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Ovalbumin으로 유발시킨 喘息에 대한 黃芩의 물 추출물의 효과
황대룡,이성철,신호동,신민교,김재홍,정종길,송호준 대한본초학회 2004 大韓本草學會誌 Vol.19 No.4
Objectives : To evaluate effect of allergy by Radix Scutellariae Water Extract(RS), the biochemical changes associated with allergy were measured in Broncho Alveola Lavage Fluid(BALF), serum, splenocyte and lung of mice. Methods : After induction of allergic inflammation asthma by treatment of Ovalbumine(OVA), RS were taken orally for five successive days on mice, respectively. Results : In the total cell of BALF , the RS(1000mg/kg) treated group was significantly reduced compared to control level, and the reduction of eosinophil showed significantly at concentration of RS(300, 1000 mg/kg). Substantial decrease IgE antibody formation was significantly observed by administration with RS(300, 1000㎎/㎏), whereas IgG1, IgG2a antibody formation was not affected in serum from RS treated mice. The content of IL-4 exhibited physiological role in lung, splenocyte was not significantly reduced compared to control group after treatment of RS, but IL-5 was significantly reduced at concentration of RS (300, 1000㎎/㎏). Conclusions : From the above result, it could be concluded that Radix Scutellariae Water Extract showed beneficial effect on the allergic asthma.
황대룡 ( Dae Ryong Hwang ),강영성 ( Young Sung Kang ),김성수 ( Sung Soo Kim ),김대한 ( Dae Han Kim ),신민교 ( Min Kyo Shin ),송호준 ( Ho Joon Song ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.2
N/A Objective : To evaluate the effect of Semen Armeniaceae Amarum (SAA) on allergy, studies were done experimentally. Methods : After induction of allergic inflammation asthma by treatment of ovalbumin, water extract from SAA were taken orally for five successive days on mice respectively. We were measured in BALF, serum IgE, FCA on the biochemical change associated with allergy. Results : In the total cell of BALF, the SAA extract 48Omg/kg treated group was significantly reduced compared to control group and the reduction of eosinophil showed significantly at concentration of 240, 48Omg/kg. The SAA extract (480mg/kg) group was significantly decreased compared to control group on IgE antibody formation. SAA dose-dependently also significantly inhibited to passive cutaneous anaphylaxis(PCA) activated by anti - dinitropheny 1 (DNP) IgE. Conclusions : These results indicate that Semen Armeniaceae Amarum showed benefical effect on the allergic asthma.
변종호 ( Jong Ho Byun ),강영성 ( Young Sung Kang ),김성수 ( Sung Soo Kim ),김대한 ( Dae Han Kim ),황대룡 ( Dae Ryong Hwang ),신민교 ( Min Kyo Shin ),송호준 ( Ho Joon Song ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.2
N/A Objective : To evaluate effect of allergy by Tripterygiwn regelii (TR), the biochemical changes associated with allergy were measured in BALF. serum splenocyte and lung of mice. Methods : After induction of allergic inflammation asthma by treatment of ovalbumine, water extracts from stem and leaf (SL) or flower (FL) of TR were taken orally for five successive days on mice, respectively. Result : In the total cell of BALF. the SL-TR extract (lCKhwk, h.w)-treated group was significantly reduced compared to control level and the reduction of eosinophil showed significantly at concentraton of 360 and loo0 dks, b.w. On the other hand, substantial decrease in IgE antibody formation was significantly observed by administration with SL-TR extract, whereas IgGZa was not affected. IgCl antibody formation appeared to be decreased inserum from SL-TR treated mice(l000 mg/kg, b.w). The content of IL-4 exhibited physiological role in splenocyte and lung was significantly reduced in the examined group compared to that of control after treatment of SL-TR extract(l@X/kg, b.w). In the case of IL-5, however, it was significantly reduced by FL-TR extract. In addition, IL-5 content in splenocyte was significantly reduced at concentration of 360 and loo0 d k g . b.w. by SL-TR dose, respxtively, and that of lung was significantly reduced dose-dewndently(l20, 360 and 1000mp/kg, b.w). Cnnclusion : It could be conduded that TripteTygiwn regelii showed beneficial effect on the allergic asthma and especially, its leaf and stem is more effective than flower.
이종화 ( Joung Hwa Lee ),양현웅 ( Hyun Woong Yang ),이강창 ( Kang Chang Lee ),박상면 ( Sang Myeon Park ),김상수 ( Sang Su Kim ),서부일 ( Bu Il Seo ),강영성 ( Young Seung Kang ),김성수 ( Seung Soo Kim ),황대룡 ( Dae Ryoung Hwang 대한본초학회 2003 大韓本草學會誌 Vol.18 No.1
N/A Objectives : To clarify the myocardial toxicity of FeSO_4 in cultured rat myocardial cells, toxic effect was measured by MTT assay. Methods : Myocardial cells were incubated for 12hours in the media containing 10~80㎛ concentrations of FeSO_4. And also, the protective effect of Alli Macrostemi Bulbus(AMB) was measured in these cultures. Results : Cell viability was remarkably decreased in a dose- and time-dependent manners when cultured myocardial cells were exposed to 40 ㎛ FeSO_4 for 12hours. In the cytoprotective effect of AMB on FeSO_4-induced cytotoxicity, AMB blocked the FeSO_4-induced myotoxicity in these cultures. Conclusions : From the above results, it is suggested that FeSO_4 is toxic on cultured rat myocardial cells and AMB is effective in the prevention of FeSO_4-induced myocardial toxicity.