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RISS 인기검색어
- 검색키워드
- 저자 : ( Anna L. Chien ) (검색결과 3 건)
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( Hyojin Kim ),( Sewon Kang ),( Anna L. Chien ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Backgrounds: Visible light (VL) induces differential effects across light and dark skin types. We previously showed that these variations are influenced by irradiance. Objectives: This study aimed to assess the clinical response to different irradiance of VL in light and dark skin types. Methods: Subjects (n=29) were classified into two groups based on L value (L< 55 [=darker] vs L >55 [=lighter]) measured on photoprotected skin. Two photoprotected sites were irradiated with VL (95.3% VL, 1.5% UVA, 3.2% infrared) at 480J/cm<sup>2</sup> daily over 4 consecutive days. In L< 55 group, 150mW, 175mW, 200mW were used while 150mW, 175mW, 200mW, 225mW, 250mW, 275mW were used in L >55 group. Colorimetry assessments were conducted before and after treatment. Results: A total of 54 sites were irradiated (L< 55=20, L >55=34 sites). Blister developed in 9 sites in L< 55, 1 in L >55. Average change in L and a* from baseline of non-blistered sites (n=44) at day 5 showed significant difference between L< 55 and L >55 regardless of the irradiance (L< 55: L=-5.30, a*=-0.17; L >55: L=-2.12, a*=1.55, p<0.05). In the L<55 group, L value decreased immediately after treatment in a dose-dependent manner (p< 0.05). In L >55 group, a* value increased in a dose-dependent manner (NS; p>0.05). Conclusions: Human skin response to VL is dose-dependent, but is also influenced by the constitutive skin color. These variables are important to consider in devising strategies to lessen the deleterious consequences of VL on human skin.
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Periocular Dark Circles: Correlates of Severity
( Hester Gail Y. Lim ),( Alexander H. Fischer ),( Sarah Sung ),( Sewon Kang ),( Anna L. Chien ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.5
Background: Periocular dark circles (PDCs) are a common cosmetic complaint. Grading systems based on objective measures have been used but no standard system is in place. Objective: To determine factors associated with subjective and objective PDC severity. Methods: Enrolled patients (n=100) completed a questionnaire comprised of demographic variables, medical history, and self-perception of PDC. Those perceiving PDC graded dissatisfaction on a 10-point scale. Clinical severity (grades 0∼4) and subtype (constitutional, post-inflammatory, vascular, shadow effects, or others) were determined. A Konica Minolta CR-400 chromameter was used to obtain colorimetry measurements (L*a*b* values). The objective average difference in darkness (ΔL*) between the periocular region and the cheek was determined. Comparisons were made using Spearman correlation coefficients (r). Results: Patient dissatisfaction correlated with both clinical severity (r=0.46, p<0.001) and the ΔL* by colorimetry (r=0.35, p=0.004). Factors associated with subjective dissatisfaction were female sex (r=0.38, p=0.002), higher Fitzpatrick skin type (r=0.42, p=0.001), fewer hours of sleep (r=-0.28, p=0.03), and use of concealer (r=0.35, p=0.004). Factors associated with objective measures were higher Fitzpatrick skin type (r=0.36, p=0.0007 and r=0.28, p=0.009, respectively), family history of PDC (r=0.34, p<0.001 and r=0.20, p=0.05), and history of eczema (r=0.45, p<0.001 and r=0.20, p=0.0504). Clinical severity grading correlated with colorimetric severity (r=0.36, p=0.0003). Conclusion: Overall, subjective dissatisfaction was associated with clinical severity. However, factors associated with subjective severity did not necessarily overlap with factors associated with objective severity. These findings highlight the importance of patient-reported grading. There may be added value in incorporating a component of subjective grading into the traditionally objective PDC grading scales. (Ann Dermatol 33(5) 393∼401, 2021)
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( Katherine G. Thompson ),( Barbara M. Rainer ),( Corina Antonescu ),( Liliana Florea ),( Emmanuel F. Mongodin ),( Sewon Kang ),( Anna L. Chien ) 대한피부과학회 2020 Annals of Dermatology Vol.32 No.1
Background: Associations between acne and gastrointestinal comorbidities suggest that microbial dysbiosis and intestinal permeability may promote inflammatory acne, a condition often managed with oral antibiotics. Objective: We performed a case-control study to investigate the skin and gut microbiota in 8 acne patients before and after receiving oral minocycline compared to controls matched by age ±5 years, sex, and race. Methods: DNA was extracted from stool samples and facial skin swabs. Sequencing of the V3V4 region of the bacterial 16S rRNA gene was performed using Illumina MiSeq and analyzed using QIIME/MetaStats 2.0 software. Results: Acne patients included 7 female and 1 male, ages 20∼ 32. Shannon diversity was not significantly different between the skin (p=0.153) or gut (p<0.999) microbiota of acne patients before and after antibiotics. The gut microbiota in pre-antibiotic acne patients compared to acne-free controls was depleted in probiotics Lactobacillus iners (p=0.001), Lactobacillus zeae (p=0.001), and Bifidobacterium animalis (p=0.026). After antibiotics, the gut microbiota of acne patients was depleted in Lactobacillus salivarius (p=0.001), Bifidobacterium adolescentis (p=0.002), Bifidobacterium pseudolongum (p=0.010), and Bifidobacterium breve (p=0.042), while the skin microbiota was enriched in probiotics Bifidobacterium longum (p=0.028) and Leuconostoc mesenteroides (p=0.029) and depleted in Staphylococcus epidermidis (p=0.009) and Prevotella nigrescens (p=0.028). At the phylum level, significant enrichment of Bacteroidetes in stool of acne patients following antibiotic treatment (p=0.033) led to a decreased Firmicutes to Bacteroidetes ratio. Conclusion: Minocycline produces significant derangements in the microbiota of the skin and gut, including many probiotic species, highlighting the potential for more targeted antimicrobial treatments for acne. (Ann Dermatol 32(1) 21∼30, 2020)
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