[연극(4)] 재공연되는 두 작품에 대한 단상

현재원 현대미학사 2004 공연과 리뷰 Vol.46 No.-

암 환자에서 연수막 전이 진단표지자로서의 뇌척수액 CYFRA 21-1

현재원,김선영,신형식,윤지영,김소연,김수현,김종국,정지향,유헌,곽호신,김호진 대한신경과학회 2019 대한신경과학회지 Vol.37 No.2

Background: The early and accurate diagnosis of leptomeningeal metastasis (LM) has become important because of introduction of new therapeutic strategies for LM and increasing incidence of LM along with longer survival of cancer patients. We aimed to evaluate the role of cerebrospinal fluid (CSF) CYFRA 21-1 as a diagnostic indicator for LM in patients with cancer. Methods: CSF CYFRA 21-1 level was analyzed using electro-chemiluminescent immunoassay. The difference in concentration of CSF CYFRA 21-1 between 91 patients with LM and 339 control groups (patients with other neurological disease or healthy controls) was investigated. The cut-off value of CSF CYFRA 21-1 as a diagnostic indicator for LM and its diagnostic performance were evaluated. Results: The CSF CYFRA 21-1 was significantly higher in LM patients than control groups (p<0.001). A cut-off value of diagnosis for LM in patients with cancer was 1.59 ng/mL. The sensitivity, specificity, accuracy, and positive and negative predictive values of CSF CYFRA 21-1 were 80.2%, 96.2%, 92.8%, 84.9%, 94.8% for diagnosis of LM. Conclusions: These results suggested that CSF CYFRA 21-1 can be an additional diagnostic indicator for cancer patients with LM.

새로운 農村指導事業 方向

현재원 한국농촌지도학회 1995 농촌지도와 개발 Vol.2 No.1

수면 연관 장애과 중추신경계 염증성 질환

현재원,김수현,김호진 대한수면연구학회 2020 Journal of sleep medicine Vol.17 No.2

Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory diseases of the central nervous system and inflammatory conditions involving sleep-related anatomical structures, associated with sleep-related disorders. After the identification of pathogenic anti-aquaporin-4 antibodies, NMOSD–previously considered a variant of MS–is now regarded as a distinct entity. A higher prevalence of sleep-related disorders is reported in individuals with MS compared to the general population, and recent evidence suggests the same is true in NMOSD. Timely recognition and multidisciplinary therapeutic approaches for sleep-related disorders in individuals with MS or NMOSD improve the patient’s quality of sleep and life. Therefore, this review aims to provide clinicians with a comprehensive understanding of the comorbid conditions and diagnostic and therapeutic strategies in clinical practice.

카프 연극대중화론에서 이동식 극장의 역할과 의미

현재원 成均館大學校 大學院 1994 首善論集 Vol.19 No.-

[연극(4)] 원작의 하중, 극적 재미, 그리고 연출가

현재원 현대미학사 2004 공연과 리뷰 Vol.45 No.-

Therapeutic Outcome of Alemtuzumab in Korean Patients with Multiple Sclerosis: 2-Year Follow-Up

현재원,신현준,장현민,박나영,김수현,김호진 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.3

Background and Purpose Alemtuzumab has shown high efficacy in clinical trials that primarily involved Western multiple sclerosis (MS) patients. To evaluate the therapeutic outcome of alemtuzumab in Korean patients with MS. Methods This study enrolled 23 consecutive patients who were treated with alemtuzumab from 2015 to 2018. Efficacy was evaluated using the annualized relapse rate (ARR), Expanded Disability Status Scale (EDSS), and radiological activity. No evidence of disease activity (NEDA) was defined as no clinical relapse, no worsening of the EDSS score, and no radiological activity. The safety profiles were also assessed. Results The mean age was 36 years and 16 of the patients were female. Seventeen and 12 of 23 patients were followed up for 1 year and 2 years, respectively. The ARR was markedly reduced from 1.52 during the 1-year period preceding alemtuzumab administration to 0.21 after initiating alemtuzumab (p<0.001). During the first and second years after initiating alemtuzumab, EDSS worsening was observed in 3 (18%) and 0 (0%) patients, respectively, and radiological activity was exhibited in 9 (53%) and 4 (33%). NEDA was observed in 6 (35%) patients during the first year and in 8 (67%) patients during the second year. Intriguingly, one patient experienced 2 severe clinical exacerbations, which occurred at 10 months after the first and 10 months after the second infusion of alemtuzumab. Nineteen of the 23 patients exhibited infusion-associated reactions and 3 patients exhibited herpes zoster infection. Thyroid dysfunction occurred in two patients at 18 and 20 months after initiating alemtuzumab. Conclusions Consistent with observations in Western populations, alemtuzumab therapy in Korean MS patients led to marked reductions of disease activity without unexpected safety issues.

임상간호사의 도덕적 용기에 영향을 미치는 요인

현재원,김도연,박지수,최연수,최윤영,김상희 한국의료윤리학회 2021 한국의료윤리학회지 Vol.24 No.1

Although moral courage can play an important role in resolving some of the ethical dilemmas faced by clinical nurses, the concept of moral courage is in need of greater clarification. This study investigates some of the factors that influence moral courage, including moral sensitivity, ethical decision-making confidence, and ethical environment. A total of 148 nurses agreed to participate in an online survey for this study. The collected data were analyzed with Pearson’s correlation coefficient and multiple regression using the IBM SPSS 24 program. The analysis indicates that moral courage has a significant correlation with moral sensitivity (r=.55, p<.001), ethical decision-making confidence (r=.65, p<.001), and ethical environment (r=.66, p<.001). Ethical decision-making confidence and ethical environment were derived as factors that affect moral courage, and the explanatory power of these variables is 52.0% (F=20.94, p<.001). These findings justify the creation of ethical clinical environments in which nurses’ ethical decision-making confidence can be expressed as actual behavior. In addition, it is argued that ethical regulations and guidelines within clinical settings should be clarified in order to establish support systems that protect the well-being of patients and reflect the true value of professional nurses. 본 연구는 임상간호사를 대상으로 도덕적 민감성, 윤리적 의사결정 자신감, 윤리적 환경과 도덕적 용기의 정도와 관계를 파악하고 더 나아가 도덕적 용기에 영향을 미치는 요인을 파악하고자 시도되었다. 자발적으로 연구 참여에 동의한 임상간호사를 대상으로 온라인 설문조사 프로그램을 통하여, 총 148명의 응답 자료를 수집하였고 최종 분석에 사용하였다. 수집된 자료는 SPSS/WIN 24.0 프로그램을 이용하여 빈도와 백분율, 평균, 표준편차, Independent t-test, ANOVA, Pearson’s correlation coefficient와 Multiple regression으로 분석하였다. 연구결과 임상간호사의 도덕적 용기는 도덕적 민감성(r=.55, p<.001), 윤리적 의사결정 자신감(r=.65, p<.001), 윤리적 환경(r=.66, p<.001)과 통계적으로 유의한 상관관계가 있었고, 임상간호사의 도덕적 용기에 유의한 영향을 미치는 요인으로 윤리적 의사결정 자신감과 윤리적 환경이 도출되었으며, 이들 변수의 설명력은 52.0%로 나타났다(F=20.94, p<.001). 본 연구결과를 바탕으로 임상간호사의 윤리적 의사결정 자신감이 실제 행위로 표출될 수 있도록 하는 윤리적 임상 환경 조성이 필요하며, 아울러 간호 조직 내 생명윤리 규정이나 지침을 구체화하여, 조직의 불명확한 규정이나 지침 때문에 간호사가 다수의 의견에 휩쓸리거나 동료 간 신의를 지키기 위해 행동하는 것이 아니라 대상자의 안녕을 유지하고 전문직 간호사로서의 가치를 실현할 수 있도록 하는 지지적 체계가 구축되어야 할 것이다.

Comparison of Neuropathic Pain in Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis

현재원,장현민,유재빈,박나영,김수현,허소영,김우준,박민수,오지영,박기덕,김호진 대한신경과학회 2020 Journal of Clinical Neurology Vol.16 No.1

Background and Purpose To compare the characteristics of neuropathic pain in neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). Methods From 2016 to 2018, 500 patients with NMOSD and MS from 6 referral hospitals in Korea underwent pain investigation. After the patients with current pain were matched for sex ratio and disease duration as confounding factors, PainDETECT questionnaires were assessed in 99 NMOSD and 58 MS patients to investigate neuropathic pain. The short form of the Brief Pain Inventory from 74 patients with neuropathic pain component was also analysed. Results According to the PainDETECT questionnaire, mechanical allodynia (p=0.014) and thermal hyperalgesia (p=0.011) were more severe in NMOSD patients than in MS patients. Strong involvements (score >3) of the pain in domains of tingling/prickling sensation (p=0.024), mechanical allodynia (p=0.027), sudden pain attacks (p=0.018), and thermal hyperalgesia (p=0.002) were significantly more frequent in NMOSD compared to MS patients. Among the patients experiencing pain with a neuropathic component, total pain-related interference (p= 0.045) scores were significantly higher in NMOSD patients than in MS patients. In daily life, pain interfered with normal work (p=0.045) and relationships with other people (p=0.039) more often in NMOSD patients than in MS patients. Although pain medication was prescribed more frequently in NMOSD patients, the percentage of patients experiencing medication-related pain relief was lower in those patients. Conclusions The severity of neuropathic pain and the pain-related interference in daily life were greater in NMOSD patients than in MS patients. Individualized analgesic management should be considered based on a comprehensive understanding of neuropathic pain in these patients

[공연] 독재철학과 이성주의의 대결 - 〈불의 가면 - 권력의 형식〉

현재원 새가정사 1993 새가정 Vol.- No.-