[유기성 폐기물 처리 / 자원화] 매립장 대체 복토재로서 하수슬러지탄화물의 활용 가능성 평가 -유기물질의 특성 변화 중심으로

이헌영,김용진,양민우 한국폐기물자원순환학회 2008 한국폐기물자원순환학회 학술대회 Vol.2008 No.1

만성 간질환에 있어서 혈청 담즙산 측정의 의의

이헌영 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.2

To evaluate the significances of fasting levels of serum bile acid in chronic parenchymal liver diseases, 41 patients with chronic persistent heratitis, chronic active hepatitis or liver cirrhosis and 15 cases of normal control were examined. The samples were measured by enzymatic spectrophotometry and the result were found as the followings. 1. Mean value of 15 normal control's fasting serum bile acids was 3.1±1.2 ,umol/2. 2. Sensitivity of fasting serum bile acid assay for the detection of liver disease was 87.8% in chronic liver disease and the sensitivities in chronic active hepatitis and liver cirrhosis were very high (91.7%, 90.9%). 3. The fasting serum bile acid levels in patients with liver cirrhosis, chronic active hepatitis and chronic persistent hepatitis were 30.0±38.4, 14.5±12.7 and 12.9±10.5/umol/ℓ, respectively. And the levels of serum bile acid were corelated well with degrees of parenchymal damage. 4. In the group of liver cirrhosis, the levels of serum bile acid have significant correlation with the levels of AST, total bilirubin and alkaline phosphatase.

[유기성 폐기물 처리 / 자원화] 하수슬러지 탄화물을 이용한 매립지에서 소수성유기화합물질의 배출 저감

이헌영,김용진 한국폐기물자원순환학회 2008 한국폐기물자원순환학회 학술대회 Vol.2008 No.1

腹腔妊娠의 2例

李憲榮,蔡裕秉,朴熙卨,董亨根 大韓産婦人科學會 1966 大韓産婦人科學會雜誌 Vol.9 No.4

생쥐 배아발달에 미치는 인슐린의 효과

이헌영,배석년,김장흡,이진우,유영옥,임용택,안웅식,김진흥 대한산부인과학회 1993 Obstetrics & Gynecology Science Vol.36 No.7

표유동물의 신진대사와 세포성장, 증식 및 분화에 관여한다고 알려진 인슐린의 착상전 배아에 어떤 영향을 미치는지 알기위해, 시헌관내에서 생쥐 수정란을 포배시기까지 일정한 배양액 즉 인슐린과 2-cell 배아 발육정지 현상을 일으키는 hypoxanthine 그리고 EDTA를 각각 혹은 혼합투여한 배양액에서 배양하였다. 배아난할 및 배아발달을 비교 관찰하였고, 포배발달에 필요한 인슐린의 EC50을 알아보았으며, 아울러 면역세포화확적 방법으로 인슈린 수용체을 확인하여 이를 통해 작용하는 인슐린의 단백질 합성과의 관계를 배아발달 시기별로 측정하여 다음과 같은 결론을 얻었다. 1. mEBSS 배양액에서 생쥐 수정란의 1차 난할율은 첨가제와 관계없이 약 90%였으나 이후 상실배 및 포배발달은 대조군에서는 40.6%와 23.6%였고, hypoxanthine 투여군에서는 10%이하로 차단된 반 면(P$lt;0.001), 인슐린과 EDTA투여군에서는 80%와 60%이상의 높은 배아발달을 보였다(P$lt;0.001) 2. 인슐린을 각 실험군에 첨가했을때 EDTA의 포배발달율을 20% 더 촉진시켰으며(p$lt;0.01), hypoxanthine의 2-cell 배아 발육정지 현상을 효과적으로 차단시켰다(p$lt;0.001). 3. 시험관내에서 2-cell 배아로부터 포배발달을 유도할 수 있는 인슐린의 EC50는 13.1nM이었다. 4. 면역세포화학적 염색법으로 포배에서 인슐린수용체을 발현시켰다. 5. 인슐린 투여군 및 대조군 모두에서 배아발달에 따라 단백질 합성을 증가시켰지만 인슐린 투여군 이 대조군에 비해 8-cell시기에 13%(P$lt;0.05), 상실배에서 64%(P$lt;0.05), 포배에서 99%(P$lt;0.01)더 높은 효과를 나타냈다. 6. 인슈린 항체투여는 배아 단백질 합성에는 효과가 없었으나 인슐린의 촉진작용을 상실배와 포배 시기게 효과적으로 억제하였다(P$lt;0.05 와 P$lt;0.01). 이상과 같은 실험결과로 볼 때 인슐린은 착상전 생쥐 배아에서 배형성 및 발달에 중요한 성장인자로써 작용하고 있다고 사료된다, 위 논문은 가톨릭 중앙의료원 학술연구 조성비로 이우러짐. Although insulin is recognized as an important fetal growth factor, interaction with embryonic cells during the early development stages prior to the appearance of a functional pancreas has not been definde. But there is evidence that insulin binding to the cells of the preimplantation mouse embryos can be detected first at the morula stage, while autoradiographic studies have confirmed that insulin binding is receptor mediated. Other sutides have provided evidence that insulin is capable of stimulating glucose transport and protein synthesis in preimplantation mouse embryos. In this study, to investigate the effect of insulin on development of mouse preimplantation embryos, we performed the culture of mouse embryos from 1-cell zygote to blastocyst in modified Earle`s blanced salf solution(mEBSS), A chemically defined simple medium, supplemented with porcine insulin,hypoxanthine and/or ethylenediaminetetraacetic acid(EDTA), and the embryo development was scored at 24hours(2-cell) and 96hours(morula,blastocyst)of culture. We also measured EC for blastocyst development form 2-cell enbryos inmEBSS supplemented with various concentrations of insulin, And the mouse embryos were stained to express the insulin receptor by immunohistochemical nethod usingan anti-insulin receptor immunoglobulinG.In addition to the immunohistochemical studies for localization of insulim receptor,experiments were undertaken to evaluate whether of not insulin exerts a stimulation of protein synthesis at early stages of mammalian enbryo genesis. The results were as follows: 1. The first cleavage rate of embryos derived from random-bred female mice was appoximately 90% in all experimental groups. In addition, although 40.6%and23.6% of 2-cell embryos developed to morula and blastocyst stage, respectively,in the control group, fewer than10% developed beyond 2-cell stage the hypoxanthine-supplemented medium(p$lt;0.001)but significantly more embryos developed to morula($gt;80%)and blastocysts($gt;60%)in the presence of insulin of EDTA (p$lt;0.001). 2. Insulin caused an increase of 20% in blastocyst development in the presence of EDTA(p$lt;0.01)and dffectively reversed the $quot;2-cell block$quot; by hypoxanthine(p$lt;0.001). 3. The EC of insulin for induction of blastocyst development form 2-cell embryos was 13.1nM in the presence of0.45 bovine serum albumin. 4. Insulin receptor was expressed by immunohistochemical staining using an antiinsulin receptor immunoglobulin G at the blastocyst stage of mouse embryos. 5. Culture with insulin for 4hour caused an increase of13% in protein synthesis by 8-cell embroy(p$gt;0.05), 64% by morula(p$lt;0.05), and 99% by blastocyst(p$lt;0.01) respectively compared with control. 6. Addition of anti-insulin antibody to control had no effect on protein synthesis but it completely blocked the effect of insulin in both-supplemented medium at the mourla and blastocyst stage(P$lt;0.05 and P$lt;0.01, respectively). From the above results, we conclude that insulin may play a role as an important growth factor in embryogenesis early development of mouse preimplantation embryos by the insulin-receptor mediated interaction.

수도권 임금 근로자의 성별 임금격차 : 직종 숙련특성에 따른 직종 간 임금격차와 직종 내성별 임금격차

이헌영,최예술,김민영,임업 한국지역학회 2014 지역연구 Vol.30 No.4

본 연구는 수도권 임금 근로자를 대상으로 위계적 선형모형을 이용하여 임금의 직종 간 차이 및 직종 내 성별 임금격차를 통합적으로 분석한다. 그 동안 성별 임금격차를 다뤘던 다수의 선행연구들은 개인과 직종 변수들을 다루는 데 있어 단일 수준에서의 모형을 구축하는 데 그쳤다면 본 연구는 이를 보완하여 두 층위의 변수를 동시에 다룰 수 있는 위계적 선형모형을 이용하였다. 또한 한국직업사전에서 제공하는 직종 숙련 정보를 요인분석을 통해 신체적 숙련, 인지적 숙련, 조작적 숙련, 소통적 숙련으로 구분하였다. 실증분석 결과에 따르면, 개인수준의 변수의 효과의 경우 기존 연구결과와 유사한 것으로 나타났다. 직종수준에서는 신체적 숙련 및 조작적 숙련 수준이 높을수록 직종의 임금 수준이 낮은 반면, 인지적 숙련 및 소통적 숙련 수준이 높을수록 임금 수준이 높은 것으로 나타났다. 또한 직종 내부의 성별 임금격차는 조작적 숙련과 소통적 숙련 수준이 높은 직종에서 감소하는 것으로 나타났다. This study examines the causes and structures of gender wage gaps focusing on wage workers in metropolitan areas using a hierarchical linear model. Previous studies have conducted their research on gender wage gaps only at one level, such as at the individual level or at the occupational level, and they have limits to reflect the characteristics of skills at the occupational level. Thus, we extracted the four main factors which best represent occupation-specific skills by using factor analysis to expand the concept of skills. The extracted four main factors are physical skills, cognitive skills, operational skills, and communicative skills. Our empirical findings show that individuals, who are involved in the occupation which cognitive skills or communicative skills are high, are more likely to guarantee higher wages. The results of physical skills and operational skills revealed the opposite results of cognitive skills and communicative skills. Our findings also indicate that gender wage gaps tend to decrease within occupations whose operational skills or communicative skills are high.

개원가에서 흔히 볼 수 있는 골절의 진단 및 치료

이헌영 대한가정의학회 1986 Korean Journal of Family Medicine Vol.7 No.12

간경화증 환자에 병발된 Cryptococcal meningitis의 1례

이헌영,김선영 충남대학교 의과대학 지역사회의학연구소 1982 충남의대잡지 Vol.9 No.1

The most common fungal etiology of central nervous system infection is C. Neoformans and above a half of whole cases are complicated in immunosuppressive disease. A case of cryptococcal meningitis, complicated in liver cirrhosis, was presented with review of references. The chief complaint was drowsy mental state and physical findings were severe general weakness, blindness of left eye, deafness of left ear, decreased liver dullness, neck stiffness, positive Kernig sign and right Babinski sign, urinary incontinence and decreased calculation power. Diagnostic work up was performed under the impression of liver cirrhosis accompanied by meningitis. C. S. F. smear and culture for cryptococcus revealed as positive. After administration of garlic oil and amphotericin-B, illness was recovered progressively exception of deafness, blindness and mild degree of walking disturbance.

가토를 이용한 실험적 위궤양 출혈에 대한 Nd: YAG laser 광선응고법에 관한 연구

이헌영,김석진,문동규,임덕,선덕재,박성회 大韓消化器病學會 1982 大韓消化器病學會誌 Vol.14 No.2

만성 간질환에 대한 DDB(Biphenyl Dimethyl Dicaboxylate)의 임상적 효과

이헌영,임의혁,김성걸,김진희,육은주,성자원,김병호,정형용,강대영,김영건 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

To investigate the effects of short-term administration of DDB(Biphenyl Dimethyl Dicarboxylate) for decreasing elevated serum aminotransferase levels in chronic liver diseases, authors applied 3 capsules of DDB per day at each meal time for 35 patients and compared with 35 patients treated with other conservative management. The following results were obtained. 1. Serum alanine aminotransferase (ALT) levels significantly decreased from 247.1± 180.0 IU/L of pretreatment level to 96.6±126.0 IU/L, 61.1±62.7 IU/L and 38.0±26.8 IU/L after 1, 3 and 6 months of treatment(p<0.05) and effective rates were observed in 60.0%, 71.4% and 88.6% of patients after 1, 3 and 6 months of treatment. 2. Serum aspartate aminotransferase (AST) levels decreased also significantly from 167.8±96.9 IU/L of pretreatment levels to 124.4±155.0 IU/L, 77.9±49.6 IU/L, 60.6± 46.9 IU/L after 1, 3 and 6 months of treatment(p<0.05), but decreasing pattern of serum AST was less significant than that of serum ALT. 3. No significant difference were observed in the serum ALT and AST changes according to the cause and duration of hepatitis. 4. No significant adverse effects were observed in whole patients treated with DDB. It is suggested that small dose administration of DDB is effective for decreasing serum aminotrans ferase levels in chronic liver disease in which other conservative management was not effective.