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뇌실내 Calcitonin 투여로 인한 위산분비 억제에 대한 뇌내 신경전달체의 역할
장우익(Woo Ick Jang),이동기(Dong Ki Lee),권상옥(Sang Ok Kwon),고창만(Chang Mann Ko),현재헌(Jae Hun Hyun),김상태(Sang Tae Kim),이상인(Sang In Lee),최흥재(Heung Jai Choi),김경환(Kyung Hwan Kim) 대한내과학회 1991 대한내과학회지 Vol.40 No.5
N/A Peptides that are common to the brain and gut are thought to play intermediary roles as neurotransmitters or neuromodulators in the regulation of gut function. Calcitonin is a polypeptide hormone of 32 amino acid residues. Recently, much evidence has been accumulated to suggest that calcitonin may inhibit gastric acid secretion by a central action, but the neurohumoral pathways mediating the antisecretory effects of calcitonin in rats are not well elucidated. In the present study, using a gastric perfusion technique, the effects of ICV administration of calcitonin on gastric acid secretion stimulated by baclofen were investigated in rats. We also investigated whether the serotonergic system is involved in calcitonin's effect of gastric acid secretion. The results obtained were as follows: 1) ICV administration of baclofen stimulated gastric acid secretion in a dose-dependent manner. Central administration of baclofen was approximately 200-400 times more sensitive than subcutaneous administration. 2) Baclofen-induced gastric acid secretion was partially suppressed by bilateral vagotomy. 3) Gastric acid secretion stimulated by baclofen was markedly suppressed by ICV administration of calcitonin. 4) Depletion of brain serotonin with the neurotoxin 5, 7-dihydroxytryptamine did not influence calcitonin-induced gestric acid suppression. In this study it was demonstrated that centrally- administered calcitonin suppresses baclofen-induced gastric acid secretion. Also. it is suggested that the serotonergic system is not involved in calcitonin-induced gastric acid suppression.