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이돈일,유재신,범진필,최준식 ( Do Nil Lee,Jae Sin You,Jin Pil Burm,Jun Shik Choi ) 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.1
N/A This study was attempted to investigate the pharmacokinetic interaction of vancomycin (10 ㎎/㎏, i.v.) and probenecid (7.5, 15, and 30 ㎎/㎏, oral) in rabbits. The area under curve (AUC) of plasma vancomycin concentration was significantly increased (p<0.01) in rabbits when the probenecid was coadministrated. Volume of distribution (Vd) was significantly decreased (p<0.05) in rabbits coadministrated with probenecid (15 and 30 ㎎/㎏) and total body clearance (CLt) was decreased significantly (p<0.05, p<0.01) in rabbits coadministrated with probenecid (7.5, 15 and 30 v). There was significant correlation between AUC and probenecid dose. From the results of this experiment, it is desirable to adjust dosage regimen of vancomycin for reduction of side or toxic effect when the probenecid is coadministered in clinical practice.
李敦日,朱興珪,徐華中,文永熙,安榮根 조선대학교 약학연구소 1979 藥學硏究誌 Vol.2 No.1
The tea beverage from Acanthopanax sessiliflorum forma Chungbunensis which has tonic effects was experimentally manufactured, The output of the extract tea product was about 11.2% The contents of the total Ash, total nitrogen, ether extract, tannin and fragrance of the product were a little less than the coffee, but sugar content was more than coffee, the lethal dose of the pure extract from the product or materials was 1,040 ㎎ per ㎏ of mouse, which are much less toxic than the coffee. It was proper that the usual dose of the tea product follows that of the coffee in consideration of its flavour. When this dose was prepared as beverage 94% approved for drinking 72% for taste by making up a questionnaire.
Spectrophottometer에 依한 韓國産 毒劇性 藥用植物에 對한 미량금속의 定量(I)
李敦日,文永熙,丁梧鎭 조선대학교 약학연구소 1979 藥學硏究誌 Vol.2 No.1
시판중인 韓國産 讀劇性植物中에 含有된 無機成分을 U.V Spectrophtometer와 A.A. Spectrophotometer로 測定한 結果는 다음과 같다. ① Fe는 249㎚에서 Mn은 280㎚, Cu는 325㎚에서 최대치를 나타내었다. ② 草烏, 半夏, 大黃, 白附子, 南星에 Fe가 모두 含有되어 있었고 그 중에서 神經痛, 관절염에 使用되고 있는 草烏가 100.6ppm으로 Fe함량이 가장 높았고 대장성설사약으로 사용되는 大黃이 15.00ppm으로 Fe함량이 가장 낮았다. ③ Cu는 上記 5가지 시료중에 모두 含有하고 있지만 大黃을 제외하고는 Fe 含량보다 적게 나타났다. ④ Cu는 大黃이 20.00ppm으로 가장 높고 白附子가 6.4p.p.m으로 가장 낮았다. ⑤ Mn은 南星에서 21.6ppm이 검출되었으며 다른 試料에서는 검출 되지 않았다. The content of micro inorganic compound in the five kinds of toxic crude drugs cultered in Korea was determined with Atomic Absorption Spectrophotometer (Hitachi model 207) and U. V. Spectrophotometer(Hitach Co.) The results obtained were as follows; 1. Fe, Mn and Cu were appeared the maximum absorption spectra at 249, 280 and 325㎚, respectively. 2. The contents of Cu and Fe were detected in all the sample(Acoitum Ciliare, Pinellia ternata, Rheum undulatum, Aconitum Koreanum and Arisaema amurense) and among them, the Aconitum Ciliare which are using as aneuralgia and imframmation contained the highest content of iron in the capacity of 100.6 p.p.m. and the Rheum undulatum which are using as a binding medicine contained the lowest content of iron in the capacity of 15.00 p.p.m. 3. Except for the Rheum undulatum, content of Cu was small rather than iron 4. The Rheum undulatum contained the highest content of Cu in the capacity of 20.00 p.p.m. and the Aconitum Koreanum contained the least content of Cu in the capacity of 6.4 p.p.m. 5. Only the Arisaema amurense Var. Serratum contained 21.6 p.p.m. -Mn.
Dimethy1-esculetin이 Carbon tetrachloride 負荷家兎의 serum total cholesterol에 미치는 影響
李敦日,金成鎬 朝鮮大學校 1978 藥學硏究誌 Vol.1 No.1
In order to confirm the effect of dimethyl-esculetin on the change of serum total cholesterol, this study was performed. The ten rabbits were equally divided into two groups : A and B. The A group was injected carbon tetrachloride, 0.1 ml per Kg. was used to study for control group. The B group had been treated with dimethyl-esculetin for 7 days before carbon tetrachloride injected 30㎎ per day. The result of the serum total cholesterol of each group is following ; The group pretreated with dimethyl-esculetin showed available protective effect on the liver damage of rabbit injected carbon tetrachloride.
이돈일 경찰대학 치안정책연구소 1998 치안정책연구 Vol.- No.11
◎ 일본은 제2차 대전 패전 후 점령군 사령부의 일본 민주화 개혁의 일환으로 1948년 형사소송법을 개정, 경찰을 제1차 수사 주재자로 명문화하여 독자적 수사권을 인정하고 ◎ 동시에 간이재판소가 설치됨에 따라 종래의 즉결심판제도(-> 현행 우리제도)를 폐지하고 이와 유사한 미죄처분제도(微罪處分制度) 및 구(區)검찰청제도와 교통사건 즉결재판제도를 각각 도입
李敦日,丁明鉉,金成鎬,李治榮 조선대학교 약학연구소 1978 藥學硏究誌 Vol.1 No.1
To investigate the effects of the Trichosanthes Radix on the alloxan diabeties, the authers observed the effect of watery fractional extract of the Trichosanthes Radix on the blood sugar. The obtained results were as follows : 1) The blood sugar which increased by alloxan was decreased by administration of watery factional extract of the Trichosanthes Radix. 2) The blood sugar of Control group was also decreased by administration of watery fractional extract of the Trichosanthes Radix. 3) However, the large dosage appeared that blood sugar was increased.