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허환(Hwan Herr),김영태(Young Tae Kim),김재홍(Jae Hong Kim),김중환(Joong Hwan Kim) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.4
Fifty six year old woman with liver cirrhosis and 31 year old man in good health had similar skin lesions which were well-defined, round to oval, isolated or confluent, scaly brown patches on her lower back, and his trunk and thighs, respectively, without any symptom. The biopsy specimens taken from the lesions showed slight hyperkeratosis with occasional follicular pluggings, presence of a granular layer, and epidermal flattening in case 1; increased melanin pigment in the basal layer in case 2. In both cases, the upper dermis revealed minirnal perivascular lymphohistiocytic inf iltration. We, therefore, present two cases of pityriasis rotunda and review the literature.
단순 포진 바이러스에 기인된 것으로 사료되는 재발성 다형 홍반
허환(Hwan Herr),이창우(Chang Woo Lee) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.6
We describe four patients with herpes-associated erythema multiforme, who had clinical and histopathological features consistent with the so-called erythema multiforme minor. The appearance of lesions of herpes simplex were followed with intervals between 6 and 10 days by the recurrent developments of erythema multiforme several times in a year in each patient. Sinee herpes simplex virus infection is considered one of the major factors provocating erythema multiforme one may have to pay more attention to patient's history to define the nature of erythema multiforme.
허환(Hwan Herr),김영태(Young Tae Kim),김중환(Joong Hwan Kim) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.1
The patient was a sixty-year-old obese woman with the long history of hypertension, amenorrhea and occasional psychic disturbances. She had eigbt, thumb to adult-fist sized, slightly movable, relatively soft, and painful subcutaneous nodules with tenderness and paresthcsia, of which overlying skin appeared to be normal except senile changes, on the abdomen and both upper extremities for 10 years. There was no evidence of inheritance in her family. Laboratory data revealed no abnormalities in lipid metabolism or in a variety of endocrinological functions. Microscopically, an excised mass from the forearm showed thin connective tissue capsule encircling numerous lobules cornposed entirely of the mature fat. cells vith minimal focal capillary proliferatios.
단순 남성 임질에 대한 Norfloxacin의 치료 효과
김중환(Joong Hwan Kim),윤정용(Jeong Yong Yoon),허환(Hwan Herr),김영태(Young Tae Kim) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.5
From November 18 to December 31, 1986, seventy-five male patients with unconplicated gonococcal urethritis at the Venereal Disease Clinic of Choong-ku Public Health Center in Seoul were allocated randomly into one of two treatment regimens, and seventy patients were followed. All thirty-five patients including PPNG infections, treated with single oral dose of norfloxacin 600mg, were recovered(100%). One of thirty-five patients treated with a single oral dose of norfloxacin 800mg, failed. This failed case was one of eighteen nonPPNG infections (failure rate of 5.6%). Susceptibility test with disks containing norfloxacin 10ug showed the inhibition zone greater than 30mm. It is suggested that a single oral dose of 600mg or 800mg norfloxacin has good effect in the treatment of gonococcal urethritis with minimal side effects. Because of high prevalence of PPNG, it can be recommended as the first line treatment for gonorrhoea in Korea.
방기태 ( Ki Tae Bang ),허환 ( Hwan Herr ),김명진 ( Myoung Jin Kim ),이보한 ( Bo Han Lee ),배강우 ( Kang Woo Bae ),김유찬 ( Yoo Chan Kim ),장현규 ( Hyun Kyu Chang ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.4
Systemic polyarteritis nodosa is a necrotizing vasculitis that involves small and medium-sized muscular arteries in the multiple organ systems, whereas cutaneous polyarteritis nodosa (CPAN) is a localized disease characterized by necrotizing vasculitis of small and medium-sized arteries in the skin without life-threatening organ involvement. CPAN is usually limited to skin, muscle, and joints. It is chronic but takes a benign course. The most common cutaneous manifestations include nodules, ulcers and a livedo reticularis pattern on the extremities. We describe three cases with CPAN showing necrotizing vasculitis on the skin without systemic symptoms or visceral involvement. In Korea, most previously published cases with CPAN have shown a good response to a short term of corticosteroids or colchicine administration. However, two of our three patients required another immunosuppressive agent in addition to corticosteroids to manage their intractable skin lesions, and the remaining one showed a good response to a short course of prednisolone. In addition, there was one patient with CPAN having hepatitis B surface antigen, which might be associated with his refractory skin disease.
김재홍(Jae Hong Kim),허환(Hwan Herr),김중환(Joong Hwan Kim) 대한피부과학회 1986 大韓皮膚科學會誌 Vol.24 No.3
This survey was made on 1462 cases in different age groups, from the neonate to the age of 15, to analyse the data statistically concerning the prevalence, size, shape, site and color of Mongolian spot. The results were as follows: 1) Of 1462 cases, Mongolian spot(s) was(were) present in 759(51. 9%) with the sex ratio of male to female, 1: l. 2. The prevalence could be divided into 3 stages, high(neonate to 3years), abruptly declined(4 to 9year), steadily declined (10 to 15years) 2) The mean and standard deviation of diameter represented 4. 56+2. 96cm(M +SD), ranging from 0. 5 to 21 cm. 3) The two most common shapes were ovoid(45. 5%,) and irregularly circular (31.4%). 4) The two most common sites were sacrococcygeal(80. 1%,) and gluteal(75. 1%). 5) The two most common colors were blue(75. 1 %) and purple-blue(13. 5%).
김정혁 ( Jung Hyuk Kim ),허환 ( Hwan Herr ),방기태 ( Ki Tae Bang ),배강우 ( Kwang Woo Bae ),장현규 ( Hyun Kyu Chang ),이명용 ( Myoung Yong Lee ),이인선 ( In Sun Lee ),윤보영 ( Bo Young Yoon ),이윤우 ( Yun Woo Lee ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.3
Behcet`s disease (BD) is a chronic inflammatory disease, involving several organs. It is well known that there are the marked regional differences in the disease expression of BD. In case of the vascular involvement in BD, the frequency rate has been described in 25∼30% among the patients from the Middle East, whereas it has been noted in 5∼15% in our country. In general, BD associated with large vessel lesions is named vasculo-BD. On the other hand, the cardiac involvement in BD has rarely been reported in the literature. Ebstein anomaly is a kind of malformation that is characterized by a downward displacement of the tricuspid valve into the right ventricle. We reported a 54-year-old male patient with vasculo-BD who had inferior vena cava obstruction and Ebstein anomaly. The association of Ebstein anomaly with vasculo-BD is considered to be coincidental. To the best of our knowledge, this is the first case of Ebstein anomaly associated with BD.
결체 조직 질환의 희귀한 피부 증상 ( IV ) - 수포성 병변을 가진 전신성 홍반성 루푸스 -
이창우(Chang Woo Lee),박기범(Ki Bum Park),허환(Hwan Herr),은희철(Hee Chul Eun),윤재일(Jail Il Youn),이유신(Yoo Shin Lee) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.3
The cases of bullous eruption of systemic lupus erythematosus in this study were two females. They were the age of 18 and 15. Both of them met ARA criteria for a diagnosis of SLE, and the eruptions developed long after the diagn- osis. In both cases bullae were presented on the face, neck and upper extremities. Administration of dapsone showed complete clearing of lesions within several days. Routine histology of the lesion showed subepidermal blisters, an intact epider- mis, ancl neutrophilic microabscess in dermal papillae. Direct munofluorescence of perilesional and normal forearm skin showed coarse linear pattern of immune deposits at the basement membrane zone in both cases. Circulating anti-basement membrane zone IgG auto-antibodies were detected at a titer of 1: 32 and 1: 16 in each case on NaC1 separated skin substrates.
원발성 담즙성 견경변증과 Isolated pulmonary hypertension을 동반한 미만성 경피증(Diffuse scleroderma)
장현규 ( Hyun Kyu Chang ),정상식 ( Sang Sig Chung ),정행섭 ( Haing Sub R. Chung ),이성희 ( Sung Hee Lee ),허환 ( Hwan Herr ) 대한류마티스학회 1997 대한류마티스학회지 Vol.4 No.2
Primary biliary cirrhosis is frequently associated with a variety of disorders presumed to be autoimmune in nature, such as Sjogren`s syndrome, scleroderma, rheumatoid arthritis, systemic lupus erythematosus, and autoimmune thyroiditis. Scleroderma has been recognized in association with primary biliary cirrhosis. Most cases present as the CREST (calcinosis cutis, Raynaud`s phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) syndrome. Isolated pulmonary hypertension develops in a small proportion of patients, nearly all of whom have limited cutaneous involvement. We report a case who has diffuse scleroderma associated with primary biliary cirrhosis and isolated pulmonary hypertension.