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알레르기성 질환의 감감작 치료효과와 피부반응지수 변화의 상관관계
한효수,박장규 대한천식알레르기학회 1986 천식 및 알레르기 Vol.6 No.1
The symptom improvement, changes of the skin test reactivity index, total serum IgE level and peripheral blood eosinophil count were observed before treatment and during the 24 months of immunotherapy in 25 allergic diseases. (allergic rhinitis: 20, urticaria: 3, bronchial asthma: 2) The results were as follows: 1. The skin test reactivity index decreased significantly 2 months after the immunotherapy (P < 0.05). 2. If the skin test reactivity index of an allergen was above 0.7, it decreased significantly with immunotherapy (P < 0.01). 3. If the total serum IgE level was more than 400 I.U./ml, there was significant decrease in serum IgE level after 2 months since the immunotherapy was begun (P < 0.005). 4. Ninety-six percent of the patients improved clinically, 24 months after hyposensitization with specific desensitization vaccine. 5. The peripheral blood eosinophil count showed no significant relation with immunotherapy til 24 months later (P > 0.1). 6. There was no correlation with decrease of skin test reactivity index and serum IgE level during immunotherapy.
Southern Blot Hybridization을 이용한 반성 어린선의 진단과 보인자의 검색
한효수(Hyo Su Han),김경훈(Kyung Hoon Kim),서기범(Ki Beom Suhr),이증훈(Jeung Hoon Lee),박장규(Jang Kyu Park) 대한피부과학회 1993 大韓皮膚科學會誌 Vol.31 No.6
Beckgraurld: The skin changes of X-linked recessive ichthyosis are cnused by the deficiency of the enzyme steroid sulfatase, which usually results from deletions of this gene in Caucasian populations. Objective and Methods : To disgnose X-linked recessive ichthyosis and detect its carrier, we have investigated distinctive gene deletion and measured gene dosage of steroid sulfatase gene by southern blot hybridization in Korean patients with X-linked recessive ichthyosis Results : Patients from 8 of 9 unrelated families exhibited deletions, if the steroid sulfatase gene. Of 6 families showing a family history compatible with X-linked recessive inheritance, One family exhibited a normal pattern of hybridization. All but one family showed deletion of steroid sulfatase gene. All three patients lacking a fami1y history of the disease exhibited gene deletions. The ratio of the steroid sulfatsse specific band density to the Factor VIII specific band density was measured in 8 obligate carriers using a laser densitometer. The average ratio exhibited by the car riers was less than half that of normal women. Conclusian: These results suggest that the X-linked recessive ichth osis patient and its carrier can also be diagnosed and detected by Southern blot hybridization of steroid sulfatase gene in Korea. (Kor J Dermatol 1993;31(6):857-865)