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      • KCI등재

        Clinical Impact of F-18 FDG PET-CT on Biopsy Site Selection in Patients with Suspected Bone Metastasis of Unknown Primary Site

        유수웅,Sunny Anam Chowdhury,전수빈,강세령,이창호,Jabin Zeenat,김자혜,조상건,송호천,범희승,민정준,권성영 대한핵의학회 2020 핵의학 분자영상 Vol.54 No.4

        Purpose We investigated the clinical role of F-18 fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) in the identification of the primary site and the selection of the optimal biopsy site in patients with suspected bone metastasis of unknown primary site. Methods The patients with suspected bone metastasis who underwent PET-CT for evaluation of primary site were enrolled in this study. The primary sites were identified by the histopathologic or imaging studies and were classified according to the FDG uptake positivity of the primary site. To evaluate the guiding capability of PET-CT in biopsy site selection, we statistically analyzed whether the biopsy site could be affected according to the presence of extra-skeletal FDG uptake. Results Among 74 enrolled patients, 51 patients had a metastatic bone disease. The primary site was identified in 48 of 51 patients (94.1%). Forty-six patients were eligible to test the association of clinical choice of biopsy site with PET positivity of extra-skeletal lesion. The extra-skeletal biopsies were done in 42 out of 43 patients with positive extra-skeletal uptake lesions. Bone biopsies were inevitably performed in the other three patients without extra-skeletal uptake lesions. The association came out to be significant (Fisher’s exact test, P < 0.001). Conclusion F-18 FDG PET-CT significantly contributed not only to identify the primary site but also to suggest optimal biopsy sites in patients with suspected bone metastasis.

      • SCOPUSKCI등재

        좌심방 점액종 1례 보고

        유수웅 대한흉부심장혈관외과학회 1978 Journal of Chest Surgery (J Chest Surg) Vol.11 No.3

        Myxoma constitue about 50% of a II primary cardiac, tumor (incidence 0.03%) and occur in any of the cardiac chambers, but about 75% of themare found in the left atrium. As is well known, left atrial myxoma usually simulates mitral valvular disease, and it tends to bring about postural syncope and frequent embolic manifestaticns. The clinical manifestation of left atrial myxoma upon the circulation are obstructive effects, embolic effects and constitutional effects. Diagnosis is now most of all important since surgery can be dramatically curable, whereas untreated myxoma apparently invariably lead to deadful course. Preaprative diagncsis by echocardiogram is so simple and accurate for detection of myxoma that awareness of mitral valvular heart disease with rapid deterioration must be screened. We have diagnosed one case of the left atrial myxoma preopratively by phonocardiogram, echocardiogram and levophase pulmonary angiograJ;n and successfully treated by operation under extra corporeal circulation. A 38 years old housewife was admitted to the National Medical Center because of dyspnea, and paroxysmal cough on occasions for prior to hospitalization. Operation was carried out by median sternotomy and left atriotomy with mild hypothermia under E.C.C. The left atrial myxoma was extirpated including endocardial fragment and its weight was 23gm. The hospital course was not eventful and she can work nowadays without symptoms.

      • 肺血流 再分布와 血力學的 考察 : Ⅱ. 先天性 心臟疾患 Ⅱ . Congenital heart disease

        柳秀雄 최신의학사 1978 最新醫學 Vol.21 No.12

        Lung scanning provides clinically important information concerning many flow forms of congenital heart disease and regional distribution of PBF through the lungs influenced by posture, exercise, total pulmonary blood flow and changes in pulmonary artery pressure and pulmonary venous pressure. In the present study the lung scan using conventional 99mTcFeMA and hemodynamic parameter in 14 cases of a various congenital heart disease (Table I & II) were observed to investigate the changes of pulmonary blood flow in the forms of obstruction of pulmonary outflow tract: a low pulmonary artery pressure and low pulmonary blood flow and increased pulmonary blood flow; elevated pulmonary artery pressure with left to right circulatory shunt, and to define the alterations of pulmonary blood flow before and after total correction of tetralogy of Fallot and subclavian to pulmonary artery anastomosis. The upper and lower zone flows were low in patients with Tetralogy of Fallot and increased after total correction of-intracardiac anomalies. Routine lung perfusion scan before and after operation for complex of pulmonary stenosis provides an early noninvasive means of assessment of its effect on pulmonary perfusion and it is important to know whether or not the systemic artery and pulmonary artery anastomosis is functoning properly. Increased pulmonary blood flood with left to right circulatory shunt showed essentially similar perfusion in both lungs that of normal but increasing pulmonary artery pressure and elevated pulmonary vascular resistance had a higher flow through both upper lung zone but not more than lower, lung zone, and eventually Eisenmenger state with systemic trapping of radioactivity. Patients with elevated pulmonary pressure & pulmonary vascular resistance of PDA had a shifting of blood flow to the oppsite site of lung with increasing radioactivity to the right lung and more on upper lung zone,

      • KCI등재

        Non-ablative Fractional Thulium Laser Irradiation Suppresses Early Tumor Growth

        유수웅,박희진,오경석,황순주,윤미선,왕태준,서영석,민정준,김기현,김응삼,Young L. Kim,정의헌 한국광학회 2017 Current Optics and Photonics Vol.1 No.1

        In addition to its typical use for skin rejuvenation, fractional laser irradiation of early cancerous lesions may reduce the risk of tumor development as a byproduct of wound healing in the stroma after the controlled injury. While fractional ablative lasers are commonly used for cosmetic/aesthetic purposes (e.g., photorejuvenation, hair removal, and scar reduction), we propose a novel use of such laser treatments as a stromal treatment to delay tumorigenesis and suppress carcinogenesis. In this study, we found that non-ablative fractional laser (NAFL) irradiation may have a possible suppressive effect on early tumor growth in syngeneic mouse tumor models. We included two syngeneic mouse tumor models in irradiation groups and control groups. In the irradiation group, a thulium fiber based NAFL at 1927 nm was used to irradiate the skin area including the tumor injection region with 70 mJ/spot, while no laser irradiation was applied to the control group. Numerical simulation with the same experimental condition showed that thermal damage was confined only to the irradiation spots, sparing the adjacent tissue area. The irradiation groups of both tumor models showed smaller tumor volumes than the control group at an early tumor growth stage. We also detected elevated inflammatory cytokine levels a day after the NAFL irradiation. NAFL treatment of the stromal tissue could potentially be an alternative anticancer therapeutic modality for early tumorigenesis in a minimally invasive manner.

      • Carl Orff의 Carmina Burana 분석연구

        유수웅 경복대학 1998 京福論叢 Vol.2 No.-

        본문에서 다루고자 하는 Carmina Burana는 전통적인 형식 및 화성구조에 악곡의 구조원리를 두지 않고 가사에서 파생된 리듬을 주로 하여, 단순한 화성구조 위에 주제를 집요하게 반복 사용하고, 복잡한 대위법을 인용하여 선명한 구조를 이루고 있어, 전체적으로 단순함과 리듬을 강하게 느끼게 하는 음향중심의 악곡으로 Carl Off의 음악적 특징들을 잘 나타내는 곡이다. 본 연구의 목적은 Orff의 대표적 작품인 Carmina Burana를 표현적인 방법을 통하여 20세기의 새로운 합창곡으로 Orff는 20세기 전반기를 지배한 주류-인상주의음악, 표현주의음악, 신고전주의음악 등에 얽매이지 않고 스스로의 의식을 고수하며 독창적인 방법을 만들어 가는 한편, 극음악을 통하여 원시성 극대화를 추구하였다. 기초성과 단순성을 가장 중심에 두는 그의 원시주의는, 엄격성과 인위적으로 조직된 복합성을 바탕으로 삼는 Stravinsky의 원시주의와는 또 다른 창의력을 보여주고 있기 때문이다. 그는 그의 동시대에 유행하던 낭만주의, 인상주의 등의 조류에 따르지 않고 원시적인 미를 느끼게 하는 기본적이고 직접적인 독자적 음악어법을 전개하였고, 무대음악 작곡에 전념한 독특한 작곡가였으며 리듬을 통한 새로운 음악 교육법을 주장한 음악교육자이며 또한 음악학자로서도 널리 알려져 있다. On this thesis, with a propose to study on Orff's characteristic, musical mode of expression, then his representative work, "Carmina Burana" has been analysed. In analysis those pieces, because Orff's music didn't follow traditions types of harmonious structures, but centered on sounds which characterize a repeat and simplicity stressed (emphasized) on rhythms derived from the song-text's moderation the characteristics of each element's musical structures and methods of combination, etc. were analyzed so mindly without adapting a tractional analytic method, taking regular section having the same elements (rhythm accompaniment-type, melody-composition, ect.) as "one-section" then Block-Section into several composing elements. His musical idea based on the unification of the three elements, music, language and action (specially dancing element). And as a drama performed by a resultant of those three, being called a "worldly shadow" (worldly drama:Welt Theater), a spread of drama as a "worldly shadow" became a basis for his creation of the stage-musics. He wa a characteristic composer who had developed a sole mode of expression of his own, without being tied with such as fashionable tendencies; Romantism, Impressionism, Expresionism, etc., which had dominated first over the first half or 20 century. He tried a Maximization of Primitivity, and his primitivism was on basis, simple and basical, which is entirely distinguishable with Stravinsky's primitivism strict, artificial and complex.

      • 經中隔左心房穿刺法 : l. Pulmonary wedge pressure and left atrial pressure

        柳秀雄 최신의학사 1976 最新醫學 Vol.19 No.12

        The transseptal method of left heart catheterization described first by Ross is now widely used and is generally considered to be the method of choice for hemodynamic assessment of mitral and aortic valve disease. Improvements in the equipment and technique for transseptal left. heart catheterization appear to have largely overcome the major problems and complications. Brockenbrough modification of the transseptal technique has been adopted in our laboratory and a few experiences of which with a brief description is given below.

      • 전자음악 및 대중음악에 관한 비교문석 연구

        유수웅 경복대학 2000 京福論叢 Vol.4 No.-

        인류 문명의 역사는 20세기에 이르러 이전의 그 어느 시기보다도 빠른 속도로 발전되었다. 이 가운데 대중문화의 발전은 각 문화의 독자적인 성장과 함께 여러 다양한 문화들의 상호 작용에 의하여 복합적인 형태를 형성하며 발전하게 된다. 이러한 대중문화의 한 부분인 대중음악 또한 대중문화의 유사한 모습의 발전양상을 띄게 되고 이것은 1950년대에 형성된 전자음악이라는 새로운 음악 경향을 흡수하게 되면서 보다 혁신적인 성장을 이루게 된다. 1960년대 말엽부터 형성되기 시작한 테크노음악은 전자음향기기의 발전과 많은 음악적 성장을 통하여 1990년대에 이르러서는 대중음악의 주류로서 자리하려는 움직임을 보이게 된다. 이 같은 테크노음악의 생성과 발전은 대중음악에 접목된 전자음악의 새로운 경향이라고 할 수 있으며 그 결과 다음과 같은 점을 발견 할 수 있었다. 첫째, 테크노음악은 전자음악의 대중화된 모습으로서 초기 전자음악의 실험적이고 전문적인 음악적 성향을 가지고 있으면서도 실제 대중들에게 소비되어지는 형태를 취하고 있다. 둘째, 테크노음악은 대중음악에 전자음악이 접목되는 가운데 생성된 형태로 그 과정에서 복합적인 음악의 성장을 이루게 되고 그 결과 세분화된 다양한 하위음악 장르를 형성하게 된다. 무엇보다도 테크노음악이 대중음악계에 미친 영향은 발전적인 새로운 음악 경향의 생성이라는 결론과 함께 테크노음악이 발전되면서 나타난 여러 가지 음악문화의 발전에 있다. 예를 들어 댄스 음악문화의 형성, 클럽문화의 정착화, 라이브 문화와 레코드 문화사이의 상호작용 등이 그것이라 할 수 있다. 또한 테크노음악의 미래지향적이고 도전적인 성격은 앞으로의 대중음악의 전망을 밝게 하고 있다. We have made so much rapid development in our human cultural history since 20th century than any other past, in this process, the development of mass culture has grown up and each culture has made unique process by mutual actions of various civilizations. Popular music as a part of mass culture has entered on similar shape with that and has made an innovating development by assimilation of new trend in music. Techno Music which has been building up through the end of 1960's intended to get the main position by development of electronic sound machinery and popular music. These formation and growth of Techno Music IS may be said as anew tendency of electronic music involved with popular music and as a result I could find several factors like these. In the first place, Techno Music has an experimental and special disposition of primary electronic music as a popularized form, but also can be used up by the real consumer. Secondly, Techno Music a kind of form which has sprung from the linkage of electronic music to popular music. In the process of correlation, complex music genre has grown and diverse, detailed subcategoried sort of music genre have arisen. More than anything else, the impact of Techno Music on popular music is the rise of new paradigmatic music pattern and the progress of various music culture triggered by the Techno Music development. We can easily see the influence in the formation of 'dance music' culture, the settlement of club culture, and the interplay of live performance culture with 'ever-prepared record-type products' culture.

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