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좌골신경 손상 후 스트렙토조토신 유도성 당뇨병에 의한 축사재생의 지연 효과
황진연,김기중,남궁욱 大田大學校 附屬 韓方病院 2020 惠和醫學 Vol.29 No.1
Objective: The goal of this study is to investigate whether peripheral axonal regeneration is affected by diabetes in experimental animals. Method: Sprague Dawely rat was injected with 45~50 mg/kg of streptozotocin (STZ) to generate an animal model of diabetes. Three months after STZ injection, sciatic nerve (2 cm length) was removed and the same length of nerve segments from STZ-injected animal or from control animal (CTL) was transplanted into STZ-injected animals (STZ-STZ and STZ-CTL respectively). Similarly, sciatic nerve segments from STZ-injected animal or from control animal were grafted into the control animals (CTL-STZ and CTL-CTL respectively). All animals were sacrificed 2 weeks after transplantation. Sciatic nerve sections were prepared and subjected to immunofluorescence staining analysis. Results: Immunofluorescence staining for NF-200 showed that distal elongation of regenerating axons reached 40~80% of proximal neve in both CTL-STZ and CTL-CTL groups. However, distal elongation in both STZ-STZ and STZ-CTL groups were 20~60% of proximal nerve. Furthermore, measurement of axonal regeneration after immuno-staining with SCG10 showed that the scores of distal elongation relative to proximal nerve were 50~90% in CTL-CTL and CTL-STZ groups and 10-60% in STZ-CTL and STZ-STZ. Conclusions: Our data showed that the levels of axonal regeneration were not affected irrespective of whether they were from STZ- or CTL graft, but were greatly reduced when the nerves were transplanted into the STZ host.
황진연,박맹언,김희준,김대철,송용선,백인성,정상용,송시태 한국수산학회 1988 한국수산과학회지 Vol.21 No.4
진주만에 분포하는 점토공물의 평균 함량비는 illite 55.1% kaolinite 23%, chlorite 22.5%, 그리고 smectite가 0.4%이다. 부근의 남해 대륙붕에 비해 illite는 10∼20% 정도 낮고, kaolinite는 10% 정도 더 높다. 남강의 방류로 인해 조립질 퇴적물이 대량으로 유입되는 진주만 동북쪽 지역인 사천만을 제외하면 진주만에 분포하는 세립질 퇴적물은 초량천 등 하동-산청 지역의 고령토 지대를 집수구역으로 하는 하천들이 주 공급원이고, 일부는 비교적 활발한 조수유동으로 노량수도와 삼천포수도를 통하여 대륙붕으로부터 공급되었으리라 생각된다. 또한, 진주만 중앙부의 수심이 얕은 지역은 관곡천에서 진교만으로 유입된 퇴적물의 퇴적작용에 영향을 받은 것으로 생각된다. Semi-quantitative analysis of less-than-2㎛ clay minerals in thirty-nine superficial sediments from the Chinju Bay, southern coast of Korea, was made to reveal the distribution, provenance and dispersal pattern of fine-grained sediments. Additional nine samples were also taken from the Choryang Cheon (a river draining the kaolin-rich Hadong area) to investigate the influence of river discharge. Grain size analysis for the Chinju Bay sediment samples was performed simultaneously as an aid to understand the sediment types and depositional environments. Except for the northeastern part. clayey mud predominates the entire bay. Average relative abundance of the four major clay minerals, i.e., illite, kaolinite, chlorite and smectite, is 55.1%, 23%, 21.5% and 0.4%, respectively. Although illite is dominant clay mineral, the average content is about 10∼20% lower than that of the nearby continental shelf area. On the contrary, kaolinite content in the bay is about 10% higher than that of the shelf area. Recent clay minerals of the Chinju Bay are mainly derived from the nearby inland area through numerous rivers and streams. Transport from shelf area, however, also seems to be important.
황진연,남궁욱 대한배뇨장애요실금학회 2020 International Neurourology Journal Vol.24 No.S1
Purpose: The goal of this study is to investigate the role of cyclin-dependent kinase 5 (Cdk5) in axonal regeneration in dorsal root ganglion (DRG) neurons after peripheral nerve injury.Methods: Crush injury was given on the sciatic nerve in rats. The DRG tissues were prepared 1, 3, and 7 days after injury and used for western blotting and immunofluorescence staining experiments. Primary DRG neurons were prepared and treated with Cdk5 inhibitor roscovitine or used for transfections with plasmid constructs. After immunofluorescence staining, neurite length of DRG neurons was analyzed and compared among experimental groups. In addition, roscovitine was injected into the DRG <i>in vivo</i>, and the sciatic nerve after injury was prepared and used for immunofluorescence staining to analyze axonal regeneration in nerve sections.Results: Levels of Cdk5 and p25 were increased in DRG neurons after sciatic nerve injury (SNI). Levels of S727-p-STAT3, but not Y705-p-STAT3, were increased in the DRG. Immunofluorescence staining revealed that Cdk5 and STAT3 proteins were mostly colocalized in DRG neurons and Y705-p-STAT3 signals were localized within the nucleus area of DRG neurons. A blockade of Cdk5 activity by roscovitine or by transfection with dominant negative Cdk5 (dn-Cdk5) and nonphosphorylatable forms of STAT3 (S727A or Y705F) resulted in significant reductions of the neurite outgrowth of cultured DRG neurons. <i>In vivo</i> administration of roscovitine into the DRG markedly attenuated distal elongation of regenerating axons in the sciatic nerve after injury.Conclusions: Our study demonstrated that Cdk5 activity induced from DRG neurons after SNI increased phosphorylation of STAT3. The activation of Cdk5-STAT3 pathway may be involved in promoting axonal regeneration in the peripheral nerve after injury.
소아에서의 원위 수지 절단의 재접합술에 대한 임상적 고찰
황진연,서영석,Hwang, Jin Yeun,Suh, Young Suk 대한미세수술학회 2000 Archives of reconstructive microsurgery Vol.9 No.1
From Jan. 1998, 28 young children patients with complete amputations at zone I or II were replanted using a microscopic technique. Children's average age was 4.5 years and the amputation levels were zone I in 12 cases and zone II in 16 cases. Overall survival rate was 57%(16 cases). In children, the advantages of the replantation for distal digital amputations are nearly normal length, good soft tissue coverage with nail and cosmetically high patient satisfaction but surgical technical difficulties are much greater than in adults.
경북 감포지역 제3기층에 산출되는 불석광물 및 점토광물의 산상 및 분포
황진연 부산대학교 기초과학연구소 1988 부산대학교 기초과학연구소 연구논문집 Vol.8 No.-
감포지역 제3기층의 응회암질암석 중에는 clinoptilolite, mordenite, smectite 및 cristobalite 등의 변질광물이 X선회절분석에 의해 많이 검출된다. 이들 광물의 광물조합에 의해 4개의 변질분대로 구분되었다. 즉, I. 미변질유리대, II-A. 점이대, II-B. clinoptilolite대, II-C. mordenite대이다. I,II-A 및 II-B대는 전동층에 주로 분포되며, II-C대는 장항층에 분포되어 나타난다. 변질광물의 분포상태 및 광물학적 성질등으로 보아, 이들 변질분대는 속성변질작용에 의한 것으로 생각된다. 그러나 본지역의 일부지점에서는 국부적인 열수변질작용에 의한 것으로 생각되는 광물도 관찰된다. In the Tertiary tuffaceous rocks of Gampo area, the alteration minerals such as clinoptilolite, mordenite, smectite and cristobalite are detected by using the powder X-ray diffraction method. On the basis of the mineral assemblages, the alteration zones are grouped into four zones; I. unaltered glass zone, II-A. transitional zone, II-B. clinoptilolite zone, II-C. mordenite zone. The zones, I. II-A and II-B are distributed in the Jeondong Formation, and the zone II-C is found in the Janghang Formation. Judging from the distribution and mineralogical properties of the alteration products, it is recognized that the alteration zones were formed by diagenetic alteration process. Besides the diagenetic alteration minerals, hydrothermally altered minerals are locally observed in some parts of this area.
황진연,배숙향,이정민,김동균,안지혜,김민식,김영대,백희경,조용락,박태호 대한심장학회 2010 Korean Circulation Journal Vol.40 No.11
Cardiovascular manifestations in hyperthyroidism occur frequently with various phenotypes. An association between hyperthyroidism and pulmonary arterial hypertension has been reported. In previously reported cases, the hemodynamic and symptomatic recovery of pulmonary arterial hypertension is usually concomitant with achievement of euthyroidism. We report a patient who had pulmonary arterial hypertension associated with Graves’ disease, which persisted after euthyroidism was obtained.