Prevalence of Plasmid-Mediated Quinolone Resistance Genes Among Escherichia coli in the Gut of Healthy People in Fuzhou, China

Bin Ling,Yao Chen,Zhiyun Wu,Zhichang Zhao,Juan Wu,Yingping Cao 대한진단검사의학회 2018 Annals of Laboratory Medicine Vol.38 No.4

The intestinal tract may be an important reservoir for antibioticresistant genes [1]. Determining the prevalence of quinolone resistance in intestinal bacteria within the community is important for both healthy subjects and hospital patients as quinolone is one of the most commonly used antibiotics in China. The prevalence of plasmid-mediated quinolone resistance (PMQR) geneharboring Enterobacteriaceae in the gut flora among healthy humans was previously unknown, so we assessed the prevalence of PMQR genes among commensal Escherichia coli in healthy persons from one region in China. This study was approved by the Ethics Committee of the Fujian Medical University Union Hospital (No. 2012KY085). Written informed consent was obtained from all participants.

WEAKLY ALMOST PERIODIC POINTS AND CHAOTIC DYNAMICS OF DISCRETE AMENABLE GROUP ACTIONS

Ling, Bin,Nie, Xiaoxiao,Yin, Jiandong Korean Mathematical Society 2019 대한수학회지 Vol.56 No.1

The aim of this paper is to introduce the notions of (quasi) weakly almost periodic point, measure center and minimal center of attraction of amenable group actions, explore the connections of levels of the orbit's topological structure of (quasi) weakly almost periodic points and study chaotic dynamics of transitive systems with full measure centers. Actually, we showed that weakly almost periodic points and quasiweakly almost periodic points have distinct orbit's topological structure and proved that there exists at least countable Li-Yorke pairs if the system contains a proper (quasi) weakly almost periodic point and that a transitive but not minimal system with a full measure center is strongly ergodically chaotic.

Weakly almost periodic points and chaotic dynamics of discrete amenable group actions

Bin Ling,Xiaoxiao Nie,Jiandong Yin 대한수학회 2019 대한수학회지 Vol.56 No.1

The aim of this paper is to introduce the notions of (quasi) weakly almost periodic point, measure center and minimal center of attraction of amenable group actions, explore the connections of levels of the orbit's topological structure of (quasi) weakly almost periodic points and study chaotic dynamics of transitive systems with full measure centers. Actually, we showed that weakly almost periodic points and quasi-weakly almost periodic points have distinct orbit's topological structure and proved that there exists at least countable Li-Yorke pairs if the system contains a proper (quasi) weakly almost periodic point and that a transitive but not minimal system with a full measure center is strongly ergodically chaotic.

Intensity-Modulated Radiotherapy versus Three-Dimensional Conformal Radiotherapy in Definitive Chemoradiotherapy for Cervical Esophageal Squamous Cell Carcinoma: Comparison of Survival Outcomes and Toxicities

Nai-Bin Chen,Bo Qiu,Jun Zhang,Meng-Yun Qiang,Yu-Jia Zhu,Bin Wang,Jin-Yu Guo,Ling-Zhi Cai,Shao-Min Huang,Meng-Zhong Liu,Qun Li,Yong-Hong Hu,Qi-Wen Li,Hui Liu 대한암학회 2020 Cancer Research and Treatment Vol.52 No.1

Purpose The purpose of this study was to compare the survival and toxicities in cervical esophageal squamous cell carcinoma (CESCC) treated by concurrent chemoradiothrapy with either three-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiotherapy (IMRT) techniques. Materials and Methods A total of 112 consecutive CESCC patients were retrospectively reviewed. 3D-CRT and IMRT groups had been analyzed by propensity score matching method, with sex, age, Karnofsky performance status, induction chemotherapy, and tumor stage well matched. The Kaplan- Meier method and Cox proportional hazards model were used for overall survival (OS) and progression-free survival (PFS). Toxicities were compared between two groups by Fisher exact test. Results With a median follow-up time of 34.9 months, the 3-year OS (p=0.927) and PFS (p=0.859) rate was 49.6% and 45.8% in 3D-CRT group, compared with 54.4% and 42.8% in IMRT group. The rates of grade ! 3 esophagitis, grade ! 2 pneumonitis, esophageal stricture, and hemorrhage were comparable between two groups, while the rate of tracheostomy dependence was much higher in IMRT group than 3D-CRT group (14.3% vs.1.8%, p=0.032). Radiotherapy technique (hazard ratio [HR], 0.09; 95% confidence interval [CI], 0.01 to 0.79) and pretreatment hoarseness (HR, 0.12; 95% CI 0.02 to 0.70) were independently prognostic of tracheostomy dependence. Conclusion No survival benefits had been observed while comparing IMRT versus 3D-CRT in CESCC patients. IMRT with fraction dose escalation and pretreatment hoarseness were considered to be associated with a higher risk for tracheostomy dependence. Radiation dose escalation beyond 60 Gy should be taken into account carefully when using IMRT with hypofractionated regimen.

Analysis of Cancer Incidence in Zhejiang Cancer Registry in China during 2000 to 2009

Du, Ling-Bin,Li, Hui-Zhang,Wang, Xiang-Hui,Zhu, Chen,Liu, Qing-Min,Li, Qi-Long,Li, Xue-Qin,Shen, Yong-Zhou,Zhang, Xin-Pei,Ying, Jiang-Wei,Yu, Chuan-Ding,Mao, Wei-Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14

Objective: The Zhejiang Provincial Cancer Prevention and Control Office collected cancer registration data during 2000 to 2009 from 6 cancer registries in Zhejiang province of China in order to analyze the cancer incidence. Methods: Descriptive analysis included cancer incidence stratified by sex, age and cancer site group. The proportions and cumulative rates of 10 common cancers in different groups were also calculated. Chinese population census in 1982 and Segi's population were used for calculating age-standardized incidence rates. The log-linear model was used for fitting to calculate the incidence trends. Results: The 6 cancer registries in Zhejiang province in China covered a total of 60,087,888 person-years during 2000 to 2009 (males 30,445,904, females 29,641,984). The total number of new cancer cases were 163,104 (males 92,982, females 70,122). The morphology verified cases accounted for 69.7%, and the new cases verified only by information from death certification accounted for 1.23%. The crude incidence rate in Zhejiang cancer registration areas was $271.5/10^5$ during 2000 to 2009 (male $305.41/10^5$, female $236.58/10^5$), age-standardized incidence rates by Chinese standard population (ASIRC) and by world standard population (ASIRW) were $147.1/10^5$ and $188.2/10^5$, the cumulative incidence rate (aged from 0 to 74) being 21.7%. The crude incidence rate was $209.6/10^5$ in 2000, and it increased to $320.20/10^5$ in 2009 (52.8%), with an annual percent change (APC) of 4.51% (95% confidence interval, 3.25%-5.79%). Age-specific incidence rate of 80-84 age group was achieved at the highest point of the incidence curve. Overall with different age groups, the cancer incidences differed, the incidence of liver cancer being highest in 15-44 age group in males; the incidence of breast cancer was the highest in 15-64 age group in females; the incidences of lung cancer were the highest in both males and females over the age of 65 years. Conclusions: Lung cancer, digestive system malignancies and breast cancer are the most common cancers in Zhejiang province in China requiring an especial focus. The incidences of thyroid cancer, prostate cancer, cervical cancer and lymphoma have increased rapidly. Prevention and control measures should be implemented for these cancers.

中韓虎故事比較硏究

왕분령(Wang Bin Ling) 한국어문교육학회 2004 어문학교육 Vol.29 No.-

Directions of APEC Future Policy for ICT in Education

Mohamad Zaini bin Mohd,Zhou Ling,Zabani bin Darns,Ranbsun Wiboonupptaum,Thapanee Thummetha APEC국제교육협력원 2007 Asia-Pacific Cybereducation Journal Vol.3 No.1

'Directions of APEC Future Policy for JCT in Education' aims at identifYing trends of APEC policy for ICT in education, its related issues, and makes recommendations for future policies. The results of this research are expected to provide a benchmark for educational ICT policy making in APEC economies with reference to policy trends produced by this project. They also provide insights and hindsight on ICT educational policymaking to all parties concerned. APEC economies should find the results beneficial in terms of new policymaking and enhancement of present policies. The recommended policy areas should be translated to generate businesses suited for industries related to ICT and education. As to the methodology, from eleven APEC economies the sample is reduced to eight due to complications in communications and documentation. Information needed was obtained through the internet. The project leader organized and distributed the collected data online to other members of the project (PR. China & Thailand) for analysis. The technique of content analysis was applied and trends on APEC educational JCT policy were identified. Findings from the data analysis were tabulated and are attached as appendices in the APEC white paper.

Two-way open innovation and firm growth: the moderating effect of external environment

Ling Zhang,Mian-Bin Zheng 기술경영경제학회 2016 ASIAN JOURNAL OF TECHNOLOGY INNOVATION Vol.24 No.1

A few researchers have studied the relationship of open innovation and firm performance, butthe results are controversial. One of the reasons for this inconsistence may be the ignorance ofthe impact on the external environment. Under the context of open innovation, innovationactivities are divided into inbound open innovation and outbound open innovation. Basedon a sample of 224 Chinese entrepreneurs from the Pearl River Delta and Yangtze RiverDelta, the relationship between the two kinds of open innovation and firm growth isdiscussed, and how this relationship is being affected by environment competitiveness (EC)and environment munificence (EM) is explored. Results show that both the inbound openand outbound open innovations have a positive effect on firm growth. Both EC and EMweaken the relationship between inbound open and firm growth. The study also finds anegative effect of both EC and EM on the relationship between outbound open innovationand firm growth significantly. Limitations and suggestions are proposed for future researchon the implementation of open innovation under different circumstances.

Improved Production of Live Cells of Lactobacillus rhamnosus by Continuous Cultivation using Glucose-yeast Extract Medium

Ling Liew Siew,Mohamad Rosfarizan,Rahim Raha Abdul,Wan Ho Yin,Ariff Arbakariya Bin The Microbiological Society of Korea 2006 The journal of microbiology Vol.44 No.4

In this study, the growth kinetics of Lactobacillus rhamnosus and lactic acid production in continuous culture were assessed at a range of dilution rates $(0.05 h^{-1}\;to\;0.40h^{-1})$ using a 2L stirred tank fermenter with a working volume of 600ml. Unstructured models, predicated on the Monod and Luedeking-Piret equations, were employed to simulate the growth of the bacterium, glucose consumption, and lactic acid production at different dilution rates in continuous cultures. The maximum specific growth rate of L. rhamnosus, ${\mu}_{max}$, was estimated at $0.40h^{-1}$I, and the Monod cell growth saturation constant, Ks, at approximately 0.25g/L. Maximum cell viability $(1.3{\times}10^{10}CFU/ml)$ was achieved in the dilution rate range of $D=0.28h^{-1}\;to\;0.35h^{-1}$. Both maximum viable cell yield and productivity were achieved at $D=0.35h^{-1}$. The continuous cultivation of L. rhamnosus at $D=0.35h^{-1}$ resulted in substantial improvements in cell productivity, of 267% (viable cell count) that achieved via batch cultivation.

ENERGY CONSUMPTION ANALYSIS OF DIFFERENT BEV POWERTRAIN TOPOLOGIES BY DESIGN OPTIMIZATION

Bin Wang,David Ling-Shun Hung,Jie Zhong,Kwee-Yan Teh 한국자동차공학회 2018 International journal of automotive technology Vol.19 No.5

Flexible layout of electric motors in battery electric vehicles (BEVs) has enabled different powertrain topologies to be used. However, these different powertrain topologies also affect the overall efficiency of energy conversion from the electrochemical form stored in the battery to the mechanical form on the driving wheels for vehicle propulsion. In this study, a methodology combining an energy-based BEV simulation model with the genetic algorithm optimization approach is applied to evaluate the energy efficiency of three different BEV powertrain topologies. The analysis is carried out assuming two different urban driving conditions, as exemplified by the New European Drive Cycle (NEDC) and the Japanese JC08 drive cycle. Each of the three BEV powertrain topologies is then optimized − in terms of its electric motor size and, where applicable, gear reduction ratio − for minimum energy consumption. The results show that among the three powertrain topologies, the wheel-hub drive without gear reducers consumes the least energy. The energy consumption of BEVs under the more aggressive JC08 drive cycle is consistently 8 % above that under NEDC for all three powertrain topologies considered.