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Imidazole Trimer-Water Complexes in Superfluid Helium Nanodroplets: Water Stretching Modes
Ahn, Ah-Reum,Lee, Seung-Jun,Lee, Seul-Ki,Min, Ah-Reum,Kim, Yu-Sic,Jung, Hyeon-Jin,Hong, Seong-Min,Lee, Joon-Hwa,Choi, Myong-Yong,Miller, Roger E. Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.4
Ah Reum Lee,Yu Ock Shin,Joo Young Lee,Min Yeong Kim,Sung Ho Shin,Bu-Il Seo,Young-Bae Seo,Man Hee Rhee,TakakoYokozawa,Chan Hum Park,Seong-SooRoh 한국약용작물학회 2015 한국약용작물학술대회 발표집 Vol.2015 No.05
Purpose Rhei Rhizoma (RR) is one of the herbal medicines traditionally used to treat diverse inflammatory diseases. The present study was undertaken to elucidate the antioxidant and anti-inflammatory activities of Rhei Rhizoma on experimental reflux esophagitis (RE) in rats. Methods The antioxidant activity of RR in vitro was measured in terms of radical scavenging capacity such as DPPH and ABTS. RE was produced by ligating both the pylorus and the transitional junction between the forestomach and the corpus. Rhei Rhizoma (125 and 250 mg/kg) were administered every day for 7 days, and its effect was estimated on comparison with RE control and normal rats. Results RR scavenged DPPH and ABTS effectively and IC50ofDPPH and ABTS radical scavenging activity of RR were 4.8 μg/ml and 15.75 μg/ml. The administration of RR decreased the elevated serum ROS in RE control rats. The RE control rats exhibited the down-regulation of antioxidant-related proteins such as Nrf2 and HO-1expression levels in the esophagitis; however, the level in the RR-treated RE rats was significantly higher than that in the RE control rats. Moreover, RE control rats exhibited the up-regulation of the protein expression related to oxidative stress at the esophagitis, but RR administration significantly reduced the expression of inflammatory proteins through the MAPK-independent signaling pathways. The expression of inflammatory mediators and cytokines by NF-κB activation was modulated through blocking the degradation of IκBα. In addition, the oral administration of RR regulated the gastric mucosal damage in RE rats. Conclusion The administration of Rhei Rhizoma effectively ameliorates the inflammatory damage of esophageal mucosa through radical scavenging activity and the activation of the Nrf2/HO-1 pathway.
( Ah Reum Khang ),( Eun Ki Kim ),( Eun Shil Hong ),( Hyung Jin Choi ),( Chan Soo Shin ),( Kyong Soo Park ),( Seong Yeon Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Parathyroid cysts are very rare among the causes of primary hyperparathyroidism (PHPT). They are divided into functional and nonfunctional cysts. Operative removal is a treatment of choice for a functional cyst. 99mTc-Sestamibi parathyroid scan is a highly effective and sensitive diagnostic tool for localization of hyperparathyroidism, however it shows a false-negative result, occasionally. We found one case which was presumed to have cystic parathyroid adenoma based on clinical findings and neck computed tomography (CT) with negative finding in parathyroid scan. A male patient who was 44 years-old visited to hospital due to legs pain and it was occurred 5months ago and deteriorated gradually. In addition, he presented with the compressive symptoms such as dysphagia and hoarseness. Serum calcium level was 14.4 mg/dl, phosphorus 2.0 mg/dl, creatinine 0.99 mg/dl and intact parathyroid hormone (iPTH) was increased to 478.1 pg/ml. On neck CT, 6.2×3.8×2.7 cm sized cystic nodule was found in inferior part of right thyroid gland. Sestamibi uptake for the found nodule was not detected on 2 hour delayed imaging of 99mTc-Sestamibi parathyroid scan. Fine needle aspiration for diagnosis and localization was done and intracystic iPTH was increased to 61,600 pg/ml. The iPTH monitoring for focused parathyroidectomy led to successful enucleation of right inferior parathyroid. It was a parathyroid adenoma and serum calcium, phosphate and iPTH was normalized after operation. A cystic parathyroid adenoma can be hardly detected on 99mTc-Sestamibi parathyroid scan sometimes. The multidisciplinary approach which considered clinical findings, laboratory results, physical examination and other imagings (CT, Ultrasound, etc) is important for differential diagnosis of hyperparathyroidism. The iPTH monitoring helps the focused parathyroidectomy.
Kang, Ah-Reum,Ahn, Sung-Won,Lee, Seong-Jae,Lee, Byung-Hwan,Lee, Sung-Sik,Kim, Ju-Min 한국유변학회 2011 Korea-Australia rheology journal Vol.23 No.4
Medium viscoelasticity contributes to the lateral particle migration and particle segregation under channel flows. It is recently reported that the equilibrium positions of the particles in dilute suspensions are greatly affected in a rectangular microchannel by the relative ratio of the medium viscoelastic and inertial forces (Yang et al., 2011). Here, we summarize the forces which may exert on the particles in concentrated suspensions under the viscoelastic flows including inertial lift force, and the shear-induced migration effect arising from particle-particle interaction. In addition, we report some preliminary results regarding particle segregation in concentrated suspensions (i.e., ${\phi}_{bulk}=0.05$, 0.1) under both inertial and inertialess viscoelastic flows in the rectangular microchannel. Similar to our previous results in dilute suspensions (Yang et al., 2011), the particles tend to migrate toward low first normal stress regions, and the particle migration is greatly affected by existence of inertia. We firstly report the formation of multi-layered particle trains along the corners in this work. These results give an insight that the medium viscoelascticity would contribute to the design of particle separation devices in complex suspensional flows (e.g. blood cell separation), and also the understanding of particle dynamics in confined environments under viscoelastic flows.