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( Bo Ram Kang ),( Ho Kim ),( Sung Hee Nam ),( Eun Young Yun ),( Seong Ryul Kim ),( Mi Young Ahn ),( Jong Soo Chang ),( Jae Sam Hwang ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.2
Our previous study demonstrated that CopA3, a disulfide dimer of the coprisin peptide analogue (LLCIALRKK), has antibacterial activity. In this study, we assessed whether CopA3 caused cellular toxicity in various mammalian cell lines. CopA3 selectively caused a marked decrease in cell viability in Jurkat T, U937, and AML-2 cells (human leukemia cells), but was not cytotoxic to Caki or Hela cells. Fragmentation of DNA, a marker of apoptosis, was also confirmed in the leukemia cell lines, but not in the other cells. CopA3-induced apoptosis in leukemia cells was mediated by apoptosis inducing factor (AIF), indicating induction of a caspase-independent signaling pathway. [BMB reports 2012; 45(2): 85-90].
Kang, Bo Ram,Yu, Woo Jong,Kim, Ki Kang,Park, Hyeon Ki,Kim, Soo Min,Park, Yongjin,Kim, Gunn,Shin, Hyeon-Jin,Kim, Un Jeong,Lee, Eun-Hong,Choi, Jae-Young,Lee, Young Hee WILEY-VCH Verlag 2009 Advanced functional materials Vol.19 No.16
<P>Here, a pyrolytically controlled antioxidizing photosynthesis coenzyme, β-Nicotinamide adenine dinucleotide, reduced dipotassium salt (NADH) for a stable n-type dopant for carbon nanotube (CNT) transistors is proposed. A strong electron transfer from NADH, mainly nicotinamide, to CNTs takes place during pyrolysis so that not only the type conversion from p-type to n-type is realized with 100% of reproducibility but also the on/off ratio of the transistor is significantly improved by increasing on-current and/or decreasing off-current. The device was stable up to a few months with negligible current changes under ambient conditions. The n-type characteristics were completely recovered to an initial doping level after reheat treatment of the device.</P> <B>Graphic Abstract</B> <P>Pyrolytically controlled antioxidizing photosynthesis coenzyme is used to generate stable n-type doping of carbon nanotubes under ambient conditions. The device is stable up to a few months with negligible current changes under ambient conditions. The n-type characteristics were completely recovered to an initial doping level after reheat treatment of the device. <img src='wiley_img/1616301X-2009-19-16-ADFM200801712-content.gif' alt='wiley_img/1616301X-2009-19-16-ADFM200801712-content'> </P>