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현진남 ( Jin Nam Hyun ),이준호 ( Jun Ho Lee ),이지연 ( Ji Yeon Lee ),김소미 ( So Mi Kim ),유우주 ( Woo Joo Yoo ),김석영 ( Seok Yeong Kim ),유현주 ( Hyun Ju Yoo ) 대한내과학회 2007 대한내과학회지 Vol.73 No.5
저자들은 급격히 발생한 복통을 주소로 내원한 환자에서 상부 위장관 내시경 검사, 대장내시경검사, 내시경하 생검조직의 조직학적 검사, 복부 전산화 단층 촬영 및 복수 천자 검사 등을 시행한 결과 전 장관을 침범한 장막형 호산구성 위장염으로 진단하였고, 스테로이드 치료로 빠르게 호전되었기에 문헌고찰과 함께 보고하는 바이다. Eosinophilic gastroenteritis is an uncommon disease of unknown cause characterized by eosinophilic infiltration in various areas of the gastrointestinal tract with gastrointestinal symptoms. It is generally classified according to the layer of the gastrointestinal tract involved. Eosinophilic infiltration of the serosa is the rarest form of presentation and may manifest eosinophilic ascites. We report a case of a 29-year-old woman who experienced rapidly progressing abdominal distension and pain. A diffuse erythematous change of the gastric mucosa was observed on gastroscopy. An abdominal computed tomography and colonoscopy showed diffuse wall thickening of the small bowel and colon with a large amount of ascites. Eosinophilic infiltration was confirmed by multiple biopsies of the gastrointestinal tract and peritoneal fluid analysis. The patient was treated with corticosteroid and responded dramatically.(Korean J Med 73:535-538, 2007)
이지연,이현정,이종섭,현진남,김소미,김석영,이원준,최승진,전일영,오동준 대한소화기내시경학회 2007 Clinical Endoscopy Vol.35 No.2
Double pylorus is a rare abnormality of the gastrointestinal tract and it presents as two openings between the gastric antrum and the duodenal bulb. The acquired type is more common than the congenital one and this acquired type arises secondary to peptic ulcer disease. A 68-year-old man visited the gastrointestinal clinic and he presented with chronic epigastric pain and dyspepsia. Upper endoscopy showed double pylorus with an accessory channel on the lesser curvature side of the prepyloric antrum and also an active duodenal ulcer. Upon review of the patient's past history and examination, the findings of the upper endoscopy that was done 7 years previously were within the normal limits. The patient was diagnosed as having a double pylorus secondary to duodenal ulcer and he treated conservatively with anti-ulcer therapy. We report here on a case of double pylorus along with the brief review of the literature. (Korean J Gastrointest Endosc 2007;35:96-99) 중복 유문은 십이지장 구부와 위 전정부 사이를 연결하는 교통로인 유문륜이 두 개인 드문 위장관 기형 중 하나이다. 중복 유문의 원인은 게실이나 낭종 등에 의한 선천적인 경우와 소화성 궤양 등에 의한 후천적인 경우로 생각할 수 있으나 명확하진 않다. 7년 전 시행한 상부 위장관 내시경 검사에서 만성 위염 외에 특이 소견이 없었던 68세 남자 환자가 상복부 통증과 소화 불량을 주소로 본원에 내원하였다. 내시경 검사에서 십이지장 궤양과 함께 중복 유문이 관찰되었고 3개월 후 시행한 추적 내시경 검사에서 십이지장 궤양은 치유되었으나 중복 유문은 지속되는 것이 관찰되었다. 저자들은 십이지장 궤양에 의해 후천적으로 발생된 중복 유문 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.
Validation of the Oxford Classification of IgA Nephropathy: A Single-Center Study in Korean Adults
이호영,이설희,서미선,현진남,전진석,노현진,한동철,황승덕,진소영,권순효 대한내과학회 2012 The Korean Journal of Internal Medicine Vol.27 No.3
Background/Aims: The recently published Oxford classification of IgA nephropathy (IgAN) proposed a split system for histological grading, based on prognostic pathological features. This new classification system must be validated in a variety of cohorts. We investigated whether these pathological features were applicable to an adult Korean population. Methods: In total, 69 adult Korean patients with IgAN were analyzed using the Oxford classification system at Soonchunhyang University Hospital, Seoul, Korea. All cases were categorized according to Lee’s classification. Renal biopsies from all patients were scored by a pathologist who was blinded to the clinical data for pathological variables. Inclusion criteria were age greater than 18 years and at least 36 months of follow-up. We excluded cases with secondary IgAN, diabetic nephropathy combined other glomerulopathies, less than 36 months of follow-up, and those that progressed rapidly. Results: The median age of the patients was 34 years (range, 27 to 45). Mean arterial blood pressure was 97 ± 10 mmHg at the time of biopsy. The median follow-up period was 85 months (range, 60 to 114). Kaplan‑Meier analysis showed significant prognostic predictions for M, E, and T lesions. A Cox proportional hazard regression analysis also revealed prognostic predictions for E and T lesions. Conclusions: Using the Oxford classification in IgAN, E, and T lesions predicted renal outcome in Korean adults after taking clinical variables into account. Background/Aims: The recently published Oxford classification of IgA nephropathy (IgAN) proposed a split system for histological grading, based on prognostic pathological features. This new classification system must be validated in a variety of cohorts. We investigated whether these pathological features were applicable to an adult Korean population. Methods: In total, 69 adult Korean patients with IgAN were analyzed using the Oxford classification system at Soonchunhyang University Hospital, Seoul, Korea. All cases were categorized according to Lee’s classification. Renal biopsies from all patients were scored by a pathologist who was blinded to the clinical data for pathological variables. Inclusion criteria were age greater than 18 years and at least 36 months of follow-up. We excluded cases with secondary IgAN, diabetic nephropathy combined other glomerulopathies, less than 36 months of follow-up, and those that progressed rapidly. Results: The median age of the patients was 34 years (range, 27 to 45). Mean arterial blood pressure was 97 ± 10 mmHg at the time of biopsy. The median follow-up period was 85 months (range, 60 to 114). Kaplan‑Meier analysis showed significant prognostic predictions for M, E, and T lesions. A Cox proportional hazard regression analysis also revealed prognostic predictions for E and T lesions. Conclusions: Using the Oxford classification in IgAN, E, and T lesions predicted renal outcome in Korean adults after taking clinical variables into account.