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RISS 인기검색어
- 검색키워드
- 저자 : ( Berik Rovgaliyev ) (검색결과 3 건)
- 무료
- 기관 내 무료
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The Effects of Various Immunosuppressants to Epitheli al-Mesenchymal Transition on HCC Cell Line
( Berik Rovgaliyev ),( Kwang Woong Lee ),( Seung Cheol Oh ),( Kuyng Cheol Yoon ),( Suk Kuyng Hong ),( Kyung-suk Suh ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The purpose of this study was to elucidate the effect of various immunosuppressants to epithelial-mesenchymal tran sition (EMT), which strongly correlated with tumor growth and metastasis of HCC. Methods: The effect of various immunosuppressive drugs will investigate on tumor growth and lymph node metastasis in a Balb/c nude mice model of HCC. Cell proliferation and invasion were monitored in vitro using the CCK8 and Matrigel Invasion Chambers, respectively. Levels of expression specific markers of EMT were measured using Western blots analysis. Results: Various immunosuppresses showed differing results to the proliferation of HCC in vitro study. Treatment with high and low doses of Tacrolimus and Cyclosporine A in high doses resulted in increase in the invasive potential of SK-Hep1 cells by enhancing EMT in vitro and there was no significant effect of Sirolimus and MMF on cell migration and invasion. The Western blotting analysis revealed that Tacrolimus increased the levels of expression of TGF-ß, N-Cadherin, ZEB1, Slug in the HCC tumor cells, while Cyclosporine A, Sirolimus and MMF did not have a significant effect on the expression of these proteins. The in crease in expression level was especially pronounced in TGF-ß, N-Cadherin, ZEB1 proteins when using high doses of Tacrolim us (100ng/ml) and moderately expressed, however, higher than other immunosuppressors using a low dose (5ng/ml) of the drug. The use of other immunosuppressors in different doses did not significantly affect the expression of all proteins. Conclusions: Tacrolimus and high doses Cyclosporine A in creased the invasive potential of HCC cells in our in vitro study.
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( Nam-joon Yi ),( Kwang-woong Lee ),( Kyung-suk Suh ),( Suk Kyun Hong ),( Kyung Chul Yoon ),( Dongkyu Oh ),( Berik Rovgaliyev ),( Joon Koo Han ),( Min Uk Kim ),( Jeong Min Lee ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Biliary complication (BC) is prevalent in pediatric liver transplantation (PLT), with reported rates from 12% to 50%. This study analyzed which factors of perioperative variables caused BCs and how BCs affected graft and patient survival in PLT. Methods: A retrospective analysis reviewed 237 consecutive pediatric recipients from 1988 to 2015 in a Korean high-volume living donor LT (LDLT) center. The median follow-up was 80.3 (range, 28.7-153.9) months. Results: Of these 237 patients, 23 (9.7%) patients developed BCs. The overall 1-, 5-, and 10-year patient and graft survival rates were 89.8%, 87.8%, and 86.9% and 88.2%, 86.7%, and 85.8%. The 1-, 5-, and 10-year BC-free survival rates were 91.8%, 89.8%, and 89.0%. There was no significant difference of both patient and graft survival rate between the patients with and without BCs (P >0.05). In multivariate analysis, type of liver transplant (LDLT 12.8% vs. whole LT 5.0% vs. split LT 2.4%), portal vein complication (21.7% vs. 6.5%), and hepatic vein complication (26.0% vs. 8.9%) were revealed as significant contributor to BCs (P<0.05). Conclusions: Despite of BCs, graft and patient survival rates were not significantly affected. Although the rate of BC was acceptable, LDLT was one of the risk factors of BCs in PLT, and meticulous technique to avoid vascular complication could also improve the outcome of biliary reconstruction.
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Split Liver Transplantation for Retroperitoneal Immature Teratoma Masquerading as Hepatoblastoma
( Dongkyu Oh ),( Nam-joon Yi ),( Hyeyoung Kim ),( Hyun-young Kim ),( Hyoung Jin Kang ),( Myungsu Lee ),( Kyoung Bun Lee ),( Kwang-woong Lee ),( Kyung-suk Suh ),( Berik Rovgaliyev ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Extragonadal teratoma originating from retroperitoneum represents less than 5% of all teratomas, and accounts for less than 10% of all pediatric retroperitoneal neoplasm. Until now, there is no report in the English literature about teratoma managed with liver transplantation (LT). The present study reports the case of an infant aged 3 months with retroperitoneal immature teratoma involving hepatic hilum and refractory to the chemotherapy, treated with liver transplantation. Methods: The patient was referred to our hospital for management of growing abdominal mass. The pathologic report for fine needle aspiration of the tumor lesion suggested the possibility for the hepatoblastoma with teratoid features. Cisplatin based chemotherapy was initiated at first. However, in spite of two cycles of chemotherapy, the tumor was rapidly growing with encasing the proper hepatic artery. LT was then planned, and split LT was carried out. Results: Pathological examination of explanted liver revealed the involvement of numerous neuroepithelial components, confirming the diagnosis of Norris grade III immature teratoma. Conclusions: The patient recovered well and was discharged at the 19th day after LT. He is now on postoperative day 84, under adjuvant chemotherapy based on vinblastine and doxorubicin, and the long-term outcome of a LT for immature teratoma should be followed up.
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