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B16-F10 Murine Melanoma 세포의 암전이 억제에 미치는 Diallyl Disulfide의 효과
강미경(Mi-Kyung Kang),전혜승(Hye-Seung Jun),염영나(Yung-Na Yum),황명실(Myung-Sil Hwang),박미선(Mi-Sun Park),김옥희(Ok-Hee Kim) 한국독성학회 2006 Toxicological Research Vol.22 No.4
Diallyl disulfide (DADS), an oil-soluble organosulfur compound in garlic has been reported to suppress tumor growth and to induce apoptosis in cancer. In the present study, we investigated the effects of DADS on pulmonary metastasis of B16-F10 murine melanoma cells. DADS (i.p. 40 ㎎/㎏) significantly (p < 0.05) reduced the number of pulmonary metastatic nodules (48%) in experimental pulmonary metastasis assay. We also found that DADS inhibited adhesion, invasion and migration of B16-F10 melanoma cells in a dose-dependent manner. To study the antimetastatic potential of DADS, we performed the effects of DADS on matrix metalloproteinase activity. DADS significantly inhibited the expression of matrix metalloproteinase-2 activity in B16-F10 cells by gelatin zymography. These results suggest that DADS prevent metastasis in part through suppression of migration of B16-F10 melanoma cells by inhibiting matrix metalloproteinase-2 responsible for degradation of extracellular matrix.
위해인지도 맵을 이용한 나노기술 리스크 커뮤니케이션 연구
최찬웅(Chan-Woong Choi),정지윤(Ji-Yoon Jeong),황명실(Myung-Sil Hwang),정기경(Ki-Kyung Jung),이효민(Hyo-Min Lee),이광호(Kwang-Ho Lee) 환경독성보건학회 2010 환경독성보건학회지 Vol.25 No.3
Nanotechnology is the fastest growing area in scientific research and it has important applications in a wide variety of fields. Nevertheless, consumers encountered this new technology without any identification of risks and benefits. Also until now, there are no specific safety evaluation methods for nanotechnology. For this reason, we studied risk communication strategy for nanotechnology to prepare its application in commercialized products on public. A survey was conducted to identify the differences in perception between public (N=110) and expert (N=37) toward applied nanotechnology in food, drugs and cosmetic products. The survey results were used to draw up a risk cognitive map which was introduced by Paul Slovic, and the perception level of public and expert on nanotechnology was evaluated. As a result of the survey, public recognized nanotechnology as unknown but low dread risk factor, but expert recognized it as unknown and high dread risk factor. These results indicate that there are perception differences between two groups. Several risk communication strategies are reported including care, consensus and risk communication. In the case of nanotechnology, it contains both risks and benefits. Considering the nature of nanotechnology, the consensus communication which informs consumers about risks and benefits of issues is the most appropriate strategy.