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RISS 인기검색어
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- 저자 : ( Bo Xing Yin ) (검색결과 4 건)
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Triterpenoid saponins from Clinopodium chinense (Benth.) O. Kuntze and their biological activity
Yin-Di Zhu,Jing-Yi Hong,Feng-Da Bao,Na Xing,Ling-Tian Wang,Zhong-Hao Sun,Yun Luo,Hai Jiang,Xudong Xu,Nai-Liang Zhu,Hai-Feng Wu,Gui-Bo Sun,Jun-Shan Yang 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.12
Four new ursane-type triterpenoid saponins, clinopoursaponins A–D (1–4), six new oleanane-type triterpenoid saponins, clinopodiside VII–XII (5–10), as well as eight known triterpene analogues (11–18), were isolated from the aerial parts of Clinopodium chinense (Benth.) O. Kuntze. The structures of the new compounds were determined based on extensive spectral analyses, including 1D (1H and 13C) and 2D NMR experiments (COSY, NOESY, HSQC, 2D TOCSY, HSQC-TOCSY and HMBC), HR-ESI-MS and chemical methods. Compounds 1–18 were evaluated for their protective effects against anoxia/reoxygenation-induced apoptosis in H9c2 cells and cytotoxicities against murine mammary carcinoma cell line 4T1. Compounds 8, 9 and 18 exhibited significant protective effects, while compound 1 exhibited cytotoxic activity with IC50 value of 7.4 μm compared to 7.6 μm for the positive control 10-hydroxycamptothecin.
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Behavior of headed shear stud connectors subjected to cyclic loading
Fa-xing Ding,Guo-an Yin,Hai-bo Wang,Liping Wang,Qiang Guo 국제구조공학회 2017 Steel and Composite Structures, An International J Vol.25 No.6
The objective of this study is to investigate the actual behavior of studs in structures under earthquake load through laboratory tests and numerical simulation. A test program including eighteen specimens was devised with consideration of different concrete strengths and stud diameters. Six of specimens were subjected to monotonically increasing loading while the others were subjected to cyclic loading. Mechanical behavior including the failure mechanism, load-slip relationship, stiffness degradation, energy dissipation and the damage accumulation was obtained from the test results. An accurate numerical model based on the ABAQUS software was developed and validated against the test results. The results obtained from the finite element (FE) model matched well with the experimental results. Furthermore, based on the experimental and numerical data, the design formulas for expressing the skeleton curve were proposed and the simplified hysteretic model of load versus displacement was then established. It is demonstrated that the proposed formulas and simplified hysteretic model have a good match with the test results.
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Deng, Yangbin,Liu, Minghao,Qiu, Bowen,Yin, Yuan,Gong, Xing,Huang, Xi,Pang, Bo,Li, Yongchun Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.1
Dual-cooled annular fuel allows a significant increase in power density while maintaining or improving safety margins. However, the dual-cooled design brings much higher Zircaloy charge in reactor core, which could cause a great threaten of hydrogen explosion during severe accidents. Hence, an innovative fuel combined dual-cooled annular geometry and SiC cladding was proposed for the first time in this study. Capabilities of fuel design and behavior simulation were developed for this new fuel by the upgrade of FROBA-ANNULAR code. Considering characteristics of both SiC cladding and dual-cooled annular geometry, the basic fuel design was proposed and preliminary proved to be feasible. After that, a design optimization study was conducted, and the optimal values of as-fabricated plenum pressure and gas gap sizes were obtained. Finally, the performance simulation of the new fuel was carried out with the full consideration of realistic operation conditions. Results indicate that in addition to possessing advantages of both dual-cooled annular fuel and accident tolerant cladding at the same time, this innovative fuel could overcome the brittle failure issue of SiC induced by pellet-cladding interaction.
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( Da Wei Chen ),( Zhen Quan Yang ),( Xia Chen ),( Yu Jun Huang ),( Bo Xing Yin ),( Fei Xiang Guo ),( Hai Qing Zhao ),( Jia Di Huang ),( Yun Wu ),( Rui Xia Gu ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.5
Accumulating evidence indicates that lactic acid bacteria could improve host physiology and lipid metabolism. To investigate the effect of the gut microbiota on host lipid metabolism, a hyperlipidemic rat model was established by feeding rats a high-fat diet for 28 days, and the gut microbiota of the rats was analyzed using real-time PCR before and after administration of Lactobacillus rhamnosus hsryfm 1301 and its fermented milk for 28 days. The findings showed that the Lactobacillus spp., Bifidobacterium spp., Bacteroides spp., and Enterococcus spp. content in the hyperlipidemic rats gut was increased significantly (p < 0.05), while the Clostridium leptum and Enterobacter spp. content was decreased significantly after intervening with L. rhamnosus hrsyfm 1301 and its fermented milk for 28 days (p < 0.05). Furthermore, the lipid levels of the serum and the liver were decreased significantly (p < 0.05) and the fecal water content was increased significantly (p < 0.05) in the hyperlipidemic rats after the intervention, and hepatocyte fatty degeneration of liver tissues was also prevented. A positive correlation was observed between the Clostridium leptum content and the level of serum cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein, and a negative correlation was observed between the Enterobacter spp. content and the Lactobacillus spp. and Bifidobacterium spp. content in the hyperlipidemic rats gut. These results suggest that the gut microbiota and lipid metabolism of hyperlipidemic rats could be improved by supplementation with L. rhamnosus hsryfm 1301 and its fermented milk.
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