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Methimazole에 의한 무과립세포증에 합병된 경부농양 1예
이진호,김현만,이관우,채봉남,김윤정,이성규,홍은경,박준성,하창영,정윤석 대한내분비학회 1998 Endocrinology and metabolism Vol.13 No.4
The thiourea derivatives, propylthiouracil and methimazole are in widespread use for the treatment of hyperthyroidism. The untoward side effects of these drugs are not infrequent and agranulocytosis is the most serious side effect them. We observed one case of methimazole induced agranulocytosis complicated by deep neck abscess. A 54-year-old woman was admitted because of fever, chilling and sore throat for 1 week. The symptom was developed after receiving methimazole 30mg daily day due to hyperthyroidism during last 3 months. Physical examination revealed hyperemic, enlarged tonsils and tender swelling of the right lower neck The peripheral blood total leukoeyte count was 1,500/mm' (absolute neutrophil count, ANC 9) and a peripheral blood smear revealed few neutrophil. The patient was administered G-CSF 2 mg/kg daily, and on the fifth day of hospitalization, fever subsided and ANC increased to 3,431. On the 11th day, fever developed again and the tenderness and swelling in both lower neck area were aggrevated. Computed tomography of the neck was performed, and revealed a large deep neck abscess. After pus aspiration and antibiotics therapy, the neck abscess was disappeared (J Kor Soc Endocrinol 13:617-621, 1998).
Negligible Effect of Ginkgo Biloba Extract on the Pharmacokinetics of Cilostazol
( Hye Jin Chung ),( Nam Sun Kim ),( Eun Jeong Kim ),( Tae Kon Kim ),( Keun Ho Ryu ),( Bong Yong Lee ),( Dong Hyun Kim ),( Chang Bae Jin ),( Hye Hyun Yoo ) 한국응용약물학회 2009 Biomolecules & Therapeutics(구 응용약물학회지) Vol.17 No.3