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Cao,Jain Min,Wu,Chuan Liang,Shen,Wen ZhEng,Huang,Chang,Li,Yin Bo,Xu,Yang Zhen 대한전자공학회 1997 ICVC : International Conference on VLSI and CAD Vol.5 No.1
Start with 2D simulation of hot-carrier injection current. in this pier, we have discussed the influence of different silicon film thickness (Tsi), gate oxide thickness (Tox1) and substrate doping (Na) an the hot-carrier effects of thin-film deep submicron SOI/MOSFET. Simulation results indicate that, with reduction of Tsi, the hot-carrier current is reduced (by more than 2 orders); and in Tsi range of 0.05-0.1μ. the hot carrier carrent is smallest and insensitive to Tox1, Na and Tsi. These are helpful to the design of high reliability SOI/MOSFET.
Immunoprofiling of the Tryptophan-Rich Antigen Family in <i>Plasmodium vivax</i>
Wang, Bo,Lu, Feng,Cheng, Yang,Chen, Jun-Hu,Jeon, Hye-Yoon,Ha, Kwon-Soo,Cao, Jun,Nyunt, Myat Htut,Han, Jin-Hee,Lee, Seong-Kyun,Kyaw, Myat Phone,Sattabongkot, Jetsumon,Takashima, Eizo,Tsuboi, Takafumi,H American Society for Microbiology 2015 Infection and immunity Vol.83 No.8
<P>Tryptophan-rich antigens (TRAgs) are an antigen family that has been identified in human and rodent malaria parasites. TRAgs have been proposed as candidate antigens for potential vaccines. The <I>Plasmodium vivax</I> TRAg (PvTRAg) family includes 36 members. Each PvTRAg contains a tryptophan-rich (TR) domain in the C-terminal region. In this study, we recombinantly expressed all 36 PvTRAgs using a cell-free expression system, and, for the first time, profiled the IgG antibody responses against all PvTRAgs in the sera from 96 vivax malaria patients and 40 healthy individuals using protein microarray technology. The mean seropositive rate for all PvTRAgs was 60.3%. Among them, nine PvTRAgs were newly identified in this study and showed a seropositive rate of >50%. Five of them, PvTRAg_13, PvTRAg_15, PvTRAg_16, PvTRAg_26, and PvTRAg_29, produced higher levels of IgG antibody, even in low-endemicity countries. In addition, the results of an immunofluorescence analysis suggest that PvTRAgs are, at least in part, associated with caveola-vesicle complexes, a unique structure of <I>P. vivax</I>-infected erythrocytes. The mechanism of formation and the function of these abundant membrane structures are not known. Further investigation aimed at determining the functions of these proteins would lead to a better understanding of the blood-stage biology of <I>P. vivax</I>.</P>
Linlin Fan,Bo Wei,Lingling Xu,Yang Liu,Wanlu Cao,Ning Ma,Hong Gao 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.8
In this study, flower-like Bi2MoO6/BiOI heterostructure photocatalysts were synthesized via an anion exchange method using BiOI as precursor. The composition of Bi2MoO6/BiOI can be easily controlled by adjusting the MoO2- 4 /I- molar ratio. Photocatalytic activity studies based on the degradation of Rhodamine B (RhB) show that Bi2MoO6/BiOI = 50% photocatalyst exhibited the best performance under visible light excitation. The radical scavengers test demonstrated that holes was the main reactive species for the degradation of RhB, and O2- also took part in the photodecomposition process. Photoelectrochemical measurement reveals that the Bi2MoO6/ BiOI = 50% exhibit enhanced carrier densities, charge separation and photocurrent compared with the original Bi2MoO6 and BiOI. Our results show that bismuth-based heterojunctions fabricated through the anion exchange method could be a cost-effective approach to improve the photocatalytic activity and photoelectrochemical performance of BiOI.
The Boundary Element Analysis of Wave Force acting on Multiple Cylinders
Kim, Nam-Hyeong,Cao, Tan Ngooc Than,Yang, Soon-Bo Korean Institute of Navigation and Port Research 2012 한국항해항만학회지 Vol.36 No.7
In this paper, the boundary element method is applied to solve the diffraction of waves by multiple vertical cylinders under the assumption of linear wave theory. A numerical analysis by boundary element method is based on Green's theorem and introduced to an integral equation for the fluid velocity potential around the cylinders. The numerical results obtained in this study are compared with the experimental data and the results of the theory using multiple scattering techniques. The comparisons show strong agreement. This numerical analysis method developed by using boundary element method could be used broadly for the design of various offshore structures to be constructed in coastal zones in the future.
Kong, Wei-Dong,Cao, Jian-Ming,Xu, Jian,Chen, Bo,Yang, Tao,Xu, Tan-Tan,Lu, Guang-Ming,Li, Jun,Huang, Xin-En Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
Objectives: To explore the impact of low- vs conventional-dose chemotherapy via transcatheter arterial chemo-embolization (TACE) on serum fibrosis indicators and treatment efficacy of hepatocellular cancer patients (HCC). Materials and Methods: Patients fulfilling the eligibility criteria were assigned to TACE in Group A (with low-dose chemotherapy) or Group B (conventional-dose chemotherapy). Four serum fibrosis related indicators, hyaluronic acid(HA), human pro-collagen type-III (hPC-III), laminin (LN), and collagen type-IV(IV-C) before TACE were compared with the values 7 days after TACE. The response rate and survival time were also compared between the two groups. Results: Fifty patients with HCC were enrolled in this study, including 25 in Group A and 25 in Group B. No significant differences were detected between the two groups in the four indicators before TACE. After TACE, the value of the four serum indicators increased significantly in Group B. However, no significant differences regarding these four indicators were found in Group A after TACE. Significant differences were demonstrated between the two groups after TACE, but median survival time and 1 or 2 year overall survival rates did not differ (P>0.05). Conclusions: Low-, compared with conventional-dose chemotherapy exerts the same impact on the variation of fibrosis related indicators and has no influence on median survival time and survival rate after TACE in HCC patients.
Zhaokun Xiong,Jinyan Cao,Bo Lai,Ping Yang 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.59 No.-
The performance of mFe/Cu/O3 and mFe0/O3 processes was comparatively investigated through optimized the key operational parameters for degradation of p-nitrophenol (PNP). The COD removal attained by mFe/Cu/O3 process was higher than that of mFe0/O3 process under the corresponding conditions. Additionally, under the optimal conditions, the COD removal (93.6%) obtained by mFe/Cu/O3 process was more than twice of the sum (44.6%) of that by ozone (35.3%) and mFe/Cu alone (9.3%). Finally, the key active materials in mFe/Cu/O3 system, degradation pathway of PNP and reaction mechanism of mFe/Cu/O3 process were proposed according to the analysis results of intermediate products, SEM–EDS and XRD.
Shu Wang,Houpu Yang,Jiajia Guo,Miao Liu,Fuzhong Tong,Yingming Cao,Bo Zhou,Peng Liu,Lin Cheng,Fei Xie,Deqi Yang,Jiaqing Zhang 한국바이오칩학회 2011 BioChip Journal Vol.5 No.1
Neo-adjuvant chemotherapy for breast cancer substantially benefits patients who achieve pathological response. However, clinical or pathological response information can only be obtained a period of time after chemotherapy. The identification of novel bio-markers or the application of new technique that can be used to predict treatment response before che-motherapy would allow therapy to be tailored on an individual patient basis. The purpose of this study is to identify the chemo-sensitivity and chemo-resistance related proteins using antibody microarray profiling, and to develop a multi-protein predictive model for breast cancer. Total protein was extracted from core needle biopsy samples obtained from 15 patients before treatment with neo-adjuvant TA(combination of taxanes and anthracycline) chemotherapy. Protein profiling was analyzed by antibody microarray. 10 pati-ents were used as training set to develop the predictive model using the software PAM(prediction analysis of microarray). Another 5 patients were used as a validation set to test the model. In cross-validation, the mole-cular predictive model showed an accuracy of 90%, in independent validation, the model classified the cases with an accuracy of 80%. In conclusion, the proteomic predictive model has the potential to predict pathological response to neo-adjuvant TA chemotherapy.
( Xi Guo ),( Peng Geng ),( Quan Wang ),( Bo Yang Cao ),( Bin Liu ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.10
Severe acute respiratory syndrome (SARS), a disease that spread widely in the world during late 2002 to 2004, severely threatened public health. Although there have been no reported infections since 2004, the extremely pathogenic SARS coronavirus (SARS-CoV), as the causative agent of SARS, has recently been identified in animals, showing the potential for the re-emergence of this disease. Previous studies showed that 27 single nucleotide polymorphism (SNP) mutations among the spike (S) gene of this virus are correlated closely with the SARS pathogenicity and epidemicity. We have developed a SNP DNA microarray in order to detect and genotype these SNPs, and to obtain related information on the pathogenicity and epidemicity of a given strain. The microarray was hybridized with PCR products amplified from cDNAs obtained from different SARS-CoV strains. We were able to detect 24 SNPs and determine the type of a given strain. The hybridization profile showed that 19 samples were detected and genotyped correctly by using our microarray, with 100% accuracy. Our microarray provides a novel method for the detection and epidemiological surveillance of SARS-CoV.
Si-Qi Dong,Tong-Min Wang,Jiang-Bo Zhang,Yong-Qiao He,Wen-Qiong Xue,Zi-Yi Wu,Da-Wei Yang,Lian-Jing Cao,Jing-Wen Huang,Xi-Zhao Li,Pei-Fen Zhang,Xiao-Hui Zheng,Wei-Hua Jia 대한암학회 2021 Cancer Research and Treatment Vol.53 No.3
Purpose Capecitabine is an extensively used oral prodrug of 5-fluorouracil in treatment of colon cancer and is known to cause hand-foot syndrome (HFS). As the target enzyme for capecitabine, thymidylate synthase (TYMS) plays a key role for 5-fluorouracil metabolism and has been associated with some side effects caused by capecitabine. The aim of our study is to identify the possible genetic predictors of capecitabine-induced HFS (CAP-HFS) in Chinese colorectal cancer patients.Materials and Methods Whole exons of TYMS were sequenced for 288 extreme phenotype HFS patients, including 144 severe or early-onset (first 2 cycles) moderate HFS extreme cases and 144 extreme controls with no reported HFS. The associations between polymorphisms and CAP-HFS were analyzed using logistic regression under an additive model.Results We identified a novel risk mutation (c.1A>G, chr18:657743), was associated with severe HFS in an extreme case who was affected during the first cycle of treatment. Moreover, we identified three new variants, rs3786362, rs699517, rs2790, and two previously reported variants, 5’VNTR 2R/3R and 3′-untranslated region 6-bp ins-del, which were significantly associated with CAP-HFS (p < 0.05). In silico analysis revealed that the effect of these polymorphisms in the TYMS region on the development of HFS might not be restricted solely to the regulation of TYMS expression, but also the TYMS catalytic activity through the indirect effect on ENOSF1 expression.Conclusion This study identified new polymorphisms in TYMS gene significantly associated with CAP-HFS, which may serve as useful genetic predictors for CAP-HFS and help to elucidate the underlying mechanism of HFS.
Evaluation of the Dosimetric Accuracy for a Couch-Based Tracking System (CBTS)
Kyung Hwan Chang,Suk Lee,Kwang Hyeon Kim,Jang Bo Shim,Dae Sik Yang,Young Je Park,Won Sup Yoon,Chul Yong Kim,Yuanjie Cao 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.69 No.2
In this study, the geometric and dosimetric accuracy of an in-house-developed couch-based tracking system (CBTS) was investigated using both film and in-house-developed polymer gel dosimeters. We evaluated the 1D and the 2D motion accuracies of our couch system by using Gafchromic EBT film. For the 1D test, the couch system was moved 5, 10, and 20 mm in the X, Y, and Z directions, respectively. Meanwhile, for the 2D test, it was moved along the XY, YZ, and ZX directions. We compared the profiles, full widths at half maximum (FWHMs), and penumbras between the static and the tracking fields. For the 3D test, we quantitatively compared the dose distribution between the static and the tracking fields by using the polymer gel dosimeter when it was simultaneously moved in the XYZ directions. We confirmed that the film was moved according to motion amplitudes of 5, 10, and 20 mm in the X, Y, and Z directions, respectively, in the 1D and 2D motion tests. The value of the FWHM of the static field and the three tracking fields were 51.88, 53.28, 57.67, and 64.43 mm, respectively. Two types of penumbras became wider with increasing amplitudes compared to the static field. For the 3D test, the dose distribution of the XYZ tracking field was qualitatively larger than that of the static field. We conclude that this CBTS has the potential for pre-clinical applications in adaptive radiation therapy.