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황인구,권오규,Hwang, In-Koo,Kwon, Oh-Kyu 대한전자공학회 1990 전자공학회논문지 Vol.27 No.10
이 논문은 비선혀성, 모델링오차 그리고 잡음입력이 존재하는 선형 및 비선형시스템에서의 모델에 근거한 이상검출방법을 제시한다. 대상 시스템은 연속형이나 이산형 모두에 적용할 수 있도록 통합연산자$(unified operator)^[5]$로써 표시한다. 이 논문에서 제시되는 이상검출법은 잡음과 모델의 부정합과 비선형성을 고려한 것이다. 모델링 오차는 더하기꼴로 나타내며 계수추정에서 불확실성의 한계를 정량화시키기 위해 공칭모델 분모는 사건실험을 통해 고정시키는 것으로 한다. 공칭모델의 분자 계수들은 최소자승법으로 추정한다. 컴퓨터 모의실험을 추정하여 이 논문에서 제시한 방법이 기존의 방법보다 우수한 성능을 지니고 있음을 보인다. This paper proposes a model-based fault detection method for linear/nonlinear system having modelling errors, nonlinearities and measurement noise. The system model is represented by the unified operator [5] in order to apply to both the continuous-time and discrete-time problems. The fault detection method suggested here accounts for the effects of noise, model mismatch and nonlinearities. Modelling errors are depicted by additive forms and the nominal model denominator is fixed via prior experiments in order to quantify the nucertainty bound on the parameter estima-tion. The least square method is used to estimate the numerator parameters of the nominal model. performance than traditional methods.
IVF/ET Program에 있어서 과배란 유도 방법에 대한 비교 연구
황인구,김선행,나중열,구병삼,Whang, In-Gu,Kim, Sun-Haeng,Rha, Jung-Yol,Ku, Pyong-Sahm 대한생식의학회 1989 Clinical and Experimental Reproductive Medicine Vol.16 No.2
The aim of this study was to compare the response and their outcome of superovulation induction protocol in IVF-ET program. One hundued seventy seven infertile women were stimulated by FSH/hMG(group I, N=128), clomiphene citrate/hMG(group II, N=51), and hMG(group III, N=18) for the purpose of ovulation induction. The results were as follows; 1. The mean ages of patients were $31.9{\pm}3.8$ in group I, $30.6{\pm}3.3$ in group II, and $29.3{\pm}2.5$ in group III. 2. The day of hCG administration was $11.1{\pm}1.8$ in group I, $12.1{\pm}2.0$ in group II, and $13.7{\pm}6.8$ in group III. The hCG administration day of group III was significantly delayed compared with that of group I (p<0.001). 3. The terminal E2 pattern in group II was different from those of group I and III, but there was no significant difference. 4. The mean numbers of mature eggs aspirated were $5.5{\pm}3.8$ in group I, $5.0{\pm}3.3$ in group II, and $5.6{\pm}5.4$ in group III. There was no significant differences in the mean numbers of mature eggs retrieved among the three groups. 5. The fertilization rate of eggs was significantly higher in group II (67.9%) than that of group I (52.2%)(p<0.001). 6. The cleavage rate of group I (67.0%) was significantly lower than those of group II (93.2%) and group III (95.8%) (p<0.0001). 7. The mean numbers of embryos transfered were $3.3{\pm}1.4$ in group I, $3.1{\pm}1.3$ in group II, and $3.2{\pm}1.6$ in group III and the ET rate was 69.0% in group I, 77.3% in group II, and 100% in group III. There was significant difference in ET rate between group I and group III (p<0.005). 8. The pregnancy rates per OPU cycle or ET cycle were not significantly different among the three groups, but delivered and ongoing pregnancy rates were significantly different between group I (36.8%) and group II (p<88.8%) (p<0.05).
황인구,이충현,유기연,최정훈,Ok Kyu Park,임순성,강일준,권대영,박진서,이재선,배영수,원무호 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.5
Onion has several well-known biological functionalities, including antioxidant effects, and contains quercetin (3,3′,4,5,7-pentahydroxyflavone), a powerful antioxidant. In the present study, we observed neuroprotective effects of onion extract (OE) and its major component, quercetin, on ischemic damage in the gerbil hippocampus, which is related to memory function. Repeated treatment with 100mg/kg OE and 20mg/kg quercetin for 15 days before ischemic surgery protected pyramidal neurons of the hippocampal CA1 region from ischemic damage. In the OE-treated ischemic group, gliosis (activation of astrocytes and microglia) was attenuated in the CA1 4 days after ischemia/reperfusion. In addition, treatment with OE and quercetin decreased protein levels of 4-hydroxy-2-nonenal (a marker for lipid peroxidation) in the ischemic CA1. We suggest that repeated administration of OE and quercetin can protect against neuronal damage from transient cerebral ischemia.