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홍준식,이소정,전가영,정지용,박진희,안정열,조은경,신동복,이재훈 대한혈액학회 2016 Blood Research Vol.51 No.2
BackgroundThe association between baseline renal impairment (RI) and the prognosis of diffuse large B-cell lymphoma (DLBCL) was previously not defined. The aim of this study was to evaluate the prognostic value of RI in patients with DLBCL treated with three-weekly rituximab plus cyclophosphamide, Adriamycin, vincristine, and prednisolone immunochemotherapy (R-CHOP21).MethodsPatients with newly diagnosed de novo DLBCLs treated with ≥1 cycle of R-CHOP21 were analyzed retrospectively. Pretreatment blood samples were collected and the glomerular filtration rate (GFR) was calculated. RI was defined by a GFR of <60 mL/min/1.73 m2 ac-cording to the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula.ResultsOf the 185 patients enrolled in the present study, 19 patients (10.3%) had RI. The reasons for baseline RI were pre-existing CKD (N=5), acute kidney injury due to either obstruction (N=2) or electrolyte imbalance (N=2) related to DLBCL, and undefined causes (N=10). Patients with baseline RI showed inferior overall survival (OS) compared to those without RI (P<0.001). In multivariate analysis, RI was identified as an International Prognostic Index (IPI)-independent prognostic indicator. A baseline hemoglobin level of <10 g/dL and the presence of RI effectively discriminated a portion of the patients with far inferior event-free survival and OS among the patients having high or high-intermediate risk can-cers according to either the standard- or the National Comprehensive Cancer Network-IPI.ConclusionPretreatment RI was an independent prognostic marker for inferior OS in patients with DLBCL treated with R-CHOP21 immunochemotherapy.
Korean Patients with Superwarfarin Intoxication and Their Outcome
홍준식,임호영,방수미,배성화,유영진,윤성수,윤휘중,김승택,지현숙 대한의학회 2010 Journal of Korean medical science Vol.25 No.12
This observational study aimed at evaluating recent superwarfarin intoxication of Korean patients. Ten patients were diagnosed as or highly suspicious for superwarfarin intoxication. Case report forms described by attending hematologists of the patients were collected and analyzed. Bleeding symptoms were varied among the patients. Patients uniformly showed prolonged prothrombin time (PT) and activated thromboplastin time (aPTT) with decreased activity of vitamin K dependent coagulation factors. Positive serum brodifacoum test results in 4 of 5 requested patients contributed to confirmatory diagnosis. Psychiatric interview revealed an attempted ingestion in one patient. High dose vitamin K1 therapy promptly corrected prolonged PT and aPTT, but hasty discontinuation caused repeated bleeding diathesis in 6 patients. Route of intoxication was unknown or not definite among 8 of 10 patients. Three patients had a possibility of environmental exposure considering their occupations: there might be intoxication by transdermal absorption or inhalation. Therefore, high dose and prolonged use of vitamin K1 therapy is necessary for effective detoxification. Further detailed investigation on environmental exposure and efforts to improve availability of the blood level test in clinic are requested.
독립성분해석 기법과 인근평균 및 정규화를 이용한 영상분류 방법
홍준식,유정웅,김성수,Hong, Jun-Sik,Yu, Jeong-Ung,Kim, Seong-Su 한국정보처리학회 2001 정보처리학회논문지B Vol.8 No.4
본 논문에서는 독립 성분 해석(Independent Component Analysis, ICA) 기법과 인근 평균 및 정규화를 이용한 영상 분류 방법을 제안하였다. ICA에 잡음을 주어 영상을 분류하였을 때, 잡음에 대한 강인성을 증가시키기 위하여, 제안된 인근 평균 및 정규화를 전처리로 적용하였다. 제안된 방법은 전처리 없이 ICA에 주성분 해석(Principal Component Analysis, PCA)을 이용한 것에 비해 잡음에 대한 강인성을 증가시키는 것을 모의 실험을 통하여 확인하였다.
홍준식 대한내과학회 2024 대한내과학회지 Vol.99 No.1
Myelodysplastic syndrome (MDS) is a heterogeneous disorder with diverse prognoses influenced by cytopenias, genetic variants, and myeloblast proportions in the bone marrow. Accurate prognosis prediction and tailored treatment plans are essential. The International Prognostic Scoring System-Molecular (IPSS-M), which additionally reflects the impact of MDS-related genetic mutations to the clinical and laboratory information, is anticipated to offer superior prognostic accuracy compared to existing systems like the Revised International Prognostic Scoring System (IPSS-R). Despite its statistical complexity, its web-based calculation and ease of discussing results with patients using intuitive data sets provide notable advantages. Progress in MDS treatment, exemplified by effective anemia correction with an erythropoiesis-maturation agent in SF3B1-mutated cases and efforts to refine poor prognoses in TP53-mutated cases, reflects the evolving landscape of genetic-based interventions in MDS. Advancements in genetic diagnostic technology, combined with enhanced knowledge of the bone marrow niche, are anticipated to lead to significant improvement in MDS treatment outcomes in the future.
PCR 핵산 지문법에 의한 Dianthus속의 유연관계분석
홍준식,이문원,강권규 안성산업대학교 2002 論文集 Vol.33 No.-
This study was conducted to evaluate the ressibility of various Dianthus species as ornamental plants based on morphological characteristics and to analyze the genetic relationship among the Dianthus species. D. chinensis, D. curthusiamoum, D. arenorisus, D. superbus and D. barbatus possessing spendour flowering cluster with pink and red color could be suggested for garden plant, with D. caryophyllus having red flower clusters with linear leaf shape for pot flower or garden plant. Twelve oligonucleotide random primers were used to amplify genomic DNA of Dianthus species using polymerase chain reaction. Ninety-five polymorphic bands in the range of 300 to 3,500 bp were obtained from PCR fingerprinting. Similairity matrix of PCR fingerprinting profiles was generated by coefficient value, and the data were subjected to cluster analysis. Thirty-four Dianthus species analyzed were classified into 5 groups with similarity coefficient value of 0.84 and 12 groups with the value of 0.88. PCR fingerprinting rusults showed similar trends as the morphological characteristics of the plants.
A case report of hidradenitis suppurativa after subdermal excision for axillary osmidrosis
홍준식,Jung Hwan Kim,Gyu Yong Jung,Joon Ho Lee,Tae Jung Jang,Hea Kyeong Shin 대한미용성형외과학회 2020 Archives of Aesthetic Plastic Surgery Vol.26 No.2
Hidradenitis suppurativa (HS) is a chronic inflammatory condition with an unclear etiopathogenesis that is considered to be a follicular occlusive disease. We present a case of HS that was suspected to have developed as a complication of subdermal excision. A 19-year-old man who had undergone subdermal excision due to osmidrosis presented 7 months after surgery with a persistent painful mass in his left axilla. Despite medical treatment, incision, and drainage, a painful enlarged abscess recurred in the left axilla and was cured completely by deroofing surgery. However, 15 months after subdermal excision, he revisited the hospital because of a painful mass in the right axilla. The patient’s condition met the diagnostic criteria of HS. After several recurrences, a cure was achieved by radical wide excision. Mechanical stress like that associated with subdermal excision is considered to be a possible etiological factor of HS. In addition, pathological changes at the sebofollicular junction allow rupture and leakage of folliculopilosebaceous units upon exposure to mechanical stress, which may result in the aggressive subcutaneous extension of inflammation. We suggest that HS should be considered in patients with a recurrent abscess after subdermal excision, and recommend surgical treatment as a possible option if conservative treatment is clinically ineffective.