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골다공증 발생요인에 따른 골대사 생화학적 지표의 변동 고찰
이혜자,Lee Hye-Ja 대한물리치료학회 2002 대한물리치료학회지 Vol.14 No.4
The use of biochemical markers of bone turnover may be particular interest in the investigation of bone disorders with osteoporosis. Serum osteocalcin(OC), total alkaline phosphatase and procollagen C, reflecting bone formation, and urinary pyridinium cross-links excretion, reflecting bone reabsorption have been measured in hyperthyroidism, postmenopause women, after testosterone supplementation, androgen, testosterone and estrogen deficiency, bone mineral density degree, age duration. Bone marks which is reflect to metabolic bone disorders are biochemical indices method to measure enzyme activity about bone formation, bone absorption and bone components in blood or urine. Bone metabolism biochemical marks are correlated with osteophorotic agents and also represent significantly different between bone mineral density and bone biochemical marks. Therefore if we develope and use bone metabolism marks which have higher sensitivity and specificity in bone formation and bone absorption, I think that these bone biochemical marks can have utility in the clinical application to predict osteoporosis risk group, bone loss, bone fracture and response degree to treatment of osteoporosis risk groups.
이혜자,임승순,전동원,Lee, Hye-Ja,Im, Seung-Sun,Jeon, Dong-Won 한국섬유공학회 1989 한국섬유공학회지 Vol.26 No.5
Triethylene glycol dimethacrylate (TGD3) crosslinked macroreticular type polyacrylonitril (PAN) was synthesized. Toluene added as diluent lowered the polymerization capability of acrylonitril (AN) monomer, especially in low degree of crosslinking. Maximum surface area of crosslinked PAN was obtained at 60~90% dilution over all the experimenal range of 5~20% degree of crosslinking. Amidoximated-PAN(Ami-PAN) chelate resin has an excellent adsorption capability for Cr+2, UO2+2 regardless of pH and concentration of metal ion. Adsorption of metal ion was not governed by surface area of Ami-PAN resin matrix.
李慧子(Hye-Ja Lee) 한국차학회 2005 한국차학회지 Vol.11 No.1
This study was conducted to find out various types of proprieties of Confucian tea rituals, the results were obtained from the home proprieties during the Yi dynasty. Confucian tea ceremonies have been appeared in the home proprieties taught by Ju-ja. The proprieties of tea ceremony during the Yi dynasty greatly contributed to the promotion of morality and established good customs such as the coming-of-age ceremony, marriage ceremony, the ceremonies of mourning, memorial service and proprieties at home.
CCl₄에 의한 간손상 정도 차이에 따른 Xylene 대사 변동
이혜자(Hye-Ja Lee),윤종국(Chong-Guk Yoon),박원학(Won-Hark Park) 한국독성학회 1999 Toxicological Research Vol.15 No.3
To evaluate an effect of various degree of liver damage on xylene metabolism, a study was conducted. Various degree of liver damage was induced in rats with pretreatment of 50% CCl₄in olive oil (0.1 ml/100 g body weight) intraperitoneally every other day 4, 8, 12 and 16 times. Xylene was administered to the animals after 24 hours since the last pretreatment of CCl₄. Rats were sacrificed after 24 hours since the last injection of these xenobiotics. The increasing rate of liver weight/body weight (%), serum ALT activities and hepatic peroxide contents showed a gradual increase from the first group, 4 times injection of CCl₄, throughout the whole course of the experiments. In all groups, the ultrastructural changes revealed in the liver cells as time elapsed. In the present experimental animal model, by the xylene treatment the urinary hippuric acid concentration and hepatic aniline hydroxylase activities were lower in all liver damaged animals than control, but different values were not found among these liver damaged animal groups. On the other hand, hepatic alcohol dehydrogenase activities showed the similar between the xylene treated rats pretreated with CCl₄four times and only xylene treated rats, but these enzyme activities showed a gradual decrease from the first group, xylene treated animals pretreated CCl₄four times, throughout the experiments. Furthermore, hepatic aldehyde dehydrogenase activities were more significantly decreased in all CCl₄pretreated groups and by the pretreatment of CCl₄decreased values of these enzyme in xylene treated animals were rather gradually increased throughout the whole course of experiments. These results suggested that the rats induced liver damage with CCl₄may reduce the xylene metabolism. But the degree of liver damage with CCl₄under acute conditions may not influence upon the xylene metabolism.
식이성 단백질 함량에 따른 흰쥐에 사염화탄소 투여시 Lipoprotein 분획비의 변동
이혜자(Hye-Ja Lee),윤종국(Chong-Guk Yoon),이상일(Sang-Il Lee) 한국식품영양과학회 1993 한국식품영양과학회지 Vol.22 No.2
단백식이조건을 달리하여 성장시킨 동물에 CCl₄를 투여하였을 때 혈청중 lipoprotein 분획비의 변동 및 이의 원인을 검토할 목적으로 흰쥐를 저단백식이(7% casein : LP) 및 고단백식이(20% casein : HP)로 성장시킨 후, 50% CCl₄(v/v in olive oil)를 복강내 주사한 다음 간 중량 및 혈청 ALT 활성도 측정으로 간손상을 확인함과 동시에, 혈청지질과 혈청 lipoprotein 분획비를 측정하였다. CCl₄투여시 체중 당 간무게 및 혈청중 ALT의 활성도는 대조군에 비해 증가하였으며 그 증가율은 HP군이 LP군보다 더 높게 나타났다. 혈청중 총지질, 총 cholesterol 및 triglyceride의 함량은 대조군간에 별다른 차이를 관찰할 수 없었으나, CCl₄투여로 인해 이들 지질은 대조군에 비해 감소하였으며, 그 감소율은 HP군이 LP군보다 높게 나타났다. CCl₄투여로 인한 lipoprotein분획비의 변동은 대조군에 비하여 양군 공히 pre β-lipoprotein비율 및 α-lipoprotein 비율은 감소되었고, 그 감소율은 HP군이 LP군에 비해 더 크게 나타났다. 한편 β-lipoprotein비율은 CCl₄ 투여로 인하여 두군 공히 증가하였으며 그 증가율은 HP군에서 높게 나타났다. 이상의 실험결과와 문헌상의 지견을 종합해 볼때 CCl₄투여시 LP군에 비하여 HP군에서 간손상이 보다 더 심하게 나타나며, 이로 인하여 apoprotein의 합성억제현상이 초래됨으로써 혈청중 lipoprotein분획비의 변동이 높게 나타날 것으로 생각된다. To evaluate an effect of dietary protein on lipoprotein profile serum of carbon tetrachloride-treated rats, carbon tetrachloride (50% in olive oil) was twice given at 0.1ml/100g body weight at intervals of 24hours to the male rats and then the degree of liver damage in carbon tetrachloride-treated animals fed a low protein diet was compared with that fed a high protein diet. The increasing rate of liver weight/body weight and the serum levels of alanine aminotransferase in carbon tetrachloride-treated rats to the control group were higher in rats fed high protein diet than those fed low protein diet. In the serum levels of lipid (total lipid, total cholesterol and triglyceride) remarkable differences were not found between low protein diet group and high protein diet group. But these serum lipids in carbon tetrachloride-treated rats were decreased and the decreasing rate of serum lipids to control group were higher in carbon tetrachloride-treated rats fed high protein diet than those fed low protein diet. Under the animal model as identified by the present data herein, serum pre β-lipoprotein and α-lipoprotein fractions were decreased in carbon tetrachloride-treated rats, but the serum levels of β-lipoprotein were rather increased in the both group by the injection of carbon tetrachloride. Especially, the decreasing rate of α-lipoprotein fraction was higher in CCl₄-treated rats fed a high protein diet than those fed a low protein diet to its control group and the increasing rate of serum β-lipoprotein fraction was also higher in CCl₄-treated rats fed high protein diet than those fed low protein diet.