노인성 폐렴환자 1례에 대한 증례보고

현민경,정병무,최은영,윤철호,정지천,신원용,Hyun, Min-Kyung,Jeong, Byoung-Mu,Choi, Eun-Young,Yoon, Cheol-Ho,Jeong, Ji-Cheon,Shin, Won-Yong 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.1

Pneumonia is an inflammation that forms at the mesopulmonum and alveolus that is also an acute infection with fever and cough. It is difficult for doctors to diagnose pneumonia in elderly patients, due to the variety of symptoms. For this reason, it, with its complications, is a major cause of death for the elderly. In this case, improvement was seen in an elderly patient diagnosed with pneumonia by X-ray, and by using Si-Kyung-Ban-Ha-Tang-Ka-Mi-Bang as a way of Kong-Bo-Kyum-Si, because in this case pneumonia was presumed Dam-Yel-Ong-Pye and Ki-Eum-Yang-Huh due to the weakness associated with old age. This thesis proposes that the elderly are better treated differently from other pneumonia patients due to the weakness that comes with old age.

Streptozotocin으로 유발된 당뇨쥐에 대한 백강잠(白?蠶)의 혈당 및 당대사 효소활성에 관한 효과

현민경,신원용,김미랑,신현철,윤철호,정지천,정병무,Hyun, Min-Kyung,Sin, Won-Yong,Kim, Mi-Rang,Shin, Hyeon-Cheol,Yoon, Cheol-Ho,Jeong, Ji-Cheon,Jeong, Byoung-Mu 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.2

Objective : This study was undertaken to investigate how Bombycis corpus (BC) effects the development and progress of complications occurring in Diabetes Mellitus (DM). Methods : Laboratory rats were seperated into three groups; normal, rats with DM and treated with BC, and rats with DM and not treated. In this study DM was experimentally induced through injection of streptozotocin. The BC treated group was given BC extract p.o. for 15 days. Then, The activities of glucose phosphatic enzymes and polyol pathway channels were observed. Results : The blood glucose level greatly increased in the DM groups after injection of streptoztocin, but it significantly decreased in the BC treated group. Significantly enhanced levels of serum insulin levels were seen in the BC treated group, while supressed levels were seen in the untreated DM group. Weight was recovered by the BC treated group, matching the normal group. Decreased enzyme activity of aldose reductase, sorbitol dehydrogenase and glucose-6-phosphatase were seen in BC treated diabetic rats. Increased enzyme activity, of the glucokinase and hexokinase were seen in BC treated diabetic rats. Conclusions : This study suggests that BC normalized the blood glucose and serum insulin levels destablized by DM. Because increased activity of glucose phosphatic enzymes, glucokinase and hexokinase, and decreased glucose-6-phosphatase activity, and suppression of polyol pathway enzymes, aldose reductase and sorbitol dehydrogenase, were all seen, these observations suggest that BC suppresses blood glucose levels and prevents complications due to DM.

현훈과 돌발성 난청을 주소로 하는 뇌교경색

현민경,신원용,김미랑,신현철,정지천,윤철호,정병무,Hyun, Min-Kyung,Sin, Won-Yong,Kim, Mi-Rang,Shin, Hyeon-Cheol,Jeong, Ji-Cheon,Yoon, Cheol-Ho,Jeong, Byoung-Mu 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.4

Anterior inferior cerebellar artery(AICA) is a branch of the basilar artery which supplies the bloods for ventrolateral cerebellum and the lateral tegmentum of the lower two-thirds of pons. AICA occlusion can cause such symptoms as acute-onset unilateral deafness, vertigo, facial weakness and ataxia. A case of sudden hearing loss, facial palsy and vertigo caused by AICA territory infarction recently presented itself. Korean Oriental and Western medical therapy were applied in combination. Facial palsy and vertigo improved, but hearing loss did not improve. This case is reported with a brief overview of related literatures.

초기임신에서 자궁경부 분비물내 angiogenin 및 interleukin-6 농도와 임신 경과와의 연관성

현민경 ( Min Kyung Hyun ),정복경 ( Bok Kyung Jung ),심재윤 ( Jae Yoon Shim ),원혜성 ( Hye Sung Won ),이필량 ( Pil Ryang Lee ),김암 ( Ahm Kim ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.6

목적: 본 연구는 임신 10주 이내의 임신부를 대상으로 자궁경부 분비물내 angiogenin과 interleukin (IL)-6 농도를 측정하고, 해당 임신의 경과를 확인하여 이들 물질들의 농도와 초기임신의 예후가 관련성이 있는지 확인하고자 하였다. 연구방법: 2001년 1월부터 2001년 12월까지 전향적으로 임신 10주 이전에 연속적으로 서울아산병원 산부인과를 처음 방문한 단태임신부를 대상으로 모체 혈청 β-hCG 및 progesterone 농도의 측정하였으며, 자궁경부 분비물을 채취하여 angiogenin과 IL-6의 농도를 ELISA kit를 이용하여 측정하였다. 또한 질초음파를 시행하여, 정둔장, 융모막하출혈 유무, 태아 심박동수 등을 측정하였다. 결과: 총 121명의 임신부를 대상으로 하였으며, 이 중 임신 20주 이전에 자연유산된 임신부는 10명(8.3%)이었다. 모체 혈청 progesterone 농도,자궁경부 분비물내 angiogenin과 IL-6 농도는 임신주에 따른 유의한 변화를 보이지 않았다. 임신 20주 이후까지 임신을 유지한 임신부에 대해 최종월경일과 초음파검사를 통한 임신주수가 서로 6일 미만으로 일치하는 군과 6일 이상 차이가 나는 군으로 나누고, 임신 20주 이내에 자연유산된 군은 따로 분류하였다. 모체 혈청 progesterone 농도는 각 군 간의 유의한 차이를 보이지 않았으나, 자궁경부 분비물내 angiogenin 농도는 유의한 차이를 보였으며(P=0.041), 자궁경부 분비물내 IL-6 농도는 각 군 간에 차이를 보이는 경향을 보였다(P=0.059). 결론: Angiogenin이 초기임신 경과에 결정적 역할을 할 것이라 예상되며, 자궁경부 분비물내 angiogenin 농도는 예후 예측 표지자로서 중요한역할을 할 수 있을 것이다. Objective: To investigate the association between the cervical angiogenin and interleukin-6 levels and its outcome during early pregnancy. Methods: One hundred and seventy-fi ve pregnant women were included consecutively at the time of their fi rst prenatal visit after less than 10 weeks of gestation. The gestational age was calculated according to their menstrual history and/or ultrasonography. We measured the cervical angiogenin and interleukin-6 levels using ELISA kits. We also measured the maternal serum progesterone concentrations using radioimmunoassay. Spontaneous abortion was defi ned as when a pregnancy ended spontaneously within 20 weeks of gestation. If an index pregnancy lasted longer than 20 weeks of gestation, it was regarded as showing a normal pregnancy outcome. Results: Fifty-four pregnancies were excluded because of an incomplete study (n=36) or follow-up loss (n=18). Of the remaining 121 pregnancies, spontaneous abortion occurred in 10 pregnancies (8.3%) in which there were no significant gestational agedependent changes in the maternal serum progesterone, cervical angiogenin, and interleukin-6 levels. The maternal serum progesterone, cervical angiogenin, and interleukin-6 levels were not signifi cantly different between the spontaneous abortion group and the normal control group. However, the cervical angiogenin level was significantly decreased in the groups with discordant gestational age and spontaneous abortion compared to the group with concordant gestational age (median, 798.0 pg/mL vs. 723.4 pg/mL vs. 1039.8 pg/mL; inter-quartile range, 222.8-1054.7 pg/mL vs. 257.1-1213.3 pg/mL vs. 480.4-1534.4 pg/mL) (P<0.041). Conclusion: First trimester cervical angiogenin measurement may be valuable for predicting the early pregnancy outcome.

Laparoscopic transpertioneal pelvic and paraaortic Lymphadenectomy in gynecologic malignancies; analysis of 520 patients at single institution, 1997-2006

현민경 ( Min Kyung Hyun),Jeong Yeol Park,Dae Yeon Kim,Jong Hyeok Kim,Yong Man Kim,Young Tak Kim,Joo Hyun Nam 대한산부인과학회 2008 대한산부인과학회 학술대회 Vol.94 No.-

안면신경마비 후유증 정안침 증례보고

이은지(Eun Ji Lee),김성태(Sung Tae Kim),권민구(Min Gu Kwon),신현권(Hyun Kwon Shin),고용준(Yong Jun Koh),강수우(Su Woo Kang),나재일(Jae Il Na),설재욱(Jae Uk Sul),조현정(Hyun Jung Jo),정필선(Pil Sun Jung),현민경(Min Kyung Hyun),정민영(Min 한의병리학회 2015 동의생리병리학회지 Vol.29 No.4

이정환(二精丸)이 노화과정에 미치는 영향

정지천,현민경,Jeong, Ji-Cheon,Hyun, Min-Kyung 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.2

Objectives: It is well known that aging and aging-related diseases are linked to the increased level of oxidative stress caused by reactive oxygen species(ROS) and reactive nitrogen species(RNS). Nonprotein-SH decreases during aging, while substances such as ROS, nitric oxide(NO), peroxynitrite($ONOO^-$), myeloperoxidase(MPO), and dityrosine show a significant increase. This study investigated the effect of Ichungwhan on the aging process by examining its effect on the generation of the above-mentioned substances. Methods: Four comparison groups of SD rats were used. They were 6 month-old rats, 24 month-old rats, and 24 month-old rats fed with food containing 0.1% and 0.3% of Ichungwhan extract. The amount of NO, $ONOO^-$, and ROS in the rats' kidneys were examined using a fluorescence microplate reader. The reagents used for this purpose include: dihydrorhodamine 123 (DHR 123), 2',7' -dichlorodihydrofluorescein, diacetate(DCFDA), and 4,5-diaminofluorescein(DAF-2). A spectrophotometer was used to investigate the reactivity of nonprotein-SH and myeioperoxidase(MPO), using reagents such as trichloroacetic acid(TCA) and tetramethylbenzidine(TMB). The amounts of MPO protein and dityrosine were measued by western blot. Results: The observed effects of Ichungwhan on rats were as follows: increase of nonprotein-SH; effective decrease of RNS level by suppression of the generation system of $ONOO^-$ and NO; decrease of ROS level; decrease of the MPO reactivity and the subsequent reduction of amount of MPO protein; retardation of dityrosine formation. It can be hypothesized, therefore, that Ichungwhan affects both the earlier and later phases of the molecular inflammatory process, and retards the aging process. Conclusions: Empirical evidence in this study supports a role for Ichungwhan in generation mechanisms of aging process-linked substances ROS, NO, $ONOO^-$, nonprotein-SH, MPO and dityrosine. Affects contrary to the aging process observed in rats beg further empiricism to investigate potential application of Ichungwhan as a medication for age-related diseases in humans.

산전진단된 배벽갈림증의 임상적 분석

차경희 ( Kyung Hee Cha ),박선경 ( Sun Kyung Park ),현민경 ( Min Kyung Hyun ),나성훈 ( Sung Hun Na ),김유진 ( Eu Gene Kim ),심재윤 ( Jae Yoon Shim ),원혜성 ( Hye Sung Won ),이필량 ( Pil Ryang Lee ),김암 ( Ahm Kim ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.10

목적: 태아 배벽갈림증의 주산기 경과 및 태아 치료와 산후 결과를 분석하고자 한다. 연구 방법: 1997년 3월부터 2007년 4월까지 배벽갈림증으로 진단된 35예에 대해 의무기록을 이용하여 후향적으로 분석하였다. 결과: 28명에 대해 추적관찰이 가능하였고 이 중 17명은 생존 출생하였다. 22명의 태아에서 염색체검사를 시행하였으며 모두 정상 소견이었다. 12명 (34.2%)에서 동반기형이 발견되었다. 이 중 8명은 양막대증후군 (22.9%), 6명은 척추측만 (17.1%)이었고, 구개열, 태아수종, 뇌수종, 무뇌증은 각각 1명 (2.9%)이었다. 태아 치료를 위해 4명이 양수주입술과 양수교환술을 동시에 시행 받았다. 4명 (23.5%)이 제왕절개술로 분만되었다. 신생아들은 모두 출생 직후 외과적 치료를 받았다. 8명 (47.1%)에서 수술 후 합병증을 보였다. 3명은 사망하여 전반적인 생존율은 82.4%이었다. 영아의 평균 재원기간은 36일 (2~210일)이었다. 결론: 산전진단된 배벽갈림증은 외과적 치료의 예후가 좋고 전반적인 생존율도 높았다. 이러한 결과는 기존의 연구와 일치하고 있으며, 배벽갈림증으로 산전 진단 받은 산모를 상담하는데 도움을 줄 수 있을 것으로 기대된다. Objective: The aim of this study is to analyze the perinatal courses, fetal treatment and postnatal outcomes of fetal gastroschisis. Methods: A retrospective review of the medical records of 35 cases with a prenatal diagnosis of gastroschisis was conducted between March 1997 and April 2007. Results: Twenty-eight fetuses were followed up and 17 fetuses of them were born alive. Chromosomal study was performed in 22 fetuses and no abnormality was detected in them. Associated anomalies except for gastrointestinal anomalies were found in 12 (34.2%) cases: amniotic band syndrome (n=8), scoliosis (n=6), cleft lip (n=1), hydrops (n=1), hydrocephalus (n=1), acrania (n=1). In 4 fetuses, amnioinfusion and amnioexchange were performed simultaneously for treatment. Four cases (23.5%) were delivered by cesarean section. All neonates received corrected operation immediately after birth and 8 (47.1%) of them had postoperative complications. Three of them were died and the overall survival rate was 82.4%. The average length of hospital stays for the survivors was 36 days (2~210days). Conclusion: Fetal gastroschisis diagnosed prenatally has a good prognosis and high survival rates. The result of this study was not different from that of preexisting studies and will be a useful guide in counseling parents with a prenatal diagnosis of gastroschisis.

모야모야질환을 동반한 산모 9예의 임상적 고찰

박선경 ( Sun Kyung Park ),현민경 ( Min Kyung Hyun ),차경희 ( Kyung Hee Cha ),심재윤 ( Jae Yoon Shim ),원혜성 ( Hye Sung Won ),이필량 ( Pil Ryang Lee ),김암 ( Ahm Kim ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.11

To describe the clinical manifestations and to establish the management of pregnancy and delivery in pregnant patients with Moyamoya disease. We identified nine women with Moyamoya disease. Six of these patients underwent cesarean section. General anesthesia was administered to only one patient, while epidural or combined spinal-epidural anesthesia was used for the others. The patient diagnosed during pregnancy was epidural anesthesia used for vaginal delivery and two patients diagnosed during post-delivery were delivered vaginally without anesthesia. Three patients showed pregnancy-related complications: intracranial hemorrhage, severe pre-eclampsia, and stroke. Five patients had term delivery, and four had pre-term delivery. The babies were healthy and had no complications. As blood pressure control is the most important factor for the pregnant women with Moyamoya disease, we recommend a spinal or epidural anesthesia in order to reduce the potential complications. Management of the patient`s underlying disease is also crucial.

청신경초종 수술 후유증 환자 증례 1례

김재우,현진오,현민경,신원용,임성우,최은영,Kim, Jae-Woo,Hyun, Jin-Oh,Hyun, Min-Kyung,Sin, Won-Yong,Lim, Seong-Woo,Choi, En-Young 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3

The purpose of this study is to develop an aproach to diagnosis and treatment of sequelae after removal of vestibular schwannoma through Oriental Medicine. An eighty year-old woman with sequelae after removal of vestibular schwannoma was observed and treated. She had difficulty of hearing, facial nerve palsy, dizziness and was generally weak. She was treated with herb medications for these symptoms. Having been treated for 27 days in hospital her symptoms improved. This report provides evidence for application of herbal medicine in treatment of sequelae. However, more cases are required for an in depth study of oriental treatments for this ailment in order to open this method of treatment to general application.