongly suggests that <I>BCL2L1</I> and <I>DLC1</I> can serve as targets for novel GC therapies.</P><P>Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. Recent high-throughput analyses of genomic alterations revealed several driver genes and altered pathways in GC. However, therapeutic applications from genomic data are limited, largely as a result of the lack of druggable molecular targets and preclinical models for drug selection. To identify new therapeutic targets for GC, we performed array comparative genomic hybridization (aCGH) of DNA from 103 patients with GC for copy number alteration (CNA) analysis, and whole-exome sequencing from 55 GCs from the same patients for mutation profiling. Pathway analysis showed recurrent alterations in the Wnt signaling [<I>APC</I>, <I>CTNNB1</I>, and <I>DLC1</I> (deleted in liver cancer 1)], ErbB signaling (<I>ERBB2</I>, <I>PIK3CA</I>, and <I>KRAS</I>), and p53 signaling/apoptosis [<I>TP53</I> and <I>BCL2L1</I> (BCL2-like 1)] pathways. In 18.4% of GC cases (19/103), amplification of the antiapoptotic gene <I>BCL2L1</I> was observed, and subsequently a <I>BCL2L1</I> inhibitor was shown to markedly decrease cell viability in <I>BCL2L1</I>-amplified cell lines and in similarly altered patient-derived GC xenografts, especially when combined with other chemotherapeutic agents. In 10.9% of cases (6/55), mutations in <I>DLC1</I> were found and were also shown to confer a growth advantage for these cells via activation of Rho-ROCK signaling, rendering these cells more susceptible to a ROCK inhibitor. Taken together, our study implicates <I>BCL2L1</I> and <I>DLC1</I> as potential druggable targets for specific subsets of GC cases.</P>

      • Ultrasonic spray pyrolysis synthesis of reduced graphene oxide/anatase TiO<sub>2</sub> composite and its application in the photocatalytic degradation of methylene blue in water

        Park, Jeong-Ann,Yang, Boram,Lee, Joongki,Kim, In Gyeom,Kim, Jae-Hyun,Choi, Jae-Woo,Park, Hee-Deung,Nah, In Wook,Lee, Sang-Hyup Elsevier 2018 CHEMOSPHERE - Vol.191 No.-

        <P><B>Abstract</B></P> <P>Reduced graphene oxide (RGO)/anatase TiO<SUB>2</SUB> composite was prepared using a simple one-step technique—ultrasonic spray pyrolysis—in order to inhibit the aggregation of TiO<SUB>2</SUB> nanoparticles and to improve the photocatalytic performance for degradation of methylene blue (MB). Different proportions (0–5 wt%) of RGO/TiO<SUB>2</SUB> composites were characterized by scanning electronic microscopy (SEM), dispersive X-ray spectrometry (EDS), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) surface area, X-ray photoelectron spectroscopy (XPS), X-ray diffractometry (XRD), Raman spectroscopy, UV–vis spectroscopy, and electrochemical impedance spectroscopy (EIS) to verify mechanism. From these analysis, TiO<SUB>2</SUB> nanoparticles are distributed uniformly on the RGO sheets with crumpled shape during ultrasonic spray pyrolysis and surface area is increasing by increasing portion of RGO. Band gap of RGO<SUB>5</SUB>/TiO<SUB>2</SUB> (5 wt% of RGO) composite is 2.72 eV and band gap was reduced by increasing portion of RGO in RGO/TiO<SUB>2</SUB> composites. The RGO<SUB>5</SUB>/TiO<SUB>2</SUB> composite was superior to other lower content of RGO/TiO<SUB>2</SUB> composites with a rapid transport of charge carriers and an effective charge separation. The highest removal efficiency of MB was obtained at the RGO<SUB>5</SUB>/TiO<SUB>2</SUB> composite under UVC irradiation, which coincided with the EIS, and the optimal dose of the composite was determined to be 0.5 g/L. The RGO<SUB>5</SUB>/TiO<SUB>2</SUB> composite improve the photocatalytic degradation rate of MB over the TiO<SUB>2</SUB> due to a retardation of electron-hole recombination. The MB adsorption capacity and photocatalytic degradation efficiency were greatly affected by pH changes and increased with increasing pH due to electrostatic interactions and generation of more hydroxyl radicals. The reusability of RGO<SUB>5</SUB>/TiO<SUB>2</SUB> composite was examined during 3 cycles.</P> <P><B>Highlights</B></P> <P> <UL> <LI> RGO/TiO<SUB>2</SUB> composite was successfully prepared by one-pot ultrasonic spray pyrolysis. </LI> <LI> The highest MB removal efficiency was obtained at the proportion of 5 wt% RGO. </LI> <LI> The MB adsorption capacity of RGO<SUB>5</SUB>/TiO<SUB>2</SUB> was enhanced at high solution pH. </LI> <LI> RGO/TiO<SUB>2</SUB> composite retarded electron-hole recombination verified with EIS. </LI> <LI> RGO/TiO<SUB>2</SUB> composite had reduced E<SUB>bg</SUB> and improved the photocatalytic MB degradation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

      • S-8 Comparison of tenofovir versus entecavir therapy in nucleos(t)ide-naive chronic hepatitis B

        ( Boram Min ),( Joong Gi Bae ),( Hyun Seong Lee ),( Young Min Shin ),( Kyung Hye Park ),( Byung Uk Lee ),( Jae Ho Park ),( Byung Gyu Kim ),( Seok Won Jung ),( In Du Jeong ),( Sung-jo Bang ),( Jung Woo 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

        Backgrounds:?Entecavir (ETV) and tenofovir (TDF) are nucleoside analogues with high potency for profound and durable viral suppression and genetic barriers against resistance; these drugs are recommended for the first-line treatment of chronic hepatitis B (CHB) in current guidelines. But rare data are available on the comparison of TDF and ETV therapy in CHB patients with baseline high viral load (HVL), defined as having hepatitis B virus (HBV) DNA >8 log10 copies/mL (7.3 log10 IU/mL).?Methods:?We performed a retrospective analysis of the efficacy of TDF therapy, as compared to that of ETV therapy, in patients with HVL. A matched study population was constructed to compare the antiviral efficacy of TDF therapy and ETV therapy by a propensity score analysis. The primary endpoint was a virological response (VR), defined as an HBV DNA level of <12 IU/mL.?Results:?Three hundreds two patients were selected after matching propensity score with 1:1 ratio. VR was observed in 66.2% (100/151) of patients in the TDF group and in 63.6% (96/151) of the patients in the ETV group. The VR rates were not different between the two groups (78.1 vs. 76.2% at month 12, and 99.0 vs. 95.8% at month 24; log rank p=0.432). During therapy, 74.8% of patients in the TDF group, and 70.2% of patients in the ETV group had partial VR, respectively (p=0.367). ALT normalization rates also did not differ between both the treatment groups (94.2% and 92.1% in the TDF and ETV therapy groups, respectively; p=0.476). During therapy, 13.7% (18 of 131) of patients in the TDF group, and 21.2% (28 of 132) of patients in the ETV group achieved HBeAg seroconversion, respectively (p=0.111). Nineteen patients experienced a virological breakthrough. Among them, twelve patient (7.9 %) was in the TDF group and 7 patients (4.6 %) were in the ETV group (p=0.236). Conclusions:?In patients with a baseline HBV DNA level >8 log10 copies/mL (7.3 log10 IU/mL), TDF therapy was as effective as ETV therapy, in maintaining the viral suppression.

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        Comprehensive genomic analyses associate <i>UGT8</i> variants with musical ability in a Mongolian population

        Park, Hansoo,Lee, Seungbok,Kim, Hyun-Jin,Ju, Young Seok,Shin, Jong-Yeon,Hong, Dongwan,von Grotthuss, Marcin,Lee, Dong-Sung,Park, Changho,Kim, Jennifer Hayeon,Kim, Boram,Yoo, Yun Joo,Cho, Sung-Il,Sung, BMJ Publishing Group 2012 Journal of medical genetics Vol.49 No.12

        <P><B>Background</B></P><P>Musical abilities such as recognising music and singing performance serve as means for communication and are instruments in sexual selection. Specific regions of the brain have been found to be activated by musical stimuli, but these have rarely been extended to the discovery of genes and molecules associated with musical ability.</P><P><B>Methods</B></P><P>A total of 1008 individuals from 73 families were enrolled and a pitch-production accuracy test was applied to determine musical ability. To identify genetic loci and variants that contribute to musical ability, we conducted family-based linkage and association analyses, and incorporated the results with data from exome sequencing and array comparative genomic hybridisation analyses.</P><P><B>Results</B></P><P>We found significant evidence of linkage at 4q23 with the nearest marker D4S2986 (LOD=3.1), whose supporting interval overlaps a previous study in Finnish families, and identified an intergenic single nucleotide polymorphism (SNP) (rs1251078, p=8.4×10<SUP>−17</SUP>) near <I>UGT8</I>, a gene highly expressed in the central nervous system and known to act in brain organisation. In addition, a non-synonymous SNP in <I>UGT8</I> was revealed to be highly associated with musical ability (rs4148254, p=8.0×10<SUP>−17</SUP>), and a 6.2 kb copy number loss near <I>UGT8</I> showed a plausible association with musical ability (p=2.9×10<SUP>−6</SUP>).</P><P><B>Conclusions</B></P><P>This study provides new insight into the genetics of musical ability, exemplifying a methodology to assign functional significance to synonymous and non-coding alleles by integrating multiple experimental methods.</P>

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