사용후기가 제품에 대한 판단에 미치는 영향: 정정 메시지와 시간경과의 역할을 중심으로

홍석순,전우영 한국사회및성격심리학회 2010 한국심리학회지 사회 및 성격 Vol.24 No.3

This study examined the effects of online reviews, correction messages and the passage of time on judgments of a product. The results indicate that the influence of online reviews on participants' judgements of the product decreases when the correction message was provided, compared to the case with no correction message. In addition, the effect of the online reviews on the purchase intention was observed to be weaker as time passing when the correction message was not present. The role of online reviews, correction messages and the passage of time in internet shopping and their implications on judgments and decision makings were discussed. 본 연구에서는 사용후기가 제품에 대한 판단에 미치는 영향이 정정 메시지와 시간경과에 의해 어떻게 변화되는지를 알아보았다. 연구 결과에 의하면, 사용후기가 제품판단에 미치는 영향은 정정 메시지가 제공되었을 경우, 정정 메시지가 제공되지 않았을 때 보다, 감소되는 것으로 나타났다. 또한 사용후기가 구매의도와 관련된 판단에 미치는 영향은, 정정 메시지가 주어지지 않았을 경우에, 정보제공 후 바로 판단이 이루어졌을 때 보다 일정시간이 지난 후 판단이 이루어졌을 때 감소하는 것으로 나타났다. 논의에서는 인터넷 쇼핑 상황에서 사용후기, 정정 메시지 그리고 시간경과의 역할과 이것이 판단 및 의사결정에 시사하는 점에 대하여 살펴보았다.

β-Lactam 유도체의 합성과 항균작용에 관한 연구

洪錫淳,金京洙,金泳秀,姜馨龍,高玉鉉 조선대학교 약학연구소 1991 藥學硏究誌 Vol.13 No.1

7β-〔5-(4-Nitrobenzyl)-2H-tetrazolyl-2acetamido〕cephalosphoranic acid was synthesized by condensation of 7-Aminocephalosporanic Acid(7-ACA) with 〔5-(4-Nitrobenzyl)-2H-tetrazol-2-yl〕acetyl chloride. This compound was tested for antimicrobial activity in vitro against Bacillus licheniformis ATCC 14580, Bucillus subtilis ATCC 6633, Candida albicans ATCC 10231, Escherichia Coli ESS, Micrococcus luteus ATCC 9341, Pseudomonas aeruginosa IFO 13130, Staphylococcus aureus ATCC 25923, Staphylococcus aureus FDA-209p and Salmonella typhimurium SL 1102. This comound revealed significant antibacterial activity against Bacillus subtilis ATCC 6633, Micrococcus luteus ATCC 9341, Staphylococcus aureus ATCC 25923, and Staphylococcus aureus FDA-209p. but showed less antimicrobial activity than cephradine and cefazoline for other organisms.

Cortisone이 肺胞貪細胞의 貪食機能에 미치는 影響에 關한 電子顯微鏡的 硏究

郭碩淳,洪錫宰 慶北大學校 醫科大學 1973 慶北醫大雜誌 Vol.14 No.2

Cortisone이 肺胞貪細胞의 貪식機能에 미치는 影響에 關한 電子顯微鏡的 硏究

郭碩淳,洪錫宰 慶北大學校 醫科大學 1973 慶北醫大誌 Vol.14 No.2

著者는 正常白鼠 및 cortisone을 多量으로 投與한 白鼠에 墨汁을 血管內로 注入하고 肺胞食細胞들의 食 機能과 이들 細胞內小器官들의 變化 그리고 肺胞上皮細胞들의 變化를 病理組織學的 및 電子顯微鏡的으로 檢索하여 다음과 같은 結果를 얻었다. 1) 光學顯微鏡的으로는 cortisone을 多量으로 投與하여 綱內系를 塡塞한 實驗群에 있어서 肺組織의 炭粉沈着程度는 cortisone을 投與하지 않고 墨汁만 注入한 對照群에 있어서의 그것과 別差異가 없었으며 또 特記할만한 組織所見도 認定되지 않았다. 2) 電子顯微鏡的으로는 墨汁만 注入한 對照群에 있어서는 肺胞食細胞들은 活潑하게 炭粉을 食 하고 있었으나, cortisone을 投與하고 墨汁을 注入한 實驗群에 있어서는 炭粉이 極히 微弱한 程度로 탐식되었다. 그리고 對照群 및 實驗群에서 다같이 Ⅱ型 肺胞細胞의 osmiophilic inclusion body內의 多量의 炭粉이 沈着되어 있는 것이 特異하였다. 3) 上記 實驗成績으로 보아 墨汁을 血管內로 注入할 때에 肺에 있어서는 肺胞食細胞에 依한 食 보다도 더 많은 量의 炭粉이 Ⅱ型 肺胞細胞의 osmiophilic inclusion body內에 沈着되는 것으로 推定되며, 이 Ⅱ型 肺胞細胞內 炭粉沈着 現象은 cortisone의 影響을 別로 받지 않는 것으로 보인다. It is well known that the phagocytic action of the cells of the reticuloendothelial system play an imoprtant role in the immunological reaction and as a barrier against foreign bodies. It is also known that when the reticuloendothelial system is blockaded by cortisone, and adherence of the foreign bodies to the cell membranes of the phagocytes, an initial step of the phagocytic mechanism, and an absorption of the foreign bodies into the cytoplasms of the phagocytes are considerably disturbed. An investgation was undertaken to study this phagocitic activity of the alveolar macrophages and phagocytic functional aspect of the alveolar lining cells when sufficient doses of cortisone were dministered to experimental animals with a resultant reticulocendothelial system blockade, by light and electron microscopic examination. Eighteen albino rats, maintained on a stock diet, weighing about 200 gm average, were divided into 3 experimental groups. Group 1. congrol group. No intravenous injection of india ink given. a. 3 rats, untreated. b. 3 rats: a dose of 25 mg of cortisone acetate was given intramuscularly for 3 consecutive days. Group 2. 6 rats: A single dose of 2.0ml of 2% india ink in normal saline was given into the each tail veins. Group 3. 6 rats: A dose of 25mg of cortisone acetate was given intramucularly, once a day, for 3 consecutive days, Starting on the 4th day, a 2.0ml of 2% india ink in normal saline was administered once intravenously. The experimental rats were sacrificed each 15 minutes (3 rats) and 30 minutes (3 rats) after the treatment of india ink preparation from the group 2 and 3. The control group was sacrificed 24 hours after the last treatment of cortisone acetate. The the lung was extirpated and inspected for carvon pigmentation of the lung tissue, followed by both light and electron microscopic examinations. The results were as follows: 1. Light microscopic observations: In the experimental group of rats treated with 25mg doese of cortisone acetate with a resultant reticuloendothelial system blockade followed by an india ink injection (group 3), the degree of carbon particle deposition in the lung tissue was not diminshed over the group of rats treated with india ink only (group 2). 2. Electron Microscopic observations: In the control group of rats treated with india only (group 2), the alvolar macrophages were very active in engulfing the carbon paticles. In this group, a large quantity of carbon particles were found to be contained in phagosomes. However, in contrast to the control group, in the experimental group of rats treated with cortisone followed by an india ink injection (group 3), the phagocytic activity of the alveolar macrophages were poorly recognizable. Only a few pahgosomes bearing particles were found in the alveolar macrophages. Unexpectedly, a large quantity of carbon particles were accumulated in the osmiophilic inclusion bodies of the type Ⅱ alveolar cells in both the control and experimental groups. In conclusion then, as aslready described above, it was found that a considerably large quantity of carbon paricles were found in the osmiophilic inclusion bodies of the type Ⅱ alvolar cells than found in the alveolar macrophages when 2% india ink preparation was administered into the tail veins of both experimental and control group rats with or without cortisone pretratment. This massive accumulation of carbon particles in the osmiophilic inclusion bodies of the type Ⅱ alveolar cells does not appear to be affcted by cortisone administration with a resultant reticuloendothelial system blockade as is the case of alvelar macro phages which were singificantly inhibited of their phagccytic activity by cortisone treatment.

7β-〔2-Ethoxymethyl-3-(5-Nitro-2-Furyl) Acryl〕Aminocephalosporanic Acid의 合成 및 抗菌作用에 關한 硏究

金京洙,金永秀,洪石淳,高玉鉉,姜馨龍 조선대학교 약학연구소 1991 藥學硏究誌 Vol.13 No.1

7β〔2-Ethoxymethyl-3-(5-nitro-2-furyl) acryl〕aminocephalosporin was synt hesized by condensation of 7-Aminocephalosporanic acid(7-ACA) with 2-Ethoxymethyl-3 (5-nitro-2-furyl) acrylchloride. This compound was tested for antimicrobial activity in vitro against nine species of bacteria, such as Bacillus licheniformis ATCC 14580, Bacillus subtillus ATCC 6633, Candida albicans ATCC 10231, Escherichia coli ESS, Micrococcus luteus ATCC 9311, Pseudomonas aeruginosa IFO 13130, Staphylococcus aureus ATCC 25923, Staphylococcus aureus FDA 209p and Salmonella typhimurium SL 1102. This compound revealed significant antibacterial activity against Bacillus subtilis ATCC 6633 and Micrococcus luteus ATCC 9341, but showed less antimicrobial activity than cephradine and cefazoline for other microorganisms.

교단기관 / 기관란 / 여전도회

배가례,이옥희,홍석순 기독교대한성결교회 활천사 1971 활천 Vol.356 No.-

7β-(5-Phenyl-2H-Tetrazolyl-2-Acetamido) Cephalosporanic Acid의 合成 및 抗菌作用에 관한 硏究

高玉鉉,姜馨龍,金京洙,金泳秀,洪石淳,金燦範 조선대학교 약학연구소 1992 藥學硏究誌 Vol.14 No.1

7β-(5-Phenyl-2H-tetrazolyl-2-acetamido) cephalosporanic acid was synthesized by condensation of 7-aminocephalosporanic acid(7-ACA) with(5-phenyl-2H-tetrazol-2-yl) acetyl chloride. This compound was tested for antimicrobial activity in vitro against Bacillus licheniformis ATCC 14580, Bacillus subtilis ATCC 6633, Candida albicans ATCC 10231, Escherichia coli ESS, Micrococcus luteus ATCC 9341, Pseudomonas aeruginosa IFO 13130, Staphylococcus aureus ATCC25923, Staphylococcus aureuss FDA-209p and Salmonella typhimurium SL 1102. This compound revealed excellent antibacterial activity against Bacillus subtilis ATCC 6633, Micrococcus luteus ATCC 9341, Staphylococcus aureus ATCC 25923 and Staphlococcus aureus FDA 209p. This compound have no antimicrobial activity against Candida albicans ATCC 10231, Pseudomonas aeruginosa IFO 13130 and Salmonella typhimurium SL 1102.

전남지역강수의 산성도와 무기이온농도에 관한 연구 ( I ) - ph 와 전기전도도를 중심으로 - ( Studies on the Acidity and Nonorganic ions of Precipitation in Chonnam Area ( I ) - pH and Conductivity -

양수인,강광성,양정고,박찬옥,홍석순,박귀님,김익산,김경수,오길영 한국대기환경학회 1995 한국대기환경학회 학술대회논문집 Vol.- No.-

초록집 ( 1993 . 4 . 15 ) : 1993 년도 신약개발 연구결과 / 미발표 결과 목차 ; 신규 베타락탐계 항생제 합성과 항균성

고옥현,강형룡,유진철,김경수,홍석순,김영수,황화영,하재천 한국응용약물학회 1993 학술대회 Vol.1993 No.1

NF-κB 활성 저해를 통한 협죽도 에탄올 추출물의 항염증 효능

김태환(Tae-Hwan Kim),고석순(Seog Soon Ko),박철(Cheol Park),박상은(Sang-Eun Park),홍상훈(Sang-Hoon Hong),김병우(Byung Woo Kim),최영현(Yung Hyun Choi) 한국생명과학회 2010 생명과학회지 Vol.20 No.8

정상세포뿐 만 아니라 형질 전환된 세포의 증식조절에 중요한 역할을 하는 것으로 알려진 COX-2는 전사조절 인자인 NF-κB에 의해서 조절되며, 염증반응에 있어서 중요한 역할을 하는 PGE2의 생성에 관여하는 것으로 알려져 있다. 본 연구에서는 U937 인체혈구세포에서 염증유발인자인 PMA에 의해서 유발되는 염증반응에 있어서 중요한 역할을 하는 COX-2 및 COX-2의 산물인 PGE2와 COX-2의 발현에 영향을 미치는 전사조절인자인 NF-κB의 발현에 협죽도 잎 및 줄기의 에탄올 추출물인 ENIL 및 ENIS가 어떠한 영향을 미치는 지를 조사하였다. PMA가 처리된 U937 세포에서 COX-1의 발현에는 아무런 영향을 미치지 못하였지만 COX-2의 발현 증가가 유도되었고 이에 따른 PGE2의 생성이 증가되었다. PMA에 의해서 증가된 COX-2의 발현이 ENIS 선처리에 의하여 거의 완벽하게 억제되었고 그에 따른 PGE2의 생성도 현저하게 감소되었다. ENIS에 의한 COX-2의 발현 및 PGE2의 생성억제가 전사조절인자인 NF-κB와 상관성이 있는지를 조사한 결과, 핵 내로의 NF-κB 이동이 ENIS 선처리에 의하여 억제되는 것으로 나타났다. 이는 ENIS가 NF-κB의 활성 억제를 통하여 COX-2의 발현 및 PGE2의 생성을 효과적으로 억제함으로서 항염증 효능을 가진다는 것을 의미하는 결과이다. 하지만 ENIL의 경우에는 이상에서와 같은 이러한 변화들이 매우 약하게 나타나는 것으로 조사되어 ENIS와 비교해서 항염증 효능이 낮은 것으로 나타났다. 본 연구 결과는 협죽도의 항염증기전에 대한 생화학적 해석 및 이를 활용한 향후 지속적인 연구를 위한 귀중한 자료가 될 것으로 생각된다. Nerium indicum, an India-Pakistan-originated shrub belonging to the oleander family, is reported to possess many pharmacological activities including cardiac muscle stimulation, and anti-diabetes, anti-angiogenesis, anti-cancer and neuro-protective activities. However, the anti-inflammatory properties of N. indicum were unclear. In this study, we investigated the effects of ethanol extract of the N. indicum leaf and stem (ENIL and ENIS) on the expression of anti-inflammatory mediators in U937 human pre-monocytic cell models. In U937 cells stimulated with phorbol 12-myristate-13-acetate (PMA), pre-treatment with ENIS significantly inhibited the expression of both cyclooxygenase-2 (COX-2) mRNA and protein, which are associated with inhibition of the release of prostaglandin E₂ (PGE₂), whereas the inhibitory effects appeared weakly in ENIL. Moreover, ENIS significantly attenuated PMA-induced IkappaB (IκB) degradation and suppressed elevated nuclear factor kappa B (NF-κB) nuclear translocation. Taken together, these findings provide important new insights that N. indicum exhibits anti-inflammatory properties by suppressing the transcription of pro-inflammatory cytokine genes through the NF-kB signaling pathway.