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      • 진폐요양환자에서 결핵 발생율

        황주환,최병순 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.0

        분진작업(dusty work)이란 토석(earth), 암석(rock) 또는 광물(minerals)을 취급하는 작업 중 그 작업에 종사하는 근로자가 진폐증(pneumoconiosis)에 걸릴 우려가 있는 것으로서 대통령령으로 정하는 작업을 말한다. 진폐증이란 분진을 흡입하여 폐에 생기는 섬유증식성 (fibroplastic) 변화를 주된 증상으로 하는 질병으로 “진폐의 예방과 진폐근로자의 보호 등에 관한 법률” 제2조제2호에 따라 진폐의 소견이 있는 자가 진폐의 진행과 관련하여 걸리는 활동성 폐결핵(pulmonary tuberculosis), 흉막염(pleurisy), 기관지염(bronchitis), 기관지확장증 (bronchiectasia), 기흉(pneumothorax), 폐기종(pulmonary emphysema), 폐성심(cor pulmonale), 원발성 폐암(primary lung cancer), 그리고 비정형 미코박테리아 감염(non-tuberculosis mycobacteria infection)의 어느 하나에 해당하는 질병을 합병증(complication)으로 정의 하고 있다. 이번 연구에서는 근로복지공단 종합정보분석시스템의 자료를 이용하여 2004년부터 2014년까지 진폐요양환자들 중에서 활동성 폐결핵으로 진단받은 환자 수를 파악하여 진폐요양환자들에서 결핵 발생율을 알아보고자 하였다. 진폐요양환자 중 활동성 폐결핵환자는 2004년 1893명 중 831명(43.90%), 2005년 2173명 중 957명(44.04%), 2006년 2487명 중 1072명(43.10%), 2007년 2826명 중 1217명(43.22%), 2008년 3072명 중 1319명(42.94%), 2009년 3303명 중 1420명(42.99%), 2010년 3345명 중 1357명(4057%), 2011년 3313명 중 1309명(39.51%), 2012년 3341명 중 1308명(39.15%), 2013년 3256명 중 1277명(39.22%), 그리고 201년 3153명 중 1225명(38.85%)으로 2004년부터 20014년까지 진폐요양환자에서 결핵 발생율은 평균 41.59%로 나타났다.

      • KCI등재

        Risk Factors for Associated with Latent Tuberculosis Infection among Former Mine Workers

        황주환,신재훈,백진이,최병순 한국산업보건학회 2019 한국산업보건학회지 Vol.29 No.3

        Objectives: To identify the positive rate of and the risk factors associated with latent tuberculosis infection(LTBI) in mine workers, the objectives of the present study evaluated those among former mine workers. Methods: Between January 2015 and May 2017, former male mine workers who had been subjects for epidemiology research for work-related chronic obstructive pulmonary disease(COPD) and had received QuantiFERON-TB® Gold In-Tube(QFT-GIT) from the Institute of Occupation and Environment(IOE) under Korea Workers’ Compensation and Welfare Service(KCOMWEL) were selected as the study subjects. To identify significant variables for increased risk of LTBI, logistic regression analysis was performed. Results: A total of 736 male former mine workers were selected as study subjects. The positive rate of LTBI among subjects was 69.2%(509/736). The current smoking[odds ratio(OR), 2.3; 95% confidence interval(CI), 1.1-4.9], COPD(OR, 1.4; 95% CI, 0.9-2.3), department loading(OR, 1.8; 95% CI, 0.9-3.4) and mining(OR, 1.5; 95% CI, 0.9-2.5), and working duration of over 20(OR, 1.6; 95% CI, 0.9-3.1) and over 30 years(OR, 2.2; 95% CI, 0.9-4.9) were associated with increased risk of LTBI. The interferon-gamma(IFN-γ) level after stimulation with M y c o b a c t e ri u m t u b e r c u l o s i s (MTB)-specific antigens showed a significantly negative correlation with age( r =-0.126). Conclusions: The present study determined that the high positive rate of LTBI among mine workers was associated with not only the host factors but also the occupational exposure to mine dust.

      • KCI등재

        논 토양에서 사일리지용 수수 × 수수 교잡종 재배시 화학비료와 발효 돈분 액비 혼용 시용이 생육특성 및 영양성분에 미치는 영향

        황주환,이상무,Hwan, Hwang Joo,Lee, Sang Moo 한국초지조사료학회 2015 한국초지조사료학회지 Vol.35 No.4

        본 실험은 논 토양에서 사일리지용 수수 ${\times}$ 수수 교잡종 재배시 화학비료와 발효 돈분 액비 혼용 시용이 생육특성 및 영양성분에 미치는 영향을 조사하고자 실시하였다. 실험설계는 화학비료 100% 처리구 (C), 화학비료 70% + 돈분액비 30% 처리구 (T1), 화학비료 50% + 돈분액비 50% 처리구 (T2), 화학비료 30% + 돈분액비 70% 처리구 (T3) 그리고 돈분액비 100% 처리구 (T4)로 한, 5처리 3반복 난괴법으로 배치하였다. 이때 돈분 액비 시용은 질소량만을 기준으로 하였다 (150 kg/ha). 초장, 엽장, 엽폭 그리고 경의 굵기는 T4구가 유의적으로 작게 나타났다 (p<0.05). 경의 경도는 돈분액비 시용 비율 낮고 화학비료 시용 비율이 높을수록 유의적으로 증가하였다 (p<0.05). 생초수량은 T2구가 높았던 반면 T3구가 낮게 나타났다 (p<0.05). 그러나 건물 수량 및 TDN 수량은 처리구들 간에 유의적인 차이를 보이지 않았다. 조단백질 함량은 T1구가 다른 구에 비하여 높게 나타났다 (p<0.05). 조지방 함량은 T1, T2, T3 그리고 T4 처리구들 간에는 유의적인 차이가 없었지만, C구와는 유의적인 차이를 보였다 (p<0.05). NDF와 조섬유 함량은 각각 T3구와 C구에서 높게 나타났다 (p<0.05). 그러나 ADF 함량은 처리구들 사이에 유의적인 차이를 보이지 않았다. 총무기물 함량은 T1 > T2 > T4 > T3 > C 구 순으로 높게 나타났다 (p<0.05). 유리당 함량은 T1과 C구가 다른 처리구에 비하여 유의적으로 높게 나타났다 (p<0.05). 이상의 결과를 종합해 볼 때, 돈분액비 시용은 화학비료에 비하여 수량성, 영양성분에 크게 떨어지지 않기 때문에 사일지용 수수 ${\times}$ 수수 교잡종 재배시 돈분액비와 화학비료를 혼용 시용 하거나 돈분액비 만 시용하여도 큰 무리가 없는 것으로 판단된다. This study was conducted to investigate the influence of the mixed application of chemical fertilizer (CF) with liquid swine manure (LSM) on the agronomic characteristics, dry matter yield, minerals, and free sugar in cultivating Sorghum ${\times}$ Sorghum Hybrid (SSH) on paddy soil. The field experiment was designed in a randomized block design with three replications and consisted of CF 100% (C), CF 70% + LSM 30% (T1), CF 50% + LSM 50% (T2), CF 30% + LSM 70% (T3), and LSM 100% treatment (T4). The application of LSM was based only on the nitrogen (150 kg/ha). Plant length, leaf length, leaf width and stem diameter were significantly the lower in T4 (p<0.05). Stem hardness increased significantly (p<0.05) as the LSM application rate decreased. Fresh yield was the highest in T2, whereas the lowest in T3 (p<0.05). However, dry matter yields and TDN yield did not show significant difference among treatments. Crude protein was the highest in T1 (p<0.05). Crude fat content did not significant differences between the T1, T2, T3 and T4, but C showed a significantly different (p<0.05). NDF and crude fiber were the highest in T3 and C, respectively (p<0.05). However, ADF did not show significant difference among treatments. Total mineral contents were higher in the order of T1> T2> T4> T3> C (p<0.05). Free sugar contents were significantly higher at T1 and C as compared to other treatments. The analysis of all the above results suggests that the application of liquid swine manure is very effective, considering the yield performance and the content of mineral and free sugar. In addition, liquid swine manure may be possible to grow SSH without chemical fertilizer.

      • KCI등재

        산재요양기관 종사자에서 잠복결핵감염 유병율 및 위험요인

        황주환,정지영,최병순,Hwang, Joohwan,Jeong, JiYoung,Choi, Byung-soon 한국산업보건학회 2017 한국산업보건학회지 Vol.27 No.3

        Objectives: The major objective of this study was to investigate the prevalence of and risk factors for latent tuberculosis infection (LTBI) among employees at a workers' compensation hospital. Methods: Among the 394 employees at Incheon Hospital, 362 were enrolled in the study. An interferon-gamma release assay(IGRA) for diagnosis of LTBI was performed using QuantiFERON$^{(R)}$ TB Gold In-Tube(QFT-IT). Risk factors for LTBI were analyzed using logistic regression analysis. Results: The overall prevalence of LTBI was 32.0%(116/362). The non-medical departments have a significantly high prevalence compared to medical departments(39.7% vs 23.2%). In multivariate logistic regression analysis, experience working in the pneumoconiosis hospital(OR, 3.6; 95% CI, 1.3-10.3) was associated with development of LTBI. Conclusions: Korean guidelines for the management of tuberculosis recommend annual regular health examinations for TB and LTBI for health care workers(HCWs). Considering the high prevalence of and risk factors for LTBI among non-HCWs, it suggests a need for annual regular health examinations for TB and LTBI for all employees at workers' compensation hospitals, including pneumoconiosis hospitals.

      • KCI등재

        Alteration in Phenolic Compounds and Antioxidant Activities of Aronia melanocarpa Ethanol Extracts following Fermentation Using Different Strains of Leuconostoc mesenteroides to Develop Natural Antibiotic Alternative

        황주환,강주희,이기환,이재훈,이상무,김남형,김주영,김은중,Hwang, Joo Hwan,Kang, Ju Hui,Lee, Ki Hwan,Lee, Jae Hoon,Lee, Sang Moo,Kim, Nam Hyung,Kim, Joo Young,Kim, Eun Joong Korean Association of Organic Agriculture 2014 韓國有機農業學會誌 Vol.22 No.4

        Antioxidant activity is important for reducing oxidative stress that causes various metabolic disorders. Metabolic disorders are highly related to loss of productivity in livestock. Therefore, development of effective antioxidant compounds originating from plants is important for organic agriculture. Phenolic compounds in edible plants are regarded as major components relevant to antioxidant activity. The present study investigated the changes in antioxidant activity and phenolic compound profiles of Aronia (Aronia meloncarpa) by fermentation using different strains of Leuconostoc mesenteroides. A total of 5 strains of L. mesenteroides were used as starter cultures and their ${\beta}$-glucosidase activities were measured. A total of 6 experiment runs were prepared, one for control (uninoculated) and the others (inoculated) for treatments. For biological activity, antioxidant and antibacterial activities were measured. For phenolic compound profiling, TLC and HPLC analysis were performed. The strains of KACC12313 and KACC12315 showed greater enzyme activity than others. Treatment with KCCM35046 showed strong and broad antibacterial activity against to Listeria monocytogenes. Treatments with KCCM35046 and KACC12315 showed the highest total polyphenol content. The highest antioxidant activity was found in KACC12315 treatment. No remarkable alteration was found in thin layer chromatography (TLC) analysis. In phenolic compound profiling analysis, KCCM35046 showed notable alteration in compound area ratio compared to others and also showed the highest caffeic acid content. In chlorogenic acid, treatments with KCCM35046 and KACC12315 showed great content than others. Treatment with KACC12315 showed the greatest content of trans-ferulic acid. As a result of relative performance indexing analysis, L. mesenteroides KCCM35046 and KACC12315 were selected as the best strain for the fermentation of Aronia.

      • KCI등재

        진폐환자에서 활동성 폐결핵 발병률

        황주환 한국산업보건학회 2019 한국산업보건학회지 Vol.29 No.4

        Objects: Although active pulmonary tuberculosis(active PTB) is manifested as one of the complications of pneumoconiosis, attacks of active PTB among patients with pneumoconiosis is still unexplored. The objective of the present study was to identify the attack rate of active PTB among workers in dusty environments who were diagnosed with pneumoconiosis. Methods: The study was performed using the results of the Pneumoconiosis Examination Council’s assessment from the Korea Workers’ Compensation and Welfare Service(KCOMWEL) database between January 1, 1984 and December 31, 2017. Pneumoconiosis was defined as Category 1 or more in the radiological findings of pneumoconiosis. Active PTB was defined as a positive result for active PTB in the results of the Pneumoconiosis Examination Council’s assessment. Results: A total of 37,946 workers in dusty environments who received a health examination for diagnosing pneumoconiosis between January 1, 1984 and December 31, 2017 were selected as study subjects. The attack rate of active TB among subjects who were diagnosed with pneumoconiosis and those who were diagnosed without pneumoconiosis were 8.5% and 1.4%, respectively. In the multivariate logistic analysis including age, sex, radiological findings, complications, male[odds ratio(OR), 2.0; 95% confidence interval(CI), 1.4-3.1] and pneumoconiosis(OR, 6.5; 95% CI, 5.7-7.4) were associated with an increased risk of developing active PTB. Conclusions: The present study determined that dusty workers who were diagnosed with pneumoconiosis had a high rate of active PTB compared to TB patients and patients who were diagnosed with silicosis. Therefore, in addition to silicosis, it is necessary to include pneumoconiosis among the high-risk groups for TB.

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