http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
악성 흉선종에서 관찰된 Tc-99m MIBI와 TI-201의 섭취
현인영 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.4
Tc-99m methoxyisobutylisonitrile (MIBI) and Tl-201/technetium subtraction scintigraphy have been used for localization of abnormal parathyroid gland. The uptake mechanism of tracers has been postulated to be increased cellular density and vascularity, or dependent on the presence of mitochondria-rich cells. However, the uptake of these tracers was not specific for abnormal parathyroid gland. The author report a case of thymic carcinoma that would have been mistaken for carcinoma of parathyroid because of Tc-99m MIBI and Tl-201 uptake.
Tc-99m MIBI and Tl-201 Uptake in a Thymic Carcinoma
현인영,Hyun, In-Young The Korea Society of Nuclear Medicine 2003 핵의학 분자영상 Vol.37 No.5
Tc-99m methoxyisobutylisonitrile (MIBI) and Tl-201/technetium subtraction scintigraphy have been used for localization of abnormal parathyroid gland. The uptake mechanism of tracers has been postulated to be increased cellular density and vascularity, or dependent on the presence of mitochondria-rich cells. However, the uptake of these tracers was not specific for abnormal parathyroid gland. The author report a case of thymic carcinoma that would have been mistaken for carcinoma of parathyroid because of Tc-99m MIBI and Tl-201 uptake.
현인영,서정기,권준,박금수,최원식,이우형 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.3
목적 : 정상 군에서 휴식 TI-201/약제 부하 Tc-99m MIBI 심근 게이트 SPECT를 시행하여 정상 좌심실 용적과 구혈률의 기준 값을 만들고자 하였다. 대상 및 방법: 총 70명을 대상으로 휴식 TI-201/약제 부하 Tc-99m MIBI 심근 게이트 SPECT를 촬영하였다. 게이트 관류 SPECT를 재구성하고 Cedars 소프트웨어로 좌심실 용적과 구혈률을 측정하였다. 성별과 사용한 동위원소에 따른 좌심실의 구혈률과 용적의 차이점을 평가하고 기준 값을 확립하였다. 결과: 사용한 동위원소에 따라 좌심실 구혈률은 유의하게 다르지 않았다(TI-201: 63±8% vs Tc-99m MIBI: 62%±7%). 그러나 사용한 동위원소에 따른 좌심실 용적의 비교시 Tc-99m MIBI (EDV; 82±25 mL, ESV; 32±15 mL)보다 TI-201 (EDV; 74±23 mL, ESV; 28±14mL)의 좌심실 용적이 유의하게 작았다(p<0.05). 여자의 좌심실 용적은 남자의 값보다 유의하게 작았고(p<0.05) 이는 두 동위원소 모두에서 관찰되었다. 그러나 TI-201을 이용하였을 때만 여자의 좌심실 구혈률(65% ± 7%)이 남자(60% ± 8%)보다 유의하게 높았고(p<0.05), Tc-99m MIBI의 경우에는 성별에 따른 좌심실 구혈률의 유의한 차이는 없었다. 결론 : 이 연구에서 우리는 게이트 SPECT로 측정한 정상 좌심실 용적과 구혈률의 기준 값을 확립하였다. 그리고 이 기준 값은 향 후 연구되는 게이트 SPECT 연구의 기본 자료로서 유의하게 쓰일 수 있을 것으로 생각된다. Purpose: We evaluated radioisotope and sex-specific differences of normal limits for left ventricle volumes (LWs) and ejection fraction (EF) using myocardial perfusion gated SPECT (g-SPECT). Materials and Methods: Rest TI-201/post-stress Tc-99m MIBI g-SPECT measurements with acquisitions of 8-frame were evaluated for 70 patients (mean age 55 ± 14, 56% female) who either had < 10% pretest likelihood of CAD (n = 12) or had normal coronary angiography (EF > 50%) (n = 58). LVEF, LWs were automatically determined by quantitative gated SPECT using QGS program. Results: Similar results wre obtained for mean LVEF between Tc-99m MIBI (62% ± 7%) and TI-201 (63% ± 8%) g-SPECT measurements. In Contrast, TI-201 g-SPECT had significantly lower LWs values (EDV; 74 ± 23 mL, ESV; 28 ± 14 mL) than Tc-99m MIBI g-SPECT (EDV; 82 ± 25 mL, ESV; 32 ± 15 mL) (p<0.05). Women had significantly lower EDV (Tc-99m MIBI; 71 ± 18 mL, TI-201; 65 ± 17 mL), and ESV values (Tc-99m MIBI; 27 ± 10 mL, TI-201; 23 ± 8 mL) compared with EDV (Tc-99m MIBI; 96 ± 27 mL, TI-201; 85 ± 24 mL), and ESV values (Tc-99m MIBI; 40± 17 mL, TI-201; 36 ± 16 mL) of men (p<0.05). Women had significantly higher LV EF values (65% ± 7%) than men (60% ± 8%) by TI-201 gated SPECT (p<0.05). Conclusion: These data suggest significant differeuces in normal limits for LWs and EF, according to genders and radiopharmaceutical. Therefore, the evaluation of cardiac function in patients should consider radioisotope and sex-matched normal values.
선천성 담도폐쇄증에서 99mTc DISIDA 신티그라피의 진단정확성 ( Diagnostic Accuracy of 99mTc-DISIDA 신티그라피의 진단정확성
현인영,이동수,이경한,김종호,정준기,서정기,이명철,고창순 ( In Young Hyun,Dong Soo Lee,Kyung Han Lee,Jong Ho Kim,June Key Chung,Jung Key Suh,Myung Chul Lee,Chang Soon Koh ) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.3
We evaluated the diagnostic accuracy of 99mTc-DISIDA scintigraphy as a mean of differentianting biliary tresia from neonatal hepatitis. Tc-DISIDA scintigraphy was visually interpreted by assessing the presence or absence of radioactivity in the intestine or gall bladder. In patients without intestinal radioactivity, we measured the hepatic retention index and the hepatic uptake index. The hepat,ic retention index was expressed as the amount of change of liver activity from 5 minutes to 30 minutes postinjection. The hepatic uptake index was graded visually with 5 minute images using the following scoring scheme :grade 0(normal hepatic uptake), grade 1(decreased hepatic up take), grade 2(hepatic uptake equal to cardiac uptake), and grade 3(hepatic uptake less than cardiac uptake). Age, total bilirubin, and hepatic uptake index were compared between the biliary atresia and the neonatal hepatitis group, between neonatal hepatitis patients with and without intestinal radioactivity, and between the biliary atresia and neonatal hepatitis patients with absent int,estinal radioactivity. The results were as follows : l) None of the 30 hiliary atresia patients showed intestinal radioactivity, while 31/40 neonatal hepatitis patients showed intestinal radioactivity, The sensitivity, specificity, and accuracy of the presence of inlestinal radioactivity .or the diagnosis of biliary atresia was 100%, 78%, and 87%, respectively. 2) In patienis with absent intestinal radioactivity the mean hepatic retention index was 1.5+0.6 in the 16 biliary atresia patient,s, and 1.1+0.2 in the 7 neonatal hepatitis patients(p<0.01). All 7 patients with hepatic retention index over 1.5 had biliary atresia. But there were 9 patients with biliary at,resia below 1.5. 3) No significant differences were found in age, total bilirubin, or hepatic uptake index between biliary atresia and neonatal hepatit.is patients. However t.here were differences in age, total bilirubin, and hepatic uptake index bet.ween neonatal hepatitis patients with and without intestinal radioactivity. The hepatic upt,ake index was significantly lower, age was old, and total bilirubin was low in the group with intestinal radioact,ivity compared the group without intestinal radioactivity(p<0.05). Relation between total bilirubin and the hepatic uptake index was that total bilirubin was relatively low at normal hepatic uptake index in biliary atresia and neonatal hepatitis patients. 4) When hepatic uptake index and hepatic retention index were high it suggest that biliary atresia is more likely, considered relation between hepatic uptake index and the hepatic retention index. Thus, we conclude that Tc DISIDA scintigraphy is accurate in the differential diagnosis of biliary atresia and neonatal hepatitis. In patients without intestinal radioactivity, the hepatic retention index and hepatic uptake index, along with the patients age and total bilirubin level may supplement diagnosis and improve diagnostic accuracy.
급성 심근 경색 환자에서 재관류 후 조기에 시행한 휴식 / 24시간 지연 T1-201 심근 SPECT 의 심근벽 운동 호전 예측능
현인영,권준 ( In Young Hyun,June Kwan ) 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.3
Purpose: We studied early rest/24 hour delay Tl-201 perfusion SPECT for prediction of wall motion improvement after reperfusion in patients with acute myocardial infarction. Materials and Methods: Among 17 patients (male/female ll/6, age: 59+13) with acute myocardial infarction, 15 patients were treated with percutaneous transcoronary angioplasty (direct:2, delay:11) and intravenous urokinase (2). Spontaneous resolution occurred in infarct-related arteries of 2 patients. We confirmed TIMI 3 flow of infarct-related artery after reperfusion in all patients with coronary angiography. We performed rest Tl-201 perfusion SPECT less then 6 hours after reperfusion and delay Tl-201 perfusion SPECT next day. Tl-201 uptake was visually graded as 4 point score from norrnal (0) to severe defect (3). Rest Tl-201 uptake <2 or combination of rest Tl-201 uptake<2 or late reversibility were considered to be viable. Myocardial wall motion was graded as 5 point score from normal (1) to dyskinesia (5). Myocardial wall motion was considered to be improved when a segment showed an improvement > 1 grade in follow up echo compared with the baseline values. Results: Among 98 segments with wall rnotion abnormality, the severity of myocardial wall motion decrease was as follow: mild hypokinesia: 18/98 (18%), severe hypokinesia: 28/98 (29%), akinesia: 5l/98 (52%), dyskinesia: 1/98 (1%), The wall rnotion improved in 85%. Redistribution (13%), and reverse redistribution (4%) were observed in 24 hour delay SPECT. Positive predictive value (PPV) and negative predictive value (NPV) of combination of late reversibility and rest Tl-201 uptake were 99%, and 54%. PPV and NPV of rest T1-201 uptake were 100% and 52% respectively. Predictive values of combination of rest Tl-201 uptake and late reversibility were not significantly different compared with predictive values of rest Tl-201 uptake only. Conclusion: We conclude that early Tl-201 perfusion SPECT predict myocardial wall motion improvement with excellent positive but relatively low negative predictive values in patients with acute myocardial infarction after reperfusion. (Korean J Nucl Med 1998;32:259-65)