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新生兒 綠膿菌性 髓膜炎 : 症例報告 및 文獻的考察 A Case Report and Literature Review
盧範洙,李慶子,李庸一 최신의학사 1970 最新醫學 Vol.13 No.3
A case of pseudomonas aeruginosa(meningitis 9 days male infant) was treated with Erythromycin and penicillin and penicillin-streptomycin as soon as admission, but general condition was not improved. Pseudomonas aeruginosa was found in the culture of the cerebrospinal fluid, the discharge of the umbilicus and blood, and so Colistin was started to administer on the 3rd hospital day. The patient was expired on the 4th hospital day, about 9 days after the onset. The portal of entry, symptoms, diagnosis and treatment of this disease was reviewed.
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Absolute bioavailability and metabolism of aceclofenac in rats
노금한,강원구,권광일,윤휘열,김은영,정태천,신범수 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.1
Aceclofenac is one of the most popular analgesicand anti-inflammatory drugs used for the relief ofpain, rheumatoid arthritis, and osteoarthritis. To date, nointravenous preparation of aceclofenac has been developedbecause of its poor water solubility. In this study, toinvestigate its absolute bioavailability and metabolism inrats, aceclofenac was dissolved in a sterile aqueous solutioncontaining urea (20 %) and trisodium citrate (10 %), andadministered via oral (20 mg/kg) and intravenous (10 mg/kg)routes. Blood samples were taken serially, and aceclofenacand its three major metabolites (40-hydroxydiclofenac,40-hydroxyaceclofenac, and diclofenac) were measured byHPLC–MS/MS. The absolute oral bioavailability of aceclofenacwas approximately 15 %. Diclofenac and40-hydroxydiclofenac were the main metabolites in rats, incontrast to 40-hydroxyaceclofenac in humans. The lowbioavailability of aceclofenac is likely due to extensive metabolism, and bioavailability may be even lower if the drug were administered as a tablet, considering its low water solubility. This study provides complete time profiles of the plasma concentrations of aceclofenac and its metabolites in rats and highlights the difference in drug metabolism between rats and humans.
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노금한,강원구,김은영,정태천,나민균,백문창,Kwang-Hyeon Liu,박필훈,신범수 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.12
Glimepiride, a second-generation sulfonylurea, is a glucose-lowering agent widely used to treat diabetes mellitus. It is converted into metabolite M1 by CYP2C9, and M1 is then transformed into the carboxyl derivative M2 by cytosolic enzymes. In this study, we introduce a sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for determining glimepiride, M1, and M2 in human plasma. After simple protein precipitation with acetonitrile, the analytes were chromatographed on a reversed-phase CN column with a mobile phase of 10 mM ammonium acetate aqueous solution and acetonitrile (1:1, v/v). The accuracy and precision of the assay were in accordance with FDA regulations for the validation of bioanalytical methods. This method was used to measure the concentrations of glimepiride, M1, and M2 in plasma after a single oral 2-mg dose of glimepiride in volunteers.
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팀장의 변혁적 리더십과 팀 적응성과 간의 관계 : 공유멘탈모델의 매개효과
배범수(Bae, Bum Soo),노명화(Roh, Myung Hwa) 한국인적자원관리학회 2016 인적자원관리연구 Vol.23 No.1
팀은 환경변화에 적응하는 중요한 조직의 수단으로 팀제와 관련된 많은 연구들이 팀 효과를 강화하는 요인에 대하여 초점을 맞추어 지면서, 지난 15년간 적응수행은 팀 효과를 강화하는 행위로서 주목을 받아왔다. 팀 적응성과에 있어 많이 적용되고 있는 프로세스적 관점은 실제 적응이 발생하는 메카니즘을 설명할 수 있지만, 다양한 적응과 관련된 행위를 포괄적으로 설명하는데 한계를 가지고 있으므로, 본 연구에서 는 동적인 과업수행 행위에 초점을 두고 팀 적응성과를 환경변화에 대한 대응으로 발생되는 팀 성과로서 정의하였다. 적응성과를 측정하기에 적합한 액션팀인 특수 임무팀을 대상으로 팀 적응성과의 선행요인으로서 팀장의 변혁적 리더십의 효과와 변혁적 리더십과 팀 적응성과의 관계에서 공유멘탈모델의 매개효과를 검증하였다. 본 연구를 위하여 군 조직의 89개 특수 임무팀들을 대상으로 설문조사를 실시하였고, 불성실한 응답을 제외하고, 65명의 특수 임무팀장들과 497명의 팀원들의 자료를 사용하여 통계 분석하였다. 매개효과 검증을 위하여 위계적 회귀분석을 실시한 결과, 특수 임무팀에서 팀장의 변혁적 리더십과 팀적응성과 간의 관계에서 팀 공유멘탈모델은 유의한 정적인 부분 매개효과가 있는 것으로 나타났다. 이러한 결과는 팀장의 변혁적 리더십이 팀 구성원들 개인에게 새로운 과업환경을 극복할 수 있도록 동기부여를 제공할 수 있으며 이러한 과정을 통해 구성원들은 자신의 과업환경의 변화에 적응함으로서 결과적으로 팀 적응성과를 높이는 결과를 가져오게 하며, 동시에 팀장의 변혁적 리더십은 전문성을 가진 다양한팀 구성원들이 사회적 정체성 갖도록 유도함으로서 다양한 정보의 공유를 가능하게 한다. 또한 팀장은 외부환경에 대한 중요한 정보를 제공하여 팀 구성원들이 직무환경에 대한 유용한 정보체계를 공유함으로서 팀의 적응성과에 미치는 긍정적 효과를 실증하였다. 연구결과를 토대로 본 연구의 학문적 의의 및 실무적 시사점, 그리고 한계점에 대하여 논의하였다. The purpose of this study is to verify the effects of team leaders’ transformational leadership on the team adaptive performance of team members as well as the mediating effects of shared mental models that becomes pronounced as the transformational leadership of team leaders influences the team adaptive performance of team members in the relationship between the charismatic leadership of team leaders and team efficacy. To this end, we conducted a survey of 89 team leaders and 862 team members working in action and negotiation teams in military services, and analyzed data collected from 65 team leaders and team members, except unreliable responses. As a result of a hierarchical regression analysis to confirm mediating effects, it was found that shared mental models had a partially mediating effect on the relationship between the transformational leadership of team leaders and the team adaptive performance of team members. The charismatic leadership of team leaders had a directly effect on the team adaptive performance of team members, as well as the charismatic leadership of team leaders had a indirectly effect on the team adaptive performance of team members through the shared mental models. Based on the research findings, this study discussed its academic significance, practical implications, limitations and future research tasks.
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Synthesis and characterization of functional nanocomposites for radioactive cesium adsorption
노창현,김민규,김선병,김일국,김재훈,윤인호,은희철,장범수,최만수 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
In this study, we aimed to design and synthesize a new microporous three-dimensional network composite composed of PB encapsulated by polymer beads, which were reinforced by cross-linking aminopropylfunctionalized iron phyllosilicates clay, for high adsorption and easy separation of radioactive cesium from contaminated water. The synthesized composite was confirmed by Fourier-transform infrared spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, thermal gravimetric analysis, and scanning electron microscopy. The results revealed that the composite adsorbent was highly efficient in the removal of radioactive cesium because of the good adsorption property of PB and the excellent adsorption property of the alginate/AIP clay network. Owing to the bio-compatible nature of alginate and AIP clay, they may form a potential class of adsorbents for environmental remediation.
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