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Jian‑bo Xie,Bei‑bei Liu,Xiang‑yu Wu,Jian‑xun Fu 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.5
This work aims to comprehensively summarize the types and distribution of the isolated Bi particles and MnS inclusions inthe Bi-bearing steels, to study the precipitated behavior of sulfide, and to study the effect of Bi particles on grain sizes andthe volume thermal expansion coefficients of the steels. Results show that the average percentage of the isolated Bi particles,semi-encapsulation, complete encapsulation, back-bridge, tiny encapsulation, cavity bridge Bi–MnS inclusions in the Bibearingsteels was 16.89%, 20.49%, 3.44%, 16.89%, 31.63%, 10.66%, respectively. The average equivalent diameters of thegrains in the 0 ppm, 130 ppm, 240 ppm, 760 ppm, 1200 ppm and 2300 ppm Bi content steels were 20.88, 20.17, 19.54, 18.13,13.98 and 13.25 μm, respectively. The precipitated equilibrium mass concentration product of the MnS (w[Mn]·w[S]) wascalculated to be 1.07, and the solid fraction fS value was 0.61. At 950 °C, the volume thermal expansion coefficient change(ΔVE) in 760 ppm Bi content steel was minimum 4 × 10–10%, while at 461.6 °C the ΔVE was maximum, 0.09%, which meansthat Bi affected the volume thermal expansion of the steel strongest in this temperature range.
Yan-Min Xie,Wei Tang,Fei Zhang,Bei-Bei Pan,Yaopeng Yue,Meiqiang Feng 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.2
Variable blank holder force (VBHF) is an important process parameter in sheet metal forming. The purpose of this study is to propose a sharing niching radial basis function (SNRBF) neural network for VBHF optimization. Two methods are put forward to improve the prediction accuracy of a RBF neural network. (1) A RBF neural network is trained by a sharing niching technique to achieve global optimal nodes. (2) In Latin hypercube design, Spearman correlation analysis is employed to decrease sample correlation. In addition, in order to improve the performance of the non-dominated sorting genetic algorithm (NSGA-II), excellent individuals in each class of non-dominated individuals are selected by employing immune operators. Based on the Spearman correlation analysis and the Latin hypercube method, training samples are generated and numerical simulations are performed for a double C part. The surrogate models between VBHF and forming quality are constructed by a SNRBF neural network. The Pareto frontier solutions are achieved by employing the improved NSGA-II algorithm. Grey relational analysis is applied to determine the optimal VBHF loading trajectory. The results show decreased wrinkles in the optimized forming part and greater uniformity in the plastic deformation by employing the optimized VBHF, thereby leading to improvement in the forming quality of the double C.
Yan-Min Xie,Ren-Yong Huang,Wei Tang,Bei-Bei Pan,Fei Zhang 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.19 No.4
Investigation on twist springback is important to improve the accuracy of forming parts. In this paper, a double C rail made of transformation induced plasticity 780 (TRIP 780) steel is designed, and the stamping and twist springback are simulated with ABAQUS based on three different hardening models (including Ziegler, Johnson-Cook and combined hardening models). A new index for calculating the twist springback is proposed, which is based on the angle between two end section lines of the double C rail. The experimental results of twist springback are compared with the calculation results from three different hardening models. The calculation results based on combined hardening model are the closest to the experiment data. In order to compensate twist springback, a curved surface die is designed based on the geometric shape of the double C rail after twist springback. The stamping and twist springback are simulated based on the curved surface die and combined hardening model, and the twist springback is decreased obviously after compensation, which shows that the compensation of twist springback is effective.
Xie, Xiu-Zhen,Song, Kun,Cui, Baoxia,Jiang, Jie,Zhang, You-Zhong,Wang, Bo,Yang, Xing-Sheng,Kong, Bei-Hua Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11
Objective: The aim of this retrospective study is to analyze the clinical and pathological factors related to the prognosis of Chinese patients with stage Ib to IIb cervical cancer. Methods and Results: 13 clinical pathological factors in 255 patients with stage Ib to IIb cervical cancer undergoing radical hysterectomy and systematic lymphadenectomy were analyzed to screen for factors related to prognosis. The cumulative 5-year survival of the 255 patients was 75.7%. The result of the univariate analysis suggested that clinical stage, cell differentiation, depth of cervical stromal invasion, parametrial tissue involvement, and lymph node metastasis were prognostic factors for patients with stage Ib to IIb cervical cancer (P<0.05). Compared with cases with involvement of iliac nodes, obturator nodes, or inguinal lymph nodes, cases with metastasis to the common iliac lymph nodes had a poorer prognosis (P<0.05). Cases with involvement of four or more lymph nodes had a poorer prognosis than those with involvement of three or fewer lymph nodes (P<0.05). Using multivariate Cox proportional hazards model regression analysis, non-squamous histological type, poor differentiation, parametrial tissue involvement, and outer 1/3 stromal invasion were found to be independently related to patients poor prognosis (P<0.05). Conclusion: Non-squamous histological type, poor cell differentiation, parametrial tissue involvement, and outer 1/3 stromal invasion are the independent poor prognostic factors for patients with stage Ib to IIb cervical cancer.
Lingsong Lu,Bei Liu,Chenggui Liu,Guoming Xie 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.11
A label-free amperometric immunosensor has been proposed for the detection of myeloperoxidase (MPO) in human serum. To fabricate such an immunosensor, a composite film consisting of N,N-dimethylformamide (DMF), multiwall carbon nanotubes (MWCNTs) and 1-ethyl-3-methyl imidazolium tetrafluoroborate (EMIMBF4) suspension was initially formed on a glassy carbon electrode (GCE). Then cerium dioxide (CeO2) dispersed by chitosan was coated on the GCE. After that, MPO antibodies (anti-MPO) were attached onto the nanoCeO2 surface. With a noncompetitive immunoassay format, the antibody-antigen complex formed between the immobilized anti-MPO and MPO in sample solution. The immunosensor was characterized by cyclic voltammetry, transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The factors influencing the performance of the immunosensor were studied in detail. Under optimal conditions, the current change before and after the immunoreaction was proportional to MPO concentration in the range of 5 to 300 ng mL‒1 with a detection limit of 0.2 ng mL‒1.
Colorectal Cancer Concealment Predicts a Poor Survival: A Retrospective Study
Li, Xiao-Pan,Xie, Zhen-Yu,Fu, Yi-Fei,Yang, Chen,Hao, Li-Peng,Yang, Li-Ming,Zhang, Mei-Yu,Li, Xiao-Li,Feng, Li-Li,Yan, Bei,Sun, Qiao Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7
Objectives: Understanding the situation of cancer awareness which doctors give to patients might lead to prognostic prediction in cases of of colorectal cancer (CRC). Methods: Subsets of 10,779 CRC patients were used to screen the risk factors from the Cancer Registry in Pudong New Area in cancer awareness, age, TNM stage, and gender. Survival of the patients was calculated by the Kaplan-Meier method and assessed by Cox regression analysis. The views of cancer awareness in doctors and patients were surveyed by telephone or household. Results: After a median observation time of 1,616 days (ranging from 0 to 4,083 days) of 10,779 available patients, 2,596 of the 4,561 patients with cancer awareness survived, whereas 2,258 of the 5,469 patients without cancer awareness and 406 of the 749 patients without information on cancer awareness died of the disease. All-cause and cancer-specific survival were poorer for the patients without cancer awareness than those with (P < 0.001 for each, log-rank test). Cox multivariate regression analysis showed that cancer concealment cases had significantly lower cancer-specific survival (hazard ratio (HR) = 1.299; 95 % confidence interval (CI): 1.200-1.407)and all-cause survival (HR = 1.324; 95 % CI: 1.227-1.428). Furthermore, attitudes of cancer awareness between doctors and patients were significantly different (P < 0.001). Conclusion: Cancer concealment, not only late-stage tumor and age, is associated with a poor survival of CRC patients.
Lu, Lingsong,Liu, Bei,Liu, Chenggui,Xie, Guoming Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.11
A label-free amperometric immunosensor has been proposed for the detection of myeloperoxidase (MPO) in human serum. To fabricate such an immunosensor, a composite film consisting of N,N-dimethylformamide (DMF), multiwall carbon nanotubes (MWCNTs) and 1-ethyl-3-methyl imidazolium tetrafluoroborate ($EMIMBF_4$) suspension was initially formed on a glassy carbon electrode (GCE). Then cerium dioxide ($CeO_2$) dispersed by chitosan was coated on the GCE. After that, MPO antibodies (anti-MPO) were attached onto the nano$CeO_2$ surface. With a noncompetitive immunoassay format, the antibody-antigen complex formed between the immobilized anti-MPO and MPO in sample solution. The immunosensor was characterized by cyclic voltammetry, transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The factors influencing the performance of the immunosensor were studied in detail. Under optimal conditions, the current change before and after the immunoreaction was proportional to MPO concentration in the range of 5 to $300\;ng\;mL^{-1}$ with a detection limit of $0.2\;ng\;mL^{-1}$.
Tingyuan Ren,Yuping Zhu,Suzhen Zhai,Bei Li,Ziyi Zhao,Jiao Xie 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.11
To explore hypoglycemic effect of wild Rosa roxburghii tratt (RRT) juice at different altitudes on type 1diabetes mellitus (T1DM). The T1DM mouse model was induced by streptozotocin (STZ), and the experiment included anormal group (NC), model group (MC), wild RRT juice groups high (HF), medium (MF), low altitude (DF) and cultivatedcontrol group (PC). During experiment, food intake, water intake, body weight, and fasting blood glucose were measured. After 28 days of administration, glucose tolerance, glycogen level, lipid profiles, and antioxidation levels in serum and liverwere measured, and histomorphological changes of liver and kidney were observed by hematoxylin and eosin staining. The results showed that wild RRT juice reduced blood glucose level, alleviated liver and kidney tissue damage, improvedglucose and lipid metabolism disorders and attenuated oxidative damage in T1DM mice. Western blot showed that wild RRTjuice at grown at different altitudes significantly increased protein abundance of PI3K, Akt, and GLUT2 in liver of T1DMmice. In conclusion, wild RRT juice from different altitudes improved glucose and lipid metabolism disorders and oxidativedamage in T1DM mice, which may be attributed to activation of PI3K/Akt pathway. Overall effect: MF > PC > HF > DF.