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      저자 : ( Basant Kumar Tamrakar ) (검색결과 2 건)
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      • Altered Biochemical and Hematological Profile of Fatty Liver Disease Patients in Western Nepal

        ( Mahendra Prasad Bhatt ),( Basant Kumar Tamrakar ),( Amar Nagila ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

        Aims: Fatty liver disease (FLD) is one the most common liver disease in the world, however, there are limited studies on biochemical and hematological features of fatty liver disease. Different laboratory tests are extremely useful in better understanding of diseases, and thereby, confirm clinical diagnosis for the better management of disease. The aim of the present study was to demonstrate the significant changes in biochemical and hematological parameters in FLD patients of western Nepal compared with control group. Methods: About 49 patients with FLD and 27 healthy control subjects from the outpatient clinic of the Internal Medicine Department, Fishtail Hospital and Research Centre Pokhara, Nepal were enrolled in the study. Hepatosteatosis is studied by abdominal ultrasonography to confirm the diagnosis of FLD. The anthropometric parameters: height, weight, waist and hip circumferences, blood pressure were measured, and body mass index (BMI) and waist/hip ratio (WHR) were calculated. Overnight fasting blood samples were collected from the patients and controls to analyze biochemical tests: lipid profile, liver function tests, renal function tests, blood sugar, HbA1c, and hematological tests: hemoglobin, WBC and platelet counts. Results: With the increased level of serum triglyceride in the patients with FLD, total cholesterol, LDL-cholesterol had a significantly increasing trend (P<0.05); whereas HDL-cholesterol was found significantly decreased in comparison to control group. The levels of alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and Gamma-GT were noticed significantly difference in the cases as compared to those in the controls (P<0.05). Other biochemical and hematological parameters also noticed significant difference. Conclusions: Most of the patients with FLD were found asymptomatic. The study revealed that fatty liver patients have dyslipidemias, abnormal liver function tests, increased trend of blood sugar and HbA1c, and hematological test parameters were significantly different compared to control group.

      • Serum Paraoxonase 1 (PON1) Activity and Oxidative Stress in Young Children with Non-Alcoholic Fatty Liver Disease

        ( Amar Nagila ),( Dipendra Raj Pandey ),( Basant Kumar Tamrakar ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

        Aims: The aim of this study was to determine the level of serum paraoxonase 1 (PON1) in young children with Non-Alcoholic Fatty Liver Disease compared to healthy controls, and to examine the association of biochemical and hematological parameters with oxidative stress. Methods: Anthropometric measurements, blood pressure, biochemical and hematological parameters, abdominal ultrasonography (USG) and clinical examinations were assessed in all subjects to diagnose NAFLD. Forty seven young children diagnosed Non-Alcoholic Fatty Liver Disease and Forty seven age and gender matched healthy controls were enrolled and Serum PON1 levels, total antioxidant status (TAS), total oxidant status (TOS) were measured. Oxidative stress index (OSI) was calculated to indicate the degree of oxidative stress. Results: A total of ninety four children (51 boys, 43 girls) were included in this study, with 33 children age ≤ 10 years and 61 adolescents. Serum PON1 activity is significantly reduce in NAFLD children than control (110.81±7.43 Vs 152.73±12.72, P=0.003). In children with NAFLD, TAS level is significantly lower than control (1.19±0.22 Vs 1.37±0.41, P=0.03), whereas TOS is increased significantly (0.24±0.05 Vs 0.17±0.03, P=0.05). Our results show that OSI is significantly higher in NAFLD group in comparison to the control groups (0.20±0.08 Vs 0.12±0.06, P<0.05). Conclusions: Our results suggest that NAFLD are associated with decreased PON1 activity and increased oxidative stress. Thus, in NAFLD patients, low level serum PON1activity may contribute in pathogenesis of carotid atherosclerosis from the childhood.

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