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RISS 인기검색어
- 검색키워드
- 저자 : ( Agata Gabriel Jasniok ) (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
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Unreliability of Breath Methane as a Candidate Indicator of Functional Bowel Disorders
( Krzysztof Jonderko ),( Agata Gabriel Jasniok ),( Malgorzata Szymszal ),( Anna Kasicka Jonderko ),( Barbara Blonska Fajfrowska ) 대한소화기학회 2008 Gut and Liver Vol.2 No.3
Background/Aims: The aim of this study was to examine the reproducibility of methane and hydrogen in exhaled air breath after a per-oral load of lactulose. Methods: Methane was present in the exhaled breath of 21 of 50 healthy subjects recruited by advertisement. Three methane breath tests were performed in 12 women (aged 23.6±0.5 years, mean±SEM) after they consumed 10 g of lactulose dissolved in 300 ml of water. Short- and medium-term reproducibilities were assessed by paired examinations taken 3 and 17 days (median) apart, respectively. Results: High values of coefficients of variation for paired examinations (CVp) indicated a poor short-term reproducibility of parameters characterizing either the methane or hydrogen excretion in breath air: CVp values of the maximum net increments over baseline in methane (max CH4_net), and in hydrogen (max H2_net), were 34% and 41%, respectively. Moreover, the reproducibility consistently deteriorated with increasing time gap between repeat measurements (CVp: 60% for max CH4_net and 64% for max H2_net). Conclusions: The low reproducibility of parameters characterizing quantitative methane breath excretion suggests that caution is necessary when judging the clinical usefulness of the methane breath test after a per-oral lactulose load for the purpose of diagnosing and classifying functional bowel disorders. (Gut and Liver 2008;2:180-185)
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