The cardioprotective effect of microemulsion propofol against ischemia and reperfusion injury in isolated rat heart

허민정,김희주,이동규,임상호 대한마취통증의학회 2012 Korean Journal of Anesthesiology Vol.62 No.4

Background: Lipid-emulsion propofol (LP) has cardioprotective effects against ischemia-reperfusion injury, but it has lipid-related side effects. Microemulsion propofol (MP) is a lipid-free propofol emulsified with 10% purified poloxamer 188 (PP188). PP188 is a nonionic surfactant and has cardioprotective effects. However, some reports have suggested that reduced cardioprotective effects were observed when the cardioprotective agents were used in combination even though each cardioprotective agent has cardioprotective effects. The aims of this study were to examine and compare the cardioprotective effects of MP and LP. Methods: 50 isolated rat hearts were perfused with modified Kreb’s solution. They were divided into 4 groups and underwent 30 minutes of ischemia and 60 minutes of reperfusion. Control group: ischemia-reperfusion was performed without treatment. LP, MP and PP groups: LP, MP and PP188 were infused during the pre-ischemic and reperfusion period, respectively. Hemodynamic parameters and coronary effluent flow rate (CEFR) were measured. Infarct size was determined using triphenyl-tetrazolium staining. Results: In the MP group, systolic pressure was maintained near baseline, the systolic pressure was higher than that in the other groups and HR was lower than that in the other groups during reperfusion. Diastolic pressure was transiently increased in the PP group after treatment and at 5 minutes after reperfusion compared with that in the control group and in the the LP group. There were no differences in dP/dtmax and CEFR between groups. Infarct size in the LP, MP and PP groups was smaller than that in the control group, but there were no significant differences between these three groups. Conclusions: MP has cardioprotective effects similar to those of LP. MP can be used for cardiac anesthesia in cases with ischemia-reperfusion injury to avoid the lipid-related side effects of LP.

초기 알츠하이머형 치매 환자의 음운인식

허민정,안성우,부성현 한국지체.중복.건강장애교육학회 2008 지체.중복.건강장애연구 Vol.51 No.4

The aims of this study were to investigate the phonological awareness of patients with Alzheimer's disease compared with that of normal elderly. Subjects were sixteen patients with mild Alzheimer's disease who were registered in dementia clinic and twenty one normal elderly. Subjects were assessed using phonological awareness test comprised of 5 subtests : counting, discrimination, blending, deletion and substitution for syllable and phoneme levels. Group differences were analyzed with Independent-Samples t-test. Discriminant analysis was used to identify the most efficient indices expecting onset of Alzheimer's disease. There were significant differences in all of the five subparts of phonological awareness test. As a result of discriminant analysis, syllable level task was more discriminant than phoneme level task. In terms of dimensions of phonological awareness, blending task was the most efficient variable for discriminating two groups. These results suggest that patients with mild Alzheimer's disease show difficulties in phonological process which can be one of the behavioral predictors for expecting oneset of Alzheimer's disease. Then, phonological awareness test for elderly need to develop considering demographic and test characteristics. 본 연구의 목적은 초기 알츠하이머형 치매 노인의 음운인식능력을 분석하고자 하는 것이다. 신경과와 정신과 전문의에 의해 초기 알츠하이머형 치매로 진단받은 환자 16명을 대상으로 음운인식검사를 시행하고, 이를 정상 노인 21명의 음운인식검사 결과와 비교하였다. 또한, 음운인식검사의 음절 과제와 음소 과제 중 치매 노인과 정상 노인을 효율적으로 변별해 주는 과제 수준을 파악하고, 음운인식검사의 하위 과제 중 이 두 집단을 효율적으로 변별해 주는 과제를 찾기 위하여 판별분석을 시행하였다. 그 결과 음운인식검사의 5개의 하위 영역인 수세기, 변별, 합성, 탈락, 대치 모두에서 치매 노인과 정상 노인 간에 유의한 차이가 있었다. 판별분석 결과 음소 수준의 과제보다 음절 수준의 과제가 치매 노인과 정상 노인을 잘 변별해주고, 음운인식검사의 하위 과제 중에서는 합성 과제가 가장 변별력 있는 하위 과제로 나타났다.

Brugada 증후군 환자의 경접형동 선종절제술을 위한 마취 경험

허민정,김세연 영남대학교 의과대학 2009 Yeungnam University Journal of Medicine Vol.26 No.2

Brugada syndrome is characterized by an ECG pattern of right bundle branch block and ST segment elevation in the right precordial leads (V1-V3) without structural heart disease. It is also characterized by sudden cardiac death that’s caused by ventricular fibrillation. This is a familial syndrome with an autosomal dominant inheritance pattern and it may be considerably more common in Southeast Asia. Many factors during anesthesia can precipitate malignant dysrrhythmia in these patients, so careful choice of anesthetics is required. We experienced a case of Brugada syndrome in a 59-year-old male patient who was under general anesthesia for trans-sphenoidal surgery to treat a pituitary adenoma, and the patient was diagnosed as having Brugada syndrome without any untoward cardiovascular events.

Propofol의 효과처농도에 따른 후두튜브 삽입 상태 비교

허민정,김윤진,백희정,김종학 대한마취과학회 2005 Korean Journal of Anesthesiology Vol.49 No.3

강박장애 환자에서의 성격 5요인 모델 분석

허민정,변민수,김성년,김의태,장준환,권준수,Huh, Min Jung,Byun, Min Soo,Kim, Sung Nyun,Kim, Euitae,Jang, Joon Hwan,Kwon, Jun Soo 대한불안의학회 2012 대한불안의학회지 Vol.8 No.2

Objective : The aim of this study is to evaluate the five-factor model of personality in patients with obsessive-compulsive disorder (OCD) related to obsessive-compulsive symptom severity and the distinct symptom subgroups. Methods : We recruited 95 patients with OCD and 116 normal controls in the study. We used the short version of Revised NEO Personality Inventory and the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) for the assessment. Results : Patients with OCD showed significantly higher scores in neuroticism than normal controls. On multiple linear regression analysis, we found that agreeableness and conscientiousness were associated with the total Y-BOCS scores. On subscale analysis, agreeableness and neuroticism were associated with the obsession subscale scores and only conscientiousness was associated with the compulsion subscale scores. Furthermore, we found that patients who have contamination/cleaning or symmetry/ordering/counting/arranging as a main symptom presentation had significantly higher mean scores in conscientiousness than patients who have harm due to injury/violence/aggression as a main symptom presentation. Conclusion : In this study, we found that specific personality factors are associated with the obsessive-compulsive symptom severity. In addition, this is the first study to investigate the relationship between the personality factors in the five-factor model and the distinct symptom subgroups in OCD.

학령기 아동의 인공와우이식 후 말소리 지각력과 예측변인

허민정,정성욱,안성우,부성현,김리석 대한이비인후과학회 2008 대한이비인후과학회지 두경부외과학 Vol.51 No.2

This study aims to investigate the development of open-set speech perception abilities in children who received cochlear implantation at older age and to examine the preoperative variables contributing to the postoperative speech perception outcomes. Subjects and Method:Open-set speech perception abilities were assessed with the Monosyllabic Word and Common Phrases Tests for 37 prelingually deafened children who received implantation between the ages of 7 and 17 years. Their performance was compared to that of 60 children who received implantation before 7 years of age. To identify the factors contributing to the postoperative open-set speech perception abilities, we analyzed age at hearing aid fitting, age at implantation, duration of implant use, preoperative language and speech perception abilities, and pure tone thresholds in the better ear. Results: The children who received implantation after 7 years of age significantly improved during the first year of implant use, but reached a plateau by 1.5 to 2 years after implantation, reaching scores between 60% and 70%. Children who received implantation after age 7 showed higher speech perception scores than the younger children over the first year of implant use, but showed lower scores than the younger children after 2-3 years of implant use. The variables associated with the postoperative open-set speech perception abilities were speech perception ability, language ability, and hearing levels before implantation. Conclusion:Prelingually deafened children who received implantation at older age can obtain substantial open-set speech perception understanding, but tended to reach a plateau between 1.5-2 years after implantation. Speech perception, language abilities, and hearing level before implantation contribute to the outcome. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:130-5)

1990년대와 2000년대 픽사 애니메이션에 나타난 스토리텔링 기법에 따른 재즈 음악 형식 분석 : 애니메이션 <몬스터 주식회사>, <토이 스토리>를 중심으로

허민정,이우창 글로벌문화콘텐츠학회 2017 글로벌문화콘텐츠학회 학술대회 Vol.2017 No.1

초창기 애니메이션에서는 주로 재즈 스탠더드 곡들이 사용되었고, 1990년대와 2000년대에는 재즈적인 리듬과 베이스 워킹에 맞추어 클래식의 오케스트라 형태와 재즈의 리듬이 결합되어 독특한 느낌의 음악들이 탄생하였다. 또한 화성적 진행 기법으로는 90년대에 사용되던 다양한 코드 베리에이션에서 예전 재즈스탠더드 형식으로 다시 돌아오는 고전적 재즈의 형식인 2-5-1이나 1-6-2-5 진행이 사용되는 형태로 바뀐다. 이 시기의 대표적인 애니메이션인 <몬스터 주식회사>와 <토이 스토리>의 재즈 음악 형식을 분석해 본 결과, 픽사 애니메이션에서는 같은 작곡가 일지라도 시대별로 다른 특성이 나타나고 있다는 것을 확인하였다. 본 논문에서는 시대별로 곡의 어떠한 다른 특성이 나타나고 있는지, 어떤 상황에서 주로 재즈음악이 사용되어지고 있는지를 살펴본다.

산림 생태계에 활용된 생지화학모형의 국내 적용성 분석

허민정,송철호,김지원,이우균 한국기후변화학회 2022 한국기후변화학회지 Vol.13 No.4

Identifying the carbon cycle in forest ecosystems is important when studying climate change. Since 2010, however, most of the suitable process-based biogeochemical models for forest sectors in South Korea have not been validated. For forest ecosystems, Korean and international research using a process-based biogeochemical model was collected and examined in this study. The applicability of models based on methodology, input/output parameters, and the availability of relevant spatio-temporal data was determined. After 2010, a total of 13 models, including one model commonly used by Koreans and foreign studies, were applied, with five originating domestically and nine originating internationally. Global, regional and temporal scales were used in each model, and a variety of targets, including agriculture, forestry and vegetation, were included. The input/output factors in most of the models were comparable. It was found that the CLM3.5-DGVM, MC1, VISIT and BIOME-BGC series models have been used most frequently in Korea and the models are highly applicable. Recent research, however, was limited by poor spatio-temporal resolution and lack of local characteristic data. Future research should include the creation of algorithms that represent forest management and the validation of modeling results using diverse models.

Succinylcholine 투여 후 나타나는 속상수축을 감소시키기 위한 적절한 Rocuronium의 용량

허민정 대한마취통증의학회 2007 Anesthesia and pain medicine Vol.2 No.3

Background: Subparalyzing dose of nondepolarizing muscle relaxants is often given prior to succinylcholine to reduce its adverse effects. At the same time, priming dose may worsen the intubating condition due to its antagonizing effect at neuromuscular junction. Although optimal priming dose of rocuronium is known to 0.03 0.04 mg/kg but higher priming dose may reduce interval from priming drug to succinylcholine. This study was designed to determine the maximal priming dose of rocuronium. Methods: Sixty ASA I or II adult patients were randomized into three groups: group R1 received 0.06 mg/kg of rocuronium, group R2, 0.09 mg/kg and group Scc, normal saline. About 3 minutes after priming dose, thiopental 4 mg/kg, fentanyl 1μg/kg and succinylcholine 2 mg/kg were administered for anesthesia induction. The presence and severity of fasciculations and intubating conditions were evaluated with the incidence of side effects. Results: In preventing fasciculations, group R1 and R2 were significantly better than group Scc, without significant difference between group R1 and R2. Intubation conditions were significantly worse in group R2 than in group Scc. Conclusions: The maximal priming dose of rocuronium to prevent fasciculations and optimizing intubating condition was 0.06 mg/kg.

The Impact of Personality Traits on Ratings of Obsessive-Compulsive Symptoms

허민정,심금숙,변민수,김성년,김의태,장준환,신민섭,권준수 대한신경정신의학회 2013 PSYCHIATRY INVESTIGATION Vol.10 No.3

Objective The goal of this study was to evaluate consistencies and discrepancies between clinician-administered and self-report versions of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and to examine relationships between these scales and personality traits. Methods A total of 106 patients with obsessive-compulsive disorder (OCD) participated in this study. All participants were assessed with both clinician-administered and self-report versions of the Y-BOCS. The Structured Clinical Interview for DSM-IV Axis II Disorders Personality Questionnaire (SCID-II-PQ) was used to evaluate relationships between personality traits and scores on the Y-BOCS. Results Scores on the clinician-administered Y-BOCS and its obsession subscale were significantly higher than were those on the self-report version. However, we found no significant differences in compulsion subscale scores. We also found that the discrepancies in the scores on the two versions of the Y-BOCS and its compulsion subscale were significantly positively correlated with scores for narcissistic personality traits on the SCID-II-PQ. Additionally, narcissistic personality traits had a significant effect on the discrepancy in the scores on the two versions of the Y-BOCS and its compulsion subscale in the multiple linear regression analysis. Conclusion This is the first study to elucidate relationships between personality traits and discrepancies between scores on the two versions of the Y-BOCS. Although clinicians tend to rate obsessive symptoms as being more severe than do patients, clinicians may underestimate the degree to which individuals with narcissistic personality traits suffer more from subjective discomfort due to compulsive symptoms. Therefore, the effect of personality traits on symptom severity should be considered in the treatment of OCD.