소아에서 일차성 막성 신병증의 임상-병리학적 고찰

이범희,조희연,강주형,강희경,하일수,정해일,이현순,최용,Lee Bum-Hee,Cho Hee-Yeon,Kang Ju-Hyung,Kang Hee-Gyung,Ha Il-Soo,Cheong Hae-Il,Lee Hyun-Soon,Choi Yong 대한소아신장학회 2003 Childhood kidney diseases Vol.7 No.2

목적 : 막성 신병증은 소아에서 드문 신질환이다. 저자들은 일차성 막성 신병증의 임상 경과의 이해와 치료 방침의 결정에 도움을 주고자 일차성 환자들을 후향적으로 고찰하였다. 방법 : 1977년부터 2003년에 소아 막성 신병증 환자 58명 중 42명(72.4%)이 B형 간염 연관성이었고, 16명(27.6%)이 일차성이었다. 2000년 이후 진단된 환자는 모두 일차성이었다. 임상-병리학적 소견(성별, 연령, 단백뇨, 혈청 알부민, 콜레스테롤, 크레아티닌 청소율, 신세뇨관-간질 변화, 신사구체 경화증, 고혈압, 신정맥혈전증, ACE inhibitor 및 면역억제제 사용력)을 조사하였고, 관해군과 비관해군 간 비교를 하였다. 결과 : 남자 6명, 여자가 10명이었고, 진단 시 중앙 연령은 13세 5개월이었다. 발현 증상은 신증후군(7명, 43.8%), 육안적 혈뇨(5명, 31.3%)와 현미경적 혈뇨 및 단백뇨(3명, 18.8%)였다. 고혈압(2명, 12.5%), 신정맥 혈전증(2명, 12.5%)과 저칼슘성 테타니(1명)가 동반되었다. 조직소견 상범사구체성(6명, 37.5%) 또는 분절성 경화증(5명, 31.3%), 반월체(1명)와 경도(11명, 68.7%) 또는 중등도의 신세뇨관-간질 변화(3명, 18.8%)가 보였다. 13명(86.7%)이 스테로이드를 투여 받았고, 이 중 2명은 cyclophosphamide, 1명은 cyclosporin을 투여 받았다 10명(52.5%)은 ACE inhibitor를 투여받았다. 진단 1개월 후 누락된 1명을 제외하고, 7명(46.7%)에서 단백뇨가 소실되었고, 8명(53.3%)은 단백뇨가 지속되었으며, 그 중 2명(13.3%)은 만성신부전으로 진행하였다. 관해군과 비관해군간에 임상-조직 병리학적 소견은 유의한 차이가 없었다. 결론 : 우리나라 소아에서 막성 신병증은 일차성이 막성 신병증의 대부분을 차지하게 되었는데, 그 이유는 B형 간염 예방 접종 도입 이후 B형 간염 연관성 막성 신병증이 현저하게 감소하였기 때문이다. 이 질환의 임상 경과의 이해와 치료 방침의 확립을 위해서 다기관의 전향적 연구가 필요하다. Purpose : Idiopathic Membranous Nephropathy(IMN) is a rare renal disease in children. To help better understanding of its clinical course and treatment strategies, we reviewed the clinical manifestations and pathological findings of children with IMN. Methods : Among 58 cases with MN, from 1977 to 2003, 42(72.4%) were hepatitis B virus (HBV) associated and 16(27.6%), 6 males and 10 females, were idiopathic. All cases diagnosed aster 2000 were IMN. Several clinicopathological findings(sex, onset age, proteinuria, serum albumin, cholesterol, creatinine clearance, tubulointerstitial changes, glomerular sclerosis, hypertension, renal vein thrombosis, the use of ACE inhibitor, and immunosuppressive therapy) were compared between the remission and the non-remission group of the patients with IMN. Results : The median onset age was 13.4 years. Clinical manifestations were nephrotic syn-drome(7 cases, 43.8%), gross hematuria(5 cases, 31.3%) and microscopic hematuria with proteinuria(3 cases, 18.8%). Hypertension, hypocalcemic tetany and renal vein thrombosis were accompanied in 2, 1 and 2 cases, respectively. In addition to the typical findings of MN, the kidney biopsies showed segmental sclerosis(5 cases, 31.3%) or global sclerosis(6 cases, 37.5 %), diffuse crescents(1 case), and mild(11 cases, 68.7%) or moderate tubulointerstitial changes(3 cases, 18.8%). Thirteen cases(86.7%) received oral steroid. Among them 2 cases received cyclophophamide and 1 received cyclosporin as well. Ten cases(62.5%) received ACE inhibitors. In the patients followed up, 7 cases(46.7%) became free from proteinuria (remission group) while 8(53.3%) presented continous proteinuria (non-remission group), two (13.3%) of which progressed to renal failure. Clinicopathological findings showed no significant differences between the two groups. Conclusion : With HBV vaccination, HBV associated MN decreased markedly and IMN has taken up most of MN in children. For better understanding of this rare disease, a prospective multicenter study of the clinical course and treatment strategies should be done.

소아 악성 고열증과 동반되어 발생한 횡문근융해증 1례

이범희,이진숙,조희연,강주형,강희경,정해일,최용,하일수,Lee Bum-Hee,Lee Jin-Sook,Cho Hee-Yeon,Kang Ju-Hyung,Kang Hee-Gyung,Cheong Hae-Il,Choi Yong,Ha Il-Soo 대한소아신장학회 2003 Childhood kidney diseases Vol.7 No.2

악성 고열증은 succinylcholene과 같은 유발약제의 사용을 피하고, 조기 진단과 dantrolene의 조기 투여에 의해 사망률과 이환률이 현저히 감소하게 되었다. 본 증례는 전신 마취 후 호기말 이산화탄소 분압 증가, 빈맥, 고혈압 등의 조기 징후로 악성 고열증이 발견된 14세 남자 환아에 대한 보고이다. Dantrolene의 조기 투여 후 profopol과 midazolam으로 수숱을 지속할 수 있었다. 횡문근 융해증이 발생하였으나 수액 투여와 요의 알칼리화를 유도하여 신부전이 발생하지 않았다. 환아는 수술 10일 후에 합병증 없이 퇴원하였다. Mortality and morbidity of malignant hyperthermia has decreased markedly by the avoidance of succinylcholine, and the earlier detection and introduction of dantrolene. We report a fourteen-year-old boy who developed malignant hyperthermia during general anesthesia. He showed the earlier clinical signs, such as elevation of end-tidal $CO_2$, tachycardia, and hypertension. After prompt administration of dantrolene, operation was continued with profopol and midazolam. Rhabdomyolysis and myoglobinuria followed, and were managed by hydration and alkalinization of urine. Azotemia did not occur, and he was discharged without any sequelae on the $10^{th}$ postoperative day.

사회 교과서가 초등학생의 이주민에 대한 인식에 미치는 영향:역사 영역을 중심으로

이범희(Lee, Bum-hee) 학습자중심교과교육학회 2021 학습자중심교과교육연구 Vol.21 No.21

목적 본 연구는 사회 교과서가 초등학생의 이주민에 대한 인식에 미치는 영향을 분석하는데 있다. 방법 이를 위하여 충북에 소재한 초등학교 5학년 학생 71명을 대상으로 독립변인을 교과서 차시 중 ‘임진왜란’과 ‘6.25 전쟁’으로 설정하였고, 종속변인으로 참여자들의 고정관념 구조를 분석하는 실험을 설계하였다. 결과 실험집단의 고정관념 구조에 대한 평균 차이를 ANOVA로 분석한 결과, ‘임진왜란’을 학습한 참여자들은 일본 계 이주민에 대한 고정관념의 구조 중 ‘능력’을 낮게 평가하는 경향이 나타났다. 결론 일본계 이주민에 대한 ‘능력’이 부정적으로 나타난 것과 대비하여 탈북민에 대한 고정관념의 구조에 유의한 변화가 없는 것은 사회과 역사 영역의 서술 중 일부가 민족 중심적일 가능성을 시사하고 있다. 그렇기 때문에 교과서의 차시 중 ‘임진왜란’과 같은 서술은 일본인에 대한 증오와 적개심을 키울 가능성이 높다. 따라서 교과서의 구성은 전쟁 일변도가 아닌 상호 우호적인 교류를 교과 내용에 포함시킴으로써 균형적인 서술을 할 필요가 있다. 또한 일부 주제에 세계사적인 관점을 도입하여 세계시민적으로서 사고 방식을 학습자들에게 제공할 기회를 줄 필요가 있다. Objectives The purpose of this study is to analyze the effect of social studies textbooks on elementary school students perceptions of immigrants. Methods To this end, for 71 elementary school students located in North Chungcheong Province, independent variables were set as ‘Imjin War’ and ‘6.25 War’ in textbooks, and an experiment was designed to analyze the stereotype structure of participants as dependent variables. Results As a result of the analysis, participants who studied ‘Imjin War’ tended to underestimate ‘competence’ among the structures of stereotypes about Japanese immigrants. Conclusions As a result of ANOVA analysis of the average difference in the stereotype structure of the experimental group, it was found that participants who studied the ‘Imjin War’ tended to underestimate the ‘ability’ among the stereotype structures of Japanese immigrants. The absence of a significant change in the structure of stereotypes about North Korean defectors in contrast to the negative ‘ability’ of Japanese immigrants suggests the possibility that some of the descriptions of social studies and history are ethnocentric. For this reason, descriptions such as ‘Imjin War’ in textbooks are highly likely to increase hatred and hostility toward the Japanese. Therefore, the composition of the textbook needs to be balanced by including mutually friendly exchanges in the content of the curriculum, rather than unilateral warfare. There is also a need to introduce a world-historical perspective to some topics, giving learners the opportunity to think in a cosmopolitan way.

e-C지원전략과 e-C통합전략이 장기거래에 미치는 영향에 대한 연구

이범희(Bum-Hee Lee) 국제e-비즈니스학회 2010 e-비즈니스 연구 Vol.11 No.3

자동혈구분석기 XE-2100, ADVIA-120와 Manual Differential Count의 상관성 및 Morphology Flag 평가

이범희 ( Bum Hee Lee ),변남섭 ( Nam Sub Byun ),지명석 ( Myung Suk Gee ),송순영 ( Soon Young Song ),유선우 ( Seon Woo You ),박효순 ( Hyo Soon Park ) 대한임상검사과학회 2004 대한임상검사과학회지(KJCLS) Vol.36 No.2

With technological advances in automatic hematology analyzers, primary and screening differential counts of white blood cells (WBC) are done with automatic hematology analyzers. They are using different measurement and analysis principles, so differences in WBC differentials and WBC morphology flag exist. This study was carried out to analyze WBC differential counts and WBC morphology flags comparing them with the manual method. Patient EDTA samples in Vacutainer requested for WBC differentials were analyzed with XE-2100. And those samples with suspect flags messages index over 100 were selected and were analyzed with ADVIA-120. Peripheral blood smear film was subsequently made. Three investigators counted 200 cells each (600 cells) in 111 Wright-Giemsa stained blood films. Between two automatic hematology analyzers, neutrophil, lymphocyte, eosinophil, and monocyte showed good correlations, but basophil had moderate correlation. Among automatic hematology analyzers and manual count, neutrophil, lymphocyte, and eosinophil had good correlations, but monocyte had moderate correlation. XE-2100 had higher monocyte, which was due to atypical lymphocyte and myeloblast. LUC in ADVIA-120 was not due to monocyte in XE-2100. Morphology flagging rates were 146.9% in XE-2100 and was 93.2% in ADVIA-120. Positive predictive values of morphology flag were 58.2% in XE-2100 and 54.4% in ADVIA-120. Flags such as atypical lymphocyte, immature granulocyte, and left shift had higher predictive values and those such as N-RBC, platelets clump, and blast had lower ones. Between automatic hematology analyzers, WBC differentials showed good correlations. Predictive values for morphology flags can be variable with changing criteria. Reviewing criteria for WBC differentials and morphology flags should be established in each laboratory with regards to size of laboratory and patients it serves.

Color Filtering Properties of 9.5/65/35/PLZT

李範熙(Bum-Hee Lee),余東勳(Dong-Hun Yeo),朴基燁(Gi-Yub Park),宋埈泰(Joon-Tae Song),朴昌燁(Chang-Yub Park) 대한전기학회 1993 전기학회논문지 Vol.42 No.5

통합e-SCM의 도입요인이 대리점의 운영생산성에 미치는 영향 분석 : 국내 S전자 대리점을 중심으로

이범희 ( Bum Hee Lee ) 韓國生産性學會 2008 生産性論集 Vol.22 No.2

Streptomyces sp. AMLK -135가 생산하는 항 메치실린 내성균성 항생물질의 분리,정제 및 이화학적 성질 조사

이범희 ( Bum Hee Lee ),이광근 ( Kwang Keun Lee ) 대한임상검사과학회 1999 대한임상검사과학회지(KJCLS) Vol.31 No.2

This study was carried out to isolate and purify anti-MRSA (methicillin-resistant Staphνlococcus aureus) TK784 antibiotics produced by Streptomνces sp. AMLK-135 which isolated from soil. Consequently, characteristics of purified antibiotics were investigated. The results obtained were summarized as follows 1. The culture broth of Streptomνces sp. AMLK-135 possessed anti-MRSA activity against Staphνlococcus aureus TK-784, and it showed anti-microbial activity against Bacillus subtilis IAM 1069, Staphνlococcus aureus FDA 2089, Escherichia coli AB 1157, Pseudomonas jluorescence IAM 1201, Chlorella regularis and Chlorella sp. A2dl 2. By the separation and purification of anti-MRSA antibiotic from Streptomνces sp. AMLK-135 using amberlite lRA-400 ion exchange column chromatography, butanol extraction, cellulose column chromatography, sephadex LH-20 gel permeation column chromatography and HPLC (mobile phase: 35% methanol), the antibiotic AM-1 was obtained as a single peak with excellent resolution. 3. The anti-MRSA antibiotic AM-1 possessed a oily property, soluble in MeOH and water and had a maximum UV absorption of 230 nm 4. The infrared spectrum of the antibiotic AM-1 showed absorption bands at 3500-3000 cm-1 (hydroxyl, -OH), 2520 cm-1 (amine, N-H) and 1451 cm-1 (ß-lactone, C=O, C-O)

SC,소셜커머스 소매점의 생산성 향상을 위한 전략 연구

이범희 ( Bum Hee Lee ) 한국생산성학회 2014 生産性論集 Vol.28 No.1

SC marketing is a new type of e-Commerce which generates profit to all SC companies, SC retailers, and customer. This paper classified SC products provided by SC retailers which perform SC marketing into 5 patterns made by 2 axis of differentiated high/general quality level and tengible/untengible products. Increasing productivity strategies appropriate for each patterns of SC retailers have been studied and the results are as follows. First, high quality-service goods which is provided by SC retailer are available for off season marketing strategy and useful in high quality facility and equipment business. High quality-service goods can maintain the marginal profit and loyal customers during holidays, weekdays or off season. Second, high quality-tangible products which is provided by SC retailer are available for the strategy to enhance the image during market entry of new products and useful to maintain regular customers. Third, ordinary quality-service goods which is provided by SC retailer enable to save short-term mass customers, and gain profits with using cross-selling, which means to induce additional selling. Forth, ordinary quality-tangible products which is provided by SC retailer are useful to save short-term mass customer and to improve turnover ratio while using small profit and quick return strategy. Fifth, excessive inventory goods(products) which is provided by SC retailer are useful to zeroise long-term harmful inventory. In this case, deep discount around 60∼80% is very effective strategy.

Constraints Identification in Time-varying Obstacle Avoidance for Mechanical Manipulators

이범희(Lee Bum Hee),고명삼(Ko Myoung Sam),하인중(Ha In Joong) 대한전기학회 1987 대한전기학회 학술대회 논문집 Vol.1987 No.7