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이용복,장민환 경희대학교 자연과학종합연구원 1998 자연과학논문집 Vol.4 No.-
경희대학교 천문대와 소백산천문대의 망원경을 이용하여 접촉쌍성계인 ER Orionis를 B, V, 및 R의 필터에 따라 CCD 관측을 수행했다. 관측에서 3개의 주극심시각과 2개의 부극심시각 얻었고, 이어 광도곡선을 구했다. 본 연구에서는 본 관측에서 얻어진 광도의 변화 경향을 분석하여 다른 연구자들이 구한 결과와 상호 비교했다. 이 결과 본 연구의 대상인 접촉쌍성계는 표면에 강한 활동이 일어나고 있으며, 이 쌍성계의 주기 변화도 이 활동과 밀접한 관련성이 있는 것으로 예상된다.
李龍福,金慶燮 弘益大學校 科學技術硏究所 2000 科學技術硏究論文集 Vol.11 No.-
Fatigue failure modes of symmetrical LOP fillet weldments are dependent on the characteristics of the fatigue crack initiation and propagation from the weld toe or the weld root. In this study, constant amplitude fatigue tests on symmetrical LOP fillet weldments carried out, and fatigue properties were evaluated. Also, an attempt was made to develop the fatigue strength and fatigue life of symmetrical fillet weldments containing lack of penetration. From the result of this study, fatigue crack growth characteristics of symmetrical LOP fillet weldments are found to be affected by the weld geometry, stress range and microstructures of the welding zone.
유제화에 의한 경구용 항암제인 테가푸르의 장관 임파수송
이용복,남권호,장우익,오인준,고익배 전남대학교 약품개발연구소 1996 약품개발연구지 Vol.4 No.1
W/O and O/W emulsions of tegafur (50 ㎎/5 ㎖/㎏) were orally administered to rats to compare with their mesenteric lymphatic delivery effects. And also in order to demonstrate the lymph targeting associated to the oral route, it was deemed necessary to investigate the fate of solution after oral administration as a control. Lymph and plasma samples were periodically taken from each subject of mesenteric lymphatic dud cannulated rats. Then, lymph and plasma levels of tegafur and its alive metabolite. 5-FU, were simultaneously observed. Also pharmacokinetic parameters were compared with each others. On the other hand, most previous studies of lymphatic transport have not addressed the question of whether an increase in mesenteric or thoracic lymph transport by the manipulation of a suspected variable was due to a selective delivery to the intestinal lymphatics or an overall increase availability. Therefore, based on a physiologically based pharmacokinetic model which represents the characteristics of lymphatic systems, we are also going to determine the contributions of mesenteric lymph transport versus thoracic lymph transport of tegafur reported in reference(13). In comparison with tegafur solution, AUC and mean residence time of plasma tegafur were significantly increased in W/O emulsion but significantly decreased in O/W emulsion. Lymph flow rates were similar in both solution and W/O emulsion but half in O/W emulsion. AUC of tegafur in mesenteric lymph and in plasma for W/O emulsion were 3.7 times and 2.9 times more than those for O/W emulsion. respectively. And AUC of 5-FU in thoracic lymph for W/O emulsion was 3.7 times more than that for O/W emulsion. These results suggested that lymphatic delivery of tegafur by W/O emulsion was more effective than that by O/W emulsion due to its differences of formation ability of chylomicrons.