난소임신의 2예

한치동,신수재,정승균,김성도,안재영 대한산부인과학회 1982 대한산부인과학회 학술대회 Vol.49 No.-

거대난소부종

한치동,허창규,이헌수 최신의학사 1991 最新醫學 Vol.34 No.10

자궁경관무력증에 대한 임상적 고찰

한치동,박정돈,한경환 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.1

The 68 cervical cerclage operations of incompetent internal os of the cervix(IIOC) were performed at the Taegu Catholic Medical Center from Jan. 1, 1990 to Dec. 31, 1995. The results of this study were as follows: 1. The incidence of operation for IIOC was 0.23% of total delivery. 2. Highest number of IIOC was observed in the age group of 25 to 29, and the average number of pregnancy before operation was 4.1. 3. The significant contributory factor was previous history of the induced or spontaneous abortion. 4. In all cases, cerclage method was McDonald operation. 5. The average fetal salvage rate after operation was 82.5% and from the 14th week to 16th week of gestation(43 cases), the success rate of operation was 85%. 6. The causes of operation failure were premature labor in 6 cases(55%), premature rupture of membrane in 3 cases(27%) and abortion in 2 cases(18%) in order.

간세포 Apoptosis에 대한 형태학적 연구

한치동,조창호,서인수 慶北大學校 醫科大學 1995 慶北醫大誌 Vol.36 No.4

목적 : 본 연구는 간세포에 괴사를 주로 일으키는 물질로 알려진 사염화탄소와 apoptosis를 일으키는 것으로 알려진 cycloheximide로 간세포에 일어난 괴사와 apoptosis의 차이를 형태학적으로 알아보고 또 최근 개발된 in situ nick translation방법을 이용한 ApopTag염색을 통해 apoptosis를 쉽게 찾을 수 있는가를 알아보기 위해 시도하였다. 대상 및 방법 : 표준식으로 사육한 쥐에 cycloheximide를 체중 1㎏당 1.5㎎ 또는 50㎎이 되도록 정맥내에 주사하였고, 다른 동물은 사염화탄소를 체중 1㎏당 1㎎씩 복강내로 주사하였다. Cycloheximide 주사 후 30분에서 6시간 사이에, 사염화탄소 주사 후는 12시간에서 24시간 사이에 도살하여 H-E 및 ApopTag로 염색하에 apoptosis수를 계수하였고, 전자현미경으로도 관찰하였다. 결과 : Cycloheximide군은 H-E염색상 1.5㎎/㎏군에서는 30분후 100개의 간세포당 0.82개, 6시간후에 4.29개의 apoptosis가 나타났고 50㎎/㎏투여군에서는 처음 1.85개에서 6시간 후 9.86개가 나타나 용량의존성을 보였다. 사염화탄소 군은 H-E 염색에서 처음 0.46개에서 후에 1.88개로 증가하였다. ApopTag염색에서는 cycloheximide 투여군에서는 10-15%의 검출률이 더 높았으나 사염화탄소 투여군에서는 2-3배의 검출률을 보여 상반된 결과를 보였다. 결론 : 이상의 성적으로 보아 ApopTag는 apoptosis의 쉬운 검출을 위해 매우 유용한 것으로 생각되나 괴사 세포에 양성을 보일 수도 있으므로 결과해석에는 신중한 검토가 필요할 것으로 생각된다. It is well known that there are two ways of cell death; necrosis and apoptosis. Recently apoptosis is vigrously studied in concern with mechanism of hyperplasia and tumor promotion. This study was carried out to compare the morphologic differences between necrosis and apoptosis and to verify the usefulness of recently developed ApopTag for the detection of apoptotic cells. Necrosis was induced by carbon tetrachloride and apoptosis was induced by cycloheximide. Rats were received intravenous single dose of 1.5㎎/㎏ or 50㎎/㎏ of cycloheximide and sacrificed 30 minutes, 1 hour, 3 hours, and 6 hours after injection, other rats were received intraperitoneal single does of 1㎖ of carbon tetrachloride and sacrificed 12, 15 and 24 hours after injection. Numbers of apoptotic cells were counted in hematoxylin and eosin and ApopTag stained tissue. Apoptosis was also observed under electron microscope. Cycloheximide 1.5㎎/㎏ group showed 0.82 apoptotic cells among 100 liver cell nuclei after 30minutes; 2.19 after 1 hour; 2.64 after 3 hours; 4.29 after 6 hours. Cycloheximide 5㎎/㎏ group showed 1.85 apoptotic cells among 100 liver cell nuclei after 30 minutes; 5.42 after 1 hour; 9.69 after 3 hours; 9.86 after 6 hours respectively. Apoptosis appeared very early in 30 minutes and the number was increased with time pass and there was dose-dependency. Carbon tetrachloride group also showed increased number of apoptotic cells; 0.46 apoptotic cells among 100 liver cell nuclei after 12 hours; 1.85 after 15 hours 1.88 after 24 hours. ApopTag staining showed 10-15% increased number of apoptotic cells than H-E staining in cycloheximide groups, while 2-3 times increased number of apoptotic cells in carbon tetrachloride group. Some of necrotic cells in carbon tetrachloride group were also positive. The results suggested that ApopTag staining is superior than H-E staining with easy detection of the apoptosis, but caution should be paid in interpreting the results because necrotic cell may show positive reaction.

만삭임산부에서 TLU (Translabial Utrasonogram) 를 이용한 자궁경부 길이 측정

한치동,허창규,황순구,류상철 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.12

대구 가톨릭대학병원 산부인과에서는 만삭 산모 117명을 대상으로 TLU를 이용한 자궁경부 관찰이 분만에 어떤 의미가 있는지를 관찰한 결과 다음과 같은 결론을 얻었다. 1. 만삭 자궁경부의 길이는 초산모군 81예에서 2.2+or-0.5cm, 경산모 36예에서 2.6+or-0.7cm으로 두 집단간에는 의미있는 차이를 나타내었다(p$lt;0.05). 2. 만삭 자궁경부 길이와 임신주수와는 상관관계가 없었다(p$lt;0.05). 3. 자궁경부의 길이는 분만개시일과 분만까지 소요시간과 별 상관관계가 없는 것으로 관찰되었다(p$gt;0.1). In a prospecive study of 117 pregnancies, at Department of Obstetrics and Gynecology, Taegu Catholic University Hospital, cervical lengths were documented by TLU (translabial ultrasonography) during antenatal period after 36 completed weeks of gestation, except PROM, spontaneous labor and cesarean section. The results were as follows : 1. Mean cervical length of promigravidsa were 2.2 +or- 0.5 cm, and those of multigravidas were 2.6 +or- 0.7 cm, there was a significant difference between two groups(p$lt;0.05). 2. A relationship was not found between cervical length and different gestational age in fullterm gravidas(p$gt;0.1). 3. There were no significant differences between cervical length and labor onset and cervical length and duration of labor(p$gt;0.1).

난소의 양성기형종에서 발생한 편평상피세포암 1 례와 피지선암 (Sebaceous Carcinoma) 1 례

한치동,오훈규,류상철,한경환 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.6

저자 등은 난소 낭성기형종에서 발생한 편평상피 세포암 및 피지선암종으로 악성변화를 일으켰던 2례를 보고하는 바이다. The mature cystic teratoma is the most common ovarian germ cell neoplasm and comprises approximately 10~20% of all ovarian tumors. It contains of all three germ layers. There are many complications in dermoid cyst such as rupture, torsion, infection, suppuration, and rarely malignant change. Squamous cell carcinoma or sebaceous carcinoma in a ovarian dermoid cyst is a rare entity, and especially sebaceous carcinoma is very rare case. We experienced a case of squamous cell carcinoma and a case of sebaceous carcinoma arising in mature cystic teratoma of the ovary. Two patients were performed total abdominal hysterectomy and bilateral salpingoophorectomy.

子宮筋腫의 結合組織의 超微形態學的 變化

韓治東,郭精植,孫泰重 慶北大學校 醫科大學 1986 慶北醫大誌 Vol.27 No.3

저자는 인체에서 적출된 자궁근종을 전자현미경으로 관찰하여 자궁근종의 기질조직의 미세형태학적 변화를 검색하고 자궁근종의 기질조직의 특징과 종양의 생물학적 성장과의 관계를 규명하고자 하였으며 그 결과는 다음과 같다. 자궁근종의 간질은 대부분 교원조직으로 형성되었으며 그 양은 정상자궁보다 증가되었고 교원섬유의 배열이 불규칙한 곳이 있었따. 다당류를 함유한 간질조직은 기저판과 교원섬유가 대부분이었고 기질물질에는 거의 볼 수 없었다. 탄력조직은 종양의 간질조직에 거의 없었으며 종양이 변성된 곳에는 교원섬유의 양이 감소되었으며 유기적인 구조물은 없었다. 이러한 소견으로 보아 자궁근종이 간질조직은 풍부한 교원조직으로 형성되었으며 종양의 2차적인 변성은 종양세포에서 유래된 collagenase의 역할에 의할 것이라 생각된다. The author studied on the ultrastructure of connective tissues of uterine leiomyoma extracted from the patients to investigate characteristics of connective tissues in the leiomyoma and its correlation with biological behavior of the tumor. PAM stain for study of polysccharides and Kajikawa stain for elastic tissue were performed. The interstitium of the leiomyoma was almostly composed of collagen and its amount was more abundant than that in normal myometrium. Focal disarrangement of collagen fibrils appeared. On PAM stain, collagen fibers and basal lamina of the tumor cells were positively stained. The elastic tissue was very scanty without areas aroung blood vessels. In areas of degenerated tumor tissue, the collagen fibers were decreased in amount and no organoid structures were present. Based on these findings, the interstitium of uterine leiomyoma was composed mainly of collagen tissue. It would be considered that the secondary degeneration of the uterine leiomyoma was caused by collagenase derived from the tumor cells.

악성 Brenner 종양 1 예

한치동,김용진,김미숙,박영길,지청수,홍성연,박미옥 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.7

저자들은 매우 드문 것으로 알려진 악성 Brenner 종양 1예를 경험하였기에 간단한 문헌 고찰과 함께 보고하는 바이다. The Brenner tumor is a relative rare ovarian neoplasia and the malignant Brenner tumor is very rare. We present a postmenopausal patient with a huge pelvic mass with vaginal spotting. Computed tomography scanning showed suspicious ovarian malignancy and tumor marker studies showed slightly elevated CEA and CA 125. Total abdominal hysterectomy and bilateral salpingooophorectomy with omentectomy was done. Histologic diagnosis was a malignant Brenner tumor, FIGO stage Ia. We applied postoperative chemotherapy (cyclophosphamide and cisplatin) six times. And then we report a case of malignant Brenner tumor.

난소임신 2예

한치동(CD Han),신수재(SJ Shin),정승균(SK Chung),김성도(SD Kim),안재영(JY Ahn) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.3

Primary ovarian pregnancy is comparatively rare in ectopic pregnancy and the Spiegelberg`s criteria should be fulfiled for the diagnosis of ovarian pregnancy. Thw cases of ovarian pregnancy were seen in recent years at Korea General Hospital and presented with a brief literature.

수두감염으로 인해 특발성 혈수판감소성자반증 ( ITP ) 가 병발된 만삭임부 1 례

한치동 ( CD Han ),허창규 ( CK Huh ),이헌수 ( HS Lee ) 대한산부인과학회 1991 Obstetrics & Gynecology Science Vol.34 No.11

저자들은 수두감염으로 인해 특발성 혈수판감소성자반증이 동반된 만삭임산부 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. The prevalence of varicella infection during pregnancy is reported to be about 8 per 60,000. Varicella infections during pregnancy occasionally may result in serios maternal illness and also may result in serious damage to fetus or to the newborn, specially infants born to women who develop disseminated varicella four days or less prior to delivery. We experienced a case of the I.T.P. in fullterm gravida due to chickenpox infection. Here we present this case with the brief review of references.