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기니피그 위저부 윤상근의 비아드레날린성 비콜린성 반응에 관한 연구
황일순(Il Soon Whang),송치욱(Chi Wook song),강동훈(Dong Hoon Kang),이홍식(Hong Sik Lee),이상우(Sang Woo Lee),최재현(Jae Hyun Choi),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu),현진해(Jin Hae Hyun) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.4
N/A Background/Aims: The neurogenic responses of gastrointestinal smooth muscles to electrical field stimulation(EFS) is biphasic, consisting firstly of cholinergic contraction, followed by a transient relaxation. It is well known that a transient relaxation does involve the inhibitory non- adrenergic non-cholinergic(NANC) systems. However, the exact nature of the neurotransmitter released by these neurons is controversial. This study was done to investigate the relaxing agents and their action mechanisms by the use of organ bath with platinum electrodes. Methods: In 10 guinea-pigs, muscle strips of fundus, 10mm x 2mm, were prepared in a circular axis. Isometric tension study was performed in 30ml organ baths containing Krebs bicarbonate buffer, tnaintatined at 37 'C and gassed with 5% CO and 95% Oz. Results: The fundic relaxation by EFS was suppressed by NG-nitro-L-arginine methyl ester(L-NAME) and nitric oxide(NO) synthase inhibitor, in a dose-dependent manner and these effects were reversed by L-arginine, precurssar of NO. Nitroprusside, NO-donor, suppressed the fundic basal tension largely. Methylene blue, inhibitor of guanylate cyclase, suppressed the fundic basal tension and decreased EFS-induced relaxations. Forskolin and isoprenaline, which are activators of adenylate cyclase, suppressed the fundic basal tension as rnuch as nitroprusside. Intracellularly permeable cGMP and cAMP pro- duced relaxations in the precontracted fundic muscle with noradrenaline. TEA, non-specific K' channel blocker, and aparnin, Ca ' activated K' channel blocker, increased the fundic basal tension and EFS-induced relaxations. Conclusions: Above results indicate that NO is released upon stimulation of the NANC nerves in the guinea-pig fundic muscle and play a major role in the receptive relaxation of the fundus region. The release of NO is related with K' channel, and some other inhibitory agents may be involved in transient relaxation through modulative effects on cAMP or cGMP. (Korean J Gastroenterol 1997;29:430-441)
전성국(Seong Gook Jeon),손정일(Chong Il Sohn),김지은(Jee Eun Kim),박기호(Ki Ho Park),황일순(Il Soon Whang),김은주(Eun Joo Kim),박창영(Chang Young Park),김병익(Byung Ik Kim),전우규(Woo Gyu Jeon),정을순(Eul Soon Chung),이풍렬(Poong Lyu 대한내과학회 2000 대한내과학회지 Vol.58 No.2
N/A Background : Gastroesophageal reflux disease (GERD) is considered to be less common in the Orient compared to the West, but epidemiological data on GERD in Korea are rare. The aim of this study was to determine the prevalence of symptoms of gastroesophageal reflux in routine check-up subjects. Methods : We analyzed 2243 subjects (male 716, female 1527; age range 20-69 yr) visited health promotion center for routine check-up. Subjects were given a validated self-reported questionnaire, which measured the presence, duration and severity of typical symptoms (heartburn, acid regurgitation); and the presence of atypical symptoms. At least weekly symptoms of heartburn and/or acid regurgitation were characterized as the definition of GERD. Results : The prevalence of heartburn for at least monthly, at least weekly and at least daily episodes was 6.2%, 3.4% and 3.1%, respectively. The corresponding figures for acid regurgitation were 6.1%, 2.1% and 0.7%. The prevalence of GERD was 8.5%, and was more common in female (p<0.01). Sixty eight percent of subjects with GERD reported the symptoms as having been present for less than 5 years. Seventy four percent of subjects with GERD reported these symptoms to be mild to moderate in severity. Heartburn and acid regurgitation were significantly associated with dyspepsia, chest pain, dysphagia and globus sensation (p<0.01), but not with hoarseness or chronic cough. Conclusion : The prevalence of heartburn and/or acid regurgitation experienced at least weekly is 8.5% in routine check-up subjects. Heartburn and acid regurgitation were associated with epigastric pain, chest pain, dysphagia and globus sensation.(Korean J Med 58:145-151, 2000)
현진해(Jin Hai Hyun),김열흥(Yeul Hong Kim),이형호(Hyung Ho Lee),황일순(Il Soon Whang),송치욱(Chi Wook song),류호상(Ho Sang Ryu),최진학(Jin Hak Choi) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.2
N/A Clinical observation was performed of 229 cases of acute cholecystitis who admitted to Department of Internal Medicine Korea University Hospital for 5 years from Jan. 1980 to Dec. 1984. The following results were obtained: 1) The total number of cases of acute cholecystitis was 229 which was 0.46% of total admission cases during the same period. 2) The age incidence was the highest in 6th decade. The ratio of male and female was 1: 1.3. 3) On admission the most common clinical symptom was pain in the R.U.Q. and epigastrium(75.5%), the remainders were fever(40.2%), chill(36.2%), indigestion (34.1%), and nausea with vomiting(28.0%) in order of frequency. 4) The most common physical finding was tenderness on the R.U.Q ((81. 2%), and the remainders were tenderness on the epigastrium(33. 6%), jaundice(27.l%), and fever with palpable liver(23.6%) in order of frequency. 5) Laboratory examination showed leukocytosis(45.4%), elevated E.S.R. (91.0%), elevated alkaline phosphatase(55.9%), and elevated serum total bilirubin(36.9%). 6) On the radiological examinations the gallstones were presented in 9.3% by plain abdomen. On the sonographic examination of abdomen gallbladder stones were noted in 54.2% common bile duct stone in 15.O%, and intrahepatic duct stone in 6.0% 7) The 46.3% percent were improved by the medical conservative treatment. The 49.8% percent were improved by the surgical treatment and the 1.7percent was expired. 8) The complications of acute cholecystitis were 3. 1 percent.
김억(Auk Kim),김용태(Yong Tae Kim),조진아(Jin a Cho),구자란(Ja Ran Ku),허윤(Yoon Hur),서동원(Dong Won Suh),황일순(Il Soon Whang),박기호(Ki Ho Park),김은주(Eun Ju Kim),이성공(Seong Kong Lee) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.3
Colorectal cancer during pregnancy is extremely rare. The diagnosis is frequently delayed because symptoms may be confused with those of normal pregnancy. In 1S35, Cruvethier reported the first case of colorectal carcinoma complicating pregnancy. Since then, about 200 or more cases were reported in western countries, but no case of these has been reported in Korea. We experienced a 29-year-old pregnant woman concomitantly developed an adenocarcinoma of the right colon with intestinal obstruction at 12 weeks of gestation. We performed right hemicolectomy at 14 weeks of gestation and therapeutic abortion at 17 weeks of gestation. We report a case of colon cancer during pregnancy with a review of the diagnosis and management. (Korean J Gastroenterol 1996; 28:457 - 461)
식도, 위정맥류 경화요법이 위에 미치는 영향 : 위염을 중심으로
현진해,황일순 대한내과학회 1987 대한내과학회지 Vol.32 No.2
We evaluate the gastric mucosal changes after endoscopic injection sclerotherapy(EIS) by endoscopically in 52 portal hypertension patients with esophageal and/ or cardiac varices. The results were as follows; 1) The gastric mucosa showed superficial gastritis, normal and erosive gastritis in order of frequency after EIS. 2) In 93% of complete EIS group and 83% of incomplete EIS group showed gastric mucosal changes after EIS. 3) The gastric changes were more severe and persistent in complete EIS group than in incomplete group and were improved during follow up periods. 4) Above results were considered that the gastric changes after EIS were probably caused by changes of the gastric mucosal blood flow.
이성일,김창덕,류호상,현진해,황일순,송태진,김혜랑,정성채 대한소화기내시경학회 1989 Clinical Endoscopy Vol.9 No.1
Formaldehyde is a colorless irritating gas of pungent odor, which is used as a disinfectant, antiseptic, deodorant, tissue fixative and embalming fluid, It is used in the formation of resins, alcohols and acids, and in permanent press processes in the textile industry. If formaldehyde is swallowed, severe abdominal pain and vomiting is immediately noted. Corrosive gastritis can follow with diffuse ulceration, fibrosis and contracture of the stomach, resembling linitis plastica, which may be severe enough to require gastrectomy. We report a case of cicatricial contracted stomach due to the ingestion of formalin.
장티푸스에 의한 회양말말부 활동성 출혈의 내시경적 지혈 1예
이형호,송치욱,현진해,황일순,김열홍 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1
From a purely diagnostic too, colonoscopy has evolved into a technique with excitiong therapeutic allications. In this paper, a patient with active bleedign of terminal ileum identified at emergency colonoscopy and terated by colonoscopic electrocauterization without complication. We considered that colonoscopy in patient with typhoid intestinal hemorrhage can be done for the purpose of diagnostic and therapeutic applications with relative safety.
종격기종을 유발한 Mallory-Weiss 증후군 1 예
김창덕,현진해,주영만,황일순,천종철,김현위 대한내과학회 1989 대한내과학회지 Vol.36 No.2
Mediastinal emphysema may arise spontaneous or result from trauma. Esophageal perforation is the most common and important cause of mediastinal emphysema. Esophageal perforation may rarely occur in Boerhaave`s syndrome and Mallory-Weiss syndrome after vomiting. We experienced one case of Mallory-Weiss syndrome causing esophageal perforation and mediastinal emphysema. The patient was a 45-year-old male, who complained of vomiting, hematemesis and epigastric pain one day before admission. The gastroendoscopy revealed a deep hemorrhagic laceration (length, about 3㎝) in the mucosa of esophagogastric junction. The bleeding lesion was electrocoagulated. Two hours after electrocoagulation, he complained of dyspnea and retrosternal pain. So the roentgen examination (chest P-A and lateral view) was performed and revealed mediastinal emphysema and subcutaneous emphysema. He was transferred to chest surgery department and emergent operation was performed. So we report this case with review of literature.